Effects of "Xuetangping", a herbal prescription composed of Radix Astragali, Radix Trichosanthis, Rhizoma Dioscoreae, Fructus Corni, and Radix Salviae Miltiorrizae, on serum sugar of mice or rats with diabetes mellitus induced by alloxan were studied. The result showed that "Xuetangping" (2.5g/kg, ig qd 7d or 14d ) lowered serum sugar in diabetic mice but not in normal mice.Xuetangpinec 1.5g/kg,ig qd 7d or 14d in diabetic in a dose and time dependent manner. While 14d, "Xuetangping" also decreased the value of serum lipid and the content of serum lipid peroxide. This result suggest that antiperoxide activity of this Chinese herbal formulation may be related to its reduction in serum sugar

Potassium quercetin phosphate ( PQP, iv 10~20mg/kg ) significantly decreased the size of infarction and S-T segment elevation induced by coronary artery ligation in rabbits (P

Effects of methylflavonolamine (MFA) on arachidonic acid(AA) metabolism pathway were studied. MFA (iv 40 mg ? kg-1) lightened the acute pulmonary thromboenblism signs in mice and reduced the mortality induced by AA. MFA(12. 5~200?mol ? L-1) in vitro dose-dependently inhibited rabbit platelet aggregation induced by AA. MFA(0.1~0. 4mmol ? L-1) in vitro dose - dependently inhibited rabbit platelet malondiadehyde(MDA) formation in-duced by AA. MFA(0. 4mmol?L-1) inhibited platelet MDA formation in rabbits induced by thrombin and AA. While propranolol inhibited MDA formation induced by thrombin but not by AA. MFA (0.4 mmol ? L-1) did not affect cAMP content in rabbit platelet. These results suggest that inhibitory effect of MFA on platelet AA metabolism may be one of the mechanism by which MFA inhibited platelet aggregation.

Objective To explore the value of diffusion weighted imaging (DWI)as a quantitative analysis tool for chronic cervical spondylotic myelopathy (CSM)with 3.0T MRI.Methods Cervical routine MR T2-weighted imaging(T2 WI)and diffusion weighted imaging were performed in 38 patients with cervical spondylotic myelopathy (CSM group)and 20 healthy volunteers (control group),and sagittal image of apparent diffusion coefficient (ADC)was reconstructed.The number of high T2 signal of the spinal cord were calculated in both healthy volunteers and CSM patients.The ADC values of CSM groups were measured in C3,T1 -C2 level and the compression or abnormal signal parts of the spinal cord;the control group measured C3、C4-C6 and T1 -T2 level in the spinal cord.Results There were 3 cases,1 case,6 cases and 8 cases high T2 signals in CSM patients from Ⅰ to Ⅳ levels,while there were 2 cases show high T2 signals in control group,respectively.The mean ADC values of the compression part were gradual-ly increased in CSM group from Ⅰ to Ⅳ level.There were significant differences of the mean ADC values of compression part be-tween the control group,CSMⅠ-Ⅱ level and the CSM Ⅳ level.Conclusion From our study,the change of ADC value of spine cord occured earlier than the change of signal in CSM patients.Therefore,the ADC value of spine cord might reflect the degree of spinal cord compression from CSM patients.

Effects of thioproline on thrombus formation and platelet function were studied. Thioprolline given in vitro ( 1 g/L ) or ex vivo ( iv 25mg /kg ) shortened length of thrombi and decresed the wet and dry weight of thrombi in rabbits or rats. Thioproline given iv vitro ( 1 g/L ) or ex vivo ( iv 50mg/kg ) inhibited platelet adhesion and aggregation induced by ADP in rabbits.

OBJECTIVE To investigate whether stromal cell-derived factor-1α (SDF-1α) might be able to prevent senescence of endothelial stem cell (ESC) and also study its effects on the telomerase activity. METHODS Total mononuclear cells (MNCs) were isolated from peripheral blood by density gradient centrifugation, and then the cells were plated on fibronectin-coated culture dishes. After cultured for 4 d, attached cells were divided into control and SDF-1α 1, 10, 50 and 100 μg·L~(-1) groups. ESC became senescent as determined by acidic β-galactosidase staining. The proliferation of ESC was assessed by MTT assay and colony-forming capacity. Telomerase activity was measured by telomerase-PCR ELISA and the phosphorylation of Akt was determined by using Western blotting. RESULTS Ex vivo prolonged cultivation of ESC led to rapid onset of ESC senescence. Compared with control group, SDF-1α concentration-dependently inhibited the onset of ESC senescence, maximum at 100 μg·L~(-1) (40.8±7.1 vs 17.5±3.0; P<0.01). Moreover, SDF-1α 100 μg·L~(-1) increased ESC proliferation (0.22±0.02 vs 0.39±0.04; P<0.01) and ESC colony-forming activity (7.8±2.2 vs 22.4±3.4). Compared with control group, SDF-1α 100 μg·L~(-1) also increased telomerase activity (0.34±0.05 vs 0.57±0.09; P<0.01). In addition, SDF-1α treatment of ESC stimulated a concentration- and time-dependent Akt phosphorylation. CONCLUSION SDF-1α-induced prevention of ESC senescence leads to the potentiation of proliferative activity, and clonal expansion, which may be related to the activation of telomerase and Akt phosphorylation.

ObjectiveToinvestigatetheriskfactorsofepilepticseizuresanditseffectonclinical outcome in patients w ith cerebral venous sinus thrombosis (CVST). Methods The patients w ith CVST w ere enrol ed retrospectively. The risk factors, clinical manifestations, and imaging data w ere col ected. The data of an epileptic seizure group and a non-epileptic seizure group w ere compared. Results A total of 69 patients with CVST were enroled, including 32 (46.38%) secondary epileptic seizures. In the aspect of clinical manifestations, more patients show ed hemiplegia in the epileptic seizure group (37.50%vs.15.63%; χ2 =5.240, P=0.020). Imaging examination show ed that more patients in the epileptic seizure group presented w ith bleeding ( 29.41%vs. 10.81%; χ2 = 3.818, P= 0.047 ), more lesion involving frontal lobe (31.25%vs.10.81%; χ2 =5.008, P=0.023), and temporal lobe (43.75%vs.8.11%; χ2 =7.318, P=0.005), and the thrombosis sites w ere more common in the superior sagittal sinuses (65.63%vs.40.54%;χ2 =4.264, P=0.036). Multivariate logistic regression analysis show ed that focal neurological deficits (odds ratio 5.167, 95% confidence interval 1.993-15.764; P=0.004) and superior sagittal sinus thrombosis (odds ratio 0.126, 95% confidence interval 0.042-0.370; P=0.039) w ere the independent risk factors for patients w ith secondary epileptic seizures. There w ere no significant differences in hospital mortality (6.25%vs.2.7%; χ2 =0.512, P=0.469 ) and 90 day 90-day ful recovery rate ( defined as Barthel Index >60) (81.25%vs.86.47%; χ2 =0.346, P=0.793) betw een the epileptic seizure group and the non-epileptic seizure group. Conclusions Focal neurologic deficits and superior sagittal sinus thrombosis are the independent risk factors for secondary epileptic seizures, how ever, secondary epileptic seizures is not associ-ated w ith in-hospital mortality risk and 90-day clinical outcomes in patients w ith CVST.

Objective To analyze proton MR spectroscopy (1H-MRS) characteristics of kidney in vivo, and to investigate the changes and applications of metabolites of kidney on 3.0T MR. Methods Fifteen patients with renal cell carcinoma and 50 healthy volunteers underwent single-voxel PRESS sequence MR scan on 3.0T scanner. Results Satisfied spectra of 13 patients and 48 volunteers were obtained. There were four main groups resonance peak: cholesterol and the unsaturated parts of the olefinic region of fatty acids (Chol+Unsat), water, choline metabolites (Cho) and lipids (Lip). The ratio of the Chol+Unsat to Lip was 5-fold lower in renal cell carcinomas group than that in contrast group (F=4.764, P=0.04). Conclusion A number of chemical compounds pertaining to metabolism in kidney can be quantitative analyzed, which may offer assistance for diagnosis of renal cell carcinoma.

Objective To introduce the applied value of Soap-Bubble reformatting and quantitative analysis of coronary MRA.Methods Reformatting and quantitative coronary of 3D coronary MRA were performed in twenty cases by using Soap-Bubble visualization following computer-assisted image segmentation respectively.The average vessel length,diameter and sharpness of coronary vessel can be measured.The imaging of coronary vessel was quantitative analyzed.Results 3D coronary MRA was successfully completed in 20 cases.The average vessel length of RCA /LM+LAD/LCX was(111?31) mm/(84?14) mm/(48?12) mm.The average vessel diameter of RCA /LM+LAD/LCX was(3.0?0.4 mm)/(2.9?0.3) mm/(2.4?0.2) mm.The sharpness of RCA /LM+LAD/LCX was(44?13)%/(43?15)%/(31?18)%.Conclusion Soap-Bubble enables the simultaneous display of multiple coronary segments in one 2D representation.The coronary vessel can be quantitative analyzed.

Objective: To investigate students’ satisfaction on school feeding program in 8 cities in China, and to provide the basis for improving school feeding management and lunch quality. Methods: Multi-stage random cluster sampling method was used to randomly select the second, fifth and eighth-grade students from 67 primary and middle schools in 8 cities including Beijing, Shanghai, Harbin, Shijiazhuang, Guangzhou, Changsha, Bengbu and Pinghu. Results: A total of 15 475 students participated in the survey, 15 170(98.0%) of which were valid questionnaires. A total of 13 297(87.7%) students had lunch in school. Twenty-six(38.8%), 14(20.9%) and 27(40.3%) schools served lunch by self-run canteens, custody canteens, and food delivery companies respectively. Twenty-one schools provided milk or yogurt for lunch, accounting for 31.3%. The reported rates of very satisfied, satisfied, moderate, dissatisfied, and extremely dissatisfied among students were 40.8%, 28.1%, 20.1%, 7.3%, and 3.6%, respectively. The satisfaction rate of the eighth-grade students was lower than that of the second-and fifth-grade(56.9% vs 77.1% vs 73.5%). The satisfaction rate among students from schools with self-run canteen was higher than that of custody canteens and food delivery companies(73.8% vs 60.5% vs 66.2%). The satisfaction rate of school lunch is highest in dining surrounding (75.3%), followed by amount of meals(71.6%), food hygiene(71.1%), food combination(65.4%), and the appearance of the food(60.5%), and food taste(55.9%). Conclusion The satisfaction rate of students for school lunch was acceptable. The food taste is the main factor for students’ dissatisfaction. Schools should be encouraged to provide lunch in the self-run canteens with tasty food while meeting the nutritional standard.