1.Clinical observation of ginkgo dipyridolum injection for treatment of 96 patients with acute cerebral infarction
Chinese Journal of Primary Medicine and Pharmacy 2009;16(7):1254-1255
Objective To observe the clinical curative effect of ginkgo dipyridolum injection for treatment of 96 patients with acute cerebral infarction. Methods 192 patients were divided into two groups, 96each: treated group and control group. Treated group patients was treated with ginkgo dipyridolum injection to intravenous drip, The control group patients was treated witht taushin injection. 2 weeks were 1 course. To observe and analyse the score、the clinical curative effect of dysneuria,the side effects after use the medicine. Results The clinical effective rate with ginkgo dipyridolum injection was 93.7%, the control group' s was 77.1%. The differences in the clinical effective rate between treated group and control group were significant (P < 0.05). Conclusions It is safe and has good effect to treat acute cerebral infarction with ginkgo dipyridolum injection. The clinical curative effect of ginkgo dipyridolum is better than tanshin injection's.
2.Clinical study of 22 male patients with systemic lupus erythematosns
Chinese Journal of Primary Medicine and Pharmacy 2008;15(8):1301-1302
Objective To study the clinical characteristics of systemic lupus erythematosus in male patients.Methods Clinieal data of 52 male patients with systemic lupus erythematosus were studied retrospectively.Results The age of onset of the male patients varied greatly and were predominant at the age of 10~20.Male patients were more susceptible to nephritis and more serious.The antibodies such as anti-ANA,anti-Sm and anti-ds-DNA were closely related to the severity of lupus nephritis(P<0.05 of P<0.01).Conclusion There are certain characteristics in male SLE,such as age of onset,such as age of onset,clinical manifestations and specific antibodies.
3.Application of oncolytic adenovirus in cancer gene therapy
Journal of International Oncology 2008;35(7):483-485
Oncolytic adenovirus-mediated E1A gene therapy may be a useful therapeutic approach for cancer treatment.In addition to direct lysis,viruses also mediate exogenous tumor suppressor genes inducing antitumor efficacy.Vectors need further investigation to improve the targeting and effectiveness in vivo.
4.Treatment progress of young patients with high-risk diffuse large B-cell lymphoma
Journal of Leukemia & Lymphoma 2015;24(9):566-569
Diffuse large B-cell lymphoma (DLBCL) is the most common adult lymphoid malignancy accounting for 30 %-40 % of all non-Hodgkin lymphoma (NHL).Young patients with high-risk DLBCL as a special group with poor clinical prognosis still can not receive standard treatment protocols in clinical practice at present.Conventional chemotherapy, combination of rituximab (R) to conventional CHOP chemotherapy, R-CHOP-like protocol, high-dose chemotherapy and autologous hematopoietic stem cell transplantation have not fully reversed the poor prognosis.This review focuses on the recent advances and future direction in the treatment of the young patients with high-risk DLBCL.
6.New therapeutic strategies for eradication of Helicobacter pylori in children
International Journal of Pediatrics 2016;43(12):905-908,909
Helicobacter pylori is closely related to many digestive system diseases,such as chronic gas-tritis,digestive ulcer,gastric mucosa associated lymphoid tissue lymphoma and gastric cancer,also leads to chil-dren with iron deficiency anemia,growth retardation,asthma,allergic diseases etc. So it is a key strategy to pre-vent and treat these diseases by eradicating Helicobacter pylori. Due to the increasing rates of antimicrobial resist-ance of clarithromycin and metronidazole,the eradication rate of standard triple therapy is 1ess than 80%in re-cent years. Especially in areas of high clarithromycin resistance and standard triple therapy have not been recom-mended as first-line therapy,it is necessary to investigate a new therapeutic strategy to improve the eradication rate of Helicobacter pylori. The new treatments for eradication of Helicobacter pylori in children is mainly based on sequential therapy,bismuth-based therapy,concomitant therapy and probiotics treatment. This article reviews the research progress of the new treatments in recent years.
7.Study on hospitalization benefit equity of the basic medical insurance programs in China
Yi YAO ; Yi CHEN ; Yuliang CHEN
Chinese Journal of Health Policy 2017;10(3):40-46
Objective: To analyze the equity of benefit for inpatient services under the three basic medical insurance programs in China.Methods: Using the baseline survey data collected by China Family Panel Studies (CFPS) in 2010, and the two-part model was applied to explore whether the insured groups with different income levels had different aspects on inpatient rate and the compensation of hospitalization expenses in health insurance coverage.Results: There was no significant difference in the inpatient service utilization rate for different income groups, but the highest and second highest income groups reimburse more expenses than the lowest income group, that is 36.5% and 26.3%, respectively.Specifically, the income level and the compensation amount are not significantly correlated in the Urban Employer Medical Insurance (UEMI) program;the compensation amounts to be paid by urban residents are basically increasing with the increase of the income level;and there is a moderate discrepancy between the highest and the lowest income groups in the New Rural Cooperative Medical System (NCMS).Conclusion: The benefit equity is obviously fair in terms of inpatient service utilization rate, but the benefit degree increases for higher income groups, which shows that there are unfair inequalities related to the income at the level of reimbursement.In terms of program comparison, the benefit degree equity is higher for the UEMI program, followed by the URMI program and the NCMS program is the worst.Besides, the impatient rate and reimbursement amounts are significantly lower for NCMS program participants.The government should merge URMI and NCMS programs, actively promote the integration of basic medical insurance system by strengthening the construction of the medical assistance system and improving the system of catastrophic disease medical expenditure insurance in order to achieve better benefit equity.
8.Danger points and strategy for pancreaticoduodenectomy
Chinese Journal of Digestive Surgery 2012;11(1):15-18
Pancreaticoduodenectomy (PD) is the procedure for treating adenocarcinoma in periampullary region.This involves resection of multiple organs and complex reconstructions.The modern surgery has witnessed the dramatic improvement in outcomes after PD.Mortality has dropped to less than 4%,however,the complication rate remains high,making this procedure still a big challenge for most surgeons. PD is so complicated that even small mistakes could jeopardize the whole procedure and outcomes.With experiences of over 1000 PDs,we discuss the challenges of this procedure and strategies to deal with them.
9.Yishi Oral Liquid Treat Middle and Old Aged Asthenopia 65 Cases
Journal of Zhejiang Chinese Medical University 2013;(9):1078-1079
[Objective] To observe Yishi Oral Liquid effect on treating middle and old aged asthenopia. [Method] Choose 125 cases of middle and old aged asthenopia, and randomly divide them into observation group 65 cases treated wutg Yishi Oral Liquid, and control group 60 cases with Mingmu Rehmannia Pil;meanwhile both groups reduced the time with the eye and made massage on the acupoints around the eyes. [Result] With 2~4 weeks of treatment, in the observation group, 23 cases were cured, 25 had marked effect, 13 effective, 11 had no effect, the total effective rate was 93.85%;for the control one, they were respectively 14,19,16,11 and 81.67%. The comparison showed the observation group was better than control one. [Conclusion] Yishi Oral Liquid treating middle and old aged asthenopia has good clinical effect, can obviously relieve the symptoms of blurred vision, phengophobia, lacrimation and aningerestling eyes, helpful to recovering eyesight.
10.Effectiveness of relevant examination on visual function assessment and retinal disease detection before cataract surgery
International Eye Science 2015;(2):342-345
To evaluate the effectiveness of applying visual electrophysiological examination, including flash visual evoked potentials ( FVEP ) , flash electroretinogram ( FERG ) , pattrn electroretinogram ( PERG ) , fundus photography, eye B-type ultrasound, optical coherence tomography ( OCT ) , on visual function assessment and retinal disease detection before cataract surgery. METHODS: Visual elctrophysiological examination, fundus photography, eye B-type ultrasound and OCT were applied in 148 cases ( 196 eyes ) . The positive rate was analyzed according to the results of FVEP, FERG ( or PERG ) , fundus photography, eye B - type ultrasound and OCT.RESULTS: ln 148 cases ( 196 eyes ) , vitreous opacities was showed in 165 eyes ( 84. 2%) by eye B - type ultrasound examination, 31 eyes (15. 8%) without access to B-type ultrasound image; success for fundus camera images in 161 eyes (80. 6%), and unable to get image in 35 eyes (19. 4%); the VEP and ERG in 58 eyes (29. 6%) were get valuable, and the VEP and ERG were saw no obvious abnormal in 138 eyes ( 70. 4%); success for OCT image in 167 eyes (85. 2%), without access to OCT image in 29 eyes (14. 8%). CONCLUSlON: Visual elctrophysiological detection, fundus photography, eye B-type ultrasound and OCT can predict the preoperative visual acuity of cataractous patients. A variety of inspection methods complement each other, can further improve detection rate of retinal diseases and other eye disease before cataract surgery.