Objective The purpose of the present study was to examine the reliability and validity of the Chinese version of the impulsive-premeditated aggression scale (IPAS) in a sample of Chinese adolescents with aggression. Methods 126 adolescents completed the IPAS,Barratt impulsive scale and self-report questionnaires. In order to assess test-retest reliability, the IPAS was re-administered to 30 participants 3 weeks later.Results Item analysis showed that IPAS had satisfactory item discrimination, 6 items were excluded in the later analysis. The internal consistency of the IPAS Cronbach alpha was 0.77 and the test-retest reliability was 0.74.Exploratory factor analysis demonstrated two stable factors of aggression with good internal consistency and construct validity, the value of KMO was 0.646, the χ2 value of Bartlett test was 691.93 ( P <0.001). The confirmatory factor analysis showed that the value of χ2/df,GFI,AGFI,RMSEA were 1.42,0.874,0.837 and 0.058 respectively.The whole scale and the two secondly scales all correlated with BIS-11 and MOAS.Conclusion The results of the current study indicate that the Chinese version of the IPAS is a useful tool to subtyping aggressive behavior among adolescents, but it still need to be modified to apply in China.

Objective To explore a preliminary health behavior self-efficacy scale for functional dyspepsia patients,and supply a practical evaluation tool for clinical nurses.Methods Through literature review,group discussion and expert interview,the authors established the preliminary index system.The Delphi method was used to organize two rounds of 20 experts consultations.Results In the two rounds of expert consultations,experts positive coefficients were 100％,respectively.The authoritative coefficient of experts was 0.83,respectively.The Kendall's W coefficients were 0.23 and 0.29.The evaluation system included 5 dimensions,11 evaluation indicators,and 42 evaluation items.Conclusions The reliability of the self-efficacy scale developed with Delphi method is relatively high and it can acted as an evaluation tool for self-efficacy and health education of patients with functional dyspepsia.

Objective To identify a novel HLA-B allele in Chinese Han population.Methods No full matched result was obtained in HLA-B locus in HLA typing for China marrow donor program(CMDP) using bi-allelic sequence-based typing(SBT).A confirmatory test for novel HLA allele was performed with mono-allelic SBT.Results B * 15∶05∶01 was confirmed and another allele should be a B * 54new.The B * 54new has 2 nt changes from the closest matching HLA-B * 54∶01∶01 at nt 559,560 where AC→GA(codon163ACG→GAG),led to a coding change,163T→E.Conclusion A novel HLA-B allele was confirmed and officially named HLA-B * 54∶26 under the Genbank Accession number JN209963 by the WHO Nomenclature Committee for Factors of the HLA System in February 2012.

Objective:To discuss the role of clinical pharmacists in perioperative drug treatment for a patient after renal transplan-tation. Methods:Clinical pharmacists participated in the drug therapy for a patient after renal transplantation. Pharmaceutical care and health education were performed for the patient in the aspects of immunosuppression, anti-hepatitis B virus, gastric mucosa protection, diarrhea, acute rejection and the other treatment programs. Results:The participation of clinical pharmacists in the clinical treatment for the patient improved therapeutic scheme and promoted therapeutic efficacy. Conclusion:The participation of clinical pharmacists in clinical drug therapy for patients can provide individualized service to improve reasonable, effective and economical drug use.

Objective To observe the effect of midazolam plus propofol administered for colonoscopy on cognitive function in middle-aged and aged patients. Methods One hundred and thirty six patients, ASA I and II, aged 40~75 years and undergoing colonoscopy were randomized to propofol group (group P, n=68) and propofol plus midazolam group (group PM, n=68). Baseline cognitive function was measured using Mini mental state exami-nation (MMSE) before anesthesia and the cognitive testing was repeated 10 minutes after emerging from anesthesia. BP, HR, SpO2, analgesic effect and sedative drug doses in both groups were recorded. Procedure time, recovery time and Rasmay sedation score were both recorded. Results Recovery time was significantly longer in group PM than that in group P (P<0.05). The total dose of propofol was significantly smaller in group PM than that in group P (P<0.05). MMSE score of both groups decreased, but the incidence of cognitive decline and the level of cognition in group PM were more notable than those of group P (P<0.05). Conclusions Midazolam plus propofol and propo-fol alone administered for colonoscopy could both increase the incidence of cognitive decline, and the effect of the former is more notable, but midazolam added to propofol could reduce the dosage of propofol.

Objective To find out the prevalence of bullying behaviors among urban middle school students in China. Methods An anonymous questionnaire survey was conducted among middle school students selected by multiply stage cluster random sampling in 18 provinces in China. 187 328 self- administration questionnaires were finished by students from grade 7 to 12 in urban middle school(male,86 472; female, 91 106), in which 177 578 were valid. Results Bullying was common in urban middle school students in China. Multiple bullying behavior also existed. About 66.1% of boys and 48.8% of girls suffered from one or more kinds of bullying; 8.1% of boys and 2.9% of girls suffered from four or more kinds of bullying. Boys were more likely to be bullied than girls. Malicious teasing was the most common bullying behavior(43.2%), followed by sexual bullying behavior(27.0%). In addition to malicious teasing and sexual bullying, the prevalence of other types of bullying declined when the grade was increasing. Residential students were more likely to be maliciously teased, excluded or isolated and sexual bullied than non-residential students. Students from single-parent or recomposed-families were more likely to be bullied than other students. Male and ordinary school students, students living with single or step-parents were more likely to suffer multiple bullying behaviors at the same time. Conclusion The suggesting among students was associated with personal, familiar and social factors, mobilize more social forces and comprehensive actions to be taken to prevent bullying among students.

Objective To investigate the expression of glutamine synthetase ( GS ) in prostate cancer and the utility of 13 N?NH3 PET/CT in detecting prostate cancer. Methods The uptake ratio of 13 N?NH3 and the expression of GS in PC3 and DU145 cells were measured by Western blot and PCR methods. A total of 34 patients with suspected prostate cancer underwent 13 N?NH3 PET/CT imaging and prostate biopsy. Immunohistochemistry staining of GS was performed and Gleason scores of tumors were evaluated. One?way analysis of variance, the least significant difference?t test and Spearman correlation analysis were used to an?alyze data. Results The uptake of 13 N?ammonia in PC3 and DU145 cells elevated along with the decrease of glutamine in medium. The expression of GS mRNA and protein also increased when glutamine was de?creased. In biopsy samples, the mean GS expression scores of prostate cancer, benign prostatic hyperplasia (BPH) and prostatitis were 7.76±2.57, 3.98±2.60, 3.34±0.36, respectively (F=36.85, t1=7.97, t2=4?45, all P<0.05), which had a weak correlation with Gleason scores (rs=0.52, P<0.05). In 34 patients, the mean SUVmax of prostate cancer segments (1.56±0.58 and 1.14±0.22;F=5.966, t1=2.63, t2=2.65, all P<0.05). There was a weak correlation between GS expression scores and the uptake of 13 N?ammonia in prostate cancer (rs=0.47, P<0.05). Conclusions Up?regulated expression of GS is common in prostate cancer cells. GS is the main reason for the uptake of 13 N?ammonia, which is a useful tracer for prostate cancer imaging.

Objective To investigate the elasticity and hemodynamics of femoral artery in patients with type 2 diabetes mellitus (T2DM).Methods Subjects recruited in this study were divided into three groups,healthy control ( n =30),T2DM patients with femoral arterial intima-media thickness(IMT) ＜1.0mm ( n =32) and IMT≥1.0 mm( n =22).The IMT and diameter were measured by two-dimensional ultrasound.The blood velocity in early and late systolic stages and early diastolic reverse blood velocity,resistance index and pulsatile index were measured by pulse Doppler.The stiffness parameter,pressurestrain elasticity modulus,arterial compliance,argumentation index and one-point pulse wave velocity were measured by echo-tracking technique.Results The early diastolic reverse blood velocity,resistance index,pulsatile index,stiffness parameter,pressure-strain elasticity modulus and one-point pulse wave velocity were significantly elevated in T2DM patients compared with healthy control (P ＜ 0.05),the arterial compliance was significantly lower in T2DM subjects.Stiffness parameter,pressure-strain elasticity modulus and one-point pulse wave velocity were more pronounced in the patients with IMT≥1.0 mm than those with IMT ＜ 1.0 mm ( P ＜0.05).Conclusions There is atherosclerosis in femoral arteries in patients with T2DM.A decrease in arterial elasticity occurs prior to the morphological changes in vascular atherosclerosis,the arterial elasticity abnormality causes insufficient blood supply to peripheral tissues.

Objective:To discuss the training method of teachers for clinical pharmacists. Methods:The application of problem-based learning ( PBL) in the training of teachers for clinical pharmacists was introduced. Results and Conclusion: PBL centers on trainees, and can notably improve the learning enthusiasm, expression and communication skills and logical thinking preciseness of the trainees. Meanwhile, the method shows great significance in improving the teaching ability.

Objective:To evaluate the effects of problem-based learning(PBL)mode in the clinical pharmacist teacher training. Methods:The specific implementation content,process and organizational methods of PBL mode were introduced in the clinical pharmacist teacher training. Results:Through the scientific analysis on the student marks,the results showed that the theoretical test scores of the students were increased by average 30 points when compared with those before the training,and the average score of clinical practice was more than 85 points. The achievement fully reflected the significant effect of PBL teaching courses and the reasonable design of teaching plan. Conclusion:The first application of PBL mode in the clinical pharmacist teacher training was welcomed by all the students. The teaching method not only improves the purpose and funny of learning,but also allows students to explore a targeted manner and apply theoretical knowledge in order to improve the analysis and problem-solving skills,and obtain more systematic and solid theoretical knowledge to closely integrate with the clinical needs, therefore,PBL mode is worthy of promotion.