3.Progress in research on the relationship between carcinoma-associated fibroblasts and oral carcinoma.
Chinese Journal of Stomatology 2012;47(11):701-703
Carcinoma, Squamous Cell
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metabolism
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pathology
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Chemokine CCL2
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metabolism
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Fibroblast Growth Factor 7
;
metabolism
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Fibroblasts
;
metabolism
;
pathology
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Gelatinases
;
metabolism
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Humans
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Membrane Proteins
;
metabolism
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Mouth Neoplasms
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metabolism
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pathology
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Neoplasm Invasiveness
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Neoplasm Metastasis
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Serine Endopeptidases
;
metabolism
7.A case report of tongue actinomycosis.
Ji-an HU ; Song-ying LI ; Yi-ning LI
Journal of Zhejiang University. Medical sciences 2006;35(5):579-580
Actinomycosis
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pathology
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Female
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Humans
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Middle Aged
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Tongue Diseases
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microbiology
;
pathology
9.Application of simulator first aid skills training in disaster medical rescue
Yongda MA ; Su LIU ; Hong YAN ; Liyong CHEN ; Qiang CHEN ; Yi HU ; Ji PENG
Chinese Journal of Medical Education Research 2015;(7):724-727
First aid skills are very important in the process of disaster medical rescue methods. Some first aid skills is rarely applied in clinical work at ordinary times, resulting in relevant medical personnel grasp of these skills being not enough skilled. This training method combined with the sim-ulator, has the characteristics and advantages of being close to the real, operational and repeatable. The main training program consists of 6 basic skills such as ventilation, hemostasis, bandaging, fixing, handling, basic life support. By simulating the real disaster scenario and simulation cases, we have targeted a single first aid skills training and multiple comprehensive ability training of first aid skills to trainees. To evaluate the training effect we have examined the individual skills of our trainees, with excellent performance as the goal, and in the comprehensive skills ability assessment we have paid attention to the emergency team's team cooperation ability. By the application of comprehensive simu-lation training and evaluation, the trainees can master all kinds of first aid skills in a short period of time.
10.Activation of JAK-STAT1 signal transduction pathway in lesional skin and monocytes from patients with systemic lupus erythematosus
Jie LI ; Shuang ZHAO ; Mei YI ; Xing HU ; Ji LI ; Hongfu XIE ; Wu ZHU ; Mingliang CHEN
Journal of Central South University(Medical Sciences) 2011;36(2):109-115
Objective To study the activation of Janus protein tyrosine kinase (JAK)/signal transducer and activator of transcription 1 (STAT1) signaling pathway and its inhibitor-signal transducer and activator of transcription-1(SOCS-1) in patients with systemic lupus erythematosus. Methods A total of 45 patients with active systemic lupus erythematosus (SLE) and 30 healthy controls were randomly selected. Western blot was performed to measure the expression of Stat1 protein and phospho-Stat1 protein (an activated form of Stat1 protein) in the monocytes after stimulation with recombinant high mobility group box1 (rHMGB1) at various time points. Expression of Stat1 protein in the skin or lesional skin was also detected. Phasic expressions of SOCS-1 mRNA in the monocytes after rHMGB1 stimulation were detected by real-time reverse transcription-polymerase chain reaction. SOCS-1 gene expression in the skin or lesional skin was also detected. Results The expression level of Stat1 proteins in the monocytes from patients with SLE was higher than that from healthy controls (t=9.16,P<0.01) and positively correlated with SLE disease activity index (SLEDAI) (r=0.59,P<0.01). Expression of phospho-Stat1 in the monocytes from SLE patients was time-dependently upregulated after stimulation with rHMGB1 at various time points, while expression of SOCS-1 mRNA remained unchanged(all P>0.05). Expressions of phospho-Stat1 protein and SOCS-1 mRNA in the monocytes from healthy controls were increased transiently after stimulation with rHMGB1(all P<0.05). Both expressions of phospho-Stat1 protein and SOCS-1 gene in the lesional skin from patients with SLE were upregulated compared with those in normal skin from healthy controls (all P<0.01). Conclusion There are hyperactivation of JAK-STAT1 signaling pathway and negative feedback down-regulation of SOCS-1 in patients with systemic lupus erythematosus. HMGB-1 may be partly involved in the pathogenesis of SLE by the abnormal mediating function of JAK-STAT1 signal transduction pathway.