1.Clinical analysis of 201 cases of childhood acute myelocytic leukemia.
Jun-jie FAN ; Yi-huan CHAI ; Hai-long HE
Chinese Journal of Pediatrics 2007;45(11):873-874
Adolescent
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Child
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Child, Preschool
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Female
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Humans
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Infant
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Leukemia, Myeloid
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pathology
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physiopathology
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Male
2.Clinical study of medical collagen sponge in treatment of severe hepatic trauma
Dhijian YI ; Lanlan LI ; Dayuan HE ; Ruiling FAN
Chinese Journal of General Surgery 1993;0(03):-
Objective To investigate the effects of placing medical collagen sponge on the wound surface for severe rupture of liver.Methods In 132 patients with severe hepatic trauma , 68 cases were randomly enrolled in collgan spong treatment group, in which the hepatic wound was treated with collagen sponge,while the 64cases in control group were treated with commonly used gelatin sponge. Results The therapeutic results of collagan spong group were better than those of control group in the hemostatic time [(19.65?1.28)min vs (34.3?1.2)min], hemorrhagic volume [(301.57?56.8)mL vs (642.3?61.8)mL], abdominal cavity drainage volume[(380.45?12.34)mL vs (693.2?219.4)mL], recovery time of hepatic tissue [(30.30?6.42)d vs (62.1?7.2)d], postoperation complications (re-bleeding , and hepatobiliary leakage) [11.5% and 3.0% vs 6.3% and 9.5%], and hospital time stay [(24.01?4.89)d vs (35.8?5.9)d] (all with P
4.Study of Qingjinchangfei Drink for Treating 48 Cases of Acute Exacerbation Chronic Obstructive Pulmonary Disease(AECOPD)
Yaodong ZHONG ; Yi HU ; Fuyuan FAN ; Long HE
Journal of Medical Research 2006;0(06):-
Objective To observe the clinical efficacy of Qingjinchangfei drink for treating AECOPD.Methods We Used random number table to separate 84 patients in to two groups:treatment group and control group.The treatment group used western medicine conventional treatment and Chinese medicine decoction Qingjinchangfei drink.The control group used western medicine conventional treatment.Both two groups were 14 days treatment.We recorded the improvement of symptoms and signs everyday.We compared the lung function,inflammatory cytokines,such as IL-8、IL-2 before and after treatment in the two groups.Results The total efficient in treatment group was obviously better than that in control group.The indicators such as clinical symptoms,signs,pulmonary function indicators were obviously better than that in control group.Compared with before treatment,IL-8,ET,MDA and TNF-? in sputum and blood were obviously lower but IL-2 was obviously higher.Conclusion Qingjinchangfei drink plus western medicine conventional treatment for treating AECOPD was obviously better than western medicine conventional treatment.
5.Application of virtual reality simulators and surgical demonstration in laparoscopic operation training
Zhenqiang FANG ; Xiangwei WANG ; Shanhong YI ; Fan HE ; Gang YE
Chinese Journal of Medical Education Research 2012;11(5):528-530
Virtual reality simulators and surgical demonstration were used in laparoscopic teaching combining teacher' guiding with students' practice to improve the teaching effectiveness hecause of the limitations of the traditional apprenticeship teaching methods.The new method was applied for 2 cycles and for 6 weeks.The results showed that the teaching methods of virtual reality simulators combined with surgical demonstration can significantly improve the effectiveness of laparoscopic teaching and shorten the initial learning curve,therefore it is worth promoting in laparoscopic operation training and teaching.
6.Study on antithrombogenicity and surface heparinization of small intestinal submucosa
Ben-Song HAN ; Cun-Yi FAN ; Sheng-He LIU ;
Chinese Journal of Orthopaedic Trauma 2004;0(10):-
Objective To study surface heparinization of small intestinal submucosa(SIS)and an- tithrombegenicity of beparinized SIS films with plasma initiation technique for the engineering vascular scaffolds. Methods The SIS films were grafted with heparin by hypothermia plasma initiation technique.The blood com- patibility of the modified SIS films was assessed by observing blood coagulation time in vitro and the long term pa- tency of hepafinized SIS vascular scaffolds directly under the circulation of blood.Results The hypothermia plasma initiation method could attach heparin onto the SIS surface,The water contact angle of SIS films modified with heparin was decreased while the surface free energy and hydrophilicity increased.The prothrombin time(PT),ac- tivated partial thromboplastin time(APTT)and thrombin clotting Time(TT)of the SIS films modified with heparin were prolonged obviously.Small caliber engineering vascular scaffold made of heparinized SIS films kept the patency for six weeks.Conclusion Heparin can be attached to SIS films by hypothermia plasma initiation technique.The modified surfaces provide good and persistent antithrombogenicity,and possess potent blood compatibility,
7.Correlation between N-terminal Pro-brain Natriuretic Peptide and Cardiac Diastolic and Systolic Function
Yi CAI ; Li FAN ; Kunlun HE ; Lihui YAN ; Wenxiu LENG
Chinese Journal of Rehabilitation Theory and Practice 2009;15(11):1021-1023
Objective To study the correlation between N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac diastolic and systolic function. Methods 60 New Zealand male rabbits were randomly assigned to two groups. The abdominal aorta 1 cm just above right renal artery were constricted in operated group. The clinical manifestation of heart failure was observed, and cardiac structure and function were investigated with echocardiography. Concentration of serum NT-proBNP was determined regularly. Results The concentration of NT-proBNP was correlated with Sm(r=-0.635,P=0.000), Em(r=-0.693,P=0.000), E/Em(r=0.688,P=0.000), E/Vp(r=0.707, P=0.000), and EF(r=-0.395,P=0.001). Conclusion Concentration of serum NT-proBNP could prognose the diastolic and long axis systolic function of left ventricle.
8.Changes of Systolic and Diastolic Function after Constriction of Abdominal Aorta (above Renal Artery) in New-Zealand Rabbit
Yi CAI ; Kunlun HE ; Lihui YAN ; Wenxiu LENG ; Li FAN
Chinese Journal of Rehabilitation Theory and Practice 2007;13(3):245-247
Objective To establish an animal model of heart failure with preserved ejection fraction(EF)resulting from hypertension.Methods35 male New-Zealand rabbits were randomly assigned to 2 groups:constriction was performed at the abdominal aorta 1 cm just above right renal artery in operated group(n=25),and the sham-operated animals were taken as control group(n=10).The clinical manifestations of heart failure were followed up carefully.Systolic and diastolic function,and systemic hemodynamics were investigated with echocardiography and left ventricle catheter.ResultsIn operated group,marked ventricular hypertrophy was observed 2 weeks after operation.4 weeks after operation,the clinical manifestations of heart failure presented,and IVRT and LVEDP increased,and-dp/dt max decreased.Tissue doppler image indicated that e/a ratio of annulus of mitral valve decreased(P<0.05).However,EF and +dp/dt max were preserved.ConclusionThe operated animals presented the clinical manifestation of heart failure,and diastolic function of left ventricle injured,however,ejection fraction was preserved,which corresponded with the character of heart failure with preserved ejection fraction resulting from hypertension.
9.Research progress on the G protein modulators
Yi-fan YANG ; Zhuo-rui HU ; He LIU ; Yi-xian LI ; Lu LIU ; Xiao-feng XIONG
Acta Pharmaceutica Sinica 2022;57(10):2921-2931
Heterotrimeric G proteins are classes of signal-transducing proteins that bind to guanine nucleotides and possess GTP hydrolase activity. G proteins are composed of three subunits
10.Meta analysis for effect of lead on male productive function.
Hai-hong XU ; Zhi-ping CHEN ; Yi SHEN ; Xue WU ; Fan HE
Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(10):634-636
Humans
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Lead
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toxicity
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Male
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Reproduction
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drug effects
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Sperm Count
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Sperm Motility
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drug effects