1. Effect of NMDA receptor blocker in relieving HIV-1/gp120 induced learning and memory disorder in rats and its mechanism
Mei LIANG ; Jia-Jia YU ; Xi-Yong XIANG ; Si-Yu XIA ; Shan LI ; Yi-Rong ZENG ; Li-Xuan WANG ; Yi-Un ZHOU ; Yan ZHOU ; Shan LI ; Yan ZHOU
Chinese Pharmacological Bulletin 2023;39(6):1149-1156
Aim: To investigate the alleviating effect of NMDA receptor blocking on learning and memory impairment induced by gp120 in rats and its mechanism. Methods: (1 ) Thirty-two SD rats were randomly divided into control group, sham operation group, gpl20 group, and gp120 + Memantine group. Except for the control group, the other groups underwent a bilateral hippocampal injection to establish the model of learning and memory impairment in rats. Memantine (10 mg • kg
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