HIV Infections ; virology ; HIV-1 ; physiology ; Virus Replication ; physiology

AIM:To study of hypertensive retinopathy and brachial ankle pulse wave velocity (baPWV) correlation.METHODS:Totally 89 cases 140 eyes of patients with hypertensive retinopathy in our hospital from June 2015 to December 2016 and 30 healthy subjects (60 eyes) were selected as the research objects,and were divided into the observation group and the control group,respectively.All of the subjects were examined by direct ophthalmoscope,and the results were classified according to Keith-Wagener four classification.Application of OMRON health care (China) Co.,Ltd.production of BP-203RPE network arteriosclerosis detection device for selected objects of baPWV detection.The levels of baPWV and the results of fundus examination were compared between the two groups,and the correlation between the two methods was analyzed.RESULTS:Detection of baPWV in patients was higher as the hypertension severity increased,there was statistically significant differences between groups (P＜ 0.05).The retinopathy grade was higher,the baPWV detection value was larger,the detection value of every grade was different statistically with others (P＜0.05).CONCLUSION:Elevated blood pressure is closely related to retinopathy and accelerated pulse wave velocity,relationship between the two values is notable,brachial ankle pulse wave velocity can be used to reflect the level of hypertensive retinopathy.

BACKGROUNDOff-label application of drug-eluting stents (DES) during percutaneous coronary intervention (PCI) was not uncommon in daily practice, however DES in treating Chinese patients with complex lesion subset was under-investigated. The primary objective of the FIREMAN registry was to evaluate the long term efficacy and safety of the Firebird sirolimus-eluting stent (SES) in treating patients with complex coronary lesions. Here we report the mid-term of one-year clinical outcomes and eight-month angiographic follow-up results of FIREMAN registry.

METHODSThe FIREMAN registry was a prospective multi-center registry, which included 1029 consecutive patients undergoing PCI with Firebird SES implantation between September 2006 and July 2007 in 45 centers in China. The clinical follow-up was designed to be performed at 1, 6, 12, 18, 24, 30 and 36 months post index procedure, and non-mandatory angiographic follow-up at 8 months was planned. One hundred percent site monitoring was conducted.

RESULTSLong lesions (59.2%), multi-vessel disease (50.4%), and small vessel disease (31.6%) were mostly found in angiography. Major adverse cardiac events (MACE) occurred in 51 (5.1%) patients at 1 year clinical follow-up, including cardiac mortality in 6 (0.6%), non-fatal myocardial infarction in 11 (1.1%), and target lesion revascularization in 36 (3.5%) of the patients. Definite and probable stent thrombosis (ST) by Academic Research Consortium (ARC) definition occurred in 12 (1.36%) patients at one-year clinical follow-up. The 8-month binary restenosis rate was 5.7% in-segment and 4.3% in-stent, respectively. Late lumen loss was (0.21 ± 0.40) mm in-segment and (0.23 ± 0.36) mm in-stent, respectively. Furthermore, Cox regression analysis revealed that diabetes, small vessel diameter, and chronic total occlusion were independent predictors of ST.

CONCLUSIONSThe results showed that the Firebird SES was effective and safe in treating Chinese patients with complex coronary lesions and occurrence of ST rate at one-year clinical follow-up was acceptable, however further long-term follow-up was still necessary. (NCT00552656)

Aged ; Angioplasty, Balloon, Coronary ; adverse effects ; methods ; Asian Continental Ancestry Group ; Coronary Angiography ; Coronary Disease ; diagnostic imaging ; therapy ; Drug-Eluting Stents ; adverse effects ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Sirolimus ; therapeutic use ; Treatment Outcome