Objective To investigate the relationship between CD+3CD28+T cell value and chemotherapeutic efficacy in patients with advanced digestive cancer. Methods 38 digestive cancer patients with distant metastatic lesion were included.10 healthy persons were as control group. The absolute counts of CD+3CD28+T cell were measured with flow eytometry in these patients before chemotherapy. All patients received chemotherapy, gastric cancer: DCF regimen (docetaxel plus tegafur and cisplatin, one cycle), colorectal cancer:. Folfox regimen (L-OHP plus tegafur, two cycles), esophageal cancer: mitomycin plus tegafur and cisplatin (two cycles), gallbladder or pancreatic cancer: gemzar plus tegafur and cisplatin (one cycle). According to WHO standard, the chemotherapeutic efficacy was determined, 38 patients were divided into three groups: CR+PR (complete remission plus partial remission), SD (stable of disease) and PD (progress of disease) group. Statistical analysis was used upon all data. Results There was no significant difference in value of CD+3CD28+ T cell between CR+PR group and control group (P=0.549). The value of CD+3CD28+ T cell in SD group and PD group were significantly decreased (P=0.002, P=0.000). The value of CD+3CD28+T cell in CR+PR group was more than that in PD group (P =0.001), while in SD group was more than in PD group (P = 0.044). Conclusion The efficacy is poor, if the value of CD+3CD28+ T cell in patients with advanced digestive cancer is less than that of in healthy persons in peripheral blood. Therefore, the value of CD+3CD28+ T cell is important for the early prediction of the efficacy before chemotherapy.

Objective To receive disinfection messages of sickbeds from nurse workstations and to reduce the periods of the request transfer.Methods The system transferred the request for replacing bed between wards and disinfection units by UDP messages,and informed the staff by active speaker and LCD screen.Results The time of replacing beds decreased significantly,so the wards were very satisfied with the disinfection units.Conclusion The system can reduce the time of replacing beds obviously and make the requests for replacing beds satisfied.

Objective To explore the expression of CD14 and TLR4 ( Toll like receptor - 4) in peripheral blood monocytes during the different stage of cancer patients. Methods The expression of TLR4 and CD14 on peripheral blood monocytes was determined by flow cytometry in 50 healthy control group and 80 patients with malignant tumor who were divided into stable group and advanced group according to the change of the size of tumor measured by image and/or the outcome of tumor makers. Results No significant difference was found in the expression level of CD14 between the different stage of malignant tumor ( stable group and advanced group) and healthy controls [ (6. 1600% ? 2. 32217% ,5. 8629% ? 1. 91896% ) vs (5. 5580% ? 1. 42272% ) ]. The expression of TLR4 in stable group had no significant difference as compared with control group [ ( 10. 4444 ? 3. 16225 ) % vs (8. 8780 ? 5. 24612) % ]. The expression of TLR4 in advanced group was significantly higher than that in controls and stable group [ ( 14. 7286 ? 6. 95213 ) % vs ( (8. 8780 ? 5. 24612) % , ( 10. 4444 ? 3. 16225) % ) (P

Objective To explored the moderate effect of perceived organizational support on job burnout-health complaint relationship and job burnout-task performance relationship. Methods Maslach burnout inventory-general survey, the perceived organizational support scale, health complaint scale and task performance scale were used to test 458 teachers in colleges of Armed Police. Results Emotional exhaustion and cynicism were positively related to health complaint (r = 0. 616,0. 4377;P < 0. 01). Emotional exhaustion and cynicism indicated obviously predicted effect on health complaint(β =0.562, P<0. 01;β =0. 144, P<0.05). Reduced personal accomplishment predicted task performance obviously(β = -0.248, P<0.01). Hierarchical multiple regression showed perceived organizational support can regulate the relationship between emotional exhaustion and task per-formance(△R~2 =0.031, P<0.01). Conclusion Job burnout positively predicted health Complaint. The higher the job burnout was, the more seriously the health Complaint. Reduced personal accomplishment negatively predicted task performance. Perceived organizational support had moderate effect on emotional exhaustion and task performance relationship. It relieved the negative effect of emotional exhaustion on task performance.

Cardiomyopathies ; classification ; diagnosis ; etiology ; Cardiomyopathy, Dilated ; diagnosis ; etiology ; Cardiomyopathy, Hypertrophic ; diagnosis ; etiology ; Child ; Humans ; Pediatrics ; Suggestion

Surgical resection has been accepted as a radical therapy for patients with colorectal cancer, but most of them will develop regional recurrence or distant metastasis. With the development and improvement of novel drugs and methods, they will bring survival hope to patients. In this article, we review the developments in chemotherapy for patients with advanced colorectal cancer.

With the rapid development of proteomics technology,SELDI protein chip technology has become a powerful tool for proteomics with the capacity of gathering sample separation,purification,testing and data analysis together.As its convenience,high-throughput and high-sensitivity,as well as simple and fast analysis,SELDI technology plays an important role in the diagnosis and prevention of tumor.Here we re- view the basic principles,features and recent advances of this technology in digestive tumor.

Objective To investigate the feasibility and techniques of laparoscopic biliary re-operations. Methods Laparoscopic surgery was performed in 13 patients with bile duct stones who already had undergone biliary tract operations. Results Laparoscopic choledochotomy was successfully completed in 12 cases, while a conversion to open surgery was required in 1 case. The success rate of laparoscopic surgery was 92.3% (12/13). The operation time was (101～300) min, with a mean of 155 min. No intra- or post- operative complications occurred. Conclusions Laparoscopic biliary re-operations are feasible and experiences are needed to ensure the success of surgery.

Objective To explore the correlation between the increasing of blood glucose and cytokines in malignant tumor patients after chemotherapy.Methods According to the blood glucose after chemotherapy,155 cases of malignant tumor patient were divided into 3 groups:euglycemia group,IGT(impaired glucose tolerance)group and DM(diabetes mellitus)group.The variance of cytokines in the 3 groups were analyzed.Results Compared with pre-chemotherapy,IL-6,TNF-αincreased greatly in IGT group and DM group,while IL-10 decreased greatly.The statistical difference were obvious compared with euglycemia group.Conclusion There are close correlation between the increasing of blood glucose and cytokines in malignant tumor patients after chemotherapy.

Objective To explore the role of TGF-βand TGIF in the pathogenesis of endometriosis. Methods The expression of TGF-β and TGIF was detected by immunohistochemistry method in the ectopic and eutopic endometrium of 30 cases with endometriosis (ec-topic endometrium group and eutopic endometrium group) and in the normal endometrium of 40 cases without endometriosis (control group). Result The expression of TGF -β in ectopic endometrium group was significantly higher than that in eutopic endometrium group and control group (P < 0.05). There was no significant difference in the expression of TGF- βbetween eutopic endometrium group and control group(P > 0.05). The expression of TGIF in ectopic endometrium group was significantly lower than that in eutopic endometrium group and control group( P <0.05). There was no significant difference in the expression of TGIF between eutopic endometrium group and control group(P > 0.05). There were negative correlation between the expressions of TGF - β and TGIF in ectopic endometrium group and eutopic endome-trium group(rs= - 0.769, - 0.549, P < 0.05). Conclusion The abnormal expression of TGF-β and TGIF in ectopic endometrium of pa-tients with endometriosis may be associated with the genesis and progression of endometriosis.