Objective To study the curative effect and the prognostic factors of endoscopic traumatic optic neuropathy (TON). Methods The clinical data of 53 patients with TON from 2010 to 2015 years was retrospectively analyzed. Divided the patients into the surgery group and the non-surgery group, according to whether or not accept the treatment of endoscopic optic decompression. And evaluating the potential prognostic factors in chi-square test, group t-test and multiple regression analysis. Results In 53 patients (55 eyes ), 31 eyes have no visual acuity before treated: 8 eyes’ visual acuity was improved in 16 eyes (8/16) that accepted operation; 3 eyes’ visual acuity was improved in 15 eyes (3/15) that with non-operation;24 eyes have visual acuity before treated:11 eyes’ visual acuity was improved in 14 eyes (11/14) that accepted operation;3 eyes’ visual acuity was improved in 10 eyes (3/10) that with non-operation;19 eyes’ visual acuity was improved in 30 eyes (19/30) that accepted operation, the total effective rate was 63.3%, and there was no complications happened in the patients who accepted operation. The age, eye-side, sex, visual acuity, optic canal fracture , orbit fracture , all these factors have no correlation to the prognosis (P>0.05), but the interval time between injury and operation (less than 3 days) and the way of the treatment are benefit to improve vision (P<0.05). Conclusions The endoscopic optic decompression is an effective treatment in TON, and it’s better to improve vision in 3-day after TON.

AIM To investigate the effect of recipient kidney function by CsA coadministration Ber used to induce immune tolerance in rats of allogenic cardiac transplantation. METHODS The authors established the SD to Wistar rats heterotopic cardiac transplantation model by Onos methods.Observe the cardiac allograft survival and levels of BUN and Cr in the recipients plasma. The recipients were classified into 5 groups randomly after heterotopic cardiac transplantation were performed. Group A (Wistar to Wistar)): Received placebo intraperitoneal injected for 21 days; Group B (SD to Wistar): Saline intraperitoneal injected for 21 days; Group C (SD to Wistar):CsA 2 mg?kg -1 ?d -1 intraperitoneal injected for 21 days; Group D(SD to Wistar):Ber 16 mg?kg -1 ?d -1 gastrointubation for 21 days; Group E(SD to Wistar): Ber 16 mg?kg -1 ?d -1 gastrointubation coadministration CsA 2 mg?kg -1 ?d -1 ip for 21 days. RESULTS The levels of BUN and Cr in recipint plasma is lower evidently compare with the group with CsA ip simply. CONCLUSION Ber can reduce the renal toxicity in recipients by CsA which was intraperitoneal injected (ip) over a long period time.

OBJECTIVE To investigate the effect of subcutaneousimmunotherapy(SCIT) on levels of the serum human beta defensin-2 in children with allergic rhinitis. METHODS 30 cases of children with allergic rhinitis who were treated by SIT were selected as the treatment group, 20 cases of healthy children as the control group. Serum HBD-2 concentration of the control group was tested. Serum HBD-2 concentration of the treatment group was tested at three different time points: before SCIT, half a year after SCIT and one year after SCIT. And total nasal symptom scores(TNSS) and medication scores were recorded at each time point. RESULTS The serum HBD-2 concentration of the control group, that of the treatment group before SIT, half a year after SIT and one year after SIT were 4.62[4.08; 4.87], 3.74[3.37; 4.61], 4.62[4.13; 5.54], 4.79[4.45;6.19]ng/ml. The HBD-2 concentration gradually increased after SCIT. The TNSS of the treatment group before SCIT, half a year after SCIT and one year after SCIT were 7.43±2.15, 4.17±2.16, 4.20±1.92, The medication scores of the treatment group before SCIT, half a year after SCIT and one year after SCIT were 1.25[0.75; 1.38], 0.25[0; 0.75, 0.25[0; 0.75].There was no correlation (all P>0.05) between the serum HBD-2 concentration and TNSS or medication scores of the treatment group. CONCLUSION The serum levels of HBD-2 in patients with allergic rhinitis were lower than those in normal persons. The specific immunotherapy raised the serum HBD-2 levels of allergic rhinitis patients.

Objective To Btudy effect of standardized acupuncture combined with rehabilitation therapy (function training)on improvement of comprehensive function among patients with stroke in communities,Changning District of Shanghai.Methods One hundred and seventy-six stroke patients were divided into rehabilitation therapy group(88 cases)and control group(88 cages)with block randomization.Patients in rehabilitation therapy group were treated with standardized acupuncture combined with function training in addition to regular medical treatment,and patients in control group regular medical treatment only.All the patients were evaluated with functional comprehensive assessment(FCA)scale by the end of 2-and 5-month of treatment,respectively.Results By the end of 5-month of treatment,scores of FCA in both groups increased significantly (P＜0.01),as compared to those before treatment,more in rehabilitation therapy group than that in control group(P＜0.05).Conclusions Effect of standardized acupuncture combined with rehabilitation therapy Can obviously improve their comprehensive function among stroke patients in communities.

Aged ; Female ; Femoral Neck Fractures ; diagnostic imaging ; surgery ; Fracture Fixation, Internal ; methods ; Humans ; Male ; Middle Aged ; Radiography ; Retrospective Studies ; Treatment Outcome

Objectives: To analyze the role of pharmaeconomics during drug list formulation procedure and the enlightenment to China. Methods: Using literature review and comparative analysis method, it compared the drug list formulation procedure of WHO, Australia, UK, Tailand and the role of pharmaeconomics. Results: Using pharmaeconomics method was common in international experience. The methodology of pharmaeconomics was also well developed. Conclusions: To improve China drug selection procedure, China should enhance government policy invest in pharmaeconomics usage and support the research, break down the grey benefit relation between medicine and medical.

Objective The present study was conducted to investigate the perception of haze among pregnant women and to provide basis for developing interventions.Methods A pregnant woman who has been living in Shunyi district for at least six months has been selected as the subject of investigation. A self-designed questionnaire was used to conduct field investigation. Results A total of 320 questionnaires were collected, including 308 valid questionnaires and 96.25% effective questionnaires. In terms of the cognitive aspects of haze, pregnant women think that there is a serious harm to the respiratory system, and 52.27%(161/308)of pregnant women think that the haze is harmful to the cardiovascular system. In the area of haze protection, 79.22%(244/308)of pregnant women wear masks when they go out. Pregnant women who are in the haze of 100.00% (308/308)will reduce window ventilation time. Access to information about haze information and protection knowledge is mainly including mobile phones(83.12%), network(44.16%)and TV(23.38%). The multi-factor logistic regression analysis showed that the haze was harmful to the health of the fetus (OR=0.12, 95%CI: 0.031-0.446), which was the influencing factor of the pregnant women's haze protection measures. Conclusion Pregnant women in Shunyi District have higher awareness of haze knowledge, and the influencing fact of the measures on the haze weather is the cognition that the haze is harmful to the health of the fetus.

Amino Acid Sequence ; Base Sequence ; Genes, Bacterial ; Humans ; Molecular Sequence Data ; Polymerase Chain Reaction ; Staphylococcus epidermidis ; enzymology ; genetics ; beta-Lactamases ; chemistry ; genetics

OBJECTIVETo investigate the expression of angiotensin converting enzyme 2 (ACE2) and the changes treated with angiotensin converting enzyme inhibitor (ACEI), and its signal transduction pathway.

METHODSAtrial tissues were obtained from 47 patients with RHD undergoing cardiac surgery. The mRNA of ACE2 and ACE were semi-qualified by RT-PCR and normalized to the gene beta-actin. Western blot analysis was employed to examine the expressions of ACE2, ACE, ERK1/2 and phosphorylated ERK (pERK1/2). The atrial tissue angiotensin II (Ang II) content was determined by radioimmunoassay detection.

RESULTSThe expression of ACE2 was significantly decreased (P < 0.05), the expression of ACE and pERK1/2 were significantly increased (P < 0.05), and the level of atrial tissue Ang II was significantly increased in patients with chronic atrial fibrillation group (CAF) compared with sinus rhythm group (SR) (P < 0.05). Compared with CAF patients treated without ACEI, the expression of ACE2 significantly increased (P < 0.01), and the relative activity of ERK1/2 significantly decreased (P < 0.05), whereas the expression of ACE and the level of atrial tissue Ang II remained unchanged in CAF patients treated with ACEI.

CONCLUSIONSThe study suggested that the dysequilibrium of ACE/ACE2 might play an important role in the process of atrial fibrillation, which may be related to the activation of ERK1/2 pathway. The clinical effect of long-term treatment of ACEI maybe associated with elevated ACE2 expression but not ACE expression.

Adult ; Aged ; Angiotensin-Converting Enzyme Inhibitors ; therapeutic use ; Atrial Fibrillation ; drug therapy ; metabolism ; Female ; Heart Atria ; metabolism ; Humans ; Male ; Middle Aged ; Mitogen-Activated Protein Kinase 1 ; metabolism ; Mitogen-Activated Protein Kinase 3 ; metabolism ; Peptidyl-Dipeptidase A ; metabolism ; RNA, Messenger ; metabolism ; Signal Transduction

Objective To investigate the correlation between the relevant indexes of plasma slucose and TCM symptoms and syndrome types in the patients with different complications of type 2 diabetes.Methods On the base of clinical data from 2 501 cases of type 2 diabetes Bayesian network technique was applied to analyse the network relation among 82 variables including fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin,syndrome,tongue and pulse in the patients with type 2 diabetes accompanied by encephalopathy,nephrosis and hypertension.Results In the patients with type 2 diabetes accompanied by encephalopathy when the indexes of fasting plasma glucose and 2-hour postprandial plasma glucose were abnormal the syndrome type wag qi deficiency mainly,and when the index of glycated hemoglobin was abnormal the syndrome types were qi deficiency and yin deficiency commonly.In the patients with type 2 diabetes accompanied by nephrosis when the indexes of fasting plasma gluc08e were abnormal the syndrome type Was yang deficiency mainly,and when the indexes of 2-hour postprandial plasma glucose and glycated hemoglobin were abnormal the syndrome types were mainly qi deficiency,or qi deficiency combined with excessive heat and yin deficiency.In the patients with type 2 diabetes accompanied by hypertension when the indexes of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin were abnormal the syndrome types were mainly yin deficiency or yin deficiency combined with excessive heat. The predictability of complications by common syndromes was observed. Conclusion Bayesian network technique is apposite to the objective research of TCM syndromes. This study is a reference to the early prediction of chronic complications of type 2 diabetes,and also explores initially the objective research of TCM syndromes.