Objective To explore the causes of misdiagnose of ectopic pregnancy by retrospective analysis in our hospital cases,in order to increase the diagnose and curative level in ectopic pregnancy.Methods Clinical data of the misdiagnosis of 96 cases from the 357 patients of ectopic pregnancy in our hospital from year 1993 to 2002,including materials of histories ,symptoms signs and laboratory examinations were retrospectively analyzed.Results The misdiagnosis rate of ectopic pregnancy in our hospital was 26 9%, most of them were treated as early pregnancies, threatened abortions etc. The causes of misdiagnosis were neglectful of asking essential history, no overall physical examination and misleading by the laboratory results.Conclusions The effectively preventive measures against misdiagnosing of ectopic pregnancy were strengthen vigilance of ectopic pregnancy,familiar with the knowledge of atypical ectopic pregnancy and the essential examinations on gravida.

Objective:To evaluate the current situation and the developing trend of 5-HT3 receptor antagonists used in 25 hospital of Wuhan during the period of 2003～2005 in order to provide reference for clinical doctors and pharmacists. Method:The 5-HT3 receptor antagonists were statistically analyzed in respect to the purchase sum of money,DDDs and daily costs. Result:During the 3 years, purchase sum of money of 5-HT3 receptor antagonists were yearly increasing. The share of the market of domestic drugs showed an increasing tendency,while the imported drugs decreased year by year. Granisetron, ondansetron and tropisetron were much more frequently used than others. Conclusion:The market of the oral agents of 5-HT3 receptor antagonists will further expand in China.

Electrocardiography ; Humans ; Myocardial Infarction ; physiopathology ; Myocardial Perfusion Imaging ; methods

Consensus ; Humans ; Infant, Newborn ; Jaundice, Neonatal ; diagnosis ; therapy ; Practice Guidelines as Topic

As our country lack professionals of public health,higher demand to the preventive medicine is further made with the transformation of medical model and the construction of the public health system,and the reformation in preventive medicine education of higher learning is explored to cultivate the practical professionals of public health by modulating education program and courses,modifying the cultivating plan,emphasizing the knowledge of liberal arts and management,strengthening the cultivation of ability and combining theory with practice.

BACKGROUND:The ligamentum flavum is important to connect the rear of the spine. If the flexibility of the ligamentum flavum is decreased due to degeneration, in the role of various factors, it can reduce the effective space of the spinal canal to induce spinal cord and nerve root compression, thereby resulting in neurological symptoms, even paralysis or residual disease. OBJECTIVE:To study the mechanism of over-dose fluoride on the degeneration and ossification of the ligamentum flavum in rats. METHODS:Thirty male Sprague-Dawley rats were randomly divided into two groups: experimental group was given distiled water containing NaF (mass fraction 10-4) and control group was given the same amount of distiled water. After 3 and 6 months, the bone mineral density, Ca2+ and P3+ contents in serum and bone tissue and serum alkaline phosphatase activity were detected, respectively. Meanwhile, the ligamentum flavum specimens were taken for X-ray examination and histopathological observation. RESULTS AND CONCLUSION: In the experimental group, chalk stripes or spots occurred in the lower incisors of five rats at 3 months after treatment and dental fluorosis that was mostly in chalk color was found in al the rats at 6 months after treatment; moreover, the bone density of the lumbar spine significantly increased (P < 0.05). Compared with the control group, the contents of serum Ca2+ were significantly higher, while the contents of P3+were significantly lower in the experimental group at 3 and 6 months after treatment (P < 0.05); the serum alkaline phosphatase activity was also significantly higher in the experimental group than the control group at 3 and 6 months after treatment (P < 0.05). X-ray films, at 6 months after treatment, showed that the bone density of the lumbar vertebra was increased obviously; pathological observation showed that the number of elastic fibers in the ligamentum flavum was reduced further, a large amount of colagen fibers, fibroblasts and calcium deposition were found, and the ossification of the ligamentum flavum was visible at the lamina attachment site. These findings indicate that the over-dose fluorides can lead to the degeneration and ossification of the ligamentum flavum in Sprague-Dawley rats, which may plan an important role in the ossification of the ligamentum flavum.

Objective To investigate the effects of long term exposure of 18F-FDG-PET/CT X-rays on rabbit immune system.Methods The rabbits were irradiated with 18F-FDG-PET/CT every day and this irradiation treatment continued for 3 months.At each month,the total number of white blood cells,thymus index and spleen index,phagocytic index,immune globulins,TNF-α and IL-1 in peripheral blood and serum were detected.Results After long-term 18F-FDG-PET/CT irradiation,the total number of white blood cells increased,the thymus and spleen index decreased (t =3.144-72.903,P ＜ 0.05),the phagocytic index and phagocytic percentage decreased after 1 or 2 months(t =2.719-11.859,P ＜ 0.05),and the number of immune cells marked with CD4 + increased but CD8 + decreased(t =6.433-29.877,P ＜ 0.05).In addition,the level of immune globulin in the serum decreased,but the expressions of TNF-α and IL-1β increased (t =2.720-28.775,P ＜ 0.05).Conclusions 18F-FDG-PET/CT has some damage effects on the immune system of male Japanese big ear rabbit,suggesting that the negative effects of PET-CT should be paid close attention to during clinical application.

Anemia, Hemolytic ; complications ; Child ; Humans ; Pneumonia ; complications

Objective To discuss the drug resistance and the vicissitude of Pseudomonas aerugi-nosa in Intensive Care Unit (ICU), in order to provide basis for rational use of antibiotics in clinic. Methods Identification of bacteria was performed by applying ATB Expression Identification System produced by BioMerieux Company; drug susceptibility tesr was done by using K-B method. The drug resistance of Pseudomonas aeruginosa was compared between ICU and general wards; and then the difference of drug resistance was investigated between 2006 and 2007. Resnlts The more sensitive an-tibiotics to Pseudomonas aeruginosa in ICU of our hospital were as follows, amikacin (resistance rate 6.7%-9.4%), eiprofloxacin (resistance rate 7.7%-24.7%), cefoperazone/sulbactam (resistance rate 11.5%-34%), ceftazidime (resistance rate 11.5%-37.7%), aztreonam (resistance rate 20.2%-40.6%). The drug resistance rate of ICU was higher than that of the general wards, and the drug re-sistance rates to ciprofloxacin, ceftazidime, cefoperazone/sutbaetam,meropenem, imipenem and aztreo-nam in 2007 were significantly higher than those in 2006 (P<0.01). Conclusion The drug resistance rate of Pseudomonas aeruginosa in ICU of our hospital was very high,and it is rising year by year. So it is important to retrospect the results of the drug resistance periodically and provide the up-to-the-mi-nute data of epidemiology and vicissitude of drug resistance.

Leech has a broken blood stasis effect and has been used to eliminate a variety of stasis diseases. With the development of modern pharmacology study, in recent years, leeches are widely used in clinical cancer patients, and its anti-tumor effects have been confirmed by numerous clinical and experimental studies. Based on the latest domestic and foreign literature analysis and summary, this article discussed the antitumor mechanisms of leech from the following aspects:inhibition of tumor growth and proliferation, induction of tumor cell apoptosis, inhibition of tumor angiogenesis, anti-platelet aggregation and anti-clotting effect, improvement of immunity, and anti-tumor multi-drug resistance. It also pointed out deficiencies and controversy in current studies, with a purpose to provide ideas for further researches and clinical applications.