Objective To investigate the relationship between plasma anti-β2-glycoprotein I (anti-β2-GP I )and cardiovascular disease (CVD) in systemic lupus erythematosus (SLE).Methods Eighty-onepatients with SLE [the mean age was (45±18) years old,among whom 73 were female and 8 were male] and20 controls [the mean age was (43±17) years old,among whom 14 were female,and 6 were male] wereenrolled.Plasma anti-β2-GP I was measured by ELLSA.The relationship between plasma anti-β2-GP I level and CVD in SLE patients was investigated with Logistic regression model.T-test,x2 test,Spearman's correlations and Logistic regression analysis were used for statistical analysis.Results Mean plasma anti-β2-GP I increased significantly in SLE group compared to control group [ (29± 19) vs (14±8) U/ml,t=2.035,P＜0.05].The plasma levels of anti-β2-GP I were higher in SLE patients with CVD than those without [(41±25)vs (18±12) U/ml,t=2.038,P＜0.05].Plasma anti-β2-GP I level was positively correlated with triglyceride (r=0.337,P＜0.05) and renal lesions (r=0.489,P＜0.01 ).Plasma anti-B2-GP [ level was negatively correlated with high density lipoproteins (r=-0.385,P＜0.05 ) and complement (r=-0.497,P＜0.05 ) level.Logistic regression analysis showed that plasma anti-β2-GP I (β=0.675,95％CI0.5070.816,P＜0.05) was an independent risk factor for CVD in SLE patients.Conclusion The level of plasma anti-β2-GP I in SLE patients with CVD is high,and it may play a role in the pathogenesis and progression of CVD in SLE patients.

Objective To explore the morbidity and clinical characteristics of knee osteoarthritis (OA) complicated with metabolic syndrome (MS).Methods Four hundred and ten patients with knee OA were enrolled into this survey.The subjects were divided into two groups:those with knee OA only:those with both OA and MS.Clinical data in the two groups were evaluated.Results The prevalence of MS was 40.2％ in all knee OA patients,there was significant difference between the two groups according to the ratio of male to female (x2=5.853,P=0.001),but no difference between the two groups according to age distribution respectively (P＞0.05).For metabolic parameters,waist circumference,triglyceride (TG),low density lipoprotein cholesterol (LDL-C),systolic blood pressure and glycosylated hemoglobin (HbA1c) were significantly increased in the group with both of the two diseases (OA and MS),comparing with those with knee OA only (t=3.123,4.679,2.818,3.697,2.632,2.907,P＜0.05).However,there was no difference in both group in serum total cholesterol (TC),high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose level (P＞0.05).Incidence of coronary heart disease,diabetes mellitus and hypertension was higher in the group with both OA and MS than that in knee OA only group (x2=6.676 and 104.12,P＜0.05).The incidence of diabetes mellitus was not different between the two groups (P＞0.05).Conclusion The incidence of metabolic syndrome in knee OA patients is relatively high.Effective treatment should be invited to treat knee OA with MS.

Antitubercular Agents ; pharmacology ; Drug Resistance, Bacterial ; Humans ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis ; drug effects ; isolation & purification ; Tuberculosis, Multidrug-Resistant ; diagnosis ; microbiology

AIM: To investigate the refractive distribution and analysis risk factors for aircrew ametropia.
METHODS: The number of 49 cases with ametropia from 1031 aircrew during May 2013 to May 2014 were reviewed. Various types of refraction composition, age, type, position, time of flight with the subjective assessment of aircrew were analyzed and compared.
RESULTS:Of 49 cases, 43 cases (88%) were myopia, 6 cases ( 12%) were hypermetropia. , Detection rates were higher in age over 50 years aircrew and flight time more than 3000h. Detection rates were lower in self-conscious symptom heavy aircrew, fighter aircrew and good habit of using eyes.
CONCLUSION: The myopia incidence in aircrew with age >50 years and long flight time is higher, than that of fighter pilots and good habit of using eyes. We should pay attention to the increasing late-onset myopia of aviators and habit of using eyes, work intensity and time of using eyes about aircrew.

In this paper, the TCM typing of postpartum hypolactation is introduced and the manipulation and duration of Tuina treatment for postpartum hypolactation are summarized, and the effectiveness index used in Tuina treatment is proposed. It is held that the Tuina therapy will be widely used for treatment of the postpartum hypolactation, and the convenient and effective Tuina manipulation will promote the development of postpartum nursing and will be used in gynecology department and enlarge the therapeutic range of the Tuina therapy.
Biomedical Research ; methods ; trends ; Female ; Humans ; Lactation Disorders ; therapy ; Medicine, Chinese Traditional ; methods ; trends ; Postpartum Period

Infrared radiation temperature and characteristics of infrared spectrum of meridians and acupoints are summarized in this article. The infrared radiant track along the running course of meridians might be a ubiquitous phenomenon of the vital activity. The high temperature bands below the meridian lines at the cuticular layer are often taken as the manifestation of the tract. It could be induced by various stimulations on acupoints with warm-needling as the best causative method. High temperature and low resistance are considered as 2 features of the acupoint zone. The adenosine-triphosphate energy metabolism of the acupoint zone is higher than the non-point zone, which indicates that essential physiological and pathological information are carried by infrared radiation temperature of acupoint and infrared spectrum of acupoint. However, it is realized that study on characteristics of infrared radiation only is far from enough to reveal the essence of meridians and acupoints. And much still remains to be done in strengthening basic studies of characteristics of infrared radiation, structure pattern of meridians and acupoints as well as volt-ampere characteristics.
Acupuncture Points ; Energy Metabolism ; radiation effects ; Humans ; Infrared Rays ; Meridians ; Physiological Phenomena ; radiation effects ; Radiation

OBJECTIVETo explore the efficacy of Tuina for postpartum lactation and work out a optimal protocol involved.

METHODSWith a randomized, controlled and clinical method, 84 primiparas were divided into a Tuina group and a control group. While patients in the control group received rooming-in conventional managements, those in the Tuina group were additionally treated with Tuina, including local manipulations on breasts combined with acupoint manipulations. The colostrum-time, lactation quantity and prolactin were observed to make the comparisons between two groups.

RESULTSThe scores of lactation quantity after 1th, 2nd, 3rd of the treatment were 1.660 +/- 0.785, 2.530 +/- 1.030, 2.880 +/- 1.171 in Tuina group and 1.270 +/- 0.533, 1.460 +/- 0.811, 1.500 +/- 0.583 in control group respectively, where there were significant differences in each time stage between two groups (all P < 0.001). The time of colostrum was (21.6 6 +/- 10.508) h in the Tuina group and (22.5 +/- 9.762) h in the control group, in which the difference was not statistically significant (P > 0.05). The levels of prolactin (314.35 +/- 110.37) ng/mL and (321.56 +/- 109.61) ng/mL in Tuina group, (385.78 +/- 85.19) ng/mL and (340.12 +/- 103.10) ng/mL in control group before and after treatment, there were no significant differences (both P > 0.05).

CONCLUSIONPostpartum Tuina on breasts could increase the quantity of lactation and delay the decreasing of the levels of prolactin, which contributes primiparas to lactate more and sooner.

Adult ; Amobarbital ; Breast ; secretion ; Breast Feeding ; Colostrum ; secretion ; Drug Combinations ; Female ; Humans ; Lactation ; Milk, Human ; secretion ; Postpartum Period ; physiology ; Prolactin ; metabolism ; Secobarbital ; Young Adult

Ultrasonic microbubbles were used to open blood-brain barriers (BBB) with a reversed and limited behavior feature in the study, which could improve the brain-targeted delivery of anti-tumor drugs. The glioma rat model was prepared. Low-frequency ultrasound was combined with microbubbles to affect the permeability of BBB compared with the permeability of independently administered Evans blue (EB) crossing BBB. Time point and length of ultrasound were investigated whether they affect the permeability of BBB and the damage of brain tissue. The effect of the growth time of glioma on BBB permeability was explored. Only glioma had a very little impact on BBB permeability. However, ultrasonic microbubbles opened the BBB with the features of temporary, limited and reversed behavior and improved EB and magnetic resonance imaging contrast agent penetrating BBB. A length of 30 s ultrasound is appropriate for opening BBB and no damage of brain tissue. Drugs should be injected before ultrasound so that they enter into brain as BBB opening. Ultrasonic microbubbles can open BBB effectively and safely, which improve drugs penetrating BBB under proper time point and length.
Animals ; Blood-Brain Barrier ; Contrast Media ; Drug Delivery Systems ; Glioma ; drug therapy ; Magnetic Resonance Imaging ; Microbubbles ; Permeability ; Rats ; Ultrasonics

Objective To explore an effective method for enhancing basic clinical skill of students.Methods Selective course of basic clinical skill was launched for the fourth grade clinical medicine students by using simulation-based medical education (SBME).Elective courses have 21 class hours,involving 15 items of basic clinical skills in internal medicine,surgery and nursing.Training methods include preparation,explanation,demonstration,operation,group competition,examination and questionnaire.Selective course examination includes class activation and final examination,accounting for 20％ and 80％ of the final scores,respectively.Scores were classified into A (excellent),B (good) and C (moderate) levels.Scores and questionnaire data were processed by Microsoft Office Excel 2007 software and percentages of score and questionnaire feedback were calculated.Results Results suggested that the scores of 70％ students were more than 90.Results of questionnaire indicated that the basic clinical skills of 76.6％ of the students were improved a lot.79.2％ considered that it was useful for their clinical practices.Conclusion Clinical-skill course based on SBME is conducive to enhancing basic clinical skills of students.

To study the impact of five different origin processing methods, namely natural drying, drying in baking shop, drying by microwave heating, drying in drum and drying with sulphur fumigation, on the quality of Lonicerae Japonicae Flos from Donghai cultivation base in Jiangsu Province, with the contents of chlorogenic acid and galuteolin and the similarity in HPLC fingerprints as the evaluation indicators. The results showed that different origin processing methods had significant impact on the content of chlorogenic acid and the similarity in HPLC fingerprints, but with no significant difference on the content of galuteolin. By means of drying by microwave heating and drying in drum, the samples showed higher contents of chlorogenic acid, respectively 3.67% and 3.39%. The similarities of HPLC fingerprints were 0.815 and 0.793, respectively. By means of the drying in baking shop and the drying with sulphur fumigation, the contents of chlorogenic acid in the samples were 2. 87% and 2. 53% , respectively. The similarities of HPLC fingerprints were 0.964 and 0.765, respectively. The lowest content of chlorogenic acid in naturally dried samples was 1.92%. The similarity of HPLC fingerprints was 0.940. According to the findings as well as the internal control standards for Lonicerae Japonicae Flos herbs of Jiangsu Kanion Pharmaceutical Co. , Ltd. , the optimum processing method for Lonicerae Japonicae Flos from Donghai cultivation base was the drying in baking shop. This study provided a theoretical basis for determining the processing method for Lonicerae Japonicae Flos from Donghai cultivation base of Jiangsu Province.
China ; Desiccation ; methods ; Drugs, Chinese Herbal ; chemistry ; Lonicera ; chemistry ; growth & development ; Quality Control