Aim To study the ameliorative effects of Hypericum perforatum extract(HPE)on high altitude cerebral edema(HACE)in hypoxia rats.Methods A large low-pressure oxygen chamber was used to simulate the hypoxia environment at an altitude of 7 500 m.The pathological changes of HPE on the brain tissues of HACE rats were observed,and the water content,oxidative stress and inflammatory factors related indicators of brain tissues were detected.Results Through administered HPE by gavage,the histopathological damage of HACE rats was improved,the concentration of nuclear pyknosis was reduced,the degree of vacuolization was reduced,and the inflammatory response was alleviated.At the same time,HPE decreased the water content and the contents of MDA,H2O2,IL-1β,IL-6,VEGF and TNF-α in brain tissues of HACE rats,while increased the content of GSH and the activities of T-SOD and CAT.Conclusions HPE can ameliorate HACE in hypoxic rats to some extent,the mechanism of which may be related to ameliorating oxidative stress injury and reducing inflammation response.Hypericum perforatum is expected to be developed as a drug preparation for the treatment of HACE.