AIMTo build a easy and reliable rat model of insulin resistance.

METHODSChanges concerning sugar metabolism were observed in experimental rats injected intraperitoneally by different doses of dexamethasone.

RESULTSThe changes by dexamethasone in fasting blood insulin and insulin resistance prior to that of fasting blood glucose were dose and time dependent.

CONCLUSIONIt was convenience to set up a insulin resistance model induced by dexamethasone in rats which would favor other related research.

Animals ; Blood Glucose ; analysis ; Dexamethasone ; pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Insulin ; blood ; Insulin Resistance ; physiology ; Male ; Rats ; Rats, Sprague-Dawley ; Time Factors