1.Prostate Cancer Bone Metastasis: Interaction Between Tumor Cells and Bone Microenvironment
Yi LU ; Zhi YAO ; Jian ZHANG
Chinese Journal of Biochemistry and Molecular Biology 2007;23(3):1-171
Cancer metastasis is composed of a complex cascade that involves a variety of critical steps beginning with detachment from the primary tumor and ending with growth of tumor at a distant site, such as bone. The "seed-and-soil hypothesis" predicts that the bone microenvironment expresses factors through which attract a variety of cancer cells and promote the tumor development. The ending point of tumor development in bone is achieved through the bidirectional and dynamic interaction between tumor cells and the cells in their growth microenvironment. A variety of factors produced by the bone microenvironment, contribute to the pathogenesis of cancer skeletal metastasis. In this review, using prostate cancer (CaP) as an example, some of general mechanisms of cancer metastasis will be summarized. In addition, the current understanding of the interaction between tumor cells and the bone microenvironment will be addressed. Finally, the research directions in the near future will be suggested.
3.Clinic outcome of gefitinib as the first line treatment in elderly patients with lung adenocarcinoma
Ruotian WANG ; Xiuyi ZHI ; Yi ZHANG ; Shuyang YAO
Cancer Research and Clinic 2013;(5):306-308
Objective To evaluate the efficacy and adverse effects of gefitinib as the first line treatment in elderly patients with lung adenocarcinoma.Methods 81 elderly patients of previously untreated advanced lung adenocarcinoma,who were non-smokers and unsuitable for chemotherapy,received gefitinib treatment until disease progression or intolerable toxicities occurred.The curative effect performance status of improvement and adverse effects were observed.Results All of the patients were evaluable.Partial response rate and stable disease rate of gefifinib were 25.9 % (21/81) and 48.1% (39/81),respectively.55.5 % (45/81)of patients had performance status improved after treatment.Conclusion Gefitinib has curative effect and is well tolerated in the treatment of elderly patients with previously untreated advanced lung adenocarcinoma.
4.Significance of combined detection of plasma RASSF1A and p16 gene methylation in diagnosis of non-small cell lung cancers.
Gui-zhi LIU ; Yi-ming WU ; Ji-yao YANG
Chinese Journal of Oncology 2007;29(8):613-614
Adenocarcinoma
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diagnosis
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genetics
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Carcinoma, Non-Small-Cell Lung
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diagnosis
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genetics
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Carcinoma, Squamous Cell
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diagnosis
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genetics
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Cyclin-Dependent Kinase Inhibitor p16
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blood
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metabolism
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DNA Methylation
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Genes, p16
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Humans
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Lung Neoplasms
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diagnosis
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genetics
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Tumor Suppressor Proteins
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blood
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metabolism
5.Surgical procedure and prognosis analysis for elderly stage Ⅰ NSCLC patients above 70 years old
Yi ZHANG ; Yuanbo LI ; Shuyang YAO ; Xiuyi ZHI ; Zongjun DONG
Chinese Journal of Thoracic and Cardiovascular Surgery 2011;27(10):601-603,610
Objective The purpose of this study is to evaluate Surgical Procedure and Prognosis for elderly stage 1NSCLC patients above 70 years old.Methods The patients who were stage Ⅰ non-small cell lung cancer from 2003 to 2007were enrolled ( n =71 ).The median age was 74 years ( ranged from 70 to 84 years).The median follow-up of patients was 30months( ranged from 2 to 81 months).Results The percentages of postoperative complications after sublobar resection and lobectomy patients were 36.4% and 46.9%,respectively.The period in hospital were 11.36 days and 12.24 days.The 3 year survival was 85.9% for patients undergoing sublobar resection and 78.8% for lobectomy.The 5 year survival was 56.4% and 56.9% respectively.No significant difference was observed between two types of surgical procedure in the elderly.Staging is the independent factor of prognosis.Conclusion Lobectomy is still the main therapy method for elderly stage Ⅰ NSCLC patients.Especially,for those who can undergo radical resection.But sublobar resection also appears to be a viable surgical treatment for patients with cardiopulmonary physiologic impairment.
7.Effect of puerarin on activities of cytokines secreted by neonatal cardiomyocytes during hypoxia/reoxygenation
Zhitong ZHU ; Zhi YAO ; Jianshi LOU ; Huiqiang LI ; Yi LU ;
Chinese Pharmacological Bulletin 1987;0(03):-
AIM To investigate the effect of puerarin (Pue) on tumor necrosis factor (TNF) ?, interleukin (IL) 6 secreted by neonatal rat cardiomyocytes during hypoxia/reoxygenation injury. METHOD The activities of TNF ? and IL 6 in the supernatants of cultured myocytes, which were sampled from different groups (control, model, and therapeutic groups with 1 g?L -1 Pue, 0 1 g?L -1 Pue, 0 01 g?L -1 Pue) at different time, were assayed by bioassay method. RESULTS TNF ? and IL 6 activity increased compared with that of control ( P
8.Analysis of phacovitrectomy with internal limiting membrane peeling to treat foveoschisis without macular hole in ultra-high myopia
Zhi-Yong, WU ; Yi, YAO ; Xin-Yi, LIU ; Yun-Hua, MIN ; Zhi-Yi, CHEN ; Li-Rong, HAN
International Eye Science 2017;17(6):1181-1183
AIM: To analyze the results of phacovitrectomy with internal limiting membrane(ILM) peeling to treat foveoschisis in ultra-high myopia.METHODS: Totally 32 eyes of 32 ultra-high myopia patients with foveoschisis were selected retrospectively.The preoperative refractive errors ranged from-12.00D to-20.00D with the mean of-15.78±2.16D.The best corrected visiual acuity(BCVA) were converted to LogMAR acuity, and the average BCVA was 4.1±0.4.Conventional phacovitrectomy with ILM peeling by ICG dying were performed.Gas tamponade were performed to end the operation.The BCVA and the foveoschisis cavity were observed by 1-9mo after the surgery, with the mean of 4.5mo.RESULTS: The foveoschisis cavity of 30 eyes were healed with BCVA increased and visual distortion alleviated distinctly (94%)(t=-7.91, P<0.05).CONCLUSION: Phacovitrectomy with ILM peeling is useful in treating foveoschisis in ultra-high myopia with visual function preserving.
9.Recognition of experimental animal model with kidney disease.
Yi-gang WAN ; Yan-ru HUANG ; Wei SUN ; Zhi-min MAO ; Xi-miao SHI ; Jian YAO
China Journal of Chinese Materia Medica 2014;39(21):4075-4081
Animal models with kidney disease are generally divided into two types. One belongs to the models which imitate human kidney disease by the artificial operations, such as anti-glomerular basement membrane antibody nephritis, Heymann nephritis, anti-Thyl. 1 antibody nephritis, BSA nephritis and puromycin nephropathy. The other one pertains to the models which make themselves kidney disease, and appear the pathological characteristics naturally as like as human, such as HIGA mice with IgA nephropathy and NZB/WF1 and MRL/1pr mice with lupus nephritis. In addition,the transgenic animal models with kidney disease can also be established by the modern molecular biologic techniques including gene knockout and siRNA transfection. As for the studies related with kidney disease in pharmacodynamics and pharmacology of Chinese herbal medicine (CHM), it is important to understand deeply the features of each animal model with kidney disease, and select accurately the proper models according to the different experimental objectives, and then, build the special models provided with the combination of disease with syndrome in traditional Chinese medicine (TCM). Therefore,it is the developmental direction for the further study to establish animal models with kidney disease, which should possess the characteristics of syndrome in TCM.
Animals
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Diabetic Nephropathies
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etiology
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Disease Models, Animal
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Humans
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Kidney Diseases
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etiology
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Medicine, Chinese Traditional
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Mice
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Streptozocin
10.Caesarean sections performed under general anesthesia.
Acta Academiae Medicinae Sinicae 2006;28(3):460-463
OBJECTIVETo analyse the preoperative conditions and intraoperative anesthetic managements of parturients who underwent Caesarean section and explore possible relationship between perianesthetic managements and prognosis of parturients and fetuses.
METHODSA group of 30 parturients who underwent Caesarean sections under general anesthesia were analysed retrospectively.
RESULTSAll the 30 Caesarean sections were smooth in terms of both procedure and anesthesia.
CONCLUSIONSGeneral anesthesia is still indicated in Caesarean section, although multiple risks may still exist. Considerate perinatal planning, careful preoperative preparations, and delicate intraoperative managements positively contribute to the good prognosis of parturient and fetus.
Adult ; Anesthesia, General ; Anesthesia, Obstetrical ; Apgar Score ; Cesarean Section ; Female ; Humans ; Pregnancy ; Retrospective Studies