Objective:Toinvestigate the expression of androgen recepto(rAR)and thrombospondin-1(TSP-1)in human benign prostatic hyperplasi(aBPH)and prostate cance(rPca),and to explore the relationship between them and angiogenesis.Methods:Eighty specimens from BPH(20)and Pca(60)were included in the study.The Pca was divided into low Gleason score group(Gleason score

The differential diagnosis of inguinal and scrotal emergencies in children is difficult and misdiagnosis might be associated with danger or even mortality.Early diagnosis and proper treatment are very important and explorational surgery should be carried out when diagnosis is in doubt.

Objective To analyze the effects of vascularized fibular flap combined with vacuum sealing drainage (VSD) in the repair of tibia defect.Methods Clinical data of 24 patients with chronic osteomyelitis of the tibia who accepted the operation of vascularized fibular flap combined with VSD were collected in the study.In the first operation, the lesions were completely debrided and the dead bone was removed, then the vascularized fibular was replaced from the other limb to repair the tibia defect.Later, vacuum-assisted closure was applied to cover the wound.Results All patients enrolled in the study were followed up for 13 to 50 months, with an average of 32.3 months.The sinus of 22 cases healed in 4 weeks and the healing rate was 91.7%.The other two patients received additional debridement for the sinus and they also healed soon after that.All flaps survived and the survival rate was 100%.The X-ray showed that the transplanted fibula was healed in all cases, with a healing rate of 100%.The healing time ranged from 4 to 7 months, with an average of 4.9 months.Based on the Enneking scoring system, the patients achieved an average score of 26 points out of 30 points, and the recovery rate of limb function was evaluated as 86.7%.Conclusion For patients with chronic osteomyelitis of the tibia, vascularized fibular flap combined with VSD can not only effectively repair bone defect, but also restore the continuity of limbs.The application of VSD can effectively control infection, shorten treatment course, and restore limb function.

Nuclear factor E2 related factor Nrf2 is a nuclear transcription factors involved in a variety of protein expression. As a center of oxidative stress regulation, it combines with antioxidant components (antioxidant responsive element, ARE) and activates downstream multiple anti-oxidation, anti-inflammatory and detoxifying enzyme protein expression. This signaling pathway is involved in the development of inflammation, tumor and other pathological process. This review describes the basic structure, biological effects and signaling pathways of Nrf2, summarizes the latest progress about mechanisms of factors, which are involved in the positive and negative regulations of signal pathway, providing a new target for anti-inflammatory, antioxidant, and antitumor biochemical treatment. Based on these, the paper also looks forward to applicating bioinformatics technology and providing better prospects for the development of target intervention.

Recurrent pregnancy loss (RPL) is a common complication of pregnancy, which affects 2%fertile women. A recent research has found that high level of thrombin-activatable fibrinolysis inhibitor (TAFI) can reduce the occurrence risk of early RPL. TAFI is one kind of carboxypeptidase, which can be activated as TAFIa. TAFIa can make the fibrinolysin lose its working site, which can interact with the fibrin to play a role in the regulation of fibrinolysis and the inhibition of throm?bus formation. The damage of fibrinolytic system is one of the risk factors for the occurrence of RPL in pregnant women, which has become one of the hotspots in the medical profession. In this paper, recent literature on TAFI and its relationship with recurrent pregnancy loss has been reviewed, hoping for new ways and clues in clinical treatment and prevention of RPL.

OBJECTIVE:To raise the exigency capacity of drug system to cope with the unexpected events of public heal_ th.METHODS:To set up a national drug contingency system(NDCS)for the unexpected events of public health.RESULTS:The NDCS should consist of the reserves of drugs,capacity,information and plan for emergent needs.CONCLUSION:Estab?lishment of NDCS is a way to access health mordernization.

OBJECTIVE:To provide references and information about the research and development,manufacture and use for the related departments.METHODS:The sales amount,sequence of sales and etc.of the Chinese Traditional Medicine in our hospital from1999to2003were analyzed statistically with the help of database and electronic table software.RESULTS:Percentage of sales amount of the Chinese Traditional Medicine has been lowered from43.81%to33.70%.The top5drugs on the consumption list were the blood-regulating agents,tonifying agentss,drugs for bone fractures and wounds,febrifugal ag ents and gynaecological drugs respectively;the blood-regulating agents had a big share on the top10consumption volume list.CONCLUSION:There is a decrease in the consumption of the Chinese Traditional Medicine.

OBJECTIVE:To make the economic analysis on drug stock in hospita l.METHODS:The database technique and Excel software were used to analyze the sale and stock of the drugs in our hospital from1999to2003,the business turnover rate was evaluated to measure the efficiency of drug stock.RESULTS:The turnover rates increased continuously in5years.CONCLUSION:The turnover rate should be increased in a practical way to keep the optimal control over drug stock in hos?pital.

Laboratory animal welfare is an important guarantee for the accuracy and reliability of experimental results, so it has been paid attention in scientific research .But the situation is not optimistic in the teaching practice .This paper has specially analyzed laboratory animal welfare and ethics in experiment teaching and provided specific measures involved in legislation , spread of animal welfare and implementation of 3R principle to ensure animal welfare .

Objective To investigate the efficacy and safety of low molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction.MethodsEighty patients with acute myocardial infarction were randomly divided into control group and observation group.Forty patients in the first affiliated hospital of Xinjiang Medical University from January 2013 to January 2016 were randomly divided into control group and observation group.Forty patients were treated with low molecular weight heparin combined with enteric-coated aspirin;Observation group in the control group based on intravenous thrombolytic therapy.The changes of blood vessel recanalization rate, serum factor level, treatment effect and complication were observed and compared.ResultsThe levels of serum IL-6, IL-8, IL-10 and HSP70 in the two groups were significantly lower than those in the control group (P<0.05).The postoperative complications and acute mortality were significantly lower in the observation group than in the control group (P<0.05).ConclusionLow molecular weight heparin combined with aspirin and urokinase in the treatment of acute myocardial infarction can effectively improve the rate of coronary artery opening, reduce the incidence of complications, safe and reliable, worthy of clinical promotion.