BACKGROUNDS: The molecular genetic characteristcs of cis-AB blood group have shown that its allele had C, G, C and C at nucleotide positions (nps) 526, 703, 796 and 803, respectively. And all cis-AB analysed and reported molecular genetically in Korea and Japan had T at np 467 (leucine at amino acid position 156). We report a first case of cis-AB with C at np 467 (proline at amino acid position 156). METHODS: Genomic DNA was extracted from peripheral blood of cis-AB patient and amplified by DS1/DS2 and DS3/DS4 allele-specific primers. After PCR, we analysed nps 261, 467, 526, 646, 703, 796, and 803 by restriction digestion, autoradiography and automatic sequencing. RESULTS: PCR-RFLP with DS1/DS2 primers and restriction enzyme KpnI showed that cis-AB had an 0 allele. The results of genomic sequencing, autoradiography and restriction digestion showed that cis-AB allele at nps 467, 526, 646, 703, 796 and 803 had C, C, T, G, C and C, respectively. CONCLUSION: This cis-AB showed characteristic molecular genetic features at nps 526, 703, 796, and 803. And this is a first case of A(Pro) cis-AB with C at np 467. (Korean J Blood Transfusion 10(1): 13-19, 1999)
Alleles ; Autoradiography ; Blood Transfusion ; Cytosine* ; Digestion ; DNA ; Humans ; Japan ; Korea ; Molecular Biology* ; Polymerase Chain Reaction

Hemorrhagic fever with renal syndrom is an acute febrile disease which is caused by Hantanvirus and several other viruses that belong to the genus Hantavirus. Gl and G2 glycoproteins of Hantanvirus have been thought to be involved in protective immunity against Hantanvirus infection. In this study, the antigenicity of G1 and G2 glycoproteins in cell mediated immune response was investigated. When peripheral blood mononuclear cell fraction from recovered hemorrhagic fever with renal syndrome patient was cultivated with a recombinant protein containing amino-terminal 78 amino acids of G2 glycoprotein, these cells were activated to proliferate and secreted significant amount of interleukin-2 and interferon-r. These results suggest that T cell epitope exists in the amino-terminal region of G2 glycoprotein.
Amino Acids ; Epitopes, T-Lymphocyte ; Fever ; Glycoproteins* ; Hantavirus ; Hemorrhagic Fever with Renal Syndrome ; Humans ; Interleukin-2

No abstract available.
Adenocarcinoma, Papillary* ; Thyroid Gland*

Thirty patients who had elective general anesthesia at Kyungpook National University Hospital from April to August 1986 were studied for intraocular pressure(lOP) changes after intravenous lidocaine administration. The resultg were as follows. The 30 patients comprised three groups of each 10, placebo group and lidocaine 1 mng/kg and 2mg/kg Pretreatment group. In lidocaine 1 mg/kg administration group, the IOP of 1 minute and 2 minutes after intubation were 21.8+/-3.8 mmHg, 21.3+/-2.6 mmHg and showed significant(p<0.01) increase compared with the control value. In lidocaine 2 mg/kg pretre-atment group, the IOP of I minute after intubation was 22.7+/-3.9 mmHg and showed significant(p70.05) increase, but the IOP of 2 minute after intubation was 20.2+/-3.2mmHg which not showed significant increase compared with the control value. The IOP of 2 minute after incubation in lidocaine 1 mg/kg administration group(p<0.05) and lidocaine 2 mg/kg administration group(p<0.01) showed significant decrease compared with placebo group. The incidence of coughing and arrhythmia stowed decreasing tendency according to doses of lidocaine, but not statistically significant.
Anesthesia, General ; Arrhythmias, Cardiac ; Cough ; Gyeongsangbuk-do ; Humans ; Incidence ; Intubation ; Lidocaine

In oriental medicine, classification of the Sasang constitutional types (Tae-Yang, Tae-Eum, So-Yang, and So-Eum) is important for the treatment. To classify the Sasang constitutional types, the old methods such as pulse palpation are not objective; the recent methods such as immunohematology are expensive, painful, and time consuming. To overcome this problem, a body measurement, one of the anthropological methods, has been developed. The purpose of this study was to define whether the fingerprint, other one of the anthropological methods, is helpful to classify the Sasang constitutional types. Thus, we looked for the interrelationship between the fingerprint and Sasang constitutional types. Before analyzing the fingerprint, two kinds of questionnaires for classifying the Sasang constitutional types were surveyed on 760 Koreans (465 males, 295 females). As there was no Tae-Yang individual, we only could find the fingerprint characteristics of Tae-Eum(288 persons), So-Yang (193 persons), and So-Eum(279 persons) individuals. In the fingerprints of Tae-Eum individual, the arch types were more frequent, and the loop types were less frequent. These characteristics were prominent in female, right, second, and fifth fingers. In those of So-Yang individual, the arch types were less frequent, and the whorl types were more frequent. These characteristics were prominent in male, female, left, first, second, third, and fifth fingers. In those of So-Yang individual, fingerprint ridge count was greater in fourth finger. In those of So-Eum individual, loop types were more frequent, and whorl types were less frequent. These characteristics were prominent in male, right, left, first, third, and fifth fingers. In those of So-Eum individual, fingerprint ridge count was lesser. These characteristics were prominent in male, fourth, and fifth fingers. The fingerprint seems to be helpful to classify the Sasang constitutional types.
Classification ; Dermatoglyphics* ; Female ; Fingers ; Humans ; Male ; Medicine, East Asian Traditional ; Palpation ; Surveys and Questionnaires

No abstract available.
Blood Transfusion, Autologous*

No abstract available.
Blood Transfusion, Autologous*

Transcatheter closure of patent ductus arteriosus with the Amplatzer duct occluder shows excellent results. However, there is a risk of device embolization after deployment. We report the case of a 33-year-old man in whom an embolized Amplatzer device was retrieved from the right pulmonary artery by a percutaneous method. We also review this uncommon severe complication and offer technical tips for percutaneous removal.
Adult ; Ductus Arteriosus ; Ductus Arteriosus, Patent ; Humans ; Pulmonary Artery ; Septal Occluder Device ; Surgical Instruments

OBJECTIVES: The purpose of this study is to evaluate the incidence of secondary T wave changes in WPW syndrome and the relation between the incidence of the secondary T wave changes and sex, age (duration of preexcitation), mean and maximal QRS duration (from the onset of delta wave to the end of S wave) of standard 12 lead electrocardiogram (ECG) and the site of accessory pathway (AP). The secondary purpose of this study is to evaluate the relation between the site of secondary T wave changes and the location of the AP. METHODS: Of the total 128 patients (pts) with WPW syndrome, standard 12 lead ECGs of 125 pts (mean age 35, male 71 pts) who were free from bundle branch block (n=2) and myocardial ischemia (n=1) were analyzed. The locations of Aps were divided into 4 categories (anterior, left lateral, posterior and right lateral) by intracardiac mapping. RESULTS: 82 (66%) pts of 125 pts showed secondary T wave changes. The incidence of secondary T wave changes was not related to sex or duration of preexcitation, but mean QRS duration (<0.12: 46%, 0.12: 88%, p<0.001), maximal QRS duration (<0.12: 32%, 0.12: 73%, p<0.001) and the site of AP (right: 80%, left: 54%, p=0.003). The most frequent lead showing secondary T wave changes in ECG was lateral (lead I, aVL) in pts with anterior (43%, 9 out of 21), posterior (50%, 25 out of 50) and right lateral (86%, 6 out of 7) AP. But, no secondary T wave change was found in most pts with left lateral (n=47) AP. CONCLUSION: The incidence of the secondary T wave changes in pts with WPW syndrome is high (66%). These changes are not related to sex and duration of preexcitation, but to the mean and maximal QRS duration during preexcitation and the location of the AP. The ECG lead showing secondary T wave changes in pts with WPW syndrome appears to be related to the location of the AP and the most frequent lead is I and aVL.
Bundle-Branch Block ; Electrocardiography ; Humans ; Incidence ; Male ; Myocardial Ischemia ; Wolff-Parkinson-White Syndrome

BACKGROUND: Recently, the incidence of acute myocardial infarction (AMI) rapidly increased with prolongation of life spans, improvements of food and life styles in Korea. The mortality rate of AMI is higher than other disease. The purpose of this study is to evaluate which factors can affect the early outcome of AMI in Korean. METHODS: A retrospective clinical study was done on 555 consecutive patients{Male:Female=387 (69.7%):168 (30.3%), mean age 61.3 years} with AMI who had been admitted to Dong-San Medical Center from January 1990 to May 1997 . The subjects were devided into two groups. Group I was dead patients during the in-hospital period (85 patients, 15.3%), and Group II was living patients (470 patients, 84.7%) wen they discharged from hospital. We compared clinical and laboratory results in both groups and analysed the cause of death according to the time of death during hospitalization. RESULTS: The results were as folows; 1) The mean age and female percentage of Group I (65.4 years, 43%) were higher than Group II (60.5 years, 28%). The mean of systolic/diastolic blood pressure and percentage of smoker of Group I (108/65mmHg, 48%) were lower than Group II (125/76mmHg, 65%), significantly. 2) The degree of Killip classification was higher in Group I (class 1:29.4%, II:18.8%, III:21.2%, IV:30.6%) than in Group II patients (class 1:73.4%, II:13.6%, III:8.7%, IV:4.3%), significantly. 3) 47 patients were died first day of hospitalization and the most common cause of death was cardiogenic shock (27 patients, 31%). The most common cause of death within 1 week was cardiogenic shock, afterthen congestive heart failure. 4) The most common cause of death in Killip class I patients was ventricular tachycardia or ventricular fibrillation and in Killip class II-IV patients was cardiogenic shock. CONCLUSION: The risk of in-hospital death was higher in elderly, female sex, and patients with higher killip classification. Cardiogenic shock was most common cause of death within 1 week, and was congestive heart failure after 1 week.
Aged ; Blood Pressure ; Cause of Death ; Classification ; Female ; Heart Failure ; Hospitalization* ; Humans ; Incidence ; Korea ; Life Style ; Life Support Care ; Mortality ; Myocardial Infarction* ; Retrospective Studies ; Shock, Cardiogenic ; Tachycardia, Ventricular ; Ventricular Fibrillation