With the development of modern medical detection technology,the requirement for ophthalmic diagnosis is raised,and many new measurement methods begin to apply in research and clinical,which makes the detection methods in the field of ophthalmology more accurate and comfortable.Optical coherence tomography angiography is a novel and noninvasive flow imaging technique,and it has the advantages of high resolution,fast scanning,as well as quantifying blood flow.Meanwhile,this technique can not only qualitatively analyze the shape of ocular blood vessels,but also be able to measure the ocular blood vessels and blood flow non-invasively,as well as to assess the depth of lesions.At present,with a wide clinical application in ophthalmology,optical coherence tomography angiography will be reviewed in this paper.

Cerebral infarction is a polygenic disease caused by genetic factors and environmental factors.The first discovery in the Icelanders is that the ALOX5AP and PDE4D gene polymorphism may be associated with cerebral infarction.So far,many conclusions of foreign studies are still controversial.This article will summarize the research status and the progress of these two genes.

Atherosclerosis is a chronic inflammatory disease of the vascular walls. As the essential mediators of inflammation, cytokines play important roles in atherosclerosis. Through widespread and penetrating studies, many cytokines, such as TNF-, IL-1, IL-6 and IFN-, are found involved in the development of atherosclerosis, as well as the related signal transduction pathways such as the NF- B pathway, the JNK / AP-1 pathway, and the JAK / STAT pathway. This implies that cytokines have a favorable perspective of clinical application. A few cytokines are identified as biomarkers, which help the early diagnosis of the disease and estimation of the risk of the clinical vascular events. Meanwhile, great progress has been made on the cytokine-targeted treatment of atherosclerosis, providing a novel therapy in the treatment of the disease.

Chlamydia pneumoniae(Cpn) is one of the most common pathogens causing human respiratory tract infection.They cause acute respiratory tract infection,atherosclerosis and many other diseases. Cpn infection often recur or remain persistent,which may induce Th1-type response.At the same time,antibody-mediated immune and Toll like receptor play an auxiliary role.In this review,the author summarized advances in the immune response to Chlamydia pneumoniae infection.

Acquired Immunodeficiency Syndrome ; drug therapy ; immunology ; Antiretroviral Therapy, Highly Active ; Child ; China ; HIV Infections ; drug therapy ; immunology ; Humans ; Male ; Research

OBJECTIVE To explore the status of nosocomial infection,infection sites of patients and susceptible factors of infection in neuro-intensive care unit(NICU) in order to correspondently prevent and control the occurrence of nosocomial infection.METHODS The clinical data of 471 patients admitted to NICU from Mar 2005 to Feb 2006 were investigated retrospectively.RESULTS Out of 471 cases in one year,a total of 90 cases of nosocomial infection were found.The rate of nosocomial infection was 19.11%.Among the nosocomial infection sites,the respiratory tract was the most frequent one(46.67%).The second was urinary tract(44.17%).The patients aged of more than 60 years,or with urethral catheter,mechanical ventilation,vein intubations,or with long medical intubation suffered infection more susceptibly than other patients.The infection rate of nosocomial infection was significantly different from hospitalization group.Sex was not evidently related to nosocomial infection.CONCLUSIONS The rate of nosocomial infection in NICU is largely higher than the total rate of infection.The susceptible factors are age,long-term hospitalization,invasive operations and long medical intubation.

Crisis Intervention ; Disasters ; Humans ; Stress, Psychological ; prevention & control

China ; Humans ; Mental Health ; Public Health Practice

Accurate qualitative and quantitative assessment of anterior or posterior segment structures is crucial,not only for proper diagnosis of different ocular diseases but also for optimal surgical planning and postoperative follow-up.As a noninvasive and noncontact method,optical coherence tomography (OCT) has become an essential tests for the diagnosis of retinal diseases.To a more recent technology,swept-source OCT (SS-OCT) improved the depth of imaging and the scan speed,which can perform anterior segment evaluation liking corneal graft examination.Meanwhile,this newly technology add multimodal approach such as EVV,OCTA and En face OCT,for angiography and choroid mapping.Thus,SS-OCT has become a valuable imaging strategy to understand the pathologies of retinal diseases such as PVD,diabetic maculopathy,neovascularization and macular telangiectasia.With the use of multimodal approach,SS-OCT is beneficial for optimal surgical planning and postoperative follow-up for the vitreoretinal diseases,such as epiretinal membrane,retinal detachment,and diabetic taction retinal detachment.Moreover,this technology can help us better understand the ophthalmic pathologies of glaucoma and tumors.This article reviews the technical principles of SS-OCT and the advances in clinical applications.

Tear is a complex fluid mainly secreted by lacrimal gland.It is a complex body fluid,which may contain thousands of protein/peptides and other molecules.Studies have determined that the changes in the chemical compositions of tears play an important role in some diseases and their progression.Tear components including protein,lipid and metabolites,which is easy to be obtained,not only can be used for biomarkers,can also be used to study an eye the onset of systemic disease process.Measuring the changes in composition of tear may be used to determine the critical path of the disease development,provide a new possibility for prevention and treatment.This article reviews the ophthalmic applications of tear markers in the systemic disease,which has not been determined so far.