Carcinomatous meningitis (CM) represents a devastating metastatic complication of malignant tumour, and the incident of CM is increasing in recent years. The diagnosis is made by both cerebrospinal fluid by lumbar puncture and radiological investigation, mainly magnetic resonance imaging. The therapeutic management of CM includes intrathecal administration of chemotherapy, radiotherapy, surgery and palliative care, but the treatment of CM remains controversial Individualized treatment and combined modality therapy are recommended at present, and the utilization of targeted drug may increase therapeutic effect of CM.

Objective To know the preventive effects of chemophlebitis by lidocaine mortar. Methods Divided 77 patients with chemophhbitis into the observation group (42 cases) and the control group (35 cases) randomly. Lidocaine mortar was used in the observation group to prevent chemophlebitis, while the 50% MgH2SO4 was used in the control group. Compared the preventive efficacy between the two groups. Results There were 13 cases and 2 cases of chemophhbitis in the control group and the obser-vation group respectively. The incidence rate of chemophlebifis in the observation group was significant low-er than that of in the contrel group. The condition of chemotherapy-associated pains and continue time in the observation group were better than in the control group. Conclusions The preventive efficacy of chemophlebitis by lidocaine mortar is obviously.

The mechanism of development of thymomas associated with myasthenia gravis(MG) is not completely clear. It is not hard to make diagnosis of thymomas associated with MG via clinical manifestation,radiological investigation and laboratory examination, however, the treatment of thymomas associated with MG remains controversial and there is no straightforward guidelines in the literatures. Most scholars think surgery is the first choice to treat thymomas associated with MG, but for those who are not suitable for surgery, radiotherapy and chemotherapy would be considered to be their choice combined with anti-cholinesterase and steroidsdrugs therapy.

Since 1990, the microembolic monitoring technology has been widely used in clinical practice and some progress has been made. This article reviews the new advances achieved in recent years, the problems facing and the direction of new development for microembolic monitoring in clinical research.

Objective To investigate the relationship of microembolic signals (MESs) between the degree of symptomatic carotid artery stenosis, ultrasonic characteristics of plaques, peak systolic velocity at the stenotic site and risk factors for stroke. Methods A total of 52 patients with symptomatic carotid artery stenosis were enrolled. MESs of bilateral middle cerebral arteries were monitored and detected by carotid color Doppler flow imaging. Results The positive rate of MESs on the symptomatic sides was significantly higher than that on the asymptomatic sides (28. 8% vs. 4. 5%, P < 0. 05). The positive rate was not significantly correlated with the degree of stenosis, ultrasonic characteristics of plaques, peak systolic velocity on the stenotic sides, and risk factors for stroke. Conclusions MESs mainly occurred on the symptomatic sides of carotid artery stenosis, and they were more closely correlated with unstable plaques.

Objective To approach a way to induce MSCs to dopaminergic neuron by mesencephalic conditional media and cytokines in vitro,and supply an ideal cells source for the treatment of Parkinson's disease.Methods The rat MSCs were isolated primarily from the femurs and tibias of the Wistar rats.MSCs were cultured,proliferated and purified by passage culture.Cultuered MSCs were divided into the control and the experimental group.In control group,MSCs were cultured without any induction medium.MSCs of experimental group were first cultured at medium containing bFGF for 24 hours.Then media were replaced with induction media which contained the agents as follows,respectively:GM_1,GDNF, GDNF+GM_1,GDNF+GM_1+mesencephalic conditional media.The surface markers of the differentiated neuron,such as NSE and TH were detected by immunocytoehemistry after MSCs were cultured in induction media for 3 and 7 days.Results In control groups,the NSE expression of MSCs was very lower than experimental groups.The percentage of NSE-positive cells of GDNF+GM_1+mesencephalic conditional media group in 7 day((45.257?5.999)/HP)was significantly more than other groups(control group is 2.214?0.779,GM_1 group is 22.014?3.624,GDNF group is 31.345?2.850,GDNF?GM_1 group is 40.314?4.203,P

Central serous chorioretinopathy( CSC) is an important cause for central vision loss. It mostly occurs in young and middle-aged men. It is a condition characterized by a serous detachment of neurosensory retina at the posterior pole and leakage from the retinal pigment epithelium ( RPE ) . Most patients with acute CSC will resolve spontaneously. However, in cases of chronic CSC with persistent serous retinal detachment, patients might develop progressive vision loss. This article was made a brief review of the current treatment methods, including laser, photodynamic therapy ( PDT ) , intravitreal anti-vascular endothelial growth factor therapy and the mineralocorticoid receptor antagonists.

Objective To establish a RP-HPLC method investigate the processing technique and mechanism of Eucommiae Cortex.Methods The RP-HPLC method was applied to simultaneously determining six ingredients,geniposidic acid,geniposide,genipin,chlorogenic acid,(+)-pinoresinol-di-β-D-glucopyranoside,and(+)-syringaresinol-di-β-D-glucopyranoside,in the different processed barks of Eucommia ulmoides.Results The valid method with good accuracy could be well used to study the processing technique of E.ulmoides;Besides,target ingredients in E.ulmoide were decreased within 6 h when they were processed.Conclusion Established RP-HPLC is a reliable method which could be used to research the processing technique of the barks ofE.ulmoides.Moreover,the result of this study could be provided with significant evidence of processed barks of E.ulmoides.

RhamnusL., a kind of traditional Chinese medicine, is mainly used to treat some diseases as a supplementary component in the formula. This paper, reviewed its potential medicinal value in the antibacterial activity, antioxidantactivity, anti-allergic activity and anti-tumor activity.

Objective To explore effect of CYP3A4 gene polymorphism and genetic testing on the efficacy of fentanyl in patients with extensive burns.Methods A prospective randomized controlled study, 149 patients with extensive burns were picked from Feburary to July in 2015.Patients were randomly divided into matched group ( n=56 ) and experimental group ( n=93 ) . The matched group was treated with fentanyl 5 g/kg to finish implementation of anesthesia induction.Depends on the gene detection results, the patients in experimental group were treated with 6 g/kg, 5 g/kg or 4 g/kg fentanyl.The VAS score at different time after operation in the experimental group and the control group were compared , and the dosage of fentanyl was observed.Patients whose VAS score was greater than 7 should treated with intramuscular injection of pethidine 100 mg, recorded all patients with pethidine,s additional cases and the times.At the same time, the adverse reactions of the two groups were recorded before and after hospital discharge. ResuIts The score of VAS was not significantly different after wake up immediatly after the surgery , and the score of VAS was significantly lower in the experimental group patients in 6h,12h after the surgery (P<0.05).The dosage of fentanyl in the experimental group and the number of the cases and the times were significantly decreased (P<0.05).The adverse reactions after the surgery such as nausea, vomiting, itching, drowsiness, and adverse reactions were significantly lower in the experimental group (P<0.05).ConcIusion CYP3A4 gene detection in patients with large area of burn in the individual drug use is important, because of patients’ genotype adjusting fentanyl dosagecan, it enhances significantly the analgesic effect, reduces the amount of drug use, and effectively reduces the adverse reactions.