With the development of modern medical detection technology,the requirement for ophthalmic diagnosis is raised,and many new measurement methods begin to apply in research and clinical,which makes the detection methods in the field of ophthalmology more accurate and comfortable.Optical coherence tomography angiography is a novel and noninvasive flow imaging technique,and it has the advantages of high resolution,fast scanning,as well as quantifying blood flow.Meanwhile,this technique can not only qualitatively analyze the shape of ocular blood vessels,but also be able to measure the ocular blood vessels and blood flow non-invasively,as well as to assess the depth of lesions.At present,with a wide clinical application in ophthalmology,optical coherence tomography angiography will be reviewed in this paper.

Cerebral infarction is a polygenic disease caused by genetic factors and environmental factors.The first discovery in the Icelanders is that the ALOX5AP and PDE4D gene polymorphism may be associated with cerebral infarction.So far,many conclusions of foreign studies are still controversial.This article will summarize the research status and the progress of these two genes.

Acquired Immunodeficiency Syndrome ; drug therapy ; immunology ; Antiretroviral Therapy, Highly Active ; Child ; China ; HIV Infections ; drug therapy ; immunology ; Humans ; Male ; Research

Chlamydia pneumoniae(Cpn) is one of the most common pathogens causing human respiratory tract infection.They cause acute respiratory tract infection,atherosclerosis and many other diseases. Cpn infection often recur or remain persistent,which may induce Th1-type response.At the same time,antibody-mediated immune and Toll like receptor play an auxiliary role.In this review,the author summarized advances in the immune response to Chlamydia pneumoniae infection.

Atherosclerosis is a chronic inflammatory disease of the vascular walls. As the essential mediators of inflammation, cytokines play important roles in atherosclerosis. Through widespread and penetrating studies, many cytokines, such as TNF-, IL-1, IL-6 and IFN-, are found involved in the development of atherosclerosis, as well as the related signal transduction pathways such as the NF- B pathway, the JNK / AP-1 pathway, and the JAK / STAT pathway. This implies that cytokines have a favorable perspective of clinical application. A few cytokines are identified as biomarkers, which help the early diagnosis of the disease and estimation of the risk of the clinical vascular events. Meanwhile, great progress has been made on the cytokine-targeted treatment of atherosclerosis, providing a novel therapy in the treatment of the disease.

Crisis Intervention ; Disasters ; Humans ; Stress, Psychological ; prevention & control

China ; Humans ; Mental Health ; Public Health Practice

OBJECTIVE To explore the status of nosocomial infection,infection sites of patients and susceptible factors of infection in neuro-intensive care unit(NICU) in order to correspondently prevent and control the occurrence of nosocomial infection.METHODS The clinical data of 471 patients admitted to NICU from Mar 2005 to Feb 2006 were investigated retrospectively.RESULTS Out of 471 cases in one year,a total of 90 cases of nosocomial infection were found.The rate of nosocomial infection was 19.11%.Among the nosocomial infection sites,the respiratory tract was the most frequent one(46.67%).The second was urinary tract(44.17%).The patients aged of more than 60 years,or with urethral catheter,mechanical ventilation,vein intubations,or with long medical intubation suffered infection more susceptibly than other patients.The infection rate of nosocomial infection was significantly different from hospitalization group.Sex was not evidently related to nosocomial infection.CONCLUSIONS The rate of nosocomial infection in NICU is largely higher than the total rate of infection.The susceptible factors are age,long-term hospitalization,invasive operations and long medical intubation.

The objective of this paper is to discover new potent inhibitors against EphB4 for cancer therapy via computer-aided drug design strategies including building 3D-QSAR models,virtual screening and molecular doc-king means.The first step is to generate pharmacophore models based on Catalyst/HypoGen algorithm.The best model,Hypo1,has the highest Correl value (0.96),the lowest RMS value (0.89),the closest total cost (101.26) to fixed cost (89.20),and the best Δcost (89.14).Subsequently,Hypo1 was subjected to test set validation and Fischer′s randomization verification and then was used as a 3D query to screen database.In order to further nar-row the number of hits,drug-likeness screening and molecular docking techniques were applied.Finally,23 novel molecules with diverse scaffolds were selected as possible candidates against EphB4 for further studies based on predicted activity analysis,docking scores,and binding modes analysis methods.

In recent years,there are many studies have reported that a small pupil syndrome appeared during routine phacoemulsification in patients with current or previous use of alpha-1 adrenergic receptor antagonists,with these clinical manifestations:an iris that appears floppy as it billows during normal irrigation and aspiration in the anterior chamber,a tendency for the iris to prolapse and progressive intraoperative miosis during surgery,which called intraoperative floppy iris syndrome This article mainly reviews the mobidity,pathogenesis,clinical features,complications,prophylaxis and treatment of the intraoperative floppy iris syndrome.