Purpose: The study aimed to examine the mediating effects of social support on the relationship between reality shock and turnover intention among new graduate nurses. Methods: This study included 146 new graduate nurses working in hospitals located in state G. Data were collected from August 9, 2023 to January 15, 2024.Data was collected through a survey. For data analysis, SPSS/WIN 25.0 program was used. The data were identified with frequency and percentage, mean, standard deviation, independent t-test and one-way ANOVA, Scheffé test, Pearson’s correlation coefficient, and Baron and Kenny’s 3-stage procedures. The statistical significance of the mediating effects was verified using the PROCESS macro model 4. Results: Social support exhibited a negative correlation with reality shock (r=-.47, p<.001) and turnover intention (r=-.61, p<.001). Additionally, there was a positive correlation (r=.67, p<.001) between reality shock and turnover intention. Notably, social support had a partial mediating effect on the relationship between reality shock and turnover intention (β=.49, p<.001). Conclusion This study demonstrated that social support serves as a partial mediator in the relationship between reality shock and turnover intention among new graduate nurses.Consequently, it is recommended that efforts be made to improve social support through institutional and legal improvement and the development and implementation of programs aimed at reducing turnover intention among new graduate nurses.

Purpose: The study aimed to examine the mediating effects of social support on the relationship between reality shock and turnover intention among new graduate nurses. Methods: This study included 146 new graduate nurses working in hospitals located in state G. Data were collected from August 9, 2023 to January 15, 2024.Data was collected through a survey. For data analysis, SPSS/WIN 25.0 program was used. The data were identified with frequency and percentage, mean, standard deviation, independent t-test and one-way ANOVA, Scheffé test, Pearson’s correlation coefficient, and Baron and Kenny’s 3-stage procedures. The statistical significance of the mediating effects was verified using the PROCESS macro model 4. Results: Social support exhibited a negative correlation with reality shock (r=-.47, p<.001) and turnover intention (r=-.61, p<.001). Additionally, there was a positive correlation (r=.67, p<.001) between reality shock and turnover intention. Notably, social support had a partial mediating effect on the relationship between reality shock and turnover intention (β=.49, p<.001). Conclusion This study demonstrated that social support serves as a partial mediator in the relationship between reality shock and turnover intention among new graduate nurses.Consequently, it is recommended that efforts be made to improve social support through institutional and legal improvement and the development and implementation of programs aimed at reducing turnover intention among new graduate nurses.

Purpose: The study aimed to examine the mediating effects of social support on the relationship between reality shock and turnover intention among new graduate nurses. Methods: This study included 146 new graduate nurses working in hospitals located in state G. Data were collected from August 9, 2023 to January 15, 2024.Data was collected through a survey. For data analysis, SPSS/WIN 25.0 program was used. The data were identified with frequency and percentage, mean, standard deviation, independent t-test and one-way ANOVA, Scheffé test, Pearson’s correlation coefficient, and Baron and Kenny’s 3-stage procedures. The statistical significance of the mediating effects was verified using the PROCESS macro model 4. Results: Social support exhibited a negative correlation with reality shock (r=-.47, p<.001) and turnover intention (r=-.61, p<.001). Additionally, there was a positive correlation (r=.67, p<.001) between reality shock and turnover intention. Notably, social support had a partial mediating effect on the relationship between reality shock and turnover intention (β=.49, p<.001). Conclusion This study demonstrated that social support serves as a partial mediator in the relationship between reality shock and turnover intention among new graduate nurses.Consequently, it is recommended that efforts be made to improve social support through institutional and legal improvement and the development and implementation of programs aimed at reducing turnover intention among new graduate nurses.

Purpose: The study aimed to examine the mediating effects of social support on the relationship between reality shock and turnover intention among new graduate nurses. Methods: This study included 146 new graduate nurses working in hospitals located in state G. Data were collected from August 9, 2023 to January 15, 2024.Data was collected through a survey. For data analysis, SPSS/WIN 25.0 program was used. The data were identified with frequency and percentage, mean, standard deviation, independent t-test and one-way ANOVA, Scheffé test, Pearson’s correlation coefficient, and Baron and Kenny’s 3-stage procedures. The statistical significance of the mediating effects was verified using the PROCESS macro model 4. Results: Social support exhibited a negative correlation with reality shock (r=-.47, p<.001) and turnover intention (r=-.61, p<.001). Additionally, there was a positive correlation (r=.67, p<.001) between reality shock and turnover intention. Notably, social support had a partial mediating effect on the relationship between reality shock and turnover intention (β=.49, p<.001). Conclusion This study demonstrated that social support serves as a partial mediator in the relationship between reality shock and turnover intention among new graduate nurses.Consequently, it is recommended that efforts be made to improve social support through institutional and legal improvement and the development and implementation of programs aimed at reducing turnover intention among new graduate nurses.

Purpose: : This study aimed to identify the effects of a multifaceted pediatric delirium education program for pediatric intensive care unit (PICU) nurses on their delirium knowledge, confidence in delirium nursing, and delirium evaluation accuracy. Methods: : This study used a one-group pretest-posttest design. The participants were 50 nurses in two units of the PICU at S General Hospital in Seoul. All participants took a 1-hour lecture with case-based practice for the first two weeks, and received feedback as they applied the program to clinical practice over the next two weeks. Test measures were completed before and after the four week intervention period for all participants. The delirium evaluation accuracy was measured using the Korean version of the Cornell Assessment of Pediatric Delirium. Data were analyzed using the chi-square and paired t-tests. Results: : After the Pediatric Delirium Education Program, nurses’ delirium knowledge (x2 =11.65, p =.001), confidence in delirium nursing (t=9.71, p＜.001), and delirium evaluation accuracy (t=6.07, p＜.001) improved significantly. Conclusions : Pediatric delirium education programs for PICU nurses were effective. For active application of the program in clinical practice in the future, various cases of childhood delirium and specific strategies for each subject must be developed. To achieve this, long-term intervention and research for multiple organizations are required.

Adipocyte differentiation is a very complex process in which whole-cell changes are accompanied. Among them, type I procollagen gene has been shown to specifically decrease during adipocyte differentiation; however, little is known about the molecular mechanism. To examine how type I procollagen gene expression is regulated at the level of transcription during adipocyte differentiation, 3T3-L1 preadipocyte cell line was used as an in vitro model. Northern blot analysis demonstrated that mRNA expression of type I procollagen gene was dramatically reduced during adipocyte differentiation. Time-course analysis indicated that decrease in mRNA expression occurred at early stage of differentiation. Studies on several stable cell lines showed that transcriptional activities of both alpha1 and alpha2 promoters decreased significantly during adipocyte differentiation. Despite extensive deletion-promoter analyses, however, we could not identify the cis-element responsible for the switch-off of type I procollagen gene during adipocyte differentiation, suggesting that the transcriptional repression of this gene occur through general transcription machinery rather than a specific cis-element. In conclusion, down-regulation of type I procollagen mRNA expression during adipocyte differentiation is due to repression of its promoter activity through general transcription machinery.
3T3 Cells ; Adipocytes/cytology/*metabolism ; Animal ; Cell Differentiation/*genetics ; Cell Line ; Collagen Type I/*genetics/metabolism ; Down-Regulation/genetics ; Gene Expression Regulation ; Genes, Reporter ; Kinetics ; Mice ; Mutation ; Procollagen/*genetics/metabolism ; Promoter Regions (Genetics) ; RNA, Messenger/metabolism ; Repressor Proteins/genetics/metabolism ; Transcription, Genetic

Adipocyte differentiation is a very complex process in which whole-cell changes are accompanied. Among them, type I procollagen gene has been shown to specifically decrease during adipocyte differentiation; however, little is known about the molecular mechanism. To examine how type I procollagen gene expression is regulated at the level of transcription during adipocyte differentiation, 3T3-L1 preadipocyte cell line was used as an in vitro model. Northern blot analysis demonstrated that mRNA expression of type I procollagen gene was dramatically reduced during adipocyte differentiation. Time-course analysis indicated that decrease in mRNA expression occurred at early stage of differentiation. Studies on several stable cell lines showed that transcriptional activities of both alpha1 and alpha2 promoters decreased significantly during adipocyte differentiation. Despite extensive deletion-promoter analyses, however, we could not identify the cis-element responsible for the switch-off of type I procollagen gene during adipocyte differentiation, suggesting that the transcriptional repression of this gene occur through general transcription machinery rather than a specific cis-element. In conclusion, down-regulation of type I procollagen mRNA expression during adipocyte differentiation is due to repression of its promoter activity through general transcription machinery.
3T3 Cells ; Adipocytes/cytology/*metabolism ; Animal ; Cell Differentiation/*genetics ; Cell Line ; Collagen Type I/*genetics/metabolism ; Down-Regulation/genetics ; Gene Expression Regulation ; Genes, Reporter ; Kinetics ; Mice ; Mutation ; Procollagen/*genetics/metabolism ; Promoter Regions (Genetics) ; RNA, Messenger/metabolism ; Repressor Proteins/genetics/metabolism ; Transcription, Genetic

This study was performed to develop a children's dietary life safety index required by the Special Act on Safety Management of Children's Dietary Life enacted in 2009. An analytical hierarchy process was used to obtain initial weights of dietary life safety evaluation indicators. The Delphi method was applied to develop the weights along with 98 food and nutrition professionals. Three representative policy indicators, nine strategy indicators, 11 main evaluation indicators, and 20 detailed evaluation indicators were selected for the children's dietary life safety assessment. Three policy indicators and nine strategy indicators were the following: children's food safety indicator (support level of children' safety, safety management level of children's favorite foods, and safety management level of institutional food service), children's nutrition safety indicator (management level of missing meals and obesity, nutrition management level of children's favorite foods, and nutrition management level of institutional food service), and children's perception and practice level indicator ("Dietary Life Law" perception level, perception, and practice level for dietary life safety management, perception, and practice level for nutrition management). Weights of 40%, 40%, and 20% were given for the three representative policy indicators. The relative importance of nine strategic indicators, which were determined by the Delphi method is as follows: For children's food safety, support level of children's safety, safety management level of children's favorite foods, and safety management level of institutional food service were given weights of 12%, 9%, and 19%, respectively. For children's nutrition safety, the missing meals and obesity management level, nutrition management level of children's favorite foods, and the nutrition management level of institutional food service were given weights of 13%, 11%, and 16%, respectively. The "Dietary Life Law" perception level, perception and practice level of dietary life safety management, and perception and practice level of nutrition management were given weights of 4%, 7%, and 9%, respectively.
Food Safety ; Food Services ; Korea ; Meals ; Obesity ; Safety Management ; Weights and Measures

SINE-VNTR-Alu (SVA) elements are present in hominoid primates and are divided into 6 subfamilies (SVA-A to SVA-F) and active in the human population. Using a bioinformatic tool, 22 SVA element-associated genes are identified in the human genome. In an analysis of genomic structure, SVA elements are detected in the 5' untranslated region (UTR) of HGSNAT (SVA-B), MRGPRX3 (SVA-D), HYAL1 (SVA-F), TCHH (SVA-F), and ATXN2L (SVA-F) genes, while some elements are observed in the 3'UTR of SPICE1 (SVA-B), TDRKH (SVA-C), GOSR1 (SVA-D), BBS5 (SVA-D), NEK5 (SVA-D), ABHD2 (SVA-F), C1QTNF7 (SVA-F), ORC6L (SVA-F), TMEM69 (SVA-F), and CCDC137 (SVA-F) genes. They could contribute to exon extension or supplying poly A signals. LEPR (SVA-C), ALOX5 (SVA-D), PDS5B (SVA-D), and ABCA10 (SVA-F) genes also showed alternative transcripts by SVA exonization events. Dominant expression of HYAL1_SVA appeared in lung tissues, while HYAL1_noSVA showed ubiquitous expression in various human tissues. Expression of both transcripts (TDRKH_SVA and TDRKH_noSVA) of the TDRKH gene appeared to be ubiquitous. Taken together, these data suggest that SVA elements cause transcript isoforms that contribute to modulation of gene regulation in various human tissues.
3' Untranslated Regions ; 5' Untranslated Regions ; Exons ; Gene Expression Profiling ; Genome, Human ; Genomics ; Humans ; Lung ; Organ Specificity ; Poly A ; Primates ; Protein Isoforms

Sarcoidosis is a granulomatous disease that can involve any organ, although it primarily involves the lungs, intrathoracic lymph nodes, skin, and eyes. We present a case of sarcoidosis with pancytopenia, resulting from bone marrow involvement. A 35-year-old man was admitted to hospital for chronic cough and blurred vision. On chest computed tomography, there were multiple pulmonary nodules and mediastinal lymph nodes enlargement. As the patient also showed pancytopenia, we performed a bone marrow biopsy, as well as a transbronchial lung biopsy. Both biopsies showed non-caseating granulomas. We diagnosed the patient with sarcoidosis with pulmonary, bone marrow, uvea, liver and spleen involvement. After oral steroid therapy, the patient's symptoms as well as his pancytopenia improved. We present this case to demonstrate the significance of bone marrow biopsy in cases of sarcoidosis with pancytopenia, as well the possibility of clinical improvement with steroid treatment.
Adult ; Biopsy ; Bone Marrow ; Cough ; Eye ; Granuloma ; Humans ; Liver ; Lung ; Lymph Nodes ; Multiple Pulmonary Nodules ; Pancytopenia ; Sarcoidosis ; Skin ; Spleen ; Thorax ; Uvea ; Vision, Ocular