Objective To investigate the identification role of plasma high sensitive Creactive protein (hs-CRP) and lipoprotein (a) (Lp [a]) levels in the diagnosis of patients with acute ischemic stroke according to the TOAST classification. Methods The levels of plasma hsCRP and Lp (a) in 82 acute stroke patients ( ＜24 hours) and 60 healthy controls were detected using immune scatter turbidimetry and immune transmission turbidity, and try to make use of Holter, ultrasonography, magnetic resonance imaging, magnetic resonance angiography/CT angiography/dagital subtraction angiography and other tests. Finally, they were classified according to the diagnostic criteria of the TOAST classification of ischemic stroke. Results There were significant differences in plasma hs-CRP and Lp (a) levels between all the subtypes of the acute ischemic sroke group and the control group (all P ＜0. 001). The the level of plasma hsCRP in patients with cardioembolism (CE) was highest. Hs-CRP could be used as a biological marker of CE subtype (odds ratio[OR] = 1. 84,95% confidence interval [CI] 1. 18-2. 85, P ＜ 0. 05). When its concentration was ＞ 3. 48 mg/L, the sensitivity and specificity of predicting CE were 89% and 83% respectively. The plasma level of the AT patients was highest, it could be used as a biological marker of AT subtype (OR = 1. 02, 95% CI 1. 01-1. 03, P＜0. 05); when its concentration was ＞ 183. 5 mg/L, the sensitivity and specificity of predicting AT were 87% and 85% respectively. Conclusions The plasma hs-CRP and Lp (a) levels of patients with acute ischemic stroke may provide some help for timely and accurate etiological typing.

The academic levels and contents of papers published in China on random control tests of treatment of infantile mycoplasmal pneumonia with traditional Chinese medicine were assessed and analyzed according to the current treatment of infantile mycoplasmal pneumonia with traditional Chinese medicine and the problems existed in order to further improve its clinical treatment.

Objective To investigate the therapeutic effect of hemofiltration (HF) on severe acute pancreatitis (SAP). Methods The data of 60 patients with SAP was retrospectively reviewed in terms of life vital signs, biochemical indexes and prognosis within 96 h. 30 cases (the average APACHE Ⅱ score was 16.64 ±4.21 ) underwent HF on the basis of traditional treatment while another 30 cases ( the average APACHE Ⅱ score was 15.05 ± 3.78) were treated traditionally. Results From the beginning to 96 h after treatment, vital signs and the biochemical indexes such as body temperature, respiration rate, heart rate, blood electrolytes, blood pressure, liver function and renal function were improved more obviously in patients who received HF treatment than those who only received traditional treatment. The hospitalization time was positively correlated with the disease onset time. Patients receiving HF treatment need shorter hospitalization time than patients receiving conventional treatment. There was no significant difference in terms of mortality rate between HF treatment group and conventional treatment group ( 16. 7% and 30% respectively). Conclusions HF treatment can improve some biochemical indexes and symptoms in SAP patients. For example, body temperature, respiration rate, heart rate,blood electrolytes, liver function, kidney function, lung function, abdominal pain and abdominal distension. It can shorten hospitalization time. However, HF has no significant effect on mortality rate.

In the undergraduate teaching assessment,"eaching quality control" is the core content of their inspection.This paper explained the quality control of the content,analyzed the challenge of improving the teaching quality and put forward the idea of constructing the perfect teaching quality control system from five aspects such as raising awareness and unifying thinking,establishing a sound teaching system,strengthening the organizational functions and responsibilities,grasping the key points and implementing the whole process of the quality control.

OBJECTIVE:To raise the exigency capacity of drug system to cope with the unexpected events of public heal_ th.METHODS:To set up a national drug contingency system(NDCS)for the unexpected events of public health.RESULTS:The NDCS should consist of the reserves of drugs,capacity,information and plan for emergent needs.CONCLUSION:Estab?lishment of NDCS is a way to access health mordernization.

Antiretroviral therapy(ART)has been started in an increasingly earlier period in clinical practice.However,owing to the failure of immunological reconstitution or maintenance of latent HIV-1 reservoir in present antiviral treatment,interleukin-2(IL-2)is widely used as an adjuvant to ART with a view to intensifying immunological reconstitution and to activating latent HIV-1 infections.Some conclusions could be drawn as follows,1)IL-2 can extend the half-life of CD+4 T cells and increase the number of CD+4 T cells.2)Compared with ART alone,IL-2 and HAART combination can not reduce HIV-1 related opportunistic infection or death.IL-2 clinical usage is mainly focused on purging HIV-1 reservoir.3)IL-2 combined with ART could increase out flow rate of HIV-1 latent reservoir to reduce HIV-1 infected quiescent memory cells in peripheral circulation even to an undetectable level.4)IL-2 is supposed to be used periodically and for a long period of time.

OBJECTIVE:To promote the development of hospital pharmaceutical information service(HPIS)and to bring pharmacists into full play in pharmaceutical service.METHODS:This article analyzed the running program of hospital pharmaceutical information and the existing problems in HPIS.RESULTS:New pattern of HPIS was put forward.CONCLUSION:HPIS is very important and should be promoted greatly.

OBJECTIVE:To investigate the effect of metformin on sex hormone level,insulin resistance and related indexes in women with polycystic ovarian syndrome(PCOS). METHODS:79 PCOS women were collected as PCOS group,other 86 healthy women as control group. All patients received 0.85 g Metformin tablet,twice a day,for totally 6 months. Boby mass,BMI,waist circumference,hip circumference,ratio of waist to hip,glycated hemoglobin,T,DHEA-S,E2,LH,FSH,PRL,PROG,SHBG, FPG,FINS,LH/FSH,HOMA-IR and FAI before and after treatment in PCOS group were observed and compared with control group. RESULTS:During treatment,2 patients made withdrawal because of pregnancy,3 made withdrawal because of showing gastrointestinal side effects,2 were lost to follow,totally 72 completed it. After treatment,body mass,BMI,waist circumference, hip circumference,glycated hemoglobin,FINS,HOMA-IR,T,LH,LH/FSH,PROG,FAI in PCOS group were significantly low-er than before,SHBG was significantly higher than before,glycated hemoglobin and PROG were lower than control group,while waist circumference,FINS,HOMA-IR,LH/FSH and FAI were higher than control group,the differences were statistically signifi-cant (P<0.05). There was no significant difference in ratio of waist to hip,FPG,DHEA-S,E2,FSH and PRL before and after treatment(P>0.05). CONCLUSIONS:Metformin can effectively improve the sex hormone levels and insulin resistance of patients with PCOS.

OBJECTIVE： To observe the effect of drug loading， medium composition， transdermal enhancer， lauryl alcohol and azone on percutaneous permeation of oxaprozin gel in vitro.METHODS： Drug permeation test was carried out by using modified Franz-type double compartment diffusion cell and isolated mice skin in vitro as transdermal barrier.RESULTS： Under the condition of an effective area of 5.77cm2， it was found that the result was stable and the reproducibility was well with drug loading more than 1.2g， the receiver solution ethanol to normal saline=7∶ 3(v∶ v);The transdermal enhancing effect of lauryl alcohol was superior to that of azone， the effect of mixed transdermal enhancer 3％ AZ＋ 10％ LA was the best.CONCLUSION： The selection of both the optimum release condition and the best penetration enhancers provided reference for oxaprozin transdermal delivery.The standardization of gel percutaneous test in vitro was discussed preliminarily.

The identification of the specific cause in every patient has important clinical implications, because ischemic stroke is an etiologically heterogeneous disease. The Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification can be used to define the etiology of stroke. However, TOAST classification can not be completed timely on admission of patients with acute stroke, which has impacted early guidance of clinical treatment. This article reviews the biological markers of early differential-diagnostic significance of the TOAST classification.