Objective:To evaluate the curative effect of electroacupuncture on postapoplectic incontinence of urine.Methods:One Hundred and fifty-five patients were randomly allocated into a treatment group of 102 cases and a control group Of 51 cases.The treatment group was treated with electroacupuncture and the control group with Wlestem medicine.The curative effects were evaluated after 1-2 months.Resuits:The basic cure rate.marked eriective rate,effective rate and inelyective rate were 47.0%,27.5%,1 8.6% and 6.9% respectively,with a total effective rate of 93.1%in the treatment group and 7.9%,1 7.6%,1 7.6% and 56.9% respectively,with a total effective rate of 43.1% in the control group.There was a statistically significant difference in curative effect between the two groups(P＜0.05).The curative effect was significantly beaer in the treatment group than in the control group.Conclusion:Electroacupuncture has a good curative effect on postapoplectic incontinence ofurine.

Objective:To evaluate the predictive value of 3 methods, namely plasma paraquat concentration, severity index of paraquat poisoning (SIPP), and acute physiology and chronic health evaluation (APACHE II) in severity evaluation and prognosis of acute paraquat poisoning. Methods:A total of 73 acute paraquat poisoning patients with oral administration were collected. Paraquat concentration in the plasma and other parameters on admission for SIPP and APACHE II were taken from medical records. According to the clinical outcome in the hospital or 7 days atfer the discharge, discrimination and calibration test were performed to evaluate the prognosis of the 3 methods. Results:Discrimination of the 3 methods was greater than 0.8, and the area under the receiver operator curve for SIPP (0.938) was greater than paraquat concentration in the plasma (0.857) and APACHE II (0.801) with statistical signiifcance (z=2.429, 2.021;P=0.015, 0.043). Difference in plasma paraquat concentration (0.857) and APACHE II (0.801) had no statistical signiifcance (z=0.755, P=0.450). Hosmer-Lemeshow good fit test suggested better calibration value with statistical signiifcance for the 3 methods (P>0.05). Conclusion:hTe 3 methods are valid in the severity evaluation and prognosis of acute paraquat poisoning. SIPP is the most preferred method, followed by paraquat concentration on admission. When there is no facility to measure paraqut concentration, APACHE II can be used as a reference for the death risk in acute paraquat poisoning.

Induced pluripotent stem cell ( iPS cell ) , similar to embryonic stem cell, can be repro-grammed to the pluripotent state by ectopic expression of specific transcription factors. The iPS cells have pluri-potency and can be induced into neuron cells,which represent a promising cellular tool to study human neurode-velopmental disease,drug screening,diagnosis and personalized treatment. This article reviews the latest progress on iPS cell and its applications in neural developmental disease.

Objective To evaluate the myocardial microvascular obstruction induced by occlusion of single coronary artery (OSCA) and stenosis of multi-coronary arteries (SMCA) using first-pass perfusion cardiac MRI. Methods We studied 33 patients who had acute myocardial infarct and received emergency coronary angiography and angioplasty. Coronary angiogram confirmed that 15 patients had complete occlusion of the single coronary artery and 18 patients had multi-coronary artery stenosis without occlusion. Cardiac MRI (CMRI) exam was performed at 6-12 weeks after diagnosis. Results CMRI demonstrated that 15 patients had first-pass perfusion defect in the endomyocardium. The signal intensity (SI) of the perfusion defect was significant lower than that in the normal myocardium. The maximal slope of SI showed that the there were 11 patients with occlusion of the single coronary artery and 4 patients with stenosis of multi-coronary arteries. Conclusion CMRI can show the microvascular obstruction limited in the region of endomyocardium. CMRI suggests that the occlusion of the single coronary artery may induce more severe myocardial microvascular obstruction than the stenosis of multiple coronary arteries.

Objective: This study aims to investigate the clinical effect of bronchoscopic interventional cryotherapy in the treatment of bronchial tuberculosis (BTB). Methods:158 patients admitted into our hospital from October 2012 to October 2015 were randomly divided into observation group (n=80) and control group (n=78). The control group was treated with standardized systemic chemotherapy, and the observation was treated by bronchoscopic interventional cryotherapy based on the control group in order to compare the negative rate of sputum bacteria, clinical efficacy and adverse reactions. Results: After treatment, the turn rate of the observation group was 98.75%, significantly higher than that of the control group (89.74%) (x2=5.964, P<0.05). Clinical effective rate was 97.50% in the observation group, significantly higher than the control group (84.62%) (x2=8.119, P<0.05). The adverse reactions of the observationt group were 5.00% and they were 12.82%in the control group. There was no statistical significance between the two groups (x2=2.236, P>0.05). Conclusion:It has obvious clinical curative effect of bronchoscopic interventional cryotherapy in the treatment of BTB. With simple operation, it has a higher negative rate of sputum bacteria and lower incidence of adverse reactions. It also can effectively improve the pulmonary function and protect lung tissue, which is worth popularizing in clinical application.

Consensus ; Humans ; Infant, Newborn ; Jaundice, Neonatal ; diagnosis ; therapy ; Practice Guidelines as Topic

Objective To study the expression of RASSF1A gene in gastric cancer tissues and cell lines and to investigate its clinical roles. Methods Immunohistochemistry was employed to detect the expression of RASSF1A gene in 39 cases of human gastric cancer tissues and 18 cases of normal human gastric tissues, and RT-PCR was used to examine the expression of RASSF1A mRNA in 4 gastric cancer cell lines, normal gastric cell lines GES-1 and positive control Hela cells. Correlations between expression of RASSF1A gene and clinicopathological characteristics of gastric cancer were also analyzed. Results All the normal gastric tissues (18 cases) were stained with anti-RASSF1A antibody, and significantly lower expression of RASSF1A was found in the 39 cases of gastric cancer tissues (P

Objective To evaluate the curative effect of salvage liver transplantation and repeated hepatectomy for recurrent hepatocel-lular carcinoma.Methods The data of 72 patients with recurrent hepatocellular carcinoma fulfilling Child-Pugh A and the Milan criteria from September 2004 to August 2010 were retrospectively studied.According to different treatments,53 patients were divided into repeated hepatec-tomy group,and 19 patients were divided into salvage liver transplantation group.The overall survival rates and disease-free survival rates after operation were evaluated by Kaplan-Meier method.COX proportional hazard was used for univariate analysis and multivariate analysis to eval-uate the risk factors for prognosis.Results The 1-year,3-year and 5-year survival rates were 86.79%,62.26% and 45.28% in repeated hepatectomy group,and 89.47%,68.42%and 57.89% in the salvage liver transplantation group respectively.There was no significant differ-ence in the overall survival rates between the two groups (χ2 =2.530,P =0.112).The 1-year,3-year and 5-year disease-free survival rates were 67.92%,47.17% and 35.85%in the repeated hepatectomy group,94.74%,68.42% and 52.63% in the salvage liver transplantation group respectively.There was a significant difference in the disease-free survival rates between the two groups(χ2 =4.395,P =0.036).The univariate analysis and multivariate analysis indicated that microvascular invasion,satellite lesion and multiple tumors were the independent risk factors to influence the survival.Conclusion The salvage liver transplantation obtains a better effect for the patients fulfilling Child-Pugh A and the Milan criteria,which is an effective method in the treatment of hepatocellular carcinoma.

It is the hot spot of medical information specialty to discover the value of data and information and to judge the decision making in medical and health undertakings in the big data time by effective use of information analysis management techniques.Themedical information analysis and decision-makingcourse, offered for the undergraduates of information management specialty in Guangdong Pharmaceutical College, helps them to master the theories of information analysis and knowledge application, the ability to analyze data, the ability to perform decision-making, the ability to discover knowledge, due to their trade background, characteristic specialty, and employment skills.The graduates of information management specialty from Guangdong Pharmaceutical College can thus preferably employed by medical information management institutions.

Objective To discuss the correlations between hemoperfusion(HP) times and therapeutic effects/prognosis in patients with severe acute organophosphorus poisoning(AOPP). Methods According to the frequency of HP,82 patients with severe AOPP were divided into three groups:non HP(25 cases),HP1(27 cases) and HP2(30 cases)groups. The non HP group received only routine treatment,on the basis of routine treatment,the HP1 group accepted once HP within 12 hours after poisoning and the HP2 group underwent twice or more times of HP,the interval between each time being 24 hours. The comparisions of clinical indexes,incidences of complications and rates of mortality among the three groups were performed. Results With the increase of HP times,the dosages of atropine and pralidoxime chloride were significantly reduced,the times of serum cholinesterase(ChE)activity recovery,consciousness recovery,hospitalization and mechanical ventilation were significantly shortened,the score of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score in 48 hours after admission,incidence of complications and mortality were evidently decreased(all P<0.05). Compared with those in HP1 group,the dosages of atropine(mg:164.57±68.82 vs. 256.81±97.06)and pralidoxime chloride(mg:6.95±1.40 vs. 8.76±1.64) in HP2 group were significantly reduced,the times of ChE activity recovery(day:9.03±2.46 vs. 10.96±3.44), consciousness recovery(hour:23.83±6.29 vs. 39.93±8.24),hospitalization(hour:9.57±2.39 vs. 11.52±3.02) and mechanical ventilation(hour:40.50±16.55 vs. 65.74±18.88)in HP2 group were significantly shortened;APACHEⅡscore during 48 hours after admission(11.97±3.47 vs. 14.26±2.88)was obviously decreased,and the incidences of complications,such as intermediate syndrome(10.0% vs. 18.5%),rebound phenomenon(3.3% vs. 25.9%),arrhythmia(13.3%vs. 44.4%),multiple organ dysfunction syndrome(MODS,6.7%vs. 29.6%)and mortality rate(6.7% vs. 18.5%)in HP2 group were markedly decreased(all P<0.05). Conclusion It is recommendable that combined with routine treatment,early and multiple HP application would enhance the therapeutic effect and decrease the mortality in patients with severe AOPP.