Objective:To explore the application effect of empathy nursing in patients after laparoscopic sleeve gastrectomy.Methods:Using the convenient sampling method, a total of 100 patients who underwent laparoscopic sleeve gastrectomy in Shanghai Tenth People's Hospital from January 2018 to October 2019 were selected as the research objects. According to the random number table, the patients were divided into two groups. The control group ( n=50) received routine clinical nursing, while the observation group ( n=50) received empathy nursing on the basis of the control group. The BMI, body fat percentage, abdominal circumference, the Positive Affect Scale, the Negative Affect Scale and the Chinese version of the MOS 36-item Short-Form Health Survey (SF-36) scores were compared between the two groups before and 6 months after the operation. Results:At 6 months after operation, BMI, body fat percentage and abdominal circumference of patients of two groups were lower than those before operation, and BMI, body fat percentage and abdominal circumference of the observation group were lower than those of the control group at 6 months after operation, and the differences were statistically significant ( P<0.01) . At 6 months after surgery, scores of the Negative Affect Scale and the Positive Affect Scale of patients in two groups were significantly different from those before surgery, and the differences were statistically significant ( P<0.01) . The score of the Negative Affect Scale in the observation group was lower than that in the control group, and the score of the Positive Affect Scale in the observation group was higher than that in the control group, and the differences were statistically significant ( P<0.01) . At 6 months after operation, scores of the SF-36 in each dimension of the two groups were higher than those before the operation, and scores of patients in the observation group were higher than those in the control group, and the differences were statistically significant ( P<0.05) . Conclusions:Empathy nursing for patients after laparoscopic sleeve gastrectomy can improve their mental state, reduce their weight-related indicators and improve their quality of life, which has better clinical application value.