1.A Case of Diffuse Leukoencephalopathy Caused by 5-Fluorouracil Derivatives.
Sung Sang YEUN ; Dae Il JANG ; Kyung Chun JUNG
Journal of the Korean Neurological Association 1993;11(3):471-473
A stomach cancer patient is reported, who presented with asterixis and dysarthria, after the administration of 5-fluorouracil derivatives, and progressed to a state of arnnesia and disorientation. At first impression was metastatic brain tumor however7 the result of a cerebrospinal fluid cytology for malignancy was negative, and magnetic resonance imaging study(MRI) revealed diffuse hyperintense lesion of the white matter, indicative of leukoencephalopathy. Upon discontinuing the drugs, patient recovered significantly.lly predominant muscle weakness from distal myopathy with rimmed vacuole formation While we present a young female.
Brain Neoplasms
;
Cerebrospinal Fluid
;
Distal Myopathies
;
Dysarthria
;
Dyskinesias
;
Female
;
Fluorouracil*
;
Humans
;
Leukoencephalopathies*
;
Magnetic Resonance Imaging
;
Muscle Weakness
;
Stomach Neoplasms
;
Vacuoles
2.External Fixation of Long Bone Fractures in Children
Se Hyun CHO ; Hae Ryong SONG ; Kyung Hoi KOO ; Young Sik MIN ; Yeun Chun JUNG ; Sun Chul HWANG ; Jai Soo KIM ; Ji Yeun KIM
The Journal of the Korean Orthopaedic Association 1994;29(6):1525-1535
Twenty-eight patients with 20 tibia fractures and 8 femur fractures were treated with external fixation. The average age at fracture was 10 years 10 months ranging from 5 years to 17 years 6 months. Of 28 fractures, 6 were closed fractures and 22 were open fractures. The average follow-up of these children was 23 months. Monofixators were used in 12 fractures and Ilizarov fixators in 16 fractures. The average time to healing of the fractures was 14.6 weeks(range, 6 to 44 weeks). Seven segmental bone defects(range, 2 to 17cm) were treated with the Ilizarov method of internal bone transport using the transport ring and bone grafting at the docking site. The average healing index for callus distraction was 25 days per centimeter. Seven patients had 10 major complications that necessitated additional operative procedures. There were 4 nonunions. Three patients had an infected nonunion, which was treated with the Ilizarov fixator and polymethyl-methacrylate antibiotic beads. One patient had a hypertrophic nonunion which was treated with plate fixation. Three patients who had an epiphyseal injury had shortening with angular deformity, which was treated by callus distraction. Three patients had a joint contracture, which was treated by the percutaneous tenotomy and Ilizarov fixator. The selection of the type of external fixator depends on the fracture pattern and the Ilizarov fixator is recommended for complicated fracture with severe comminution or segmental bone loss.
Bone Transplantation
;
Bony Callus
;
Child
;
Congenital Abnormalities
;
Contracture
;
External Fixators
;
Femur
;
Follow-Up Studies
;
Fractures, Bone
;
Fractures, Closed
;
Fractures, Open
;
Humans
;
Ilizarov Technique
;
Joints
;
Surgical Procedures, Operative
;
Tenotomy
;
Tibia
3.A Case of Group O without Anti-A,B due to hypogammaglobuluinemia.
Jae Ho LEE ; Kyung Hae JUNG ; Kyou Sup HAN ; Bok Yeun HAN ; Jong Hyun YOON ; Sa Ail CHUN
Korean Journal of Blood Transfusion 1996;7(2):269-273
An ABO discrepancy was observed in a 19-year-old man clinically diagnosed as congenital hypogammaglobulinemia. The patient's red cell was typed as group O, and his serum had no ABO isoagglutinins. Absence of A antigen and B antigen on patient's RBC was confirmed by adsorption- elution test and saliva test. A-transferase and B-transferase activities were not demonstrated in patient's serum. Patient's serum protein electrophoresis revealed hypogammaglobulinemia pattern, and immunoglobulin levels were markedly decreased. Complete absence of B lymphocytes was observed on patient's lymphocyte subset profile. Patient's father and mother were typed as blood group O and no abnormalities were recognized in their serum protein electrophoresis patterns and immunoglobulin concentration.
Agammaglobulinemia
;
B-Lymphocytes
;
Electrophoresis
;
Fathers
;
Humans
;
Immunoglobulins
;
Lymphocyte Subsets
;
Mothers
;
Saliva
;
Young Adult
4.Sacrococcygeal chondroma developed in young adult: a case report.
Chong Suh LEE ; Se Hyun CHO ; Hae Ryong SONG ; Kyung Hoi KOO ; Jin Myung JUNG ; Hyung Bin PARK ; Yeun Chun JUNG ; Sun Chul HWANG
The Journal of the Korean Orthopaedic Association 1992;27(7):1959-1965
No abstract available.
Chondroma*
;
Humans
;
Young Adult*
5.Chromosime Analysis from Chorionic Villi Samples in Recurrent Sponataneous Abortion.
Tae Wook YOO ; Jung Hye HWANG ; Moon Il PARK ; Sung Ro CHUNG ; Yeun Young HWANG ; Sung Han SHIM ; Chun Geun LEE ; Yool Hee CHO
Korean Journal of Perinatology 1997;8(4):408-413
Recurrent abortion has been defined as the occurrence of three or more clinically recognized pregnancy loss before 20 weeks and it occurs in 1% of women. The chromosomal abnormalities of abortuses have been suggested as the most common causes of recurrent abortion. We have studied the incidence of chromosomal abnormalities in 57 patients with recurrent abortion using the chorionic villi samples. Of the 57 abortuses analysed, 32 (56.1%) had chromosomal abnormalities. Trisomy was predominant (23 cases, 40.4%), followed by mosaicism 3 (5.2%), tetraploidy 2 (3.5%), monosomy 2 (3.5%), and structural anomaly 1 (1.8%). Trisomy for the chromosome 16 was most prevalent among trisomies. The incidence of trisomy was positively related to matemal age above 35 year-old. But there is not statistically significant. And there are no correlation between gestational age and chromosomal abnormalities. In conclusion, the incidence of chromosomal abnormalities of recurrent abortuses was 56.1% which was similar to that of the other reports. This means that the analysis of karyotype of chorionic villi, as the first test to investigate the cause of recurrent abortion, may be not useful, however, it will require further.
Abortion, Habitual
;
Adult
;
Chorion*
;
Chorionic Villi Sampling
;
Chorionic Villi*
;
Chromosome Aberrations
;
Chromosomes, Human, Pair 16
;
Female
;
Gestational Age
;
Humans
;
Incidence
;
Karyotype
;
Monosomy
;
Mosaicism
;
Pregnancy
;
Tetraploidy
;
Trisomy
6.Clinical experience of long-term home oxygen therapy.
Young Suk LEE ; Seung Ick CHA ; Chun Duk HAN ; Chang Ho KIM ; Yeun Jae KIM ; Jae Yong PARK ; Tae Hoon JUNG
Tuberculosis and Respiratory Diseases 1993;40(3):283-292
No abstract available.
Oxygen*
7.Treatment of type III open fracture with the orthofix and ilizarov fixator.
Hae Ryong SONG ; Se Hyun CHO ; Chong Suh LEE ; Kyung Hoi KOO ; Hyung Bin PARK ; Yeun Chun JUNG ; Sun Chul HWANG
The Journal of the Korean Orthopaedic Association 1993;28(2):761-773
No abstract available.
Fractures, Open*
8.Biomechanical study on the fixation with adjunctive methylmethacrylate for the femoral intertrochanteric fracture.
Hae Ryong SONG ; Chong Suh LEE ; Se Hyun CHO ; Hyung Bin PARK ; Yeun Chun JUNG ; Suk Hyun LEE ; Hong Kun LEE
The Journal of the Korean Orthopaedic Association 1991;26(5):1413-1424
No abstract available.
Methylmethacrylate*
9.PAIVS: prediction of avian influenza virus subtype
Hyeon-Chun PARK ; Juyoun SHIN ; Sung-Min CHO ; Shinseok KANG ; Yeun-Jun CHUNG ; Seung-Hyun JUNG
Genomics & Informatics 2020;18(1):e5-
Highly pathogenic avian influenza (HPAI) viruses have caused severe respiratory disease and death in poultry and human beings. Although most of the avian influenza viruses (AIVs) are of low pathogenicity and cause mild infections in birds, some subtypes including hemagglutinin H5 and H7 subtype cause HPAI. Therefore, sensitive and accurate subtyping of AIV is important to prepare and prevent for the spread of HPAI. Next-generation sequencing (NGS) can analyze the full-length sequence information of entire AIV genome at once, so this technology is becoming a more common in detecting AIVs and predicting subtypes. However, an analysis pipeline of NGS-based AIV sequencing data, including AIV subtyping, has not yet been established. Here, in order to support the pre-processing of NGS data and its interpretation, we developed a user-friendly tool, named prediction of avian influenza virus subtype (PAIVS). PAIVS has multiple functions that support the pre-processing of NGS data, reference-guided AIV subtyping, de novo assembly, variant calling and identifying the closest full-length sequences by BLAST, and provide the graphical summary to the end users.
10.PAIVS: prediction of avian influenza virus subtype
Hyeon-Chun PARK ; Juyoun SHIN ; Sung-Min CHO ; Shinseok KANG ; Yeun-Jun CHUNG ; Seung-Hyun JUNG
Genomics & Informatics 2020;18(1):e5-
Highly pathogenic avian influenza (HPAI) viruses have caused severe respiratory disease and death in poultry and human beings. Although most of the avian influenza viruses (AIVs) are of low pathogenicity and cause mild infections in birds, some subtypes including hemagglutinin H5 and H7 subtype cause HPAI. Therefore, sensitive and accurate subtyping of AIV is important to prepare and prevent for the spread of HPAI. Next-generation sequencing (NGS) can analyze the full-length sequence information of entire AIV genome at once, so this technology is becoming a more common in detecting AIVs and predicting subtypes. However, an analysis pipeline of NGS-based AIV sequencing data, including AIV subtyping, has not yet been established. Here, in order to support the pre-processing of NGS data and its interpretation, we developed a user-friendly tool, named prediction of avian influenza virus subtype (PAIVS). PAIVS has multiple functions that support the pre-processing of NGS data, reference-guided AIV subtyping, de novo assembly, variant calling and identifying the closest full-length sequences by BLAST, and provide the graphical summary to the end users.