We present a case of ovarian leiomyoma without related clinical symptoms in a 68-year-old woman. Leiomyoma arising primarily in the ovary is rare. However, it is believed that there are actually more cases than those reported because this condition is usually mistaken for a fibrothecoma or parasitic leiomyoma. Most cases previously reported were incidentally presented and coexisted with other ovarian lesions. The present case was characterized by a 9 cm, round lobulated mass that totally replaced the left ovary without uterine leiomyoma or coexisting ovarian lesions.
Aged ; Female ; Humans ; Leiomyoma* ; Ovary*

No abstract available.
Humans ; Infant, Newborn*

During inflammation of the colon, cells of the gut mucosa produce or express numerous inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1 beta), and intercellular adhesion molecule 1 (ICAM-1). These mediators have been implicated as contributory factors to the inflammatory process, which results in colitis during inflammatory bowel disease (IBD). Rebamipide is an anti-gastric ulcer drug with anti-inflammatory properties in vivo and in vitro. The effects of Rebamipide on IBD have not been largely evaluated. Therefore, this study investigated the potential of Rebamipide to regulate the production of inflammatory mediators such as TNF-alpha, IL-1beta, and ICAM-1. Mice with trinitrobenzene sulfonic acid (TNBS)-induced colitis (IBD animal model), were treated intrarectally with 2 mM Rebamipide. Body weight, macro- and micro-histological scores, and activity were evaluated. As an index of tissue edema, the thickness of the colonic wall was measured between the serosal surface and the luminal surface of the mucosa. TNF-alpha, IL-1 beta, and ICAM-1 were detected by immunohistochemical staining. Rebamipide treatment of mice exhibiting TNBS-induced colitis dramatically improved the clinical and histopathological findings of inflammation. In addition, Rebamipide suppressed TNF-alpha, IL-1 beta, and ICAM-1 expression in TNBS-treated animals. Taken together, these findings suggest that Rebamipide is a potential therapeutic agent for treating patients with IBD.
Animals ; Body Weight ; Colitis ; Colon* ; Down-Regulation* ; Edema ; Humans ; Inflammation ; Inflammatory Bowel Diseases ; Intercellular Adhesion Molecule-1* ; Interleukin-1beta ; Mice ; Mucous Membrane ; Phenobarbital ; Tumor Necrosis Factor-alpha* ; Ulcer

These are natural inhibitors of coagulation, and deficiencies of any of these factors is referred to as thrombophilia. The identified main causes of thrombophilia are deficiencies of antithrombin III, protein C, or protein S, resistance to actived protein C associated with Factor V Leiden mutation, and inherited hyperhomocystinemia. Inherited and acquired thrombophilias may also contribute to pathophysiological processes involved in recurrent pregnancy loss, fetal death, intrauterine growth restriction, placental abruption, placental infarction, and pre-eclampsia. Various therapeutic protocols with low-molecular-weight heparin (LMWH) were used. because it is associated with a low incidence of osteoporosis and thrombocytopenia. We experienced the two cases of successful deliveries by Cesarean section following a successful pregnancy maintenance in thrombophilia. we administered LMWH to prevent thromboembolism. one patient was the primi-gravidarum, with inherited thrombophilia, who has the familial history of pulmonary embolism and deep vein thrombosis. the other was the multi-gravidarum, with acquired thrombophilia, who has the past medical history of pulmonary embolism.
Abruptio Placentae ; Antithrombin III ; Cesarean Section ; Factor V ; Female ; Fetal Death ; Heparin, Low-Molecular-Weight ; Humans ; Incidence ; Infarction ; Osteoporosis ; Pre-Eclampsia ; Pregnancy Maintenance ; Pregnancy* ; Protein C ; Protein S ; Pulmonary Embolism ; Thrombocytopenia ; Thromboembolism ; Thrombophilia* ; Venous Thrombosis

OBJECTIVE: The aim of our study was to identify graft, obstetric and maternal outcomes of pregnancies in renal transplant recipients at our center. METHODS: A 14-year retrospective study between January 1990 and December 2003, 224 women 15 to 45 years of age had transplantation and were analyzed the outcomes of pregnancies, obstetric complications and graft function. RESULTS: Thirty-four pregnancies occurred in 21 of 224 patients. The mean age at the time of conception was 29.5 years (21 to 36 years) with a mean interval of 61.9 months (one to 162 months). In the pregnancy outcome, there were the 23 live births (67.6%) included 13 preterm and 10 term deliveries, 3 spontaneous abortions (8.8%), 7 artificial abortions (20.5%) and one case of ectopic pregnancy (2.9%). Obstetric complications were; preeclampsia (39.1%), preterm labor (43.4%), urinary tract infections (38.2%) and gestational diabetes (8.6%). Nine pregnancies within 2 years of transplantation had the permissible obstetric outcomes comparing with the others after 2 years (spontaneous abortion: p=0.77, artificial abortion: p=0.88, live birth: p=0.36). In twelve pregnancies appearing renal dysfunction associated with pregnancy, the abortion rate was increased comparing the others with stable renal function (p=0.006). Pre-pregnancy serum creatinine > or =1.4 mg/dl was associated with increased preterm delivery, but not significant (50.0% vs 28.5%, p=0.30). In graft function, serum creatinine 3~6 postpartum was significantly increased comparing pre-pregnancy levels (p=0.04). Five cases of 7 patients with acute rejection episode associated with pregnancy conceived after 4 years of transplantation. Two-year graft survival after delivery was 95.2% (20/21) and chronic rejection and graft failure was diagnosed in one case at postpartum 14 months. CONCLUSION: These findings suggest that, if the graft function is stable, pregnancy within 2 years after renal transplantation might be safe. Pregnancy does not appear to have adverse effects on long term graft survival.
Abortion, Induced ; Abortion, Spontaneous ; Creatinine ; Diabetes, Gestational ; Female ; Fertilization ; Graft Survival ; Humans ; Kidney Transplantation ; Live Birth ; Obstetric Labor, Premature ; Postpartum Period ; Pre-Eclampsia ; Pregnancy ; Pregnancy Outcome* ; Pregnancy* ; Pregnancy, Ectopic ; Retrospective Studies* ; Transplantation* ; Transplants ; Urinary Tract Infections

PURPOSE: Most burn scar contractures are curable with skin grafts, but free flaps may be needed in some cases. Due to the adjacent tissue scarring, local flap is rarely used, and thus we may consider free flap which gives us more options than local flap. However, inappropriate performance of free flap may lead to unsatisfactory results despite technical complexity and enormous amount of effort. The author will discuss the points we should consider when using free flaps in treating burn scar contractures METHODS: We surveyed patients who underwent free flaps to correct burn scar contractures from 2000 to 2007. We divided patients into two groups. The first group was those in which free flaps were inevitable due to exposure of deep structures such as bones and tendons. The second group was those in which free flap was used to minimize scar contracture and to achieve aesthetic result. RESULTS: We performed 44 free flap on 42 patients. All of the flaps were taken well except one case of partial necrosis and wound dehiscence. Forearm free flap was the most common with 21 cases. Most of the cases(28 cases) in which free flaps were inevitable were on the wrist and lower limbs. These were cases of soft tissue defect due to wide and extensive burns. Free flaps were done in 16 cases to minimize scar contracture and to obtain aesthetic outcome, recipient sites were mostly face and upper extremities. CONCLUSION: When using free flaps for correction of burn scar contractures, proper release and full resurfacing of the contracture should be carried out in advance. If inadequate free flap is performed, secondary correction is more challenging than in skin grafts. In order to optimize the result of reconstruction, flap thickness, size and scar of the recipient site should be considered, then we can achieve natural shape, and minimize additional correction.
Burns ; Cicatrix ; Contracture ; Forearm ; Free Tissue Flaps ; Humans ; Lower Extremity ; Necrosis ; Skin ; Tendons ; Transplants ; Wrist

PURPOSE: Cardiovascular risk assessment of atherosclerotic arterial occlusive diseases is a critical component of preoperative care. Many indexes have been developed to help identify patients at high risk for perioperative cardiac events. We sought to study guideline implementation and clinical outcomes in cardiovascular risk assessment. METHOD: We studied 75 patients who underwent preoperative cardiac risk assessment between 2003 and 2006 at the Kyung Hee University Medical Center. The American College of Cardiology/American Heart Association (ACC/AHA) guidelines were used to stratify the patients. RESULT: The mean age of patients was 67.9 years. When stratified into risk categories according to the ACC/AHA guidelines, 2 patients was high risk group, 51 intermediate risk group, and 22 low risk group. There were 3 perioperative cardiac complications (4.0%) including 2 mortalities (2.7%). There was a trend toward a higher frequency of cardiac complications when there was discordance with the ACC/AHA guidelines, but there was no significant difference (discordance 7.1%, concordance 0%, P=0.251). The guidelines recommended cardiac testing for 44 patients, but 12 patients (27.3%) were tested. The guidelines did not recommend for 31 patients, but additional cardiac tests were done for 10 patients (32.3%) and mainly associated with low risk group. CONCLUSION: Differences between clinician practice and guideline recommendations existed and did not result in a higher frequency of cardiac complications.
Academic Medical Centers ; Arterial Occlusive Diseases* ; Heart ; Humans ; Mortality ; Preoperative Care ; Risk Assessment*

OBJECTIVE: We focused the objective of this study on the obstetrical and statistical aspects of the unmarried mother, especially teenage pregnancy and 20's pregnancy. METHODS: The 112 well-documented records in the 130 unmarried mothers who delivered at Gangnam general hospital public corporation from 1998 to 2000, were enrolled in our study. Unmarried mothers were divided into three age groups; teenage group, 20's group and 30's group, then, each group was analyzed by liable methods, SPSS (Version 10.0.7) and data were processed by Student's t-test and accepted as the significant meaning within p-value less than 0.05, 95% significant level. RESULTS: In this study, teenage mothers were delivered lower birth weight babies than those of other groups (p=0.000001). Sex partners of teenage mothers, most school boy friends, were similar age to those mothers and low economic state. Despite desire of bringing up children (teenage 11% versus 20's 36%), they gave up their babies because of monetary matters and social bias. And teenage mothers felt stronger affection for babies than 20's. Teenagers' and 20's unmarried mothers have poor information about contraception (teenage group 42%, 20's 31%). CONCLUSION: The unmarried mothers have been constituting many social problems. Fortunately, the absolute number of the unmarried mothers have not increased but the teenage pregnancy has the majority of unmarried mothers (> OR =50%). It is necessary for unmarried mothers to take the education of contraceptive measures, the social systems of bringing up the boarder babies and the retraining courses of unmarried mothers.
Bias (Epidemiology) ; Birth Weight ; Child ; Contraception ; Education ; Female ; Friends ; Hospitals, General ; Humans ; Illegitimacy* ; Male ; Mothers ; Pregnancy ; Pregnancy in Adolescence ; Single Person* ; Social Problems

OBJECTIVE: We focused the objective of this study on the obstetrical and statistical aspects of the unmarried mother, especially teenage pregnancy and 20's pregnancy. METHODS: The 112 well-documented records in the 130 unmarried mothers who delivered at Gangnam general hospital public corporation from 1998 to 2000, were enrolled in our study. Unmarried mothers were divided into three age groups; teenage group, 20's group and 30's group, then, each group was analyzed by liable methods, SPSS (Version 10.0.7) and data were processed by Student's t-test and accepted as the significant meaning within p-value less than 0.05, 95% significant level. RESULTS: In this study, teenage mothers were delivered lower birth weight babies than those of other groups (p=0.000001). Sex partners of teenage mothers, most school boy friends, were similar age to those mothers and low economic state. Despite desire of bringing up children (teenage 11% versus 20's 36%), they gave up their babies because of monetary matters and social bias. And teenage mothers felt stronger affection for babies than 20's. Teenagers' and 20's unmarried mothers have poor information about contraception (teenage group 42%, 20's 31%). CONCLUSION: The unmarried mothers have been constituting many social problems. Fortunately, the absolute number of the unmarried mothers have not increased but the teenage pregnancy has the majority of unmarried mothers (> OR =50%). It is necessary for unmarried mothers to take the education of contraceptive measures, the social systems of bringing up the boarder babies and the retraining courses of unmarried mothers.
Bias (Epidemiology) ; Birth Weight ; Child ; Contraception ; Education ; Female ; Friends ; Hospitals, General ; Humans ; Illegitimacy* ; Male ; Mothers ; Pregnancy ; Pregnancy in Adolescence ; Single Person* ; Social Problems

Coronary arterioventricular fistula is a rare form of congenital malformation of coronary artery. A 29-year-old man presented with a 4-year history of shortness of breath and recently developed chest discomfort during exertion. A huge, dilated coronary arterioventricular fistula from right coronary artery to left ventricle was diagnosed with transthoracic echocardiography, transesophageal echocardiography and coronary angiography. This finding was confirmed by selective administration of the microbubble into the right coronary artery during transthoracic echocardiography monitoring. The opening of the fistula at the level of left ventricle was obliterated with autologous pericardium and the patient recovered and discharged uneventfully.
Adult ; Coronary Angiography ; Coronary Vessels* ; Dyspnea ; Echocardiography ; Echocardiography, Transesophageal ; Fistula* ; Heart Ventricles* ; Humans ; Microbubbles ; Pericardium ; Thorax