1.Clinical Features of Serious Adverse Drug Reactions in a Tertiary Care Hospital in Korea.
Yuri SEO ; Yeseul HAN ; Soo Hyun KIM ; Eun Sun SON ; Da Woon SIM ; Kyung Hee PARK ; Jung Won PARK
Korean Journal of Medicine 2017;92(4):392-400
BACKGROUND/AIMS: Several studies have reported on the clinical aspects of adverse drug reactions (ADRs). To date, no study has evaluated serious adverse drug reactions (SADRs) in Korea. The current study evaluates the clinical expression of SADRs in a Korean hospital. METHODS: We reviewed a total of 3,386 cases of SADR occurring between March 2012 and November 2015 in a single tertiary care institution (Regional Pharmacovigilance Center). RESULTS: When classified by organ system, the most common SADRs were white cell and reticuloendothelial system disorders (n = 511). Skin/appendage (n = 296) and gastrointestinal (n = 216) disorders were the fourth- and eighth-most common SADRs, respectively. The three most common single symptoms were leukopenia (n = 499 events), hypotension (n = 444) and anaphylaxis (n = 215). Leukopenia was mainly caused by anti-tumor drugs, followed by piperacilin/tazobactam (n = 28), vancomycin (n = 10) and methimazole (n = 6). Hypotension was most often caused by propacetamol injection (n = 145), while anaphylaxis was mainly caused by cefaclor (n = 19), ranitidine (n = 12), iopamidol (n = 10) and multi-vitamin infusion (n = 9). CONCLUSIONS: Significant differences were noted in the clinical aspects of ADRs and SADRs. Additional studies are warranted to further assess SADRs in response to frequently used causative drugs.
Anaphylaxis
;
Cefaclor
;
Drug Hypersensitivity
;
Drug-Related Side Effects and Adverse Reactions*
;
Hypotension
;
Iopamidol
;
Korea*
;
Leukopenia
;
Methimazole
;
Mononuclear Phagocyte System
;
Pharmacovigilance
;
Ranitidine
;
Tertiary Healthcare*
;
Vancomycin
2.Clinical Impact of Dysglycemia in Patients with an Acute Myocardial Infarction
Jae-Wook CHUNG ; Yeong-Seon PARK ; Jeong-Eon SEO ; Yeseul SON ; Cheol-Woo OH ; Chan-Hee LEE ; Jong-Ho NAM ; Jung-Hee LEE ; Jang-Won SON ; Ung KIM ; Jong-Seon PARK ; Kyu-Chang WON ; Dong-Gu SHIN
Diabetes & Metabolism Journal 2021;45(2):270-274
This study aimed to determine the impact of dysglycemia on myocardial injury and cardiac dysfunction in acute myocardial infarctions (AMIs). From 2005 to 2016, a total of 1,593 patients with AMIs who underwent percutaneous coronary intervention were enrolled. The patients were classified into five groups according to the admission glucose level: ≤80, 81 to 140, 141 to 200, 201 to 260, and ≥261 mg/dL. The clinical and echocardiographic parameters and 30-day mortality were analyzed. The peak troponin I and white blood cell levels had a positive linear relationship to the admission glucose level. The left ventricular ejection fraction had an inverted
3.Clinical Impact of Dysglycemia in Patients with an Acute Myocardial Infarction
Jae-Wook CHUNG ; Yeong-Seon PARK ; Jeong-Eon SEO ; Yeseul SON ; Cheol-Woo OH ; Chan-Hee LEE ; Jong-Ho NAM ; Jung-Hee LEE ; Jang-Won SON ; Ung KIM ; Jong-Seon PARK ; Kyu-Chang WON ; Dong-Gu SHIN
Diabetes & Metabolism Journal 2021;45(2):270-274
This study aimed to determine the impact of dysglycemia on myocardial injury and cardiac dysfunction in acute myocardial infarctions (AMIs). From 2005 to 2016, a total of 1,593 patients with AMIs who underwent percutaneous coronary intervention were enrolled. The patients were classified into five groups according to the admission glucose level: ≤80, 81 to 140, 141 to 200, 201 to 260, and ≥261 mg/dL. The clinical and echocardiographic parameters and 30-day mortality were analyzed. The peak troponin I and white blood cell levels had a positive linear relationship to the admission glucose level. The left ventricular ejection fraction had an inverted