1.A case of carbamazepine-induced toxic epidermal necrolysis.
Gi Chan NA ; Kyung Seok KIM ; Eun Gyeoung JUNG ; Kyung Rae MOON ; Sang Kee PARK ; Yeoung Bong PARK
Journal of the Korean Pediatric Society 1993;36(11):1630-1634
Drug-induced toxic epidermal necrolysis (TEN) is a bullous erythematous disease that is characterized by the appearance of scaled lesions and large sheets of pilling on the skin. A caseof TEN occured in a 10 month old female patient. The characteristic skin lesions of TEN developed after oral administration of carbamazepine for a partial seizure. Thig case consists of prodrome of malaise, fever, anorexia, and conjunctivity followed by erythema & flaccid bullae formation. Diagnosis was confirmed by histologic findings. This patient was treated with a massive systemic corticosteroid, antibiotics, fluid and electrolytes, and topical measures. Authors experienced an extremely rare case of TEN dur to carbamazepine, So report it with a brief review of literature.
Administration, Oral
;
Anorexia
;
Anti-Bacterial Agents
;
Carbamazepine
;
Diagnosis
;
Electrolytes
;
Erythema
;
Female
;
Fever
;
Humans
;
Infant
;
Seizures
;
Skin
;
Stevens-Johnson Syndrome*
2.Detection of the c-m c Oncogene Amplification in Ovarian Carcinomas by Differential Polymerase Chain Reaction.
Geun Shin LYU ; Chan Kum PARK ; Chun Geun LEE ; Youl Hee CHO ; Youn Yeoung HWANG ; Jung Dal LEE
Korean Journal of Pathology 1997;31(7):644-654
The amplification of c-myc oncogene was evaluated in 42 cases of ovarian carcinomas to correlate with clinical parameters. Using oligonucleotide primers, sequences from the c-myc exon-3 gene and from a control gene, tissue plasminogen activator (tPA), were amplified simultaneously by polymerase chain reaction (PCR). After the products of differential PCR (d-PCR) were electrophoresed, slot blot hybridization was performed, and hybridized with P32 dATP-labeled myc and tPA oligonucleotide probes and then autoradiographed. The signal intensities of the two products were quantitated by densitometry and the ratios of two products (c-myc/tPA) were measured. The ovarian carcinomas showed significantly increased amplification of c-myc oncogene Oligonucleoti compared to normal control group (p<0.05). 15 of 42 cases (35.7%) showed various degrees of the MYC gene amplification up to 27 folds in various histologic types of ovarian carcinomas. No significant differences of the MYC gene amplification according to histologic subtypes, tumor action) grades and clinical stages of ovarian carcinomas were present.
Densitometry
;
DNA Primers
;
Genes, myc
;
Oligonucleotide Probes
;
Oncogenes*
;
Polymerase Chain Reaction*
;
Tissue Plasminogen Activator
3.Two Case of Peripartum Cardiomyopathy.
In Soo LEE ; Jae Nam MA ; Yeoung Chan PARK ; Kyung Weon LEE ; Jong Cheon WEON ; Yong Pil KIM
Korean Journal of Obstetrics and Gynecology 1999;42(3):664-668
Peripartum cardiomyopathy is defined as a syndrome of cardiac failure occurring in tbe latter part of pregnancy or in the puerperium, without obvious cause and without prior evidence of heart disease. Despite its infrequency, this clinical problem may have devastating consequences upon maternal and fetal outcome. It is important to recognize the association of cardiac failure and pregnancy as a separate syndrome so that, once identified, peripartum cardiomyopathy can be treated promptly and aggressively. We experienced two cases of peripartum cardiomyopathy, and report these cases with a brief review of the literatures.
Cardiomyopathies*
;
Heart Diseases
;
Heart Failure
;
Peripartum Period*
;
Postpartum Period
;
Pregnancy
4.Clinical Analysis of 149 Cases of Twin Pregnancies.
Yeoung Chan PARK ; Sun Hee KO ; Tae In LEE ; Jae Nam MA ; Kang Woo JUNG ; Jong Cheon WEON ; Yong Pil KIM
Korean Journal of Obstetrics and Gynecology 2000;43(9):1539-1543
No abstract available.
Humans
;
Pregnancy, Twin*
6.Two Cases of Ovarian Pregnancy.
Sang Moon LEE ; Jae Hyun JO ; In Soo LEE ; Kyoung Won LEE ; Yeoung Chan PARK ; Kun Seog SEO ; Hong Ju LEE
Korean Journal of Obstetrics and Gynecology 1997;40(12):2909-2912
No abstract available.
Female
;
Pregnancy
;
Pregnancy, Ectopic*
7.Treatment Effects of MIN GLASSES for Amblyopia and Diplopia.
Byung Moo MIN ; Kil Hwan KO ; Sang Jin KIM ; Myung Mi KIM ; Yeoung Geol PARK ; Soo Chul PARK ; Chan PARK ; Jong Bok LEE ; Hyo Sook AHN ; Se Oh OH ; In Gun WON
Journal of the Korean Ophthalmological Society 1996;37(3):533-540
MIN GLASSES is specially manufactured in order to enhance satisfaction of wearer and therefore increase the effectiveness of treatment of an amblyopia and a diplopia. One of the lens is specially grounded and coated to blur vision. Cosmetically, the eye appears to wear regular glasses through the blur lens. We prospectively studied 58 amblyopic children and 10 diplopic adults. Each patient was treated with MIN GLASSES for cosmetic problems. We checked linear visual acuity of pre- and post-treatment. Questionnaires were given to the patients and parents regarding cosmetic satisfaction with treatment. In amblyopic children. 44 patients(75.9%) showed visual acuity improvement of 1.61 +/- 1.50 lines by Han's visual acuity chart. Patient compliance was 87.9%(51 patients) with patient satisfaction based on a questionnaire response. Parents were 87.9%(51 parents) positive response. In diplopic adults, 10 patients(100%) were positive response with satisfaction and demonstrated to be free of symptom of diplopia. MIN GLASSES is effective in high compliance satisfaction of amblyopia and diplopia, and improvement of visual acuity of amblyopia.
Adult
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Amblyopia*
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Child
;
Compliance
;
Diplopia*
;
Eyeglasses*
;
Glass*
;
Humans
;
Parents
;
Patient Compliance
;
Patient Satisfaction
;
Prospective Studies
;
Surveys and Questionnaires
;
Visual Acuity
8.Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in LAG for Gastric Cancer: Prospective Randomized Double Blind Study.
Min Chan KIM ; Tae Young KANG ; Ki Jae PARK ; Sung Heun KIM ; Ghap Joong JUNG ; Seung Cheol LEE ; Heui Yeoung KIM
Journal of the Korean Surgical Society 2007;72(1):32-37
PURPOSE: The method of locally administered ketorolac and bupivacaine with epinephrine in LAG patients was examined for the control of postoperative pain. METHODS: Fifty-one patients who had undergone LAG for gastric cancer from Jan. 2005 and Aug. 2005 were enrolled in this study. All the patients were administered a fentanyl patch (25 microgram/hr) on the upper back 2 hours before the entry into the OR. Upon the completion of LAG, the patients were randomly selected for a local injection of Ketolorac and bupivacaine. Ketolorac (30 mg, 1 cc) plus 0.5% bupivacaine with 1 : 100,000 epinephrine (9 cc) was injected in the peritoneum and subcutaneous tissue of the mini-laparotomy wound in the study group, and normal saline (10 cc) was injected into the control group. The postoperative pain scores were assessed at 6 hr, day 1, day 2 and day 5 using a Verbal Numerical Rating Scale by a Wound Ostomy Continence Nurse. Meperidine (25 mg iv.) was used for additional analgesia. RESULTS: The frequency of additional analgesic requirement was significantly lower in the study group and the pain score was significantly lower at 6 hr postoperatively than in the control group. CONCLUSION: Locally administered ketorolac and bupivacaine with epinephrine is a simple and cost-effective technique for alleviating postoperative pain in LAG patients with gastric cancer.
Analgesia
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Anesthesia, Local
;
Bupivacaine*
;
Double-Blind Method*
;
Epinephrine
;
Fentanyl
;
Humans
;
Ketorolac*
;
Meperidine
;
Ostomy
;
Pain, Postoperative*
;
Peritoneum
;
Prospective Studies*
;
Stomach Neoplasms*
;
Subcutaneous Tissue
;
Wounds and Injuries
9.Prognostic Significance of Bcl-2 Expression in Ovarian Cancers.
Gu KONG ; Young Ha OH ; Chan Pil PARK ; Do Soo NAH ; Yung Jin MOON ; Kyung Tai KIM ; Youn Yeoung HWANG ; Jung Dal LEE
Korean Journal of Obstetrics and Gynecology 1997;40(10):2262-2268
The protein encoded by the Bcl-2 proto-oncogene has been shown to prolong cell su-rvival by preventing cell death(Apoptosis) induced by many insults including cancer therap-eutic drugs. Recently many researches have elucidated the bcl-2 expression in several hu-man solid cancers. However, there is still a few avaiable data to determine the role of Bcl-2 expression in the ovarian carcinogenesis and its prognostic significance in ovarian can-cers. Hence, we examined the expression of Bcl-2 in 68 ovarian epithelial cancers using immunohistochemistry and determined whether Bcl-2 expression has prognostic significance in the ovarian epithelial cancers. We found Bcl-2 expression(>5% positive cell) in 31 patients(40%). Bcl-2 expression were exclusively negative in the mucinous type of the ovarian epithelial cancer. Bcl-2 exp- ression was not correlated with tumor stage(stage I & II vs III & IV, p=0.63). The patients with Bcl-2 positivity had lower recurrence rate than the patients with negativity at the se- cond look operation(p<0.01). Although there was a trend that the patients with Bcl-2 posi- tivity had better acturial survival than the patient with negativity, the stastical significance was not present(3 years acturial survival;+vs-;63%, 29%;p>0.05). These results sug- gest the Bcl-2 expression appears an early event in the ovarian carcinogenesis and has an inhibiting role in progression of ovarian tumor.
Carcinogenesis
;
Humans
;
Immunohistochemistry
;
Mucins
;
Ovarian Neoplasms*
;
Proto-Oncogenes
;
Recurrence
10.The Therapeutic Effect of Levocabastine Eye Drops on Allergic Conjunctivitis: A Multicenter Study.
Hyo Myung KIM ; Shin Jeong KANG ; Ki San KIM ; Man Soo KIM ; Jae Deok KIM ; Jae Chan KIM ; Yoon Won MYUNG ; Yeoung Gcol PARK ; Woo Chan PARK ; Jong Chul SHIN ; Kyung In WOO ; Jong Soo LEE ; Jong Hyuck LEE ; Chang Yeun LEEN ; Ila Bum LEE ; Won Ryang WEE ; Sung Kun CHUNG ; Jang Ilyun CHUNG ; Kyung Hyun JIN ; Si Hwan CHOI ; Sung Bum HONG ; Sung Pyo HONG
Journal of the Korean Ophthalmological Society 1997;38(12):2120-2128
The efficacy nd tolerance of topical administration of levocabastine(0.5mg/ml)were evaluated in patients with allergic conjunctivitis. A total of 166 patients who had a typical history of atopy and a positive skin test were recruited in this study. Five clinicl symptoms(itch, tearing, chemosis, lid edema and conjunctival injection) were assessed according to a four point scale before the treatment and at 1 and 2 weeks post-therapy. Total symptom severity score before the therapy, 6.68, was remarkably decreased to 2.86 at 1 week and 2.08 at 2 weeks after the treatment. The investigators rated the treatment as globally good or excellent in 68.1% of patients checked at 1 week and 72.5% at 2 weejs after treatment. And the patients evaluated that the therapy ws good to excellent in 66.9% at 1 week and 73.1% at 2 weeks after treatment. Levocabastine eye drops has a fast onet of action with 55.4% of the patients feeling symptom relief within 15 minutes after the first administration. The adverse effect was experienced in 44 patients. Ocular irritation sign, such as foreign body sensation or soreness, was the most frequently reported complaint. These results suggest that levocabastine eye drops is an effective and safe topical alternative for treatment of allergic conjunctivitis.
Administration, Topical
;
Conjunctivitis, Allergic*
;
Edema
;
Foreign Bodies
;
Humans
;
Ophthalmic Solutions*
;
Research Personnel
;
Sensation
;
Skin Tests