Jejungwon hospital, the first modern healthcare facility to be built in Korea, was built at Jaedong in 1885 and moved to Gurigae in 1887. Finally, it was moved to Dodong, outside the Namdaemun Gate, and its name was changed to Severance Hospital. The Jaedong Jejungwon hospital was located at a former house of HONG Youngsik, and it was expanded by renovating existing buildings and constructing new buildings in 2 years. The Gurigae Jejungwon hospital, which was located near Myeongdong Cathedral, was bigger than the Jaedong Jejungwon one and even provided residence to doctors. Jejungwon hospital was a good example of the healthcare facilities that were available in early modern Korea; however, due to a lack of historical materials, it is not easy to analyze the buildings of Jejungwon hospital. Recently, several architectural drawings made by Japanese and photographs taken by foreigners in the early 20th century were discovered, which help us to understand the buildings of the Jejungwon hospitals in Jaedong and Gurigae. This study analyzes the locations and layouts of the buildings of Jejungwon hospital and, furthermore, traces the history of Jejungwon hospital following its relocation. The Jaedong Jejungwon hospital was located at 35 Jaedong, as already known. By analyzing the architectural drawing of Kyeongseong Women's High-School Dormitory, the exact size of the existing building of Jaedong Jejungwon was calculated as 12m × 3.9m. Since the relocation of Jejungwon hospital to Gurigae in 1887, the remnants of Jejungwon buildings were used as Gwangjewon (1900-1907); a vaccine-manufacturing plant (1907-1910); and, finally, the dormitory of Kyeongseong Women's High School(1910s-1950s). The Gurigae Jejungwon hospital was assumed to be located at 193, 2nd street of Koganecho (黄金町) and 4, 1st street of Meijicho (明治町). In particular, the residence of Avison, which was built after 1894, was located at 4, 1st Street of Meijicho, the place with the highest elevation compared to surrounding areas. After 1905, Stevens, a foreign affairs adviser, lived there for one year, following which the Korean government office for agriculture and industry took over the place. The buildings that were used as the hospital at 193, 2nd street of Koganecho were transformed into the Daedong Japanese Club. By analyzing the newly found research materials, it is possible to examine and revise the previous research on the Jaedong Jejungwon and Gurigae Jejungwon hospital buildings. Furthermore, it is noteworthy that the buildings of Jejungwon hospital in Jaedong and Gurigae have been reused as healthcare facilities over the years.
Agriculture ; Asian Continental Ancestry Group ; Delivery of Health Care ; Emigrants and Immigrants ; Humans ; Korea ; Plants

The general aim of Korea National Health and Nutrition Examination Survey (KNHANES) was to assess the health and nutritional status in the Korean population. The KNHANES began in 1998 and has been conducting as a series of surveys : 1998(1st), 2001(2nd), 2005(3rd) and 2007-2009(4th). Specific aims were, in a cross-sectional study of nationally representative samples of the noninstitutionalized civilian Korean population aged > or = 1 year (4,600 households each year), to monitor trends the prevalence, awareness, treatment and control of selected chronic diseases, monitor trends in nutritional status and risk behaviors, and analyze risk factors for chronic diseases. For these purposes, with standardized high-quality methods, extensive data on health and nutrition are collected by health interview, health examination (physical examination, clinical measurements and tests) and dietary interview. In 2007, the 4th KNHANES became a continuous annual survey by highly trained field staff. In addition, the 4th KNHANES expanded examination components (addition of oral examination, pulmonary function test and laboratory test items such as ferritin, vitamin D, insulin, manganese, and arsenic), simplified survey procedure, and strengthened quality control. Further works will be focused on the selection of new examination and interview components, planning of KNHANES follow-up survey, continuous training of field staff and quality control, and improvement of dietary survey method.
Chronic Disease ; Cross-Sectional Studies ; Surveys and Questionnaires ; Diagnosis, Oral ; Family Characteristics ; Ferritins ; Follow-Up Studies ; Insulin ; Korea* ; Manganese ; Nutrition Surveys* ; Nutritional Status ; Prevalence ; Quality Control ; Respiratory Function Tests ; Risk Factors ; Risk-Taking ; Vitamin D

No abstract available.
Cerebellar Diseases ; Encephalitis ; Magnetic Resonance Imaging* ; Meningitis* ; Tuberculosis

Anemia is a common cause of referrals to gastroenterologists. Only a small number of anemia cases result from vascular abnormalities. Visceral artery aneurysms and pseudoaneurysms are rare forms of vascular disease that have significant potential for rupture, resulting in potentially life-threatening hemorrhaging. We present the case of a 70-year-old female patient with a pseudoaneurysm of the superior mesenteric artery complicated with rupture, who had no abdominal pain and only anemia.
Abdominal Pain ; Aged ; Anemia* ; Aneurysm ; Aneurysm, False* ; Arteries ; Female ; Humans ; Mesenteric Artery, Superior* ; Referral and Consultation ; Rupture* ; Vascular Diseases

CHARGE syndrome has been estimated to occur in 1:10,000 births worldwide and shows various clinical manifestations. It is a genetic disorder characterized by a specific and a recognizable pattern of anomalies. The major clinical features are ocular coloboma, heart malformations, atresia of the choanae, growth retardation, genital hypoplasia, and ear abnormalities. The chromodomain helicase DNA-binding protein 7 (CHD7) gene, located on chromosome 8q12.1, causes CHARGE syndrome. The CHD7 protein is an adenosine triphosphate (ATP)-dependent chromatin remodeling protein. A total of 67% of patients clinically diagnosed with CHARGE syndrome have CHD7 mutations. Five hundred twenty-eight pathogenic and unique CHD7 alterations have been identified so far. We describe a patient with a CHARGE syndrome diagnosis who carried a novel de novo mutation, a c.3896T>C (p. leu1299Pro) missense mutation, in the CHD7 gene. This finding will provide more information for genetic counseling and expand our understanding of the pathogenesis and development of CHARGE syndrome.
Adenosine Triphosphate ; CHARGE Syndrome* ; Chromatin Assembly and Disassembly ; Coloboma ; Diagnosis ; Ear ; Genetic Counseling ; Heart ; Humans ; Mutation, Missense ; Nasopharynx ; Parturition

Palinopsia means a visual image persisting for minutes to hours or reappearing episodically after the exciting stimulus has been removed. The anatomic correlation of palinopsia is not clear, whereas occipito-parietal and occipito-temporal lesions have been implicated. We describe a patient presenting palinopsia prior to motor seizures which was related to left posterior temporal lesion. A 36-year-old man had a generalized tonic clonic seizure after palinoptic positive visual afterimages. Brain MRI and Transfemoral cerebral angiography (TFCA) revealed an arteriovenous malformation of 1x1.5x2 cm3. We used oxcarbazepine for preventing recurrent seizures and planned gamma knife radiosurgery. Palinopsia is a very rare clinical manifestation as an aura of seizures. Palinopsia preceding clinical seizure as a localizing value, so that neuroimaging is mandatory in this clinical situation. This is the first reported case of palinopsia in Korea.
Afterimage ; Arteriovenous Malformations ; Brain ; Carbamazepine ; Cerebral Angiography ; Epilepsy ; Humans ; Korea ; Neuroimaging ; Radiosurgery ; Seizures ; Visual Perception

Background: The aim of this study was to investigate inhaler device handling in elderly patients. Inhaler devices with respect to misuse and error correction were also compared. Methods: Inhaler use technique was assessed using standardized checklists at the first visit and 3-month follow-up visit after retraining. The primary outcome was difference in the acceptable use ratio among inhaler devices. Secondary outcomes included differences in error correction, the most common step of misuse, and factors affecting the accuracy of inhaler use. Results: A total of 251 patients (mean age, 76.4 years) were included. The handling of 320 devices was assessed in the study. All patients had been trained before. However, only 24.7% of them used inhalers correctly. Proportions of acceptable use for Evohaler, Respimat, Turbuhaler, Ellipta, and Breezhaler/Handihaler were 38.7%, 50.0%, 61.4%, 60.8%, and 43.2%, respectively (p=0.026). At the second visit, the acceptable use ratio had increased. There were no significant differences among inhaler types (Evohaler, 63.9%; Respimat, 86.1%; Turbuhaler, 74.3%; Ellipta, 64.6%; and Breezhaler/Handihaler, 65.3% [p=0.129]). In multivariate analysis, body mass index, Turbuhaler, and Ellipta showed positive correlations with acceptable use of inhalers, whereas Chronic Obstructive Pulmonary Disease Assessment Test score showed a negative correlation. Conclusion Although new inhalers have been developed, the accuracy of inhaler use remains low. Elderly patients showed more errors when using pressurized metered-dose inhalers than using dry powder inhalers and soft-mist inhalers. However, there were no significant differences in misuse among inhaler devices after individual training. Results of this study suggests that repeat training is more important than inhaler type.

Background: The largest outbreak of enterohemorrhagic Escherichia coli (EHEC) O157:H7 occurred at a preschool in South Korea from June 12 to 29, 2020. This study aimed to analyze the epidemiological and clinical characteristics of EHEC infection in this outbreak. Methods: Epidemiological investigation was performed on all 184 children and 19 workers at the preschool using a standard questionnaire to assess symptoms, food intake, attendance, and special activity history. Pulsed-field gel electrophoresis analysis of confirmed cases was performed to determine genetic relevance. Results: During this outbreak, 103 children were affected, whereas only one infection was identified in adults. Of the 103 pediatric patients, 85 had symptoms (82.5%), including diarrhea, abdominal pain, bloody stool, fever, and vomiting. Thirty-two patients (31.1%) were hospitalized, 15 (14.6%) were diagnosed with hemolytic uremic syndrome, and 4 (3.9%) received dialysis treatment. Pulsed-field gel electrophoresis analysis identified 4 genotypes with high genetic relevance (92.3%). Epidemiological investigation revealed that this outbreak might have occurred from ingesting foods stored in a refrigerator with a constant temperature above 10°C, which was conducive to bacterial growth. Despite several measures after outbreak recognition, new infections continued to appear. Therefore, the preschool was forced to close on June 19 to prevent further person-to-person transmission. Conclusion Our findings from the response to the largest outbreak will help prepare countermeasures against future EHEC outbreak.