1.Left Atrium Compressed by a Traumatic Focal Aneurysm of the Thoracic Aorta.
Gun PARK ; Seung Yeong KO ; Ju Yeong KIM ; Sang Don NA ; Dong Han KIM ; Jang Hyun CHO
Korean Journal of Medicine 2014;86(3):329-333
A 78-year-old woman presented to our hospital with progressive dyspnea (NYHA class I-II) and epigastric discomfort that had developed after a traffic accident. She had a history of hypertension and cerebral infarction, but no history of cardiovascular disease. Her blood pressure was 130/70 mmHg and her heart rate was 66 beats/min and regular. The electrocardiogram showed normal sinus rhythm. The chest X-ray revealed bilateral pleural effusions. Transthoracic echocardiography (TTE) demonstrated an aneurysm of the descending thoracic aorta compressing the left atrium (LA). Left and right ventricular systolic function was preserved. Whole-body computed tomography (CT) angiography revealed that a focal 40-mm-diameter saccular aneurysm in the descending aorta at the level of T7-8, with an intramural hematoma, was compressing the LA and left pulmonary vein. After surgical management, follow-up TTE and CT showed decompression of the LA and left pulmonary vein.
Accidents, Traffic
;
Aged
;
Aneurysm*
;
Angiography
;
Aorta, Thoracic*
;
Aortic Aneurysm
;
Blood Pressure
;
Cardiovascular Diseases
;
Cerebral Infarction
;
Decompression
;
Dyspnea
;
Echocardiography
;
Electrocardiography
;
Female
;
Follow-Up Studies
;
Heart Atria*
;
Heart Rate
;
Hematoma
;
Humans
;
Hypertension
;
Pleural Effusion
;
Pulmonary Veins
;
Thorax
2.Study on Zr-xCu and Zr-xSi alloys with low elastic modulus for improving stress shield effect
Seung-Won KU ; Chung-Seok KIM ; Yeong-Mu KO
Korean Journal of Dental Materials 2021;48(3):175-190
The objective of this study was to fabricate Zr-xCu and Zr-xSi alloys with low elastic modulus for preventing bone resorption in dental biomaterials. Metallic materials are widely used for orthopedic and dental applications due to their superior characteristics of mechanical properties and biocompatibility. Many metals and alloys, such as stainless steel, Co-Cr alloys, and Ti-based alloys are commonly used. Among these dental metallic materials, pure Ti and Ti-6Al-4V alloy have become the most popular metals used for the endosseous parts of the implant, bone plates, and artificial joints due to their excellent specific corrosion resistance and high biocompatibility with natural bone. Stress shield effect results in the reduction in bone density as a result of the removal of typical stress from the bone by an implant. In general, the bone in a healthy person will remodel in response to the loads it is placed under. Therefore, if the loading on a bone decreases, the bone will become less dense and weaker because there is no stimulus for continued remodeling that is required to maintain bone mass. Although Ti-based alloys have been widely used as implant components and devices, its elastic modulus (110 GPa) is much higher than that of natural human bone (10–30 GPa). Serious damage may be easily caused in the human body when the modulus of implant materials does not match the natural bone due to the stress shield effects. Therefore, in recent, persistent efforts have been done to obtain biological hard tissue materials with low elastic modulus to transfer stress to the surrounding bones effectively. The Zr-xCu binary alloy exhibited moderate compressive strength (1291-1411 MPa), yield stress (517-552 MPa), favorable elongation (16.4–49.2%), elastic energy (6.76–7.43 MJ/m3 ) and low elastic modulus (18.5–23.1 GPa). The Zr-xSi binary alloy exhibited high compressive strength (1105-1623 MPa), yield stress (673-1514 MPa), favorable elongation (6.0–27.2%), high elastic energy (10.2–34.6 MJ/m3 ) and low elastic modulus (22.3–33.1 GPa). Consequently, Zr-xCu and Zr-xSi binary alloys have the potential to be used as biomaterials with nullifying stress shield effects for biological hard tissue materials.
3.Study on Zr-xCu and Zr-xSi alloys with low elastic modulus for improving stress shield effect
Seung-Won KU ; Chung-Seok KIM ; Yeong-Mu KO
Korean Journal of Dental Materials 2021;48(3):175-190
The objective of this study was to fabricate Zr-xCu and Zr-xSi alloys with low elastic modulus for preventing bone resorption in dental biomaterials. Metallic materials are widely used for orthopedic and dental applications due to their superior characteristics of mechanical properties and biocompatibility. Many metals and alloys, such as stainless steel, Co-Cr alloys, and Ti-based alloys are commonly used. Among these dental metallic materials, pure Ti and Ti-6Al-4V alloy have become the most popular metals used for the endosseous parts of the implant, bone plates, and artificial joints due to their excellent specific corrosion resistance and high biocompatibility with natural bone. Stress shield effect results in the reduction in bone density as a result of the removal of typical stress from the bone by an implant. In general, the bone in a healthy person will remodel in response to the loads it is placed under. Therefore, if the loading on a bone decreases, the bone will become less dense and weaker because there is no stimulus for continued remodeling that is required to maintain bone mass. Although Ti-based alloys have been widely used as implant components and devices, its elastic modulus (110 GPa) is much higher than that of natural human bone (10–30 GPa). Serious damage may be easily caused in the human body when the modulus of implant materials does not match the natural bone due to the stress shield effects. Therefore, in recent, persistent efforts have been done to obtain biological hard tissue materials with low elastic modulus to transfer stress to the surrounding bones effectively. The Zr-xCu binary alloy exhibited moderate compressive strength (1291-1411 MPa), yield stress (517-552 MPa), favorable elongation (16.4–49.2%), elastic energy (6.76–7.43 MJ/m3 ) and low elastic modulus (18.5–23.1 GPa). The Zr-xSi binary alloy exhibited high compressive strength (1105-1623 MPa), yield stress (673-1514 MPa), favorable elongation (6.0–27.2%), high elastic energy (10.2–34.6 MJ/m3 ) and low elastic modulus (22.3–33.1 GPa). Consequently, Zr-xCu and Zr-xSi binary alloys have the potential to be used as biomaterials with nullifying stress shield effects for biological hard tissue materials.
4.A Case of Kerion Celsi Caused by Microsporum gypseum.
Dong Yeob KO ; Seung Min HA ; Su Young JEON ; Kwang Sook WOO ; Jin Yeong HAN ; Ki Hoon SONG ; Ki Ho KIM
Korean Journal of Dermatology 2013;51(5):375-376
No abstract available.
Microsporum
;
Tinea Capitis
5.Relationship between Locations of Facial Injury and the Use of Bicycle Helmets: A Systematic Review.
Kun HWANG ; Yun Moon JEON ; Yeong Seung KO ; Yeon Soo KIM
Archives of Plastic Surgery 2015;42(4):407-410
The aim of this study is to review the protective effect of a bicycle helmet on each facial location systematically. PubMed was searched for articles published before December 12, 2014. The data were summarized, and the odds ratio (OR) between the locations of facial injury was calculated. A statistical analysis was performed with Review Manager (The Nordic Cochrane Centre). Bicycle helmets protect the upper and middle face from serious facial injury but do not protect the lower face. Non-wearers had significantly increased risks of upper facial injury (OR, 2.07; P<0.001) and of middle facial injury (OR, 1.97; P<0.001) as compared to helmet users. In the case of lower facial injury, however, only a slightly increased risk (OR, 1.42; 95% confidence interval (CI), 0.67-3.00, P=0.36) was observed. The abovementioned results can be attributed to the fact that a helmet covers the head and forehead but cannot cover the lower face. However, helmets having a chin cap might decrease the risk of lower facial injury.
Bicycling
;
Chin
;
Facial Injuries*
;
Forehead
;
Head
;
Head Protective Devices*
;
Odds Ratio
6.Corrected QT Interval Prolongation during Severe Hypoglycemia without Hypokalemia in Patients with Type 2 Diabetes.
Jae Won BEOM ; Jung Min KIM ; Eun Joo CHUNG ; Ju Yeong KIM ; Seung Yeong KO ; Sang Don NA ; Cheol Hwan KIM ; Gun PARK ; Mi Yeon KANG
Diabetes & Metabolism Journal 2013;37(3):190-195
BACKGROUND: To evaluate the effects of severe hypoglycemia without hypokalemia on the electrocardiogram in patients with type 2 diabetes in real-life conditions. METHODS: Electrocardiograms of adult type 2 diabetic patients during the episodes of severe hypoglycemia and the recovered stage were obtained and analysed between October 1, 2011 and May 31, 2012. Patients who maintained the normal serum sodium and potassium levels during the episodes of severe hypoglycemia were only selected as the subjects of this study. Severe hypoglycemia was defined, in this study, as the condition requiring active medical assistance such as administering carbohydrate when serum glucose level was less than 60 mg/dL. RESULTS: Nine type 2 diabetes patients (seven men, two women) were included in the study. The mean subject age was 73.2+/-7.7 years. The mean hemoglobin A1c level was 6.07%+/-1.19%. The median duration of diabetes was 10 years (range, 3.5 to 30 years). Corrected QT (QTc) intervals were significantly increased during the episodes of severe hypoglycemia compared to the recovered stage (447.6+/-18.2 ms vs. 417.2+/-30.6 ms; P<0.05). However, the morphology and the amplitude of the T waves were not changed and ST-segment elevation and/or depression were not found during the episodes of severe hypoglycemia. CONCLUSION: In this study, QTc interval prolongation during the episodes of severe hypoglycemia was observed without hypokalemia. Therefore, the distinct alterations in cardiac repolarization during the episodes of severe hypoglycemia may not be associated with hypokalemia.
Adult
;
Depression
;
Diabetes Mellitus, Type 2
;
Electrocardiography
;
Glucose
;
Hemoglobins
;
Humans
;
Hypoglycemia
;
Hypokalemia
;
Male
;
Medical Assistance
;
Potassium
;
Sodium
7.Molecular Genetic Diagnosis of Hemophilia A by Linkage Analysis of XbaI/intron 22 DNA Polymorphism Using PCR.
Young Min CHOI ; Sung Hyo PARK ; Ko Eun BACK ; Do Yeong HWANG ; Jin CHOE ; Seung Yup KU ; Chang Suk SUH ; Seok Hyun KIM ; Jung Gu KIM ; Mi Ran LEE ; Eun Joo KIM
Korean Journal of Obstetrics and Gynecology 2003;46(4):771-775
OBJECTIVE: To set up the methodology for PCR analysis of XbaI/intron 22 polymorphism of the factor VIII gene, and to identify the usefulness of XbaI/intron 22 polymorphism analysis for carrier detection and prenatal diagnosis of hemophilia A in the Korean population. DESIGN: A laboratory analysis. MATERIALS AND METHODS: A XbaI/intron 22 polymorphism of the factor VIII gene was analyzed in 56 unrelated Korean mothers of patients with severe hemophilia A, using polymerase chain reaction. RESULTS: Analysis of XbaI/intron 22 polymorphisms of the factor VIII gene were feasible by PCR method. The expected heterozygosity rates of XbaI/intron 22 polymorphism of the factor VIII gene were 44.8%. Analysis of XbaI/intron 22 polymorphism revealed heterozygous patterns in 22 (39.3%) of 56 mothers studied. Using linkage analysis with XbaI/intron 22 polymorphism, we have attempted one case of carrier detection and two cases of prenatal diagnosis in two families of patients with severe hemophilia A. CONCLUSION: These results suggest that PCR analysis of the XbaI/intron 22 polymorphism within the factor VIII gene is very useful in the carrier detection and prenatal diagnosis of hemophilia A in the Korean population.
Diagnosis*
;
DNA*
;
Factor VIII
;
Hemophilia A*
;
Humans
;
Molecular Biology*
;
Mothers
;
Polymerase Chain Reaction*
;
Prenatal Diagnosis
8.Efficacy and Safety during the Combination Therapy of Imipramine and Desmopressin in Primary Monosymptomatic Nocturnal Enuresis.
Yong Hoon PARK ; Ji Hyun YEO ; Jung Youn CHOI ; Hyo Seok CHUNG ; Kyung Soo LEE ; Cheol Woo KO ; Kyo Sun KIM ; Kee Hyuk KIM ; Jung Soe KIM ; Mee Kyung NAMGOONG ; Young Seo PARK ; Ki Soo PAI ; Kee Hwan YOO ; Kyung Yil LEE ; Dae Yeol LEE ; Seung Joo LEE ; Oh Kyung LEE ; Jae Seung LEE ; Hong Jun LEE ; Seung Hee JUNG ; Woo Yeong CHUNG ; Tae Sun HA
Journal of the Korean Society of Pediatric Nephrology 2004;8(2):129-137
PURPOSE: Nocternal enuresis is a common disorder. Tricyclic antidepressant and desmopressin have been accepted pharmacological treatment for this disorder. We conducted a cooperative study to investigate the efficacy and adverse reactions of imipramine, desmopressin and combination treatment in children with primary monosymptomatic nocturnal enuresis(PMNE). METHODS: Data from a large multicenter study were analysed. In the period of 8 months in 2002, the study comprised of 168 children(78 boys and 90 girls, 5 to 15 years old) with PMNE for imipramine, desmopressin or combination treatment. Before treatment a history, physical examination and laboratory tests were performed and the children were observed for 2 weeks. Response rate, adverse reactions and enuresis episodes after stopping drug administration were evaluated after 12-weeks of imipramine, desmopressin or combination of both. RESULTS: After 4 weeks, the frequency of bed wetting in all treated patients decreased during treatment significantly. Even though a 30-50% reduction in the number of wet nights were 68.6%, 74.4% and 86.1% during 12 weeks treatment by imipramine, desmopressin and both of them respectively, there was no significant difference between them. The most common adverse reaction was decreased appetite from imipramine administration. But no serious drug-related adverse events were reported. CONCLUSION: Efficacy of the combination therapy of imipramine and desmopressin in PMNE appears not to be better than either drug alone. It is necessary to pay attention on account of adverse reactions during imipramine treatment even though imipramine and desmopressin were generally well tolerated.
Appetite
;
Child
;
Deamino Arginine Vasopressin*
;
Enuresis
;
Female
;
Humans
;
Imipramine*
;
Nocturnal Enuresis*
;
Physical Examination
9.Endobronchial Neurilemmoma Mimicking a Bronchial Polyp.
Ryoung Eun KO ; Seung Yong PARK ; Yeong Hun CHOE ; So Ri KIM ; Heung Bum LEE ; Yong Chul LEE ; Seoung Ju PARK
Soonchunhyang Medical Science 2015;21(2):176-179
Neurilemmomas are relatively uncommon, slowly growing tumors which originate from Schwann cells. Intrathoracic neurilemmomas often occur in the chest wall and posterior mediastinum, but endobronchial neurilemmomas are exceedingly rare. These tumors in trachea or bronchus are usually detected by radiologic examinations, mostly computed tomography scan of chest. An 88-year-old man was admitted for management of pneumonia in left lower lobe and parapneumonic effusion. On bronchoscopic examination, there was a small polypoid nodule less than 1 cm in diameter mimicking an endobronchial inflammatory polyp at the bifurcation of the right anterior segmental bronchus and lateral segmental bronchus and under auto-fluorescence imaging, the nodule showed reddish brown area with defined margin. The bronchoscopic biopsy revealed that the bronchial nodule was endobronchial neurilemmoma. This is an interesting case of endobronchial neurilemmoma mimicking a bronchial polyp that is detected incidentally via bronchoscopy.
Aged, 80 and over
;
Biopsy
;
Bronchi
;
Bronchoscopy
;
Humans
;
Mediastinum
;
Neurilemmoma*
;
Optical Imaging
;
Pneumonia
;
Polyps*
;
Schwann Cells
;
Thoracic Wall
;
Thorax
;
Trachea
10.The Role of Preoperative NT-proBNP in Elderly Orthopedic Patients with Normal Left Ventricular Systolic Function.
Eun Jung KO ; Jae Youn MOON ; Yeong Min LIM ; Won Jung HONG ; Suk Pyo SHIN ; Sang Hoon KIM ; Woo In YANG ; Jung Hoon SUNG ; In Jai KIM ; Sang Wook LIM ; Dong Hun CHA ; Seung Yun CHO
Korean Journal of Medicine 2014;87(3):302-310
BACKGROUND/AIMS: Preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) is a useful predictor of postoperative cardiovascular complications. The present study investigated whether blood NT-proBNP values are suitable for predicting postoperative cardiovascular complications after non-cardiac surgery in elderly patients showing normal left ventricular (LV) function on preoperative echocardiograms. METHODS: This study was performed by analyzing the medical records of elderly patients referred to the cardiology department for the purpose of assessing their cardiac function before orthopedic surgery. Of the patients who underwent echocardiography and NT-proBNP assessment simultaneously, 275 patients aged > or = 70 years and with an LV ejection fraction of > or = 55% were included in the study. RESULTS: Major adverse cardiac and cerebrovascular events (MACCEs) occurred in 33 (12%) of the 275 patients, and the NT-proBNP concentration was higher in patients with complications than in those without complications (1,904.20 +/- 2,300.23 vs. 530.58 +/- 882.27 pg/mL, p < 0.01). The ROC area under the curve was 0.756 (95% confidence interval 0.701-0.805, p < 0.001) with an optimal cutoff of 416.3 pg/mL (69.7% sensitivity, 67.36% specificity). A multivariate analysis showed that a preoperative age of > 80 years (odds ratio, 2.313; p = 0.047) and an increased blood NT-proBNP concentration (odds ratio, 3.189; p = 0.009) were independent risk factors for the prediction of MACCEs. CONCLUSIONS: Although elderly patients scheduled to undergo non-cardiac surgery may show normal LV systolic function on echocardiography, measurement of their preoperative blood NT-proBNP concentration is useful for predicting MACCEs occurring after non-cardiac surgery.
Aged*
;
Cardiology
;
Echocardiography
;
Humans
;
Medical Records
;
Multivariate Analysis
;
Natriuretic Peptides
;
Orthopedics*
;
Risk Factors