1.Continuous Intratumoral Delivery of Chemotherapeutic Agent by Convection-enhanced Technique: Preliminary Clinical Study.
Yeung Jin SONG ; Ki Uk KIM ; Dong Geun JUNG ; Sun Seob CHOI ; Gi Yeong HUH ; Su Yeong SEO
Journal of Korean Neurosurgical Society 2004;35(3):240-245
OBJECTIVE: Because of the limited penetration into the central nervous system after systemic administration of numerous therapeutic compounds, intratumoral chemotherapy for brain tumors has also been used. However, the efficacy of intratumoral drug administration is restricted by the poor diffusion of drug through tumor and brain interstitium. In order to enhance the diffusion of chemotherapeutic agent and increase the cytotoxicity with minimal dose, the authors report the results of convection-enhanced delivery(CED) of chemotherapeutic agent to the malignant brain tumor as a method of enhancing cerebral drug delivery. METHODS: Authors used "CADD-Micro(R) ambulatory infusion pump" from Deltec, which can be programmed for continuous infusion. Intratumoral injection of chemotherapeutic drug using the pump was applied to eight patients with glioma and one patient with lymphoma. Surgery was done and tumor was removed as much as possible. The tip of catheter was placed in the center of tumor cavity. Adriamycin (0.16~0.32mg) was put in the reservoir which was connected to the proximal catheter and fixed in the pump device. Twenty-four hours after surgery, Adriamycin was infused. RESULTS: There was no adverse reaction of CED technique. Compared with current delivery techniques, the improvement of survival rate has been observed(5 patients: alive, 3 patients: dead, 1 patient: lost(alive to 5 mo.)). CONCLUSION: CED can be useful method for distributing therapeutic molecules in the interstitial space of tumor and can be utilized for chemotherapeutic agents, immunotoxins, and gene etc..
Brain
;
Brain Neoplasms
;
Catheters
;
Central Nervous System
;
Diffusion
;
Doxorubicin
;
Drug Therapy
;
Glioma
;
Humans
;
Immunotoxins
;
Lymphoma
;
Survival Rate
2.Therapeutic Consideration of Periappendiceal Abscess: an Evaluation of Non-surgical Treatment Followed by Minimally Invasive Interval Appendectomy.
Yeong Soo JO ; Song Soo YANG ; Yeong Chul IM ; Dong Jin PARK ; Gyu Yeol KIM
Journal of Minimally Invasive Surgery 2017;20(4):129-136
PURPOSE: Periappendiceal abscess (PAA) is a severe complicated appendicitis with high morbidity. Non-surgical treatment followed by interval appendectomy (IA) is associated with lower complication rate compared with emergency surgery (ES) and minimally invasive surgery (MIS) can be done more often. The purpose of this study is to assess the incidence and factors predictive of complications of surgery for PAA and to evaluate the clinical effectiveness of IA as a treatment policy to increase MIS. METHODS: Retrospectively, we reviewed 171 patients undergoing surgery for PAA between 2011 and 2016 at Ulsan University Hospital. The incidence and influence of different factors were assessed by univariate and multivariate analyses. RESULTS: In 171 patients, 28 (16.4%) developed postoperative complications, which included; wound complications (7.6%), intra-abdominal abscess (4.1%) and ileus (2.9%). In both analyses, only ES was independently associated with postoperative complications; (Relative risk, 15.0; 95% Confidence interval, 2.4~92.5). Comparing the IA and ES groups revealed that operative time, complication rate, laparoscopic approach, postoperative hospitalization, postoperative antibiotic use and bowel resection rate were significantly different. The postoperative complication rate of patients with PAA in ES group was 28.7%, which was statistically higher than that of IA group (3.6%). Especially, MIS rate was more than 9-times greater in the IA group (98.8% vs. 10.3%, p<0.001). Although the IA group required additional hospitalization, there was no statistical difference between the two groups in total length of hospital stay. CONCLUSION: Morbidity was high for patients who had emergency surgery for PAA. ES was the only factor associated with postoperative morbidity. IA can reduce the postoperative complication rate and allowed MIS to be used more often as a useful treatment policy for PAA.
Abdominal Abscess
;
Abscess*
;
Appendectomy*
;
Appendicitis
;
Emergencies
;
Hospitalization
;
Humans
;
Ileus
;
Incidence
;
Length of Stay
;
Minimally Invasive Surgical Procedures
;
Multivariate Analysis
;
Operative Time
;
Postoperative Complications
;
Retrospective Studies
;
Treatment Outcome
;
Ulsan
;
Wounds and Injuries
3.Erratum to: Therapeutic Consideration of Periappendiceal Abscess: an Evaluation of Non-surgical Treatment Followed by Minimally Invasive Interval Appendectomy.
Yeong Soo JO ; Song Soo YANG ; Yeong Chul IM ; Dong Jin PARK ; Gyu Yeol KIM
Journal of Minimally Invasive Surgery 2018;21(2):89-89
Authors requested to change the name of the hospital to proper name.
4.A Case of Subcutaneous Panniculitic T-cell Lymphoma in a Child.
Hong Seok KIM ; Ki Young HEO ; Jin Yeong HAN ; Jin A JUNG ; Ki Hoon SONG ; Ki Ho KIM
Annals of Dermatology 2004;16(1):31-38
We report a case of subcutaneous panniculitic T-cell lymphoma (SPTCL) which occurred in a 10-year-old Korean girl. Her disease presented as multiple erythematous subcutaneous nodules on the right cheek, left chest, abdomen, left flank, both calves, and left shin with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 2 months often with spiking fever. Histopathologic findings for the subcutaneous nodules revealed lobular panniculitis-like findings composed of atypical small, bland lymphocytes and histiocytes. Characteristically, atypical lymphocytes rimmed individual fat cells in a lace-like pattern and some histiocytes occasionally phagocytosed WBCs. Bone marrow findings revealed increased phagocytic histiocytes with engulfed hematopoietic cell. The immunophenotypic studies showed CD45RO (UCHLl)+, CD20-, CD4-, CD8+ and CD56+ (focal), lysozyme+, CD45 (LCA)+ and EBV-. She received three cycles of high-dose cyclophosphamide, adriamycin, vincristine, prednisolone (CHOP) and methotrexate, intrathecal methotrexate and one cycle of fludarabine, mitoxantrone and dexamethasone (FND) chemotherapy. She died of acute renal failure during multiple chemotherapy.
Abdomen
;
Acute Kidney Injury
;
Adipocytes
;
Bone Marrow
;
Cheek
;
Child*
;
Cyclophosphamide
;
Dexamethasone
;
Doxorubicin
;
Drug Therapy
;
Female
;
Fever
;
Glycogen Storage Disease Type VI
;
Histiocytes
;
Humans
;
Lymphocytes
;
Lymphoma, T-Cell*
;
Lymphoma, T-Cell, Cutaneous
;
Methotrexate
;
Mitoxantrone
;
Prednisolone
;
T-Lymphocytes*
;
Thorax
;
Vincristine
5.Cortical Trajectory Screw Fixation in Lumbar Spine Surgery: A Review of the Existing Literature
Kun-Tae KIM ; Kun-Tae KIM ; Myung-Geun SONG ; Myung-Geun SONG ; Young-Jin PARK ; Young-Jin PARK ; Dong-Yeong LEE ; Dong-Yeong LEE ; Dong-Hee KIM ; Dong-Hee KIM
Asian Spine Journal 2022;16(1):127-140
Posterior lumbar fusion is a safe and effective surgical method for diseases, such as lumbar stenosis, spondylolisthesis, lumbar instability, spinal deformity, and tumor. Pedicle screw (PS) fixation was first introduced by Bouche and has been adopted as the gold standard for posterior lumbar fusion. Santoni and colleagues introduced a new methodological screw insertion technique that uses a cortical bone trajectory (CBT), described as that from a medial to lateral path in the transverse axial plane and caudal to the cephalad path in the sagittal plane through the pedicle for maximum contact of the screw with the cortical bone. Owing to the lower invasiveness, superior cortical bone contact, and reduced neurovascular injury incidence, the CBT technique has been widely used in posterior lumbar fusion; however, these advantages have not been proven in clinical/radiological and biomechanical studies. We designed the present study to review the existing evidence and evaluate the merit of CBT screw fixation. Six electronic databases were searched for relevant articles published in August 2020 using the search terms “cortical bone trajectory,” “CBT spine,” “CBT fixation,” “cortical pedicle screws,” and “cortical screws.” Studies were analyzed and divided into the following groups: “biomechanics investigation,” “surgical technique,” and “clinical/radiological studies.” Most studies compared CBT and PS fixation, and the CBT screw fixation method showed better or similar outcomes.
6.A Case of the HELLP Syndrome treated with Postpartum Plasmapheresis.
Geun A SONG ; Goo Hwa JE ; Moon Seok CHA ; Tai Young HWANG ; Hyun Ho KIM ; Kyoung Hee KIM ; Jin Yeong HAN
Korean Journal of Obstetrics and Gynecology 1999;42(12):2846-2849
Plasmapheresis has been used for some conditions during pregnancy and puerperium, such as hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. We present one case of the HELLP syndrome which was treated with plasmapheresis and also review the indications, complications and guidelines for repetitive plasma exchange.
Blood Platelets
;
Female
;
HELLP Syndrome*
;
Hemolysis
;
Liver
;
Plasma Exchange
;
Plasmapheresis*
;
Postpartum Period*
;
Pregnancy
7.Uterine artery doppler velocimetry in growth-retarded pregnancies.
Bo Hyun YOON ; Yeong Je KANG ; Pyl Ryang LEE ; Hyun Jin SONG ; Hee Chul SYN ; Syng Wook KIM
Korean Journal of Perinatology 1991;2(2):102-110
No abstract available.
Pregnancy*
;
Rheology*
;
Uterine Artery*
8.A Clinical Analysis of Surgically Managed Tuberculous Spondylitis.
Yeong Hyeon KIM ; Jin Kyu SONG ; Ho SHIN
Journal of Korean Neurosurgical Society 1997;26(2):223-234
Fourty three patients with tuberculous spondylitis were surgically treated through the anterior approach at our hospital from January, 1989 to December, 1994. Among them, 32 cases were followed up more than 18 months postoperatively, and were included in this study. The most prevalent location was lumbar region(50%). Paraparesis was frequently seen in patients with middle and lower thoracic spinal lesions and all patients with neurologic deficits improved after decompression of spinal cord. Autogenous rib and/or iliac strut bone grafting was performed, followed by spinal instrumentation. Solid bone fusion was obtained in all patients. There was no need for prolongation of duration of antituberculous drug therapy and no increased incidence of secondary infection due to spinal instrumentation.
Bone Transplantation
;
Coinfection
;
Decompression
;
Drug Therapy
;
Humans
;
Incidence
;
Neurologic Manifestations
;
Paraparesis
;
Ribs
;
Spinal Cord
;
Spondylitis*
9.Recurrent Partial Trisomy 1q in Maternal Balanced Translocation t(1;11)(q32;q23).
Geun A SONG ; Bong Gyu KWAK ; Moon Seok CHA ; Goo Hwa JE ; Jin Yeong HAN ; Lisa G SHAFFER
Korean Journal of Obstetrics and Gynecology 2000;43(2):338-342
Abnormal offsprings from balanced translocation carriers usually inherit only one of the translocated products and are therefore partially trisomic for one chromosome and partially monosomic for another. Partial trisomy 1q usually demonstrates fetal growth restriction and anomalies of head, face, urogenital tract, heart, finger and toes with a wide range of characteristics and severities. It has been reported in a few individuals in the world and this is the first report of partial trisomy 1q in Korea. We present the case of recurrent partial trisomy 1q in maternal balanced translocation which was prenatally diagnosed by amniocentesis with fluorescence in situ hybridization(FISH) based on abnormal ultrasonographic findings and poor obstetric history.
Amniocentesis
;
Fetal Development
;
Fingers
;
Fluorescence
;
Head
;
Heart
;
Korea
;
Prenatal Diagnosis
;
Toes
;
Trisomy*
10.Abdominal Aortic Thrombosis as the Manifestation of the Primary Antiphospholipid Syndrome.
Jeong Jin PARK ; Jung Chan LEE ; Yeong Wook SONG
Korean Journal of Hematology 2004;39(1):51-54
Antiphospholipid syndrome (APS) is an autoimmune hypercoagulability syndrome. The clinical feature of the antiphospholipid syndrome is characterized by venous or arterial thromboses, recurrent fetal losses and/or thrombocytopenia with evidence of antiphospholipid antibodies, namely lupus anticoagulant, anticardiolipin antibodies. Although APS is most commonly associated with systemic lupus erythematosus or related autoimmune disease (secondary APS), APS also has been identified in patients with vaso-occlusive disease without any other manifestations of connective tissue disease (primary APS). In primary APS, aortic thrombosis has been rarely reported. We report a case of thrombosis of abdominal aorta in primary APS.
Antibodies, Anticardiolipin
;
Antibodies, Antiphospholipid
;
Antiphospholipid Syndrome*
;
Aorta, Abdominal
;
Autoimmune Diseases
;
Connective Tissue Diseases
;
Humans
;
Lupus Coagulation Inhibitor
;
Lupus Erythematosus, Systemic
;
Thrombocytopenia
;
Thrombophilia
;
Thrombosis*