1.Effects of Acupressure on Pruritus and Sleep in Patients on Hemodialysis.
Journal of Korean Academy of Fundamental Nursing 2017;24(1):9-17
PURPOSE: This study was done to investigate the effects of acupressure on pruritus and sleep among patients undergoing hemodialysis. METHODS: The study design was a nonequivalent control group repeat measures quasi-experimental study. Data were collected from June to September 2015 in the kidney center at a hospital located in B city. Participants were 42 patients; 20 in the experimental group and 22 in the control group. For the experimental group, acupressure on the spots of Sameumgyo (SP6), Zoksamli (ST36), Hyolhae (SP10), and Gokji (LI11) was provided at the time of hemodialysis three times a week for 12 weeks. The numeric rating scale (NRS) was used to measure pruritus, and sleep was measured with the sleep scale developed by Jinju Oh et al. RESULTS: There was a significant decrease in pruritus (F=7.80, p=.008) and increase in sleep (F=80.90, p<.001) in the experimental group compared to the control group. CONCLUSION: The findings confirmed in the study show that acupressure is an effective nursing intervention to decrease pruritus felt by patients on hemodialysis and to increase the quality of their sleep.
Acupressure*
;
Gyeongsangnam-do
;
Humans
;
Kidney
;
Non-Randomized Controlled Trials as Topic
;
Nursing
;
Pruritus*
;
Renal Dialysis*
2.Cardiac Arrest following Epidural Block for Postoperative Pain Control.
Jeong Ae LIM ; Yeong Joo PARK ; Po Sun KANG ; Gyu Chang LEE ; Nam Sik WOO ; Ye Chal LEE
Korean Journal of Anesthesiology 1995;28(4):590-593
The continuous epidural anesthesia is an effective method for postoperative pain control and improvement of pulmonary function. A 39-year-old man was scheduled for postoperative intestinal obstruction. After adhesiolysis under the general anesthesia, epidural anesthesia was done for postoperative pain control. Because an accidental dural puncture was noticed, the adjacent interspace of epidural anesthesia was tried and catheter was inserted. Respiratory depression, hypotension, loss of consciousness and cardiac arrest were developed about 20 minutes after the first injection of 1% lidocain 10ml. Endotracheal intubation was performed and the respiration was controlled using 100% oxygen. Self respiration and alert mentality returned after 180 minutes. No CSF leakage, delayed onset time, severe hypotension, complete recovery may be the result of subdural anesthesia and postoperative hypoxia. But radiological examination was not performed.
Adult
;
Anesthesia
;
Anesthesia, Epidural
;
Anesthesia, General
;
Anoxia
;
Catheters
;
Heart Arrest*
;
Humans
;
Hypotension
;
Intestinal Obstruction
;
Intubation, Intratracheal
;
Oxygen
;
Pain, Postoperative*
;
Punctures
;
Respiration
;
Respiratory Insufficiency
;
Unconsciousness
3.Clinical and Genetic Features of Korean Patients with Recurrent Fever and Multi-System Inflammation without Infectious or Autoimmune Evidence.
Ji Ae YANG ; Ji Yong CHOI ; Eun Ha KANG ; You Jung HA ; Yun Jong LEE ; Yeong Wook SONG
Journal of Korean Medical Science 2016;31(2):196-201
Autoinflammatory disease (AID) is a newly proposed category of disorders characterized by unprovoked episodes of inflammation without any infectious or autoimmune evidence. We aimed to characterize the clinical and genetic features of patients who had recurrent fever and multi-system inflammation but remain unclassified for any established AIDs. Medical records of 1,777 patients who visited our Rheumatology Clinic between March 2009 and December 2010 were reviewed to identify those who met the following criteria; 1) presence of fever, 2) inflammation in two or more organ systems, 3) recurrent nature of fever or inflammation, 4) no evidence of infection or malignancy, 5) absence of high titer autoantibodies, and 6) failure to satisfy any classification criteria for known AIDs. Genotyping was performed for common missense variants in MEFV, NOD2/CARD15, and TNFRSF1A. A small number of patients (17/1,777, 0.95%) were identified to meet the above criteria. Muco-cutaneous and musculoskeletal features were most common, but there was a considerable heterogeneity in symptom combination. Although they did not satisfy any established classification criteria for AIDs, substantial overlap was observed between the clinical spectrum of these patients and known AIDs. According to the newly proposed Eurofever criteria for periodic fevers, eleven of them were classified as TNF receptor-associated periodic syndrome and two as mevalonate kinase deficiency. However, no examined genetic variants including those in TNFRSF1A were found in these patients. A new set of classification criteria needs to be developed and validated for Asian patients with unclassified AIDs.
Adolescent
;
Adult
;
Cytoskeletal Proteins/genetics
;
Female
;
Fever/*etiology
;
Genotype
;
Hereditary Autoinflammatory Diseases/classification/*diagnosis/genetics
;
Humans
;
Inflammation/*etiology
;
Male
;
Middle Aged
;
Mutation, Missense
;
Nod2 Signaling Adaptor Protein/genetics
;
Polymorphism, Single Nucleotide
;
Receptors, Tumor Necrosis Factor, Type I/genetics
;
Recurrence
;
Republic of Korea
;
Retrospective Studies
;
Young Adult
4.Clinical and Genetic Features of Korean Patients with Recurrent Fever and Multi-System Inflammation without Infectious or Autoimmune Evidence.
Ji Ae YANG ; Ji Yong CHOI ; Eun Ha KANG ; You Jung HA ; Yun Jong LEE ; Yeong Wook SONG
Journal of Korean Medical Science 2016;31(2):196-201
Autoinflammatory disease (AID) is a newly proposed category of disorders characterized by unprovoked episodes of inflammation without any infectious or autoimmune evidence. We aimed to characterize the clinical and genetic features of patients who had recurrent fever and multi-system inflammation but remain unclassified for any established AIDs. Medical records of 1,777 patients who visited our Rheumatology Clinic between March 2009 and December 2010 were reviewed to identify those who met the following criteria; 1) presence of fever, 2) inflammation in two or more organ systems, 3) recurrent nature of fever or inflammation, 4) no evidence of infection or malignancy, 5) absence of high titer autoantibodies, and 6) failure to satisfy any classification criteria for known AIDs. Genotyping was performed for common missense variants in MEFV, NOD2/CARD15, and TNFRSF1A. A small number of patients (17/1,777, 0.95%) were identified to meet the above criteria. Muco-cutaneous and musculoskeletal features were most common, but there was a considerable heterogeneity in symptom combination. Although they did not satisfy any established classification criteria for AIDs, substantial overlap was observed between the clinical spectrum of these patients and known AIDs. According to the newly proposed Eurofever criteria for periodic fevers, eleven of them were classified as TNF receptor-associated periodic syndrome and two as mevalonate kinase deficiency. However, no examined genetic variants including those in TNFRSF1A were found in these patients. A new set of classification criteria needs to be developed and validated for Asian patients with unclassified AIDs.
Adolescent
;
Adult
;
Cytoskeletal Proteins/genetics
;
Female
;
Fever/*etiology
;
Genotype
;
Hereditary Autoinflammatory Diseases/classification/*diagnosis/genetics
;
Humans
;
Inflammation/*etiology
;
Male
;
Middle Aged
;
Mutation, Missense
;
Nod2 Signaling Adaptor Protein/genetics
;
Polymorphism, Single Nucleotide
;
Receptors, Tumor Necrosis Factor, Type I/genetics
;
Recurrence
;
Republic of Korea
;
Retrospective Studies
;
Young Adult
5.A Case of Sparganosis that Mimicked Recurrence of Contralateral Breast Cancer.
Seo Ae HAN ; Byung Woog KANG ; Yee Soo CHAE ; Jun Seok YOON ; Sang Kyung SEO ; Ho Young PARK ; Ji Yeong PARK
Korean Journal of Medicine 2015;89(4):470-473
Sparganosis is a rare parasitic infection caused by plerocercoid tapeworm larvae of the genus Spirometra. While initially asymptomatic, the migrating larvae initially appear as subcutaneous nodules, which can be mistaken for cancer because all parts of the body can be affected, including the abdominal cavity, genitourinary tract, gastrointestinal tract, musculoskeletal system, central nervous system, and even the breasts. Therefore, we report here a case of sparganosis that was differentially diagnosed from recurrence of breast cancer.
Abdominal Cavity
;
Breast Neoplasms*
;
Breast*
;
Central Nervous System
;
Cestoda
;
Gastrointestinal Tract
;
Larva
;
Musculoskeletal System
;
Recurrence*
;
Sparganosis*
;
Spirometra
6.Early Periventricular Leukomalacia: MRI and Ultrasonographic Correlation on First one Month of Life.
Hee Gon KIM ; Hwa Sung LEE ; Jee Yeong PARK ; Sang Ho KIM ; Yong Hwa KWON ; Jung Joo WOO ; Ju Hee HONG ; Yoon Jin OH ; Suk Wook KANG ; Soon Yong KIM ; Eun Ryoung KIM
Journal of the Korean Radiological Society 1997;36(2):325-330
PURPOSE: To compare the findings of early periventricular leukomalacia on MR imaging and on US. MATERIALS AND METHODS: MR imaging was performed in 17 neonates in whom well-demarcated increased periventricular echogenicity was seen on sonography. One more patient was included during the same period because MR imaging of this patient showed a periventricular lesion not suspected on previous US. Initial sonography was performed within 6 days of birth and was followed up between one week and one month later. MR images were obtained within the first month of life. RESULTS: Twelve of 17 neonates showed abnormal periventricular signal intensities on MR imaging. Follow up sonography revealed cystic changes in two cases and heterogeneous hyperechogenicities in three. All patients except the two with cystic changes showed normal periventricular echogenicity on final sonography, On MR imaging,11 cases showed multifocal periventricular increased signals on T1-weighted images, and two cases showed mainly decreased signals representing cysts. Positive findings were more evident on T1-weighted than on T2-weighted image. CONCLUSION: on T1-weighted imaging, the characteristic finding of early periventricular leukomalacia was multifocal periventricular hyper or hypointensities, and hyperintense lesions were more common than hypointense. In the diagnosis of early noncystic periventricular leukomalacia, MR imaging was more objective than US.
Diagnosis
;
Follow-Up Studies
;
Humans
;
Infant, Newborn
;
Leukomalacia, Periventricular*
;
Magnetic Resonance Imaging*
;
Parturition
7.Related factors of re-visit intention to the oral health care center for the disabled
Yeong-Ae CHOI ; Yun-Sook JUNG ; Jae-Min KANG ; Young-Eun LEE ; Youn-Hee CHOI ; Keun-Bae SONG
Journal of Korean Academy of Oral Health 2021;45(1):44-48
Objectives:
The aim of this study is to identify the factors related to re-visit intentions of patients who had visited the 10 oral health care centers for the disabled currently operating in Korea.
Methods:
A self-developed questionnaire (29 items) was distributed among 1,000 randomly selected patients and their guardians who had visited one of the 10 oral health care centers for the disabled, with a consent. Consequently, 874 questionnaires were collected and analysed for statistics using SPSS 25.0.
Results:
The patients traveled a long distance to visit the oral health care centers because of their specialization for the disabled. With the level of satisfaction with dentist services, dental hygienist services, and facilities increasing, the re-visit intention proportionally rose.
Conclusions
This study presents basic data that provides information on the operation of 10 oral health care centers for the disabled. It is imperative to develop a more structured questionnaire, and conduct an annual survey of the disabled visiting the centers.
8.Related factors of re-visit intention to the oral health care center for the disabled
Yeong-Ae CHOI ; Yun-Sook JUNG ; Jae-Min KANG ; Young-Eun LEE ; Youn-Hee CHOI ; Keun-Bae SONG
Journal of Korean Academy of Oral Health 2021;45(1):44-48
Objectives:
The aim of this study is to identify the factors related to re-visit intentions of patients who had visited the 10 oral health care centers for the disabled currently operating in Korea.
Methods:
A self-developed questionnaire (29 items) was distributed among 1,000 randomly selected patients and their guardians who had visited one of the 10 oral health care centers for the disabled, with a consent. Consequently, 874 questionnaires were collected and analysed for statistics using SPSS 25.0.
Results:
The patients traveled a long distance to visit the oral health care centers because of their specialization for the disabled. With the level of satisfaction with dentist services, dental hygienist services, and facilities increasing, the re-visit intention proportionally rose.
Conclusions
This study presents basic data that provides information on the operation of 10 oral health care centers for the disabled. It is imperative to develop a more structured questionnaire, and conduct an annual survey of the disabled visiting the centers.
9.Severe Hypophosphatemia-Induced Acute Toxic-Metabolic Encephalopathy in Continuous Renal Replacement Therapy
Sun Ae HAN ; Ha Yeol PARK ; Hyun Woo KIM ; Jong In CHOI ; Da Yeong KANG ; Hyun Lee KIM ; Jong Hoon CHUNG ; Byung Chul SHIN
Electrolytes & Blood Pressure 2019;17(2):62-65
Acute toxic-metabolic encephalopathy (TME) is an acute condition of global cerebral dysfunction in the absence of primary structural brain disease. Severe hypophosphatemia leads to muscle weakness and involves the diaphragm but hypophosphatemia-induced TME is very rare. Herein, we report the case of a 43-year-old woman with encephalopathy with severe hypophosphatemia during continuous renal replacement therapy. She presented with features of oliguric acute kidney injury on diabetic kidney disease due to volume depletion. At admission, her mental status was alert but gradually changed to stupor mentation during continuous renal replacement therapy. Her phosphate level was less than 0.41 mEq/L and Glasgow coma scale decreased from 15 to 5. After phosphate intravenous replacement and administration of phosphate-containing replacement solution, the phosphate level increased to 2.97 mEq/L and mental state returned to alert state. This case demonstrates that the level of phosphorus should be observed during continuous renal replacement therapy.
10.Injectable Poloxamer Hydrogel Formulations for Intratympanic Delivery of Dexamethasone
Thi Phuc LE ; Yang YU ; Ik Sung CHO ; Eun Yeong SUH ; Hyuk Chan KWON ; Sun-Ae SHIN ; Yong-Ho PARK ; Kang Moo HUH
Journal of Korean Medical Science 2023;38(17):e135-
Background:
In this study, we prepared and evaluated an injectable poloxamer (P407) hydrogel formulation for intratympanic (IT) delivery of dexamethasone (DEX).
Methods:
DEX-loaded P407 hydrogels were characterized in terms of thermogelation, drug loading capacities, particle size, and drug release. The in vivo toxicity and drug absorption of the DEX-loaded P407 formulation after IT injection were evaluated using an animal model by performing histopathological analysis and drug concentration measurements.
Results:
The P407 hydrogel effectively solubilized hydrophobic DEX and demonstrated a sustained release compared to the hydrophilic DEX formulation. The in vivo study showed that the hydrogel formulation delivered considerable drug concentrations to the inner ear and displayed a favorable safety profile without apparent cytotoxicity or inflammation.
Conclusion
P407 hydrogel can be useful as an injectable inner ear delivery formulation for hydrophobic drugs due to their biocompatibility, drug-solubilizing capacity, thermogelation, and controlled release.