No abstract available.
Animals ; Carrier Proteins* ; Chemokine CCL5* ; Macrophages* ; Mice*

OBJECTIVES: The diagnosis of ASCUS(atypical squamous cells of undetermined significance) and LSIL(low-grade squamous intraepithelial lesion) was introduced in 1988 by the Bethesda system for reporting cervical/vaginal cytologies. A significant proportion of women referred for colposcopy with low grade cervical cytologic abnormalities(ASCUS and LSIL) will have high grade cervical intraepithelial neoplasia(CIN II or CIN III) and therefore require adequate management. The purposes of this study were to evaluate the usefulness of high risk type HPV(human papillomavirus) DNA detection using PCR(polyerase chain reaction) in patients with low grade cervical cytologic abnormalities in the prediction of high grade CIN and invasive cancer and to determine the clinical triage in the management of low grade cervical cytologic abnormalities. METHODS: We reviewed 18,942 cases of Papanicolau smears that were performed at our hospital from Jan. 1995 to Mar. 1999. Colposcopically directed biopsy or LLETZ(large loop excision of transformation zone) or hysterectomy were performed on 318 patients with abnormal PAP smears of low degree. HPV PCR testing of high risk types(16 and 18) was also performed on 115 patients. RESULTS: Histologic outcome of ASCUS included 43 cases(38.4%) of high grade CIN and invasive cancer, and that of LSIL included 65 cases(47.5%) of high grade CIN and invasive cancer. In cases of high risk HPV type, 19 patients(73.1%) were at age over 30 years. A highly significant correlation was found between a positive test for high risk types of HPV and finding of high grade CIN and invasive cancer. Among 51 women with ASCUS, a positive test for high risk type had a sensitivity and specificity of 40.0% and 86.1%, and positive predictive value(PPV) and negative predictive value(NPV) of 54.5% and 77.5%, respectively. In 64 women with LSIL, a positive high risk type test was associated with sensitivity and specificity of 30.0% and 94.1%, and PPV and NPV of 81.8% and 60.4%, respectively. CONCLUSION: Our results suggest that high risk type HPV may be positively predictive of and may act as a surrogate marker for high grade CIN and invasive cancer in women with low grade cervical cytologic abnormalities. The management of women with a low grade cervical cytologic abnormalities should be active such as colposcopically directed biopsies.
Biomarkers ; Biopsy ; Colposcopy ; Diagnosis ; DNA* ; Female ; Humans* ; Hysterectomy ; Polymerase Chain Reaction ; Sensitivity and Specificity ; Triage

No abstract available.
Compliance* ; Humans ; Psychopathology*

PURPOSE: To evaluate the incidence of GB opacification, seen at CT, by contrast media injected a few hours earlier in adults with normal renal function and to assess the clinical significance of the opacification. MATERIAL AND METHODS: Seventeen patients with normal renal function were included in this study. Contrast enhanced CT scan was performed 4-13 hours after intravenous urography. As a control group, 17 patients in whom contrast media was not used in recent three days were included. The incidence of GB opacification and CT number of the GB were compared between 17 study patients and 17 control patients. RESULT: GB opacification(either homogeneous opacification or layering of contrast media and bile) was seen in 16 of 17 study patients(94%). GB was not opacified in any one of the control group. The mean CT number of GB was 174 HU in study patients, and was 27.3 HU in control patients. CONCLUSION:GB opacification seen at CT several hours after injection of water soluble contrast media seems to be a physiologic phenomenon, and that phenomenon should not be considered as a vicarious excretion due to impaired renal function.
Adult* ; Contrast Media* ; Humans ; Incidence ; Tomography, X-Ray Computed ; Urography

The congenital renal cystic disease encompasses a complex group of pathologic and clinical entities. We retrospectively reviewed 42 cases of congenital renal cystic lesions classified into four Potter types in a series of 2,063 consecutive autopsies from 1981 to 1996. According to our study based on morphologic, clinical, genetic features and associated anomalies, type I and III are relatively compatible with Potter's original definition. However, it was reasonable that type II and IV are classified to the same group because of: 1) very similar histologic findings representing dysplastic kidney, 2) many associated anomalies, 3) no evidence of inheritance, and 4) presence of a combined type. Syndrome associated cysts, such as Meckel-Gruber syndrome, were also separately classified. If the dysplastic evidence was insufficient for diagnosis to the dysplastic kidney in type II and IV, then these cases would be better classified into a cystic disease associated with congenital hydronephrosis. We propose a classification of the congenital cystic disease of the kidney to be: 1) dysplastic kidney, 2) cystic disease associated with congenital hydronephrosis, 3) polycystic kidney, and 4) syndromic cystic disease.
Autopsy ; Classification* ; Diagnosis ; Hydronephrosis ; Kidney* ; Polycystic Kidney Diseases ; Retrospective Studies ; Wills

Crohn's disease (CD) is a chronic, idiopathic, inflammatory disorder of the gastrointestinal tract. In rare cases, CD has been associated with Hirschsprung's disease (HD); however, the underlying pathophysiology of this and other comorbidities is not yet fully understood. In this report, we describe the case of a 17-year-old patient who was diagnosed with both CD and ankylosing spondylitis (AS), having undergone a long ileo-colonic anastomosis to treat HD at 12 months of age. To our knowledge, this is the first documented case of CD combined with AS in a patient with HD.
Adolescent* ; Comorbidity ; Crohn Disease* ; Gastrointestinal Tract ; Hirschsprung Disease* ; Humans ; Infant* ; Inflammatory Bowel Diseases ; Spondylitis, Ankylosing*

Purpose: This study investigated the complications and patterns of implants that confronted with the extruded natural teeth. Materials and Methods: Among patients who received implant treatment between 2006 and 2018 at Chosun University Dental Hos-pital, only implants that had a maintenance period of at least 5 years and that both implants and confronting natural teeth could bemeasured and compared on a radiograph were selected. They were divided into two groups. Group 1, experimental group consisted of Implants confronting the extruded natural posterior teeth (n = 167: maxilla (Group 1max ) = 92, mandible (Group 1man ) = 75) and Group 2, control group consisted of Implants confronting the normal natural posterior teeth (n = 656: maxilla (Group 2max ) = 272, mandible (Group 2man ) = 384). Results: The incidence of complications between Group 1 and Group 2 was statistically significant. In particular, there was a statistically significant difference between the frequency of marginal bone loss and the amount of marginalbone loss. Conclusion The extruded natural tooth may cause more frequent complications including bone resorption in the oppos-ing implant.

PURPOSE:To compare the diameter of central retinal vessels between patients with normal-tension glaucoma, primary open-angle glaucoma and healthy (control) eyes. METHODS: The authors reviewed 30 eyes of 30 normal-tension glaucoma patients, 20 eyes of 20 primary open-angle glaucoma patients and 30 eyes of normal persons who had no systemic vascular diseases. The diameters of the central retinal arteries and veins were measured and calculated using a revised Parr-Hubbard formula, and results were compared between the groups. RESULTS: The diameter of the central retinal vessel showed no statistical differences between the eyes with normal-tension glaucoma and primary-open angle glaucoma. However, there were significant differences between the eyes of patients with glaucoma and the normal control eyes (p<0.05). Conclusion: The diameter of the central retinal vessels in glaucoma patients were narrower than that in the control group. Our results suggest that the diameter of the central retinal vessels may affect the development of glaucoma both in normal tension and primary open-angle types, or that glaucomatous damage may influence the diameter of the central retinal vessels.
Eye ; Glaucoma ; Glaucoma, Open-Angle ; Glycosaminoglycans ; Humans ; Low Tension Glaucoma ; Retinal Artery ; Retinal Vessels ; Retinaldehyde ; Vascular Diseases ; Veins

No abstract available.
Humans ; Infertility* ; Luteinizing Hormone, beta Subunit*

No abstract available.
Craniopharyngioma* ; Magnetic Resonance Imaging*