The antihypertensive effect of Doxazocin were evaluated in 20 patients with essential hypertension. Two to eight mg of Doxazocin per day were administered continuously for two or eight weeks. The results were as follows : 1) Doxazocin were effective in 18 out of 20 patients(90%) at the end of 8 weeks treatment. 2) The systolic blood pressure was signigicantly decreased(173+/-20mmHg VS 144+/-33mmHg, P+/-0.001), and the diastolic blood pressure was also decreased(110+/-10mmHg VS 93+/-19mmHg, P<0.01) after treatment. 3) Triglyceride showed a decreasing tendency but statistically significance was not observed. Total cholesteral, HDL-cholesterol, BUN, creatinine, and uric acid did not change significantly before and after treatment with Doxazocin. 4) The side effects were headache in one case and dizziness in to cases. These results suggest that Doxazocin is an effective antihypertensive agent and concerning lipid profile, further long term observation is needed.
Blood Pressure ; Creatinine ; Dizziness ; Headache ; Humans ; Hypertension* ; Triglycerides ; Uric Acid

Time intervals and indices of left ventricular diastolic filling were studied by M-mode and pulsed Doppler Echocardiography in 18 dilated cardiomyopathy patients. After one two hours captopril(capril(R)) 25mg medication. 1)Systolic blood pressure, Diastolic blood pressure, Heart rate were significantly decreased. 2) Dimensions of LVSD, LVDD, LA, Aorta and EF were not changed measured by M-mode echocardiography. 3) IRT measured by M-mode and Pulsed Doppler echocardiography were significantly increased(45+/-33msec VS 74+/-35msec. 84+/-32msec VS 100+/-22msec P<0.05). 4) A2-E measured by M-mode and Pulsed Doppler echocardiography were significantly increased(114+/-45msec VS 134+/-46msec, 156+/-46msec VS 194+/-48msec, P<0.05). 5) Deceleration time was significantly increased(137+/-36msec VS 205+/-40msec P<0.05). 6) Transmitral peak flow velocities were not changed significantly. In summary captopril influences early diastolic time intervals with dilated cardiomyopathy patients and we interpreted these effects be beneficial on diastolic filling pattern.
Aorta ; Blood Pressure ; Captopril ; Cardiomyopathy, Dilated* ; Deceleration ; Echocardiography ; Echocardiography, Doppler, Pulsed ; Heart Rate ; Humans

Plain chest films are the most useful modality in diagnosis of primary lung cancer, but it is difficult tointerpret the radiologic findings by histological types. Authors reviewed chest films of 324 cases ofhistologically confirmed primary lung cancer from Jan. 1974 to April 1982 at Seoul National University. The resulsare as follows; 1. Incidence was most common in the 6th decade as 34.4%. Male to female sex ratio was 3.8:1 andthere was no sex difference in Adenocarcinoma. 2. Distrubution of histologic types of primary lung cancer asfollows; Squamous cell Carcinoma 50.6%, Small Cell Carcinoma 22.5% lange Cell Carcinoma 9.3% Bronchegenic adenocaranoma 10.5% Bronchioloalveolar Cell Carcinoma 1.9%. Adenosquamos Carcinoma 0,6%, Carcinoid Tumor 0.3%, AdenoidCystic Carcinoma 0.3%. 3. Radiologic findings by histologic types as follows; a) Squamous cell carcinoma commonlypresent as collapse(51.8%) peripheral mass (40.8%), pneumonitis(37.2%), hilar involvement(34.8%), and in singleabnormality, peripheral mass (44.4%). b) Small cell carcinoma commonly present as hilar involvement(78.1%),mediastinal wideing or mass (53.4%) and in single abnormality, hilar involvement(58.3%). c) Large cell carciomacommonly present as hilar involvement(50%) pneumonia(46.7%), collapse (40%), peripheral mass(36.7%) and in singleabnormality, large peripheral mass (33.3%). d) Bronchogenic Adenocarcinoma commonly present as peripheralmass(44.1%), collapse (41.2%), pleural effusion (35.2%) and in single abnormality, peripheral mass(50%). e)Solitary peripheral mass commonly present as lobulation(48%) and spiculated margin (51%), but no specific findingsby histologic types. Cavitary formation was most common in Squamous cell carcinoma.
Adenocarcinoma ; Carcinoid Tumor ; Carcinoma, Small Cell ; Carcinoma, Squamous Cell ; Diagnosis ; Female ; Humans ; Incidence ; Lung Neoplasms ; Lung ; Male ; Pleural Effusion ; Seoul ; Sex Characteristics ; Sex Ratio ; Thorax

During the course of evaluation and management of neck masses, consideration for Immunoglobulin G4-related disease (IgG4-RD) should be given. IgG4-RD is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis. A previously healthy 72-year-old man was referred to our clinic with a 2-month history of left cervical lymph node enlargement without systemic manifestations . A cervical lymph node biopsy was planned because of elevated serum IgG4 levels. Pathological findings showed prominent infiltration of IgG4-postive plasma cells in the lymph node. After steroid therapy, a computed tomography scan revealed a decrease in the cervical lymph node size. This case illustrates the importance of including IgG4-RD in the differential diagnosis of a cervical lymph node enlargement.
Aged ; Biopsy ; Diagnosis, Differential ; Humans ; Immunoglobulin G ; Immunoglobulins ; Lymph Nodes* ; Lymphatic Diseases* ; Neck ; Pancreatitis ; Plasma Cells

Neonatal alloimmune thrombocytopenia (NAIT) is induced by maternal antibodies to fetal platelet alloantigens. Because the main cause of NAIT is incompatibility to platelet specific antibodies, NAIT due to HLA antibodies are relatively rare. We managed a case of NAIT induced by maternal anti-HLA-B35 antibodies. The patient was a second born male. He had no petechiae or purpura at birth. He was admitted to the hospital due to fever for 5 days and a platelet count of 106x10(9)/L. The fever subsided after admission but on the 2nd day of admission, petechiae developed on the chest wall and the platelet count decreased to 25x10(9)/L. Other laboratory findings included C-reactive protein, prothrombin time, and partial thromboplastin time were normal. His mother's platelet count was normal and she had no history of bleeding. Anti-HLA-B35, B52, B56, C3, and C14 were identified in the mother's serum by a panel reactive antibody test and HLA-B35 antigen was identified in the father's and patient's sera. These finding suggested that maternal Anti-HLA-B35 antibody was a response to neonatal HLA-B35 antigen inherited from the father. The patient received concentrated platelet and intravenous immunoglobulin. The platelet count rose to 248x10(9)/L and was maintained thereafter.
Antibodies ; Antigens, Human Platelet ; Blood Platelets ; C-Reactive Protein ; Fathers ; Fever ; Hemorrhage ; HLA-B35 Antigen ; Humans ; Immunoglobulins ; Male ; Partial Thromboplastin Time ; Parturition ; Platelet Count ; Prothrombin Time ; Purpura ; Thoracic Wall ; Thrombocytopenia, Neonatal Alloimmune

BACKGROUND: The level of physical adaptation through active lifestyle can result in changes in appetite; and caused by physical activity and exercise, physical adaptation may change carbohydrate and fat metabolism during exercise. This study investigated the differences in carbohydrate and fat metabolism after moderate treadmill running and the difference in appetite response before and after exercise in active, regularly exercising individuals and those inactive. METHODS: We analyzed the effects of moderate physical activity (70% of oxygen uptake reserve, 30 minutes on the treadmill) on free fatty acids, glucose, growth hormone, insulin and an appetite visual analogue scale (VAS). Our subjects included 28 healthy males who were divided into two groups, the activity group (n=14) and the inactivity group (n=14) according to the International Physical Activity Questionnaire (IPAQ). The serum samples and VAS were collected at pre, post and 30 min post-exercise. RESULTS: The results of the serum analysis showed no significant effects on free fatty acids, glucose, growth hormone and insulin between the groups, but showed significant changes in free fatty acids and growth hormone between points of measurement. Significant increases in VAS were seen with moderate exercise in both groups, with the inactivity group expressing greater hunger than the activity group. CONCLUSIONS: This study found that inactive persons were hungrier than active persons after moderate exercise. This information might be useful to staff and participants of weight loss programs.
Appetite ; Energy Metabolism ; Exercise ; Fatty Acids, Nonesterified ; Glucose ; Growth Hormone ; Humans ; Hunger ; Insulin ; Life Style ; Male ; Motor Activity ; Oxygen ; Running ; Weight Reduction Programs ; Surveys and Questionnaires

Xanthogranuloma (XG) is a benign self-healing disorder that's characterized by multiple yellowish papulonodular lesions of the skin and other visceral organs. It appears within the first year of life in approximately 80 percent of the cases and it disappears spontaneously within 3 to 6 years. Adult XG clinically differs from juvenile XG in that the adult lesion is usually solitary, it generally does not involve internal organs and it does not resolve spontaneously. Multiple adult XG is classified as the presence of more than 5 XG lesions. A review of the literature shows that its disseminated form is exceptional, and only a few cases have been reported so far. We herein report on an atypical case ofadult XG with numerous papulonodular lesions.
Adult ; Humans ; Skin

No abstract available.
Lymphangioma*

The classic type of Kaposi's sarcoma, or multifocal hemorrhagic sarcoma histologically characterized by proliferating fibroblastic and microvascular elements was described by Kaposi as a relatively rare neoplasm. During the past nine years, we experienced three cases of sporadic, classic Kaposi's sarcomas. They were presented as multiple papules, macules and nodules on the skin of the hands, lower logs and feet without systemic involvement. Histologically, Kaposi's sarcoma is divided into three stages, early patch, plaque and nodular stages. The nodular lesions(case 1, 2 and 3) showed extensive proliferatiion of spindle shaped, somewhat pleomorphic cells having dark prominent nuclei, proliferation of small vessels with solid aggregates of endothelial cells, and extravasation of erythrocytes. In early patch stage(case 3), widely dilated, anastomosing, thin-walled vascular spaces are noted in the upper half of the dermis. In plaque stage(case I and 3), there are proliferation of spindle shaped cells with extravasated erythrocytes and aggregates of blood vessels lined by prominent endothelial cells.

No abstract available.
Humans ; Needles* ; Peritonsillar Abscess*