No abstract available.
Thyroid Gland ; Thyroiditis

After the intraocular bleeding was inuced by amputation of the rabbit retinal artery, the level and duration of the level of the intraocular pressure to control the bleeding was studied. Then, the eyes were enucleated and evaluated for the effect of the increased intraocular pressure. In 3 of 4 eyes studied, the bleeding is controlled at the height of 140-145 cm of the infusion bottle for 10 seconds. And the maintenance of the height of 125 cm for 15 seconds was effective in one eye. Although the expanded intercellular space in the outer nuclear layer, destruction of the photoreceptors and formation of the vacuoles appeared in the first week, they were only the temporary findings for they disappeared after second week. In the rebbit, the retinal arterial bleeding is able to be controlled at the level of about 100 mmHg of the IOP for about 10 seconds effectively and safely.
Amputation ; Extracellular Space ; Hemorrhage ; Intraocular Pressure ; Retina* ; Retinal Artery ; Retinaldehyde ; Vacuoles

Since Purtscher's original discriptions similar clinical signs have been described following acute compressive neck or chest injuries, chest compression, val salva maneuvers, long bone fractures, acute pancreatitis and after childbirth. The appearance of Purtscher's retinopathy are believed to be due to ischemic episodes particularly in the end arterioles around the macula and disc. We experienced two cases of Purtscher's-like retinopathy in patients with systemic hypertension who had not any recent trauma history and reviewed the available literatures regarding this disease.
Arterioles ; Fractures, Bone ; Humans ; Hypertension* ; Neck ; Pancreatitis ; Parturition ; Thoracic Injuries ; Thorax

Morning glory syndrome is a rare congenital anomaly in optic disc, which is characterized by defect in optic disc due to optic nerve dysgenesis, abnormal retinal vessels, and chorioretinal pigment disturbance around optic disc. Retinal detachment in morning glory syndrome occurs in 26% to 38% of the cases, which is thought to be non-rhegmatogenous in nature and usually develops in posterior pole of the retina. Surgical treatment is indicated in cases with bullous and total retinal detachment in morning glory syndrome. The authors successfully reattached the detached retina in a 3 year old boy with morning glory syndrome using trans pars plana vitrectomy, scleral buckling, retinotomy, silicone oid injection, and endolaser photocoagulation. The authors followed up for 15 weeks after operation, and the vision of left eye was counting finger and the retina remained to be reattached.
Child, Preschool ; Fingers ; Humans ; Light Coagulation ; Male ; Optic Nerve ; Retina ; Retinal Detachment* ; Retinal Vessels ; Retinaldehyde* ; Scleral Buckling ; Silicones ; Vitrectomy

Adult albino rabbits were used in this study. The retina was treated with laser photocoagulation around the retinal break. The histopathologic findings were evaluated with light and electron microscopes to determine how quickly chorioretinal adhesion was produced after photocoagulation. Adhesion between the rod and cone layer and the pigment epithelium appeared within 1 hour after photocoagulation, probably due to direct burn effect of the laser. A scar tissue appeared in the chorioretinal lesion 5 days after photocoagulation, derived from the proteinaceous coagulum and accompanying fibrosis.
Adult ; Burns ; Cicatrix ; Epithelium ; Fibrosis ; Humans ; Light Coagulation* ; Rabbits ; Retina ; Retinal Perforations

An improved retinal tack and applicator have been increasingly used as an adjunct in the repair of complicated retinal detachments. We used this technique in 7 consecutive cases of complicated retinal detachment. After a mean follow-up of 3 months, anatomical reattachment including partial reattachment was achieved in 5 eyes among 7 eyes, and 6 eyes had improved vision or no change(one improved to 20/70). Retinal tacks appear to be a useful tool either temporarily or permanently in preventing retraction and detachment of the retina until adjunctive diathermy, cryopexy, or photocoagulation becomes effective.
Diathermy ; Follow-Up Studies ; Light Coagulation ; Retina ; Retinal Detachment* ; Retinaldehyde* ; Vitreoretinopathy, Proliferative

Morning glory syndrome is a rare congenital anomaly in optic disc, which is characterized by defect in optic disc due to optic nerve dysgenesis, abnormal retinal vessels, and chorioretinal pigment disturbance around optic disc. Retinal detachment in morning glory syndrome occurs in 26% to 38% of the cases, which is thought to be non-rhegmatogenous in nature and usually develops in posterior pole of the retina. Surgical treatment is indicated in cases with bullous and total retinal detachment in morning glory syndrome. The authors successfully reattached the detached retina in a 3 year old boy with morning glory syndrome using trans pars plana vitrectomy, scleral buckling, retinotomy, silicone oid injection, and endolaser photocoagulation. The authors followed up for 15 weeks after operation, and the vision of left eye was counting finger and the retina remained to be reattached.
Child, Preschool ; Fingers ; Humans ; Light Coagulation ; Male ; Optic Nerve ; Retina ; Retinal Detachment* ; Retinal Vessels ; Retinaldehyde* ; Scleral Buckling ; Silicones ; Vitrectomy

Retinotomy, cutting of the retina, can be helpful in hte management of giant retinal tears, subretinal strands, and retinal incarceration. Relaxing retinotomies are used in the presence of retinal shortening or fibrous proliferation and contraction, and usually performed in the peripheral or equatorial retina. To fascilitate retinal attachment, the authors used intraocular scissors to perform radial retinotomy in the macula of two patients during vitrectomy surgery. We obtained a successful result using retinotomy in the macula as an adjunct to repair of retinal detachment with macular hole formation.
Humans ; Retina ; Retinal Detachment ; Retinal Perforations ; Retinaldehyde ; Vitrectomy

120 eyes of 119 patients with retinal detachment were treated with an encircling silicone sponge scleral buckling in the department of Ophthalmolgy, Severance Hospital, Yonsei University Medical Center from September 1, 1988, to January 31, 1991. Results were as follow 107 eyes among 120 eyes (89.2%) showed anatomical success, and 54 eyes of them (45%) showed functional success. As the preoperative factors, the case of over 20/70 vision (100%, p>0.05, 100%, p<0.05), cases of duration of detachment for less than one month (92%, p>0.05, 57%, p<0.05), cases of preoperative no hypotony (above 5mmHg) (99%, p<0.05, 56%, p<0.05), cases of no myopia (below -Sph 4.50) (85%, p>0.05,61%, p<0.05) of retinal detached eyes, and non-involved case of a macula(97%, p>0.05, 54%, p<0.05) showed favorable anatomical and functional success rate. The presence and degree of the proliferative vitreoretinaopathy affected the anatomical and functional success rate, but the age of patients did not affect the success of surgery.
Academic Medical Centers ; Humans ; Myopia ; Porifera* ; Retinal Detachment* ; Retinaldehyde* ; Scleral Buckling ; Silicones*

One of the histopathologic hallmarks of early diabetic retinopathy is the loss of pericytes. Evidences suggest that the pericyte loss in vivo is mediated by apoptosis. However, the underlying cause of pericyte apoptosis is not fully understood. This study investigated the influence of methylglyoxal (MGO), a reactive -dicarbonyl compound of glucose metabolism, on apoptotic cell death in bovine retinal pericytes. Analysis of internucleosomal DNA fragmentation by ELISA showed that MGO (200 to 800 micrometer) induced apoptosis in a concentration-dependent manner. Intracellular reactive oxygen species were generated earlier and the antioxidant, N-acetyl cysteine, inhibited the MGO-induced apoptosis. NF-kB activation and increased caspase- 3 activity were detected. Apoptosis was also inhibited by the caspase-3 inhibitor, Z-DEVD-fmk, or the NF- kB inhibitor, pyrrolidine dithiocarbamate. These data suggest that elevated MGO levels observed in diabetes may cause apoptosis in bovine retinal pericytes through an oxidative stress mechanism and suggests that the nuclear activation of NF-kB are involved in the apoptotic process.
Acetylcysteine/pharmacology ; Animals ; *Apoptosis ; Caspases/metabolism ; Cattle ; Cell Death ; Cell Survival ; DNA Fragmentation ; Dose-Response Relationship, Drug ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Glucose/metabolism ; NF-kappa B/metabolism ; Nucleosomes/metabolism ; Oxidative Stress ; Pericytes/*drug effects ; Pyruvaldehyde/*pharmacology ; *Reactive Oxygen Species ; Retina/cytology/*drug effects