During the past two decades, silicone (polydimethylsiloxane) has become one of the most extensively applied biomaterials. Although pure silicone is relatively inert and usually causes only minimal tissue reactions, it has been reported to evoke a definite foreign body reaction. We studied five cases of silicone-induced granulomas in various sites; two in the breast, one in the breast and axillary lymph nodes, one in the subcutis of the abdomen, back and extremities and one in the eyeball, to illustrate the salient histopathologic features of reactions to silicone with particular emphasis to its differences from paraffin granuloma. For this, 17 paraffinomas were also studied. Tissue reaction to silicone liquid and gel was characterized by numerous round to oval empty cystic vacuoles, mild to moderate fat necrosis, foreign body reaction, a variable degree of mononuclear inflammatory cell infiltration and mild focal fibrosis. The cystic spaces were relatively uniform and showed a snow-man like appearance. In contrast to the silicone granulomas, the paraffinomas, also refered to as sclerosing lipogranulomas showed diffuse sclerosis and frequent calcification around the cystic vacuoles. The cystic spaces in paraffinomas were swiss cheese-like configuration, and the content of the cystic spaces was dirty and frequently calcified. However, there were certain similarities between these two types of granulomas particularly in the early phases of the reaction, therefore, the history of silicone injection or implant, is sometimes critical to the diagnosis of silicone granuloma. Despite great technologic advances in the manufacturing of prostheses and medical equipment, droplets and/or particles of silicone still escape into the body tissues in a variety of ways; therefores, the pathologist should always wonder whether the histologic reaction observed is due to silicone or to some other foreign material including paraffin.

Since human listeriosis was firstly described by Nyfeldt in 1929, Listeria monocytogenes as a cause of septic abortion has been well known. It primarily affects pregnant woman and neonates, the elderly, and persons with immune-system dysfunction due to immunosuppressive drugs, malignant tumors or AIDS. Although several large epidemic listeriosis have been reported in the English literatures, it is still an underdiagnosed and underreported cause of congenital sepsis and septic abortion, because it is not always easy to isolate the organism in culture. There are 17 cases reports of Listeria monocytogenes infection in Korea, however, most of which were described about the bascteriologically proven cases. We describe placental findings of a septic abortion caused by Listeria monocytogenes at 15 weeks gestation in a 23-year-old primigravida woman. Placental examination showed characteristic and relatively specific patterns of granulomatous microabscesses composed of necrotic nuclear debris in the center and surrounding epithelioid histocytes enmeshed in fibrin between the acutely inflamed villi. There were numerous gram positive bacilli on Brown-Brenn stain.
Pregnancy ; Female ; Infant, Newborn ; Humans

A clinico-pathologic study with an immunohistochemical examination for c-erbB-2 expression in 54 cases of ductal carcinoma in situ and 16 cases of Paget's disease of the breast was performed. c-erbB-2 oncoprotein overexpression was observed in 45% (24/54) and 88% (14/16) of ductal carcinoma in situ and Paget's disease, respectively. The overexpression of c-erbB-2 oncoprotein was significantly correlated with the nuclear grade of tumors and inversely with the status of the estrogen receptor. c-erbB-2 was positive in 4 out of 5 patients with metastasis to axillary lymph nodes and 3 out of 4 patients who died of the disease. Prognostic significance of c-erbB-2 oncoprotein in ductal carcinoma in situ was highly suggested. The expression of c-erbB-2 oncoprotein in Paget's disease was well correlated with coexisting infiltrating or in situ ductal carcinoma. The high positive rate of c-erbB-2 oncoprotein in ductal carcinoma with Paget's disease could be understood with a recent hypothesis that c-erbB-2 oncoprotein is involved in promotion of cell motility and the spread of carcinoma cells.
Neoplasm Metastasis

A case of clear cell adenocarcinoma arising in the female urinary bladder, which is accompanied by endometriosis of the urinary bladder and the uterus, is reported. The carcinoma protruded into the vesical lumen as a fungating mass, and had a tubulocyotic pattern. The tumor cell had intracytoplasmic glycogen and electron microscopically short microvilli on their surface, resembling clear cell acenocarcinoma of the female genital tract including ovary. This is the fourth case report of clear cell adenocarcinoma complicating vesical endometriosis, and may support the view that clear cell carcinome arises from endometriosis which, in turn, from the Mullerian remnant.
Female ; Humans ; Adenocarcinoma

A case of clear cell adenocarcinoma arising in the female urinary bladder, which is accompanied by endometriosis of the urinary bladder and the uterus, is reported. The carcinoma protruded into the vesical lumen as a fungating mass, and had a tubulocyotic pattern. The tumor cell had intracytoplasmic glycogen and electron microscopically short microvilli on their surface, resembling clear cell acenocarcinoma of the female genital tract including ovary. This is the fourth case report of clear cell adenocarcinoma complicating vesical endometriosis, and may support the view that clear cell carcinome arises from endometriosis which, in turn, from the Mullerian remnant.
Female ; Humans ; Adenocarcinoma

Fourteen cases of double chambered right ventricle were diagnosed angiographically and of these nine caseswere confirmed after operation and autopsy at Seoul National University Hospital in recent four years since 1979.The clinical and radiological findings with the emphasis on the cinecardiographic findings were analysed. Thesummaries of the analysis are as follows; 1. Among 14 cases, 6 cases were male and 8 cases were female. Agedistribution was from 4 years to 36 years. 2. In chest X-ray findings, pulmonary vascularity was increased in 8cases, decreased in 4 cases, and nomral in 2 cases. Cardiomegaly was observed in 8 cases and other showed normalheart size. 3. In cinecardiography, 11 cases had interventricular septal defect. Among these 11 cases, VSD locatedin proximal high pressusre chamber was in 2 cases and located in distal low presssure chamber was in 9 cases. 4.The location of aberrant muscle bundle in sinus portion of right ventricule was in 8 cases. In the rest cases, andaberrant muscle bundle was located below the infundibulum of right ventricle. 5. For accurate diagnosis anddifferential diagnosis with other congenital cardiac anomalies such as Tetralogy of Fallot or isolated pulmonicstenosis, biplane cineangiography and catheterization is an essential procedure.
Autopsy ; Cardiomegaly ; Catheterization ; Catheters ; Cineangiography ; Diagnosis ; Female ; Heart Ventricles ; Humans ; Male ; Pituitary Gland ; Seoul ; Tetralogy of Fallot ; Thorax

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.