A case of myxoma of the breast was reported. A 25-year-old woman showed a lump in the left breast which was suddenly enlarged after the delivery of a baby. A tumor measuring 73.53cm was located in the upper outer quadrant of the breast. Fine needle aspiration cytology revealed scattered benign spindle shaped mesenchymal cells with abundant myxoid material. On excision, the tumor was partly solid, partly cystic and multilocular. Each nodule consisted of an abundant mucoid material with a few spindle or stellate mesenchymal cells. Pleomorphism and mitosis were absent. The mesenchymal cells showed immunoreactivities for S-100 protein, smooth muscle actin, and CD34. The myxoid stroma was positively stained with alcian blue and mucicarmine. These findings suggest that constituent cells derive from totipotential primitive mesenchymal cells.
Actins ; Adult ; Alcian Blue ; Biopsy, Fine-Needle ; Breast* ; Female ; Humans ; Mitosis ; Muscle, Smooth ; Myxoma* ; S100 Proteins

No abstract available.
Parturition*

No abstract available.

BACKGROUND: Recently, according to many studies, variable factors have been known to be associated with physical fitness. The factors such as obesity and inactivity are associated with poor physical fitness, but regular exercise is associated with good physical fitness. In our country, these studies are not yet reported. And so, this study was designed to investigate the factors associat,ed with physical fitness. METHODS: From May 1st, until July 30th 1996, we recruited the 411 subjects who visited the Health Promotion Center at Seoul National University Hospital. Data related to sex, age, exercise, job, cigarette smoking, alcohol consumption were obtained by self-administered Questionnaire. Obesity index was calculated by the percentage of standard body weight. And VO2max were obtained by submaximal bicycle ergometer test. High level exercise group was defined as the persons who had taken exercise more than 3 times a week and 20 minutes per session, and moderate exercise group was defined as the persons who had taken exercise one or two times a week and 20 minutes per session, and sedentary group was defined as the persons who had taken exercise more than 20 minutes less than one time per week. RESULTS: The subjects were 230 males(56%), total numbers were 411. The results were as follows. Compaired to women and nonexercise group, men and exercise group had high VO2max(p<0.005). The relationship between VO2max and age showed negative, and the VO2max of obese group(obesity index>_120) was greater than that of nonobese group. Any significant relationships between VO2max and job, disease were not found. In multiple regression analysis, significant relationships between VO2max and age, sex, exercise type, and obesity index were observed(p<0.01). CONCLUSIONS: We concluded that there were significant relationships between VO2max and obesity index, exercise group.
Alcohol Drinking ; Body Weight ; Female ; Health Promotion ; Humans ; Male ; Obesity ; Physical Fitness* ; Seoul ; Smoking ; Surveys and Questionnaires

PURPOSE: The purpose of this study was to identify the factors influencing regular exercise of the elderly in discriminating regular exercise and non - regular exercise groups. METHOD: The subjects of this study were 167 elderly over the age of 60, living in a rural city in Korea. The data was collected by interview and self report questionnaire in 1999. The Cronbach 's alpha of scales used this study were .66 ~.97. RESULT: 1. There were significant differences in doing regular exercise between the perceived importance of the health(p=021), the perceived health status(p=.050), the perceived need of the exercise(p=000), the perceived importance of the exercise(p= .000), the intent of participation in the exercise program(p=.000), IADL score(p= .022), the perceived benefits of exercise (p=.000), the emotion of exercise(p=.000), HPLP(p=.000), the self efficacy(p=.001), the perceived benefits of health promoting behaviors(p= .011), the perceived barriers of the health promoting behaviors(p=.002), and the Internal locus of control(p=.021) of the elderly. 2. Variables which showed significance for discriminating regular exercise of the elderly in this study were the perceived need of the exercise(p=.000) and the perceived benefits of the exercise(p=.000). By using the combination of these variables, the possibility of proper prediction for predicting regular exercise group was 84.8 %, non - regular exercise group was 93.9%, and total Hit ratio was 89.4%. CONCLUSION: To improve exercise behavior in older adults, health care providers should focus of developing interventions to strengthen the perceived benefits, the perceived needs of the exercise.
Adult ; Aged* ; Discriminant Analysis ; Health Personnel ; Humans ; Korea ; Self Report ; Weights and Measures ; Surveys and Questionnaires

The purpose of this study was to identify the factors influencing health promoting behavior of college students to develop health promoting interventions of young adults. The subjects of this study were 176 women college students, living in a small city in Korea. The data were collected by interviews and a self-report questionnaire, during the period from September, 1999 to December, 1999. The instruments for this study were the PRQ-II by Weinert(1988), the scale of Locus of Control by Wallstone et al.(1978), the scale of self efficacy by Sherer & Maddux(1982), 10 points visual analogue scale for perceived health status and the importance of health, the health promoting behavior scale by Walker et al.(1987), and the scales developed by the authors for the perceived benefits of health promoting behavior, and perceived barriers to health promoting behavior. Cronbach 's alpha of these scales were .68 ~.89. The data were analyzed using descriptive statistics, Pearson's correlation coefficients, and stepwise multiple regression. The results of this study were as follows: 1. Among cognitive perceptual factors of the Health Promotion Model by Pender(1987), the scores of the importance of health, the perceived internal control of health, self efficacy, the perceived health status, and the perceived benefits had a significantly positive correlation with the scores of the health promoting behavior of college students. In addition, the scores of the perceived barriers had a significantly negative correlation with the scores of the health promoting behavior of college students. 2. Among modifying factors of the Health Promotion Model by Pender(1987), the extent of religious activities of college students and the scores of social support had a significantly positive correlation with the scores of health promoting behavior of college students. 3.Stepwise multiple regression analysis revealed that the most powerful predictor of health promoting behavior was self-efficacy. A combination of self-efficacy, the perceived benefits, the perceived barriers, the perceived health status, and the importance of health accounted for 45.1% of the variance in health promoting behavior in college students From the results of this study, we concluded that the Health Promotion Model by Pender can be used to explain health promoting behavior of college students. In addition, we suggested that the results of this study be considered in developing health promoting programs of young adults.
Female ; Health Promotion ; Humans ; Internal-External Control ; Korea ; Self Efficacy ; Weights and Measures ; Young Adult

The purpose of this study was to identify the factors influencing health promoting behavior of the elderly for develop health promoting intervention of old people. The subjects of this study were 167 elderly person over the age of 60, living in rural city in Korea. The data were collected by interview and self report questionnaire, during the period from May, 1999 to August. 1999 The instruments for this study were the PRQ-II by Weinert(1988), the scale of Locus of Control by Wallstone et al(1978), the scale of self efficacy by Sherer & Maddux(1982), 10 points visual analogue scale for the perceived health status and the importance of health, the health promoting behavior scale by Walker et al(1987), and the scales developed by authors for the perceived benefits of health promoting behaviors, and the perceived barriers to health promoting behaviors. The Cronbach 's alpha of these scales were .84 ~.97. The data were analyzed using descriptive statistics, Pearson's correlation coefficients, and stepwise multiple regression. The results of this study were as follows: 1. Among cognitive perceptual factors of the Health Promotion Model by Pender(1987), the scores of the importance of health, the perceived internal control of health, the self efficacy, the perceived health status, and the perceived benefits were significantly positive correlation with the scores of the health promoting behavior of the elderly. In addition, the scores of the perceived barriers were significantly negative correlation with the scores of the health promoting behavior of the elderly. 2. Among modifying factors of the Health Promotion Model by Pender(1987), the pocket money of the elderly, the scores of social support were significantly positive correlation with the scores of the health promoting behavior of the elderly. In addition, ages of old people were significantly negative correlations with the scores of the health promoting behavior of the elderly. 3. Stepwise multiple regression analysis revealed that the most powerful predictor of health promoting behavior was the self efficacy. A combination of the self efficacy, the perceived barriers, the social support, the importance of health, and the perceived internal control of health accounted for 56.2% of the variance in health promoting behavior in the elderly. From the results of this study, we concluded that the Health Promotion Model by Pender will be used to explain health promoting behavior of the elderly. We suggested that the results of this study will be considered in developing health promoting programs of elderly.
Aged* ; Health Promotion ; Humans ; Internal-External Control ; Korea ; Self Efficacy ; Self Report ; Weights and Measures ; Surveys and Questionnaires

Mutation in the p53 suppressor gene is the most common genetic alteration found in human cancers including primary brain tumors. Ki-67 labeling index(LI) is known to be a marker of proliferating activity. The purpose of this study was to verify whether an immunohistochemical expression of p53 antibody and Ki-67 LI could be related to different clinicopathologic parameters including histologic grade, size, invasiveness and recurrence of the brain tumors. Materials were based on the 147 surgically resected brain tumors during the last two years. Of the 147 brain tumors, there were 35 astrocytic tumors, 35 meningiomas, 10 oligodendrogliomas, 7 craniopharyngiomas, 5 dysembryoplastic neuroepithelial tumors, 4 medulloblastomas, 5 ependymomas, 23 pituitary adenomas, 9 schwannomas, and 14 other brain tumors. The p53 expression and Ki-67 LI were higher in malignant brain tumors including astrocytic tumors, medulloblastoma, PNET and gliosarcoma. The p53 positivity was correlated with histologic grades and tumor recurrence. The brain tumors with a high Ki-67 LI(>6%) also showed a close relationship to a higher histologic grading, radiological invasiveness and recurrence. There was no evident correlation with the age and tumor size with p53 expression and Ki-67 LI. These results suggest that p53 overexpression and high proliferation potential of the tumor cells are associated with the higher histologic grade and aggressive clinical course in the central nervous system tumors.
Brain Neoplasms* ; Brain* ; Central Nervous System Neoplasms ; Craniopharyngioma ; Ependymoma ; Genes, Suppressor ; Gliosarcoma ; Humans ; Medulloblastoma ; Meningioma ; Neoplasms, Neuroepithelial ; Neurilemmoma ; Neuroectodermal Tumors, Primitive ; Oligodendroglioma ; Pituitary Neoplasms ; Recurrence

Creutzfeldt-Jakob disease(CJD) is characterized clinically by rapidly progressive dementia with pyramidal, extrapyramidal, and cerebellar symptoms and signs, and histologically by spongiform change, neuronal loss and reactive gliosis. We have experienced 2 cases of CJD. Case 1 was a 36-year-old male who had suffered from myoclonus and cerebellar symptoms including sluggish speech, gait and balance disturbance. Case 2 was a 70-year-old female who had showed cognitive dysfunction, ataxic gait and disturbance of extraocular movement. Both patients, underwent brain biopsy. Case 1 revealed marked cortical atrophy, 2mm in thickness, with neuronal loss and astrocytic proliferation extending into white matter. The spongiform change, made up of many small, usually rounded or oval, vacuoles was noted mainly in the neuropil. Case 2 revealed remarkable spongiform change throughout the cortex and cytoplasmic vacuoles compressing the nuclei of neuronal cells were numerous. Neuronal loss and gliosis were also found without considerable change in the white matter. On double immunostaining against GFAP and PrP(Prion Protein), there was a weak positive reaction for PrP in the perinuclear cytoplasm in case 1, and a strongly positive reaction in case 2. The electron microscopic examination showed numerous membrane-bound vacuoles in neuropil and perikarya of neurons. The majority of the vacuoles were multiseptated by thin membranous structures. They demonstrated curled, or disrupted membrane, that had foldings and protrusions into the vacuolar clear spaces. There were neither identifiable virus-like particles nor amyloid deposition.
Female ; Male ; Humans

OBJECTIVE: To evaluate the efficacy of low dose gonadotropin releasing hormone agonist(GnRH-a) therapy combined with high dose human menopausal gonadotrpin(hMG) following estrogen & progesteron therapy for poor responders. METHODS: From May 1997 to Feb 1999, 36 patients who were defined as poor responders on previous consecutive two and more superovulation cycles were randomly allocated to lowdose GnRH-a short protocol with high dose hMG protocol pretreated with estrogen & progesterone(E/P therapy)(n=16)(study group) and the clomiphene citrate with hMG(n=20)(control group). All patients were planned to undergone in-vitro- fertilization(IVF) and embryo transfer(ET) after controlled ovarian hyperstimulation(COH). RESULTS: Two groups were similar with respect to clinical features and basal FSH and E2 levels. The mean level of E2 on day 5, 304.3+/-148.ng/ml in study group was significantly higher than that in control group, 182+/-34.9ng/ml. The mean levels of E2 on hCG day was also significantly higher in study group than control group(1324+/-320ng/ml, vs 414+/-168ng/ml). The mean day of hCG day in study group, 12.3+/-0.3 was shorter than that in control group, 13.8+/-0.4. The concellation rates of cycles were significantly lower in study group than control group(13.2% vs 84.2%). But clinical pregnancy rates did not showed the significant difference between two groups. CONCLUSION: The study suggested that a lowdose GnRH-a short protocol with high dose hMG pretreated with estrogen & progesterone can improve the ovarian response in poor responder group.
Clomiphene ; Embryonic Structures ; Estrogens ; Gonadotropin-Releasing Hormone* ; Humans ; Pregnancy Rate ; Progesterone ; Superovulation