1.The Role of NF-kappaB in the TNFalpha-induced Hyperplasia of Synoviocytes Isolated from Patients with Rheumatoid Arthritis.
Jee Hee YOON ; Sung Hee HWANG ; So Yeon MIN ; Ho Yeon KIM
Korean Journal of Immunology 2000;22(3):131-137
No abstract available.
Arthritis, Rheumatoid*
;
Humans
;
Hyperplasia*
;
NF-kappa B*
2.The effect of lithium-carbamazepine combined therapy on hematology, hepatic and thyroid funtion in acute manic patients.
Tae Yeon HWANG ; Min Soo LEE ; Dae Hee LEE
Journal of Korean Neuropsychiatric Association 1993;32(5):724-734
No abstract available.
Hematology*
;
Humans
;
Thyroid Gland*
3.Standardization and Validity Study of Korean Nomenclatures of The Home Health Care Classification.
Hyeoun Ae PARK ; In Sook CHO ; Jee In HWANG ; Young Hee CHOI ; Hyang Yeon LEE ; Hyoun Kyoung PARK
Journal of Korean Academy of Adult Nursing 1999;11(2):252-266
The purpose of this study was to develop and test the validity of standardized Korean nomenclature of the Home Health Care Classification(HHCC), developed by Saba at the University of Georgetown. The four phases of the study were : (1) Two professors and 15 graduate students, who were taking a nursing intervention course, translated the HHCC into Korean. (2)12 nurses with various clinical backgrounds reviewed each nomenclature taking into consideration of the definition and activities, and the Delphi method was used to determine the best appropriate nomenclature for each term; (3)20 academic and clinical experts in nursing were given a questionnaire to rate the validity of each Korean nomenclature using a 5 point Likert scale ranging from very inappropriate to very appropriate; (4) Five members of the Korean Nurses Association Research Committee reviewed the survey results and determined the most appropriate Korean nomenclature for each term of the HHCC. Most of the nomenclatures had a score of more than 4.0, but several terms had a score lower than 4.0. They are Ambulation therapy(3.1.1), Anticipatory grieving(3.11), Sexual patterns alteration(3.17), Nursing care coordination(3. 22), Physical therapist service(3.22), Regular diet(3.33), and Instrumental activities of daily living(3.44). These research results will be included in the nursing vocabulary dictionary to be published by the Korean Nurses Association.
Classification*
;
Delivery of Health Care*
;
Humans
;
Nursing
;
Nursing Care
;
Physical Therapists
;
Vocabulary
;
Walking
;
Surveys and Questionnaires
4.99mTc-HMPAO regional cerebral blood flow SPECT in cerebral infarctsand ischemia.
Chi Moon HWANG ; Hye Yeon HAN ; Hee Sang KIM ; Kyung Hoi AHN
Journal of the Korean Academy of Rehabilitation Medicine 1992;16(3):265-271
No abstract available.
Ischemia*
;
Technetium Tc 99m Exametazime*
;
Tomography, Emission-Computed, Single-Photon*
5.Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K.
Ji Ho KIM ; Yeon Kyung SON ; Gun Hee KIM ; Keum Hee HWANG
Biomolecules & Therapeutics 2013;21(3):234-240
Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine beta-hydroxylase (DBH) inhibitor. IC50 values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 microM, and 43.9 microM. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The IC50 values of iproniazid were 37 microM, and 42.5 microM in our parallel examination. Moreover, IC50 value of xanthoangelol to DBH was calculated 0.52 microM. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The IC50 value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 microM and this value was higher than that of deprenyl (0.046 microM) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The IC50 value of cynaroside to DBH was calculated at 0.0410 microM. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect.
Angelica*
;
Antidepressive Agents
;
Chalcones
;
Depression
;
Dopamine beta-Hydroxylase
;
Inhibitory Concentration 50
;
Iproniazid
;
Monoamine Oxidase
;
Monoamine Oxidase Inhibitors
;
Oxidoreductases*
;
Selegiline
6.A Case of Neurenteric Cyst with Hemiplegia.
Hyery KIM ; Hee HWANG ; Su Yeon PARK ; Jong Hee CHAE ; Ki Joong KIM ; Yong Seung HWANG
Journal of the Korean Child Neurology Society 2007;15(1):126-129
Spinal neurenteric cyst results from the persistence of an abnormal communication between endodermal and neuroectodermal layer. It is a rare malformation that lead to spinal cord compression. The patient is a 22-month-old boy with sudden, progressive left side motor weakness. Preoperative magnetic resonance image revealed intradural extramedullary cyst in C4-C5 level that compressed the spinal cord on the left side. After the resection of the cyst, motor weakness of the left side was partially improved, and his motor power was completely recovered after rehabilitation. Histologic examination revealed a ciliated columnar epithelial neurenteric cyst. The pre- and postoperative clinical features of the case of neurenteric cyst is described with the review of literature.
Endoderm
;
Hemiplegia*
;
Humans
;
Infant
;
Male
;
Neural Plate
;
Neural Tube Defects*
;
Rehabilitation
;
Spinal Cord
;
Spinal Cord Compression
7.Molecular Genetic Analysis of Dystrophin Gene in Duchenne/Becker Muscular Dystrophy.
Su Yeon PARK ; Kyung Nam KOH ; Byung Chan LIM ; Ho Seok KANG ; Kyoung Yeon LEE ; Hee HWANG ; Jong Hee CHAE ; Ji Eun CHOI ; Ki Joong KIM ; Yong Seung HWANG
Journal of the Korean Child Neurology Society 2004;12(1):50-58
PURPOSE: Duchenne/Becker muscular dystrophy(DMD/BMD) is an X-linked recessive disorder caused by mutations of dystrophin genes. The purpose of the present study is to determine the frequency and the patterns of dystrophin gene deletions and to investigate the correlation of genotypes and phenotypes. METHODS: There were included a total of 89 children(88 boys and 1 girl) diagnosed as DMD/BMD by immunohistochemistry and/or genetic analysis from 1999 to 2003 at Seoul National University Children's Hospital. We analyzed the genomic DNA by multiplex PCR using a 26 dystrophin exon primer set. Direct sequencing was performed on 23 exons(in which point mutations were detected in other previous reports) in 22 patients without deletions. Phenotype and genotype relationship analysis was performed on the basis of retrospective clinical reviews. RESULTS: The frequency of dysmorphin gene deletions was 54%(32/59), which is lower than that of European and American data. Exon deletions were detected in 59 cases and the deletion "hot spots" were exon 44-54 constituting 80% of all deletions. In 6 cases without detectable deletions, 6 point mutaions(3 nonsense mutations and 3 nucleotide variants) were detected. The patients whose deletions were in the central parts or the patients with multiple exon deletions tended to show earlier symptom onsets and more rapid progressions of weakness but there were no statistical significances. CONCLUSION: Since deletions in dystrophin genes were detected in about 50% of the patients, studies on dystrophin protein expressions using muscle biopsy samples must be done for correct diagnosis.
Biopsy
;
Codon, Nonsense
;
Diagnosis
;
DNA
;
Dystrophin*
;
Exons
;
Gene Deletion
;
Genotype
;
Humans
;
Immunohistochemistry
;
Molecular Biology*
;
Multiplex Polymerase Chain Reaction
;
Muscular Dystrophies*
;
Phenotype
;
Point Mutation
;
Retrospective Studies
;
Seoul
8.Molecular Genetic Analysis of Dystrophin Gene in Duchenne/Becker Muscular Dystrophy.
Su Yeon PARK ; Kyung Nam KOH ; Byung Chan LIM ; Ho Seok KANG ; Kyoung Yeon LEE ; Hee HWANG ; Jong Hee CHAE ; Ji Eun CHOI ; Ki Joong KIM ; Yong Seung HWANG
Journal of the Korean Child Neurology Society 2004;12(1):50-58
PURPOSE: Duchenne/Becker muscular dystrophy(DMD/BMD) is an X-linked recessive disorder caused by mutations of dystrophin genes. The purpose of the present study is to determine the frequency and the patterns of dystrophin gene deletions and to investigate the correlation of genotypes and phenotypes. METHODS: There were included a total of 89 children(88 boys and 1 girl) diagnosed as DMD/BMD by immunohistochemistry and/or genetic analysis from 1999 to 2003 at Seoul National University Children's Hospital. We analyzed the genomic DNA by multiplex PCR using a 26 dystrophin exon primer set. Direct sequencing was performed on 23 exons(in which point mutations were detected in other previous reports) in 22 patients without deletions. Phenotype and genotype relationship analysis was performed on the basis of retrospective clinical reviews. RESULTS: The frequency of dysmorphin gene deletions was 54%(32/59), which is lower than that of European and American data. Exon deletions were detected in 59 cases and the deletion "hot spots" were exon 44-54 constituting 80% of all deletions. In 6 cases without detectable deletions, 6 point mutaions(3 nonsense mutations and 3 nucleotide variants) were detected. The patients whose deletions were in the central parts or the patients with multiple exon deletions tended to show earlier symptom onsets and more rapid progressions of weakness but there were no statistical significances. CONCLUSION: Since deletions in dystrophin genes were detected in about 50% of the patients, studies on dystrophin protein expressions using muscle biopsy samples must be done for correct diagnosis.
Biopsy
;
Codon, Nonsense
;
Diagnosis
;
DNA
;
Dystrophin*
;
Exons
;
Gene Deletion
;
Genotype
;
Humans
;
Immunohistochemistry
;
Molecular Biology*
;
Multiplex Polymerase Chain Reaction
;
Muscular Dystrophies*
;
Phenotype
;
Point Mutation
;
Retrospective Studies
;
Seoul
9.Ketogenic Diet in Childhood Intractable Epilepsy.
Kyung Nam KOH ; Su Yeon PARK ; Byung Chan LIM ; Ho Seok KANG ; Kyung Yeon LEE ; Hee HWANG ; Jong Hee CHAE ; Ji Eun CHOI ; Ki Joong KIM ; Yong Seung HWANG
Journal of the Korean Child Neurology Society 2004;12(1):12-20
PURPOSE: Ketogenic diet(KD) is an alternative treatment for children with intractable seizures. This study was performed to evaluate the efficacy and tolerability of ketogenic diet METHODS: A retrospective study was performed for 57 patients(31 males, and 25 females), who were enrolled in a ketogenic diet program from 1998 to 2003 in Seoul National University Children's Hospital. We investigated the overall efficacy, influencing factors such as age at diet onset, seizure type, initial fasting, adverse events and reasons for discontinuing the diet. RESULTS: The patients mean age at diet onset was 3.5 years old. They had 3.14 medications on average at the diet initiation. One month after the diet initiation, 49 of 57(86 %) remained on KD, with 37(64.9%) having more than 50% seizure reduction rates. At 6 months, half of the patients remained on KD, with 14(28%) seizure free and 22(44%) having more than 50% seizure reduction rates. At 12 months, 15 patients(34.9%) remained on KD, with 14(32.6%) having more than 90% seizure reduction rates. Seizure types, initial fasting and age at diet onset were not statistically related to the outcomes. There were a few complications during the diet. The most common reasons for discontinuing KD were ineffectiveness and poor tolerability. CONCLUSION: Ketogenic diet appears to be a relatively effective and safe treatment option for children with intractable epilepsies.
Child
;
Diet
;
Epilepsy*
;
Fasting
;
Humans
;
Ketogenic Diet*
;
Male
;
Retrospective Studies
;
Seizures
;
Seoul
10.Ketogenic Diet in Childhood Intractable Epilepsy.
Kyung Nam KOH ; Su Yeon PARK ; Byung Chan LIM ; Ho Seok KANG ; Kyung Yeon LEE ; Hee HWANG ; Jong Hee CHAE ; Ji Eun CHOI ; Ki Joong KIM ; Yong Seung HWANG
Journal of the Korean Child Neurology Society 2004;12(1):12-20
PURPOSE: Ketogenic diet(KD) is an alternative treatment for children with intractable seizures. This study was performed to evaluate the efficacy and tolerability of ketogenic diet METHODS: A retrospective study was performed for 57 patients(31 males, and 25 females), who were enrolled in a ketogenic diet program from 1998 to 2003 in Seoul National University Children's Hospital. We investigated the overall efficacy, influencing factors such as age at diet onset, seizure type, initial fasting, adverse events and reasons for discontinuing the diet. RESULTS: The patients mean age at diet onset was 3.5 years old. They had 3.14 medications on average at the diet initiation. One month after the diet initiation, 49 of 57(86 %) remained on KD, with 37(64.9%) having more than 50% seizure reduction rates. At 6 months, half of the patients remained on KD, with 14(28%) seizure free and 22(44%) having more than 50% seizure reduction rates. At 12 months, 15 patients(34.9%) remained on KD, with 14(32.6%) having more than 90% seizure reduction rates. Seizure types, initial fasting and age at diet onset were not statistically related to the outcomes. There were a few complications during the diet. The most common reasons for discontinuing KD were ineffectiveness and poor tolerability. CONCLUSION: Ketogenic diet appears to be a relatively effective and safe treatment option for children with intractable epilepsies.
Child
;
Diet
;
Epilepsy*
;
Fasting
;
Humans
;
Ketogenic Diet*
;
Male
;
Retrospective Studies
;
Seizures
;
Seoul