No abstract available.
Education*

Allelic deletions involving the short arm of chromosome 3(3p13-21.1) have been observed frequently in cervical carcinomas. Recently the fragile histidine triad(FHIT) gene was cloned and mapped to this chromosomal region(3p14.2). From various studies involving tumor cell lines and primary cancers, the FHIT gene has been presumed to be a candidate for tumor suppressor gene involving various tumors. In FHIT gene, the most common aphidicolin-inducible fragile site, FRA3B exists and the FRA3B has been considered as a region of the spontaneous integration site of HPV 16. In order to elucidate the role of the FHIT in carcinogenesis of cervical cancer, this study was designed to investigate both the expression of FHIT protein in normal, preinvasive and invasive cancer samples employing immunohistochemical study and allelic loss of FHIT gene locus against several microsatellite markers employing the PCR analysis. Immunohistochemical studies of FHIT protein revealed following features. In normal ectocervical squamous epithelium, the expression of FHIT was relatively weak and confined to the basal layer, but in normal endocervical glandular epithelium it was very strong. The expression of FHIT was reduced as the tumor progressed from early lesion to invasive cancer. The koilocytosis was associated with diminished expression of FHIT protein. The study of allelic loss of FHIT gene locus was undertaken against two intragenic (D3S1300, D3S1234) and one extragenic (D3S1295) microsatellite markers. The 5th intron, D3S1300, showed allelic change in 6 of 15 assays and 7th intron, D3S1234 showed allelic change in 10 of 29 assays. There was no apparent LOH from 29 assays in D3S1295. In conclusion, the expression of FHIT protein was markedly reduced or absent in cervical squamous cell carcinoma and the chromosome breakage in FHIT region might be related to the diminished expression of FHIT. On the basis of the reduced expression of FHIT and its encompassment of FRA3B region, it is suggested that disruption of FHIT, a putative tumor suppressor gene, might be the mechanism by which HPV infection enhances cervical tumorigenesis and clonal outgrowth.
Arm ; Carcinogenesis ; Carcinoma, Squamous Cell ; Cell Line, Tumor ; Chromosome Breakage ; Clone Cells ; Epithelium ; Genes, Tumor Suppressor ; Histidine ; Human papillomavirus 16 ; Introns ; Loss of Heterozygosity ; Microsatellite Repeats ; Polymerase Chain Reaction ; Uterine Cervical Neoplasms

No abstract available.
Aged* ; Humans

No abstract available.

No abstract available.

The purpose of this study is to modify the Korean Nomina Anatomica terminology of surface anatomy. This paper suggests that 19 terms in skeletal system, 9 terms in muscle system and 15 terms in movement area. Main principles of the modification are as follows ; 1. The terminology of surface anatomy must be modify to Korean native terms from old ones. 2. The terminology of anatomy text books must be modify in area of apply anatomy.
Democratic People's Republic of Korea*

No abstract available.
Aged* ; Humans ; Long-Term Care*

No abstract available.

No abstract available.

An in other medical fields in Korea, the terminology in pathology has to go through a long adaptation period since the liberation from Japan in 1945. The Korean Society of Pathologists (KSP) has been the driving force in establishing and adopting new pathology terms in Korean. This effort started from the time when the KSP launched the Korean Journal of Pathology in 1965, and was activated by the momentum of publishing its pathology textbook for the medical students first in Korea in 1990. The KSP organized the Terminology Standardization Committee in close collaboration with the Termonology Standardization Committee of the Korean Medical Association (KMA). The product of joint works was the third edition of Korean Medical Termonology Dictionary published by the KMA in 1992. Since then, the Termonology Standardization Committee of the KSP has continued to improve many inappropriate terms into more easily understandable ones based on the guideline. The guideline of the KSP is basically same to that proposed and adopted by the KMA. Pathology terms are expected to improve further to be standardized as the Pathology Textbook Committee of the KSP is in process of publishing the 5th edition. In the future, the KSP should be ready to establish and standardize the medical terminology in the pathology field since so many new vocabularies are coming into use in this rapidly changing medical environment.
Cooperative Behavior ; Humans ; Japan ; Joints ; Korea ; Pathology* ; Students, Medical ; Vocabulary