1.Correlations between regional characteristics of counties and the ratio of intracounty to extracounty sources of COVID-19 in Gangwon Province, Republic of Korea
Seungmin JEONG ; Chaeyun LIM ; Sunhak BAE ; Youngju NAM ; Eunmi KIM ; Myeonggi KIM ; Saerom KIM ; Yeojin KIM
Osong Public Health and Research Perspectives 2023;14(3):219-223
Objectives:
This study aimed to examine the correlations between the regional characteristics of counties in Gangwon Province, Republic of Korea and the ratio of intracounty to extracounty sources of coronavirus disease 2019 (COVID-19) infection.
Methods:
The region of the infectious contact was analysed for each COVID-19 case reported in Gangwon Province between February 22, 2020 and February 7, 2022. The population, population density, area, the proportion of urban residents, the proportion of older adults (>65 years), financial independence, and the number of adjacent counties were assessed for each of the 18 counties in Gangwon Province. Correlation coefficients between regional characteristics and the ratio of intracounty to extracounty infections were calculated.
Results:
In total, 19,645 cases were included in this study. The population, population density, proportion of older adults, and proportion of urban residents were significantly correlated with the ratio of intracounty to extracounty infections. A stratified analysis with an age cut-point of 65 years showed that the proportion of older adults had a significant negative correlation with the ratio of intracounty to extracounty infections. In other words, the proportions of extracounty infections were higher in countries with higher proportions of older adults.
Conclusion
Regions with ageing populations should carefully observe trends in infectious disease outbreaks in other regions to prevent possible transmission.
2.Pathogenicity of H5N8 virus in chickens from Korea in 2014.
Byung Min SONG ; Hyun Mi KANG ; Eun Kyoung LEE ; Jipseol JEONG ; Yeojin KANG ; Hee Soo LEE ; Youn Jeong LEE
Journal of Veterinary Science 2015;16(2):237-240
In 2014, two genetically distinct H5N8 highly pathogenic avian influenza (HPAI) viruses were isolated from poultry and wild birds in Korea. The intravenous pathogenicity indices for the two representative viruses were both 3.0. Mortality of chickens intranasally inoculated with the two H5N8 viruses was 100% with a mean death times of 2.5 and 4.5 days. Mortality rates of the contact groups for the two H5N8 viruses were 33.3% and 66.6%. Our study showed that transmissibility of the novel H5N8 viruses was different from that of previously identified H5N1 HPAI viruses, possibly due to genetic changes.
Animals
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Chickens
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Disease Outbreaks/veterinary
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Influenza A virus/*pathogenicity/*physiology
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Influenza in Birds/*mortality/transmission/virology
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Poultry Diseases/*mortality/transmission/virology
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Republic of Korea/epidemiology
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Virulence
3.Renal Pelvic Hematoma Induced by Delayed Re-bleeding After Renal Biopsy.
Dae hong JEON ; Jong Woo SEO ; Yeojin KANG ; Dong Won LEE ; Hyeon Jeong LEE ; Hyun Jung KIM ; Se Ho CHANG ; Dong Jun PARK
Korean Journal of Nephrology 2010;29(6):768-771
Renal biopsy is a useful method for the diagnosis of kidney disease. Complications may occur and are usually associated with bleeding. However, delayed recurrent bleeding is so rare. We report a case of renal pelvic hematoma and hydronephrosis occurred by delayed re-bleeding after percutaneous needle renal biopsy. A 42-year-old woman was admitted to our institution via emergency room with gross hematuria and left flank pain, which had started on that day. Renal biopsy had been done 8 days earlier. Computed tomography (CT) angiography revealed left hydronephrosis caused by pelvic hematoma and we observed bloody urine in the left ureteral orifice on cystoscopy. Hydration, diuresis and double J stent insertion restored hydronephrosis and hematuria was disappeared. Even though renal pelvic hematoma by delayed bleeding occurs rarely after percutaneous needle kidney biopsy, we should consider this complication when delayed recurrent gross hematuria occurs after kidney biopsy.
Adult
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Angiography
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Biopsy
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Cystoscopy
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Diuresis
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Emergencies
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Female
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Flank Pain
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Hematoma
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Hematuria
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Hemorrhage
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Humans
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Hydronephrosis
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Kidney
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Kidney Diseases
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Needles
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Stents
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Ureter
4.Alterations and Co-Occurrence of C-MYC, N-MYC, and L-MYC Expression are Related to Clinical Outcomes in Various Cancers
Moonjung LEE ; Jaekwon SEOK ; Subbroto Kumar SAHA ; Sungha CHO ; Yeojin JEONG ; Minchan GIL ; Aram KIM ; Ha Youn SHIN ; Hojae BAE ; Jeong Tae DO ; Young Bong KIM ; Ssang-Goo CHO
International Journal of Stem Cells 2023;16(2):215-233
Background and Objectives:
MYC, also known as an oncogenic reprogramming factor, is a multifunctional transcription factor that maintains induced pluripotent stem cells (iPSCs). Although MYC is frequently upregulated in various cancers and is correlated with a poor prognosis, MYC is downregulated and correlated with a good prognosis in lung adenocarcinoma. MYC and two other MYC family genes, MYCN and MYCL, have similar structures and could contribute to tumorigenic conversion both in vitro and in vivo.
Methods:
and Results: We systematically investigated whether MYC family genes act as prognostic factors in various human cancers. We first evaluated alterations in the expression of MYC family genes in various cancers using the Oncomine and The Cancer Genome Atlas (TCGA) database and their mutation and copy number alterations using the TCGA database with cBioPortal. Then, we investigated the association between the expression of MYC family genes and the prognosis of cancer patients using various prognosis databases. Multivariate analysis also confirmed that co-expression of MYC/MYCL/MYCN was significantly associated with the prognosis of lung, gastric, liver, and breast cancers.
Conclusions
Taken together, our results demonstrate that the MYC family can function not only as an oncogene but also as a tumor suppressor gene in various cancers, which could be used to develop a novel approach to cancer treatment.
5.Effectiveness of Self-Assessment, TAilored Information, and Lifestyle Management for Cancer Patients’ Returning to Work (START): A Multi-center, Randomized Controlled Trial
Danbee KANG ; Ka Ryeong BAE ; Yeojin AHN ; Nayeon KIM ; Seok Jin NAM ; Jeong Eon LEE ; Se Kyung LEE ; Young Mog SHIM ; Dong Hyun SINN ; Seung Yeop OH ; Mison CHUN ; Jaesung HEO ; Juhee CHO
Cancer Research and Treatment 2023;55(2):419-428
Purpose:
We developed a comprehensive return to work (RTW) intervention covering physical, psycho-social and practical issues for patients newly diagnosed and evaluated its efficacy in terms of RTW.
Materials and Methods:
A multi-center randomized controlled trial was done to evaluate the efficacy of the intervention conducted at two university-based cancer centers in Korea. The intervention program comprised educational material at diagnosis, a face-to-face educational session at completion of active treatment, and three individualized telephone counseling sessions. The control group received other education at enrollment.
Results:
At 1-month post-intervention (T2), the intervention group was more likely to be working compared to the control group after controlling working status at diagnosis (65.4% vs. 55.9%, p=0.037). Among patients who did not work at baseline, the intervention group was 1.99-times more likely to be working at T2. The mean of knowledge score was higher in the intervention group compared to the control group (7.4 vs. 6.8, p=0.029). At the 1-year follow-up, the intervention group was 65% (95% confidence interval, 0.78 to 3.48) more likely to have higher odds for having work.
Conclusion
The intervention improved work-related knowledge and was effective in facilitating cancer patients’ RTW.