Krukenberg tumor, which can account for 30-40% of metastatic cancers to the ovaries, arises in the ovarian stroma and is usually metastatic from the gastrointestinal tract, especially from the stomach. The pathognomonic feature is the presence of signet ring cells, which may be arranged in acini or appear as individual cells. We experienced a Krukenberg tumor which was bilateral and associated with left ovarian dermoid cyst. This patient was treated for a primary gastric carcinoma(Stage II) about 3 years ago. After bilateral salpingoophorectomy, she received adjuvant chemotherapy. But, she died about fow months after operation.
Chemotherapy, Adjuvant ; Dermoid Cyst* ; Female ; Gastrointestinal Tract ; Humans ; Krukenberg Tumor* ; Ovary ; Stomach

No abstract available.
Adenoma, Pleomorphic ; Mouth Mucosa

No abstract available.
Adult* ; Humans

No abstract available.
Adult* ; Humans

No abstract available.

No abstract available.

Nine typical cases of ossifying fibroma in the tibia or fibula were retrospectively reviewed for clinical and histopathological aspects of this disease. Along with the case analysis, light and polarized microscopic examinations were performed in each case. Differential points with monostotic fibrous dysplasia were as follows; 1) ossifying fibroma begins in the significantly younger age, which is in most cases below 10 years of age, 2) it is confined to diaphysis of tibia or fibula, 3) radiologically, multilocular osteolytic destructive change in eccentric pattern is usually combined with anterior or anterolateral bowing deformity, 4) microscopically, characteristic findings are presence of osteoblastic rimming, peripheral maturation, and zonal phenomenon. In the treatment of ossifying fibroma, definitive surgical treatment should be delayed until skeletal maturity, when segmental resection in wide margin including periosteum might be preferred.
Congenital Abnormalities ; Diagnosis ; Diaphyses ; Fibroma, Ossifying ; Fibrous Dysplasia, Monostotic ; Fibula ; Fluconazole ; Osteoblasts ; Periosteum ; Retrospective Studies ; Tibia

BACKGROUND: It is clear that deregulation of coil cycle progression is a hallmark of neoplastic transformation and genes involved in the G1/S transition of the coil cycle are especially frequent targets for mutations in human cancers, including lung cancer. P16 gene product, one of the G1 cell-cycle related proteins, that is recently identified plays an important role in the negative regulation of the kinase activity of the cyclin dependent kinase (cdk) enzymes. Therefore p16 gene is known, to be an important tumor suppressor gene and is also called MTS1 (multiple tumor suppressor 1). No more oncogenes have ken reported to be frequently related to multiple different malignancies than the alterations of p16 gene. Especially when it comes to non-small cell lung cancer, there was no expression of p16 in more than 70% of cell lines examined. Ann also it is speculated that p16 gene could exert a key role in the development of non-small cell lung cancer. This study was designed to evaluate whether p16 gene ould be used as a candidate for gene therapy of non-small cell lung cancer. METHODS: After the extraction of total RNA from normal fibroblast cell line and subsequent reverse transcriptase reaction and polymerase chain reaction, the amplified P16 cDNA was sukloned into eukaryotic expression plasmid vector, pRC-CMV. The constructed pRC-CMV-p16 was transfected into the NCI-H441 NSCLC cell line using lipofectin. The changes of U I cell-cycle related proteins were investigated with Western blot analysis and immunoprecipitation after extraction of proteins from cell lysates and tumor suppressive effect was observed by clonogenic assay. RESULTS: (1) p16(-) NCI-H441 cell line transfected with pRC-CMV-p16 showed The formation of p16 : cdk 4 complex and decreased phosphorylated Rb protein, while control cell line did not. (2) Clonogenic assay demonstrated that the number of colony formation was markedly decreased in p16(-) NCI-H441 cell line transfected with pRC-CMV-p16 than the control cell line. CONCLUSION: It is confirmed that the expression of p16 protein in p16 absent NSCLC cell line with the gene transfection leads to p16 cdk4 complex formation, subsequent decrease of phosphorylated pRb protein and ultimately tumor suppressive effects. And also it provides the foundation for the application of P16 gone as a important candidate for the gene therapy of NSCLC.
Blotting, Western ; Carcinoma, Non-Small-Cell Lung* ; Cell Cycle ; Cell Line* ; Cyclins ; DNA, Complementary ; Fibroblasts ; Genes, p16 ; Genes, Tumor Suppressor ; Genetic Therapy ; Humans ; Immunoprecipitation ; Lung Neoplasms ; Oncogenes ; Phosphotransferases ; Plasmids ; Polymerase Chain Reaction ; Retinoblastoma Protein ; RNA ; RNA-Directed DNA Polymerase ; Transfection*

PURPOSE: The objective of this study was to assess myocardial function before and after IVIG treatment by tissue Doppler imaging in children with Kawasaki disease. METHODS: This study was conducted on 43 patients with Kawasaki disease from April 2005 to February 2006 at Dongsan Medical Center, Keimyung University. Myocardial function of all patients was examined using echocardiography before (time 1) and after intravenous gamma-globulin (IVGG, time 2) treatment. Deceleration time (DT), isovolumic relaxation time (IVRT), fractional shortening (FS), and peak early diastolic (E), peak late diastolic (A) velocity of transmitral flow were measured by M-mode and pulsed wave Doppler. Systolic (Sm), peak early diastolic (Em), peak late diastolic (Am) velocity in apical 4-chamber and 2-chamber views were measured by tissue Doppler imaging. The author calculated modified Tei index, E/A, E/Em ratio by using measured values. RESULTS: Forty three patients were 27 boys and 16 girls. The average age of patients was 3 years and 1 month. There was 5 patients treated IVGG more than twice and no patient with definite coronary dilatation. All conventional Doppler parameters showed no significant difference statistically between control and time 1, 2. Among tissue Doppler parameters measured at time 2 in comparison to control and time 1, modified Tei index in septum, E/Em and modified Tei index in inferior wall decreased significantly and Am in inferior wall increased significantly. CONCLUSION: Although the results did not show consistency throughout all measured areas, it showed significant difference between patients and control in some areas' myocardiac function in relative recovery phase. This results are thought that the change in myocardial function may be derived from the Kawasaki disease during acute phase and recovery phase. There should be more investigations both in number and in diversity of patients with Kawasaki disease and there also should be studies to find how the changes mentioned above are different from persistent febrile group without the Kawasaki disease and whether they are temporal changes in the acute phase due to IVIG volumic overload.
Child* ; Deceleration ; Dilatation ; Echocardiography ; Female ; gamma-Globulins ; Humans ; Immunoglobulins, Intravenous ; Mucocutaneous Lymph Node Syndrome* ; Relaxation

The purpose of this study was to investigate the effect of electroacuuncture stimulation therapy in the pain threshold of the subjects. 20 patients were randomly assigned to two experimental groups. Measurement of perception and pawn threshold of post-operative patients were taken during 7 days. They were written into preformed formula by themselves. Experiments were peformed with non-acupuncture stimulated group(10 patients) and with acupuncture stimulated group(10 patients). Acupuncture stimulation is applied with 2Hz, 30minutes, 12mA, biphasic wave, combined mix, and bilaterally to meridian points(LI4, CV24, S5 etc). The following results are obtained ; 1. The visual analogue scale of pain threshold was decreased with a time both control and experimental group. 2. The statistical significance was observed between control group and experimental group at 5, 6, 7 days(P<0.05). 3. The Pearson correlation coefficency of experimental group was higher than control group (P<0.05).
Acupuncture ; Electroacupuncture* ; Humans ; Pain Threshold