1.Three Fibrotic Conditions Treated with 5% Topical Imiquimod Cream as an Antifibrotic Agent
Yeo Rye CHO ; Ho Jin KIM ; Jeong Wan SEO ; Tae Hoon KIM ; Ki Ho KIM
Korean Journal of Dermatology 2019;57(5):265-269
Imiquimod, a toll-like receptor agonist, is a topical immunomodulator that induces the production of several cytokines including interferon-alpha, which shows antifibrotic properties. We hypothesized that the antifibrotic effect of imiquimod would soften fibrotic skin lesions. Therefore, we applied topical imiquimod with topical tacrolimus or systemic acitretin in patients with refractory lesions of myxedema, angiolymphoid hyperplasia, and generalized discoid lupus erythematosus and confirmed improvement in fibrotic lesions in these patients. Thus, we conclude that use of imiquimod improves fibrotic skin lesions. This report describes our experience with the treatment of this condition along with a review of the related literature.
Acitretin
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Angiolymphoid Hyperplasia with Eosinophilia
;
Cytokines
;
Fibrosis
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Humans
;
Hyperplasia
;
Interferon-alpha
;
Lupus Erythematosus, Discoid
;
Myxedema
;
Skin
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Tacrolimus
;
Toll-Like Receptors
2.Topical Methyl Aminolevulinate Photodynamic Therapy in Porokeratosis of Mibelli: An Alternative Treatment for a Refractory Disease
Yeo Rye CHO ; Ho Jin KIM ; Jeong Wan SEO ; Tae Hoon KIM ; Ki Hoon SONG ; Ki Ho KIM
Annals of Dermatology 2019;31(3):341-343
No abstract available.
Photochemotherapy
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Porokeratosis