1.Matrix Metalloproteinase-2 and -7 Expression in Colorectal Cancer.
Seong Woo HONG ; Yun Kyung KANG ; Byungmo LEE ; Woo Yong LEE ; Yeo Gu JANG ; In Wook PAIK ; Hyucksang LEE
Journal of the Korean Society of Coloproctology 2011;27(3):133-139
PURPOSE: Matrix metalloproteinase-2 (MMP-2) and MMP-7 have been implicated in tumor growth and metastasis. This study aimed to investigate the expressions of MMP-2 and -7 in colorectal cancer and to evaluate their values as prognostic markers. METHODS: Immunohistochemical staining for MMP-2 and -7 was done in 144 resected colorectal cancer specimens. Clinicopathological data and survival results were compared with regard to the expression results. RESULTS: The expression rates of MMP-2 in tumor cells in the tumor center and the tumor border were 16.7% and 38.9%, respectively. That of MMP-2 in stromal cells was 27.8%. MMP-7 immunoreactivities of tumor cells in the tumor center and the tumor border were 6.9% and 23.6%. The expressions of MMP-2 and MMP-7 were correlated. MMP-2 expression in stromal cells was more increased in the distal part of the colorectum: 8.8% in right colon cancer, 29.5% in left colon cancer and 36.4% in rectal cancer. MMP-2 expression of tumor cells in the tumor border was correlated with T-stage. MMP-7 expression of tumor cells in the tumor border was increased in case of infiltrative cancer compared with fungating tumor. The expression patterns of MMP-2 and -7 were not correlated with other clinicopathological factors, including tumor markers, node metastasis, distant metastasis, lymphatic invasion, tumor differentiation, and recurrence. No significant associations between the overall and disease-free survival rates and the MMP-2 and -7 expression patterns were noted. CONCLUSION: The high expression rates of MMP-2 and -7 in tumor borders suggest that MMP-2 and -7 have some role in tumor invasion, but in this study, MMP-2 and -7 did not appear to be significant predictors of prognosis in colorectal cancer.
Colonic Neoplasms
;
Colorectal Neoplasms
;
Disease-Free Survival
;
Immunohistochemistry
;
Lymphatic Metastasis
;
Matrix Metalloproteinase 2
;
Matrix Metalloproteinases
;
Neoplasm Metastasis
;
Prognosis
;
Rectal Neoplasms
;
Recurrence
;
Stromal Cells
;
Biomarkers, Tumor
2.First Report and Characterization of Pestalotiopsis ellipsospora Causing Canker on Acanthopanax divaricatus.
Yeo Hong YUN ; Geum Ran AHN ; Seong Hwan KIM
Mycobiology 2015;43(3):366-370
Acanthopanax divaricatus, a member of the Araliaceae family, has been used as an invigorant in traditional Korean medicine. During disease monitoring, a stem with small, irregular, brown lesions was sampled at a farm in Cheonan in 2011. The symptoms seen were sunken cankers and reddish-brown needles on the infected twig. The isolated fungal colonies were whitish, having crenated edges and aerial mycelium on the surface, and with black gregarious fruiting bodies. The reverse plate was creamy white. Conidia were 17~22 x 3.5~4.2 microm, fusiform, 4-septate, and straight to slightly curved. The nucleotide sequence of the partial translation elongation factor 1 alpha gene of the fungal isolate, shares 99% sequence identity with that of known Pestalotiopsis ellipsospora. Based on the results of the morphological and molecular analyses, the fungal isolate was identified as P. ellipsospora. In Korea, this is the first report of canker on A. divaricatus.
Eleutherococcus*
;
Araliaceae
;
Base Sequence
;
Chungcheongnam-do
;
Fruit
;
Humans
;
Korea
;
Mycelium
;
Needles
;
Peptide Elongation Factor 1
;
Spores, Fungal
3.A Case of Incomplete Femoral Nerve Neuropathy after Total Abdominal Hystrectomy.
Sae Min CHUNG ; Yun Jin MOON ; Seung Geun PARK ; Hye Young PARK ; Ji Yeon CHO ; Yeo Hong YUN ; Yong Hun CHEE
Korean Journal of Obstetrics and Gynecology 2003;46(7):1466-1468
Total abdominal hystrectomy is the most common surgery of Gynecology. It's complication are taken very important. Although neuropathy, especially femoral nerve injury, is rare, recently we have experienced a case of femoral neuropathy after total abdominal hystrectomy. We present this case with a brief review of literature.
Femoral Nerve*
;
Femoral Neuropathy
;
Gynecology
4.A Case of Hyponatremin Encephalopathy Developed after Transsphenoidal Pituitary Sergery in Menstruant Woman.
Yeo Joo KIM ; Mi Rim KIM ; Moon Seok NAM ; Yong Sung KIM ; Jung Bae JIN ; Sang Hyun PARK ; Jun Hong KANG ; Sung Bin HONG ; Byoung Yun JUN
Journal of Korean Society of Endocrinology 1998;13(3):439-445
A 41-year-old female complaining of easy fatigue, headache, thickened extremities and deepened facial folds was admitted to the hospital. As early as 6 years ago, she had been told by family members that her voice was changed and both hands was thickened. Cranial plain radiography indicated ballooning of sella turcica. Sella MRI disclosed 2.2cm sized pituitary tumor with suprasellar extension. The pituitary tumor with hypothalamic extension was removed via a transsphenoidal approach. The postoperative course was uneventful until hyponatremia with sudden headache and respiratory arrest was developed. The case was due to hyponatremic encephalopathy on the basis of the clinical course and symptoms, and 3% hypertonic saline was infused for 12 hours until the hyponatremia was corrected. We have experienced a mortality case of hyponatremic encephalopathy in which surgieal removal of a pituitary tumor from a female acromegalic patient in menstruant period was followed by the sudden occurrence of hyponatremia, which in turn was later associated with marked brain edema.
Adult
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Brain Edema
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Extremities
;
Fatigue
;
Female
;
Hand
;
Headache
;
Humans
;
Hyponatremia
;
Magnetic Resonance Imaging
;
Mortality
;
Pituitary Neoplasms
;
Radiography
;
Sella Turcica
;
Voice
5.First Report of Leaf Rust Caused by Puccinia caricis in Farfugium japonicum in Korea.
Yeo Hong YUN ; Hyuk Woo KWON ; Hong Seok AHN ; Seong Hwan KIM
Mycobiology 2015;43(3):351-353
Farfugium japonicum is used in traditional medicine and as an edible herb in China and Korea. In July 2013, leaf spots were observed in F. japonicum seedlings at Ulleung Island, Gyeongsangbuk Province, Korea. Early symptoms on the leaf adaxial surface included roughly circular yellow spots that later developed brown, necrotic centers. The aecia were hypophyllous, cupulate, yellowish, 180~430 microm in diameter, clustered, and erumpent with a peridium with a recurved margin. The aeciospores were globoid, 14~17 x 13~16 microm, light yellow or colorless, and densely verrucose. The 28S rDNA sequence of the isolate was identical to each other and shared 99% identity with Puccinia caricis. This is the first report of rust caused by P. caricis in F. japonicum in Korea or elsewhere in the world.
China
;
DNA, Ribosomal
;
Korea*
;
Medicine, Traditional
;
Seedlings
6.A Case of Therapy-related ALL with MLL Gene Rearrangement Following Treatment of Breast Cancer.
Jinhee CHO ; Mina HUR ; Hee Won MOON ; Yeo Min YUN ; Chang Hoon LEE ; Hong Ghi LEE
The Korean Journal of Laboratory Medicine 2010;30(3):255-259
ALL with MLL gene rearrangement secondary to chemotherapy has been rarely reported. We report a case of therapy-related ALL (t-ALL) with MLL gene rearrangement in a patient who had undergone treatment for breast cancer. A 60-yr-old woman with breast cancer underwent breast-conserving surgery followed by 6 cycles of adjuvant chemotherapy (cyclophosphamide, epirubicin, and fluorouracil) and radiation therapy (dose, 5,040 cGy to the left breast and a 1,000 cGy boost to the tumor bed). A follow-up examination performed 14 months after the chemotherapy revealed no evidence of breast malignancy. However, the patient's complete blood cell count indicated acute leukemia: white blood cell count, 174.1x10(9)/L with 88% blasts; Hb level, 12.5 g/dL; and platelet count, 103.0x10(9)/L. Examination of the bone marrow aspirate smear revealed a high percentage of blasts (85.1% of all nucleated cells); the blasts showed a pro-B immunophenotype and were positive for CD19, CD79a, HLA-DR, CD34, and terminal deoxynucleotidyl transferase (TdT). Cytogenetic and FISH analyses revealed t(4;11)(q21;q23) and MLL gene rearrangement, respectively. The patient received induction chemotherapy with cyclophosphamide, vincristine, doxorubicin, and dexamethasone and achieved complete remission. Following consolidation chemotherapy, she underwent allogenic peripheral blood stem cell transplantation and has been clinically stable. To our knowledge, this is the first reported case of t-ALL with MLL gene rearrangement following treatment of breast cancer in Korea.
Antibiotics, Antineoplastic/therapeutic use
;
Blood Cell Count
;
Bone Marrow/pathology
;
Breast Neoplasms/*drug therapy/radiotherapy
;
Chemotherapy, Adjuvant
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Combined Modality Therapy
;
Cyclophosphamide/therapeutic use
;
Cytogenetic Analysis
;
Epirubicin/therapeutic use
;
Female
;
Fluorouracil/therapeutic use
;
Gene Rearrangement
;
Hematopoietic Stem Cell Transplantation
;
Humans
;
In Situ Hybridization, Fluorescence
;
Myeloid-Lymphoid Leukemia Protein/*genetics
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*etiology/genetics/pathology
;
*Translocation, Genetic
7.A Case of Synchronous Mucinous Tumor of the Ovary and Appendix.
Seo Yun TONG ; Yeo Hong KIM ; Ju Yup HUH ; Moon Ho YANG
Korean Journal of Obstetrics and Gynecology 2003;46(11):2252-2257
The coexistence of mucinous ovarian and appendiceal tumors in associated with pseudomyxoma peritonei is well established. But, ovarian and appendiceal mucinous tumors occur without involvement of other organs is unusual. When the two lesions are morphologically similar, it is difficult to determine whether one reflects a metastasis or whether the tumors are independent. The typical synchronous presentation of the ovarian and appendiceal tumors, their histologic similarity, the frequency of bilaterality of the ovarian tumors, the predominance of right-sided ovarian involvement. Adenocarcinoma of the appendix constitutes 0.2 to 0.5 percent of all gastrointestinal tumors and accounts for 6 percent of primary malignant lesion of the appendix. The authors experienced a rare case of synchronous tumor of ovary and appendix in 59 years old female patient who has suffered for 3-4 months from abdominal pain. Pathologic examination of the resected specimen revealed a synchronous mucinous type tumor of vermiform appendix and ovary.
Abdominal Pain
;
Adenocarcinoma
;
Appendix*
;
Female
;
Humans
;
Middle Aged
;
Mucins*
;
Neoplasm Metastasis
;
Neoplasms, Multiple Primary
;
Ovary*
;
Pseudomyxoma Peritonei
8.Synchronous T-cell lymphoma in patient with colon cancer: a case report.
Deuk Young LEE ; Seong Woo HONG ; Yeo Goo CHANG ; Woo Yong LEE ; Byungmo LEE ; Yun Kyung KANG
Journal of the Korean Surgical Society 2012;83(1):60-64
Colorectal cancer is the third most common malignancy in Korea. In contrast, pericolic or mesenteric lymphoma is relatively rare. We experienced an extremely rare case of synchronous primary colon cancer in the ascending colon with T-cell lymphoma in the pericolic lymph node. A 79-year-old woman presented with complaints of epigastric and right lower abdominal pain combined with anorexia and nausea. Colonoscopic evaluation and biopsy were performed, and the diagnosis was cecal adenocarcinoma. She underwent right hemicolectomy with lymph node dissection. The pathology report revealed adenocarcinoma in cecum with metastasis to 1 regional lymph node out of 37 lymph nodes. In addition, there was malignant angioimmunoblastic T-cell lymphoma in 1 pericolic lymph node. There was no evidence of lymphoma in ileum, cecum and ascending colon, so the possibility of early phase of lymphoma was suggested.
Abdominal Pain
;
Adenocarcinoma
;
Aged
;
Anorexia
;
Biopsy
;
Cecum
;
Colon
;
Colon, Ascending
;
Colonic Neoplasms
;
Colorectal Neoplasms
;
Female
;
Humans
;
Ileum
;
Korea
;
Lymph Node Excision
;
Lymph Nodes
;
Lymphoma
;
Lymphoma, T-Cell
;
Nausea
;
Neoplasm Metastasis
;
T-Lymphocytes
9.Loss of Red Cell A Antigen in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature.
Jin Hee CHO ; Mina HUR ; Hee Won MOON ; Yeo Min YUN ; Mark Hong LEE ; Sung Hee HAN
Korean Journal of Blood Transfusion 2011;22(3):277-283
Red cell antigens, A, B, and H can be weakened or lost especially in patients with hematologic malignancies. We report a 42-year-old female patient with acute myeloid leukemia, who showed loss of A antigen on her red cells. She showed the persistence of leukemia in spite of three cycles of induction chemotherapy. Her ABO blood group showed a discrepancy: the cell type was O and the serum type was A. Adsorption/elution test could not identify the presence of A antigen on her red cells, and the test for A and B transferases was negative. ABO genotyping using PCR/restriction fragment length polymorphism and sequencing of exons 6 and 7 of the ABO gene demonstrated 467 C>T substitution in exon 7 and confirmed the genotype of A102/O01. She was transfused with leukapheresis products collected from donors with blood group A, but expired of severe sepsis. This is the first Korean case, in which red cell A antigen loss was genetically proven using sequencing, and underscores the necessity of ABO genotyping to solve the ABO discrepancy and to transfuse effectively.
Adult
;
Exons
;
Female
;
Genotype
;
Hematologic Neoplasms
;
Humans
;
Induction Chemotherapy
;
Leukapheresis
;
Leukemia
;
Leukemia, Myeloid, Acute
;
Sepsis
;
Tissue Donors
;
Transferases
10.A Case of Management of maternal Vegetative State during Pregnancy.
Ji Yeon CHO ; Yeo Hong YUN ; Sae Min CHUNG ; Sang Yong SEO ; Yong Hun CHEE
Korean Journal of Obstetrics and Gynecology 2001;44(2):393-395
In the management of the traumatized gravid and her fetus, diagnostic tests and therapy should be directed primarily at the care of the mother and should not be delayed or compromised because of the pregnancy. Because many factors can damage when the mother is unconscious, fetal well-being should be assessed by serial biophysical profile scoring. If the mother's condition is stable as in the chronic vegetative state, elective delivery might best be performed at a gestational age of 32 to 34 weeks.
Diagnostic Tests, Routine
;
Fetus
;
Gestational Age
;
Humans
;
Mothers
;
Persistent Vegetative State*
;
Pregnancy*