ObjectiveTo explore the personality traits on higher vocational students with mathematics learning difficulties(MD).MethodsAll students of three grades in their first year were divided into MD students ( n =486) and outstanding students ( n =407 ) according to their final math scores.Cattell's 16 PF Questionnaires was used to assess the personality.ResultsStudents with MD got significantly higher records in personality factors of aggressiveness (6.59 ± 1.94 ),excitability ( 7.29 ± 2.24 ),sensitivity ( 5.85 ± 1.98 ),suspicion ( 3.51 ±2.03 ),fantasy(5.76 ± 1.86 ),urbane ( 5.81 ± 1.75 ),tense ( 5.63 ± 2.05 ),adapting and anxiety type ( 4.49 ±2.23 ),introverted and expert-oriented type(7.59 ± 2.43 ),and cowardice and decisive type ( 5.04 ± 1.62 ) than outstanding students(P＜0.05) ;however,they got lower records in personality factors of steadiness(5.89 ±2.19),perseverance (4.41 ± 1.98 ),independence ( 3.74 ± 1.77 ),emotional with unruffled alert type ( 5.51 ± 1.81 ),professional achievements (52.72 ± 10.66),growth ability in new environments ( 18.78 ± 3.91 ) (P ＜ 0.05 ).ConclusionHigher vocational students with MD have sensitive,suspicious,nervous,anxious,exoscopic,excited,fantasy personalities,lacking self-control,elasticity,carefulness and constancy.

Objective To analyze the phytosterol content in plant materials commonly used in functional food in China.Method Thirty kinds of food commonly used as medicines and forty kinds of Chinese herbs were chosen as samples.The contents of phytosterols(?-sitosterol,campesterol,stigmasterol,?-sitostanol) were analyzed by GC methods established by our laboratory.Results The frequency of various plant materials used in functional food was different,e-g.hawthorn about 408 times and huangqi 342 times.Phytosterols were contained in all samples analyzed,but were different in contents,some less than 10mg/100g while some more than 380mg/100g.In most samples,?-sitosterol is the largest portion of total phytosterol.Conclusion The phytosterols are important functional ingredients in plant materials frequently used in Chinese traditional medicine.The data of phytosterol contents in plant materials are valuable for utilization and further study in functional food.

Objective: To understand the personality traits and the effects of personality informed intervention among obese students in medical colleges, and to provide a scientific basis for better cultivating the healthy personality of medical students. Methods: A total of 3 760 students in the class of 2020 from 5 medical colleges were randomly selected in Shanghai. Obesity was defined according to the National Physical Health Standard for Students. A total of 80 students were divided into experiment and control group(each 40). The experimental group received 6 interpersonal group counseling interventions for 3 months, once every 2 weeks for 120 min, while the control group received no intervention. 16PF test and Interpersonal Competence Questionnaire were used for pre test and post test experiment for data analysis. Results: The overall obesity rate of students was 3.30%. Obesity rate of boys(8.07%) was significantly higher than that of girls(1.22%) ( χ 2=29.03, P <0. 01), and obesity rate of rural students(3.72%) was higher than that of urban students(2.30%) ( χ 2=41.81, P <0.01). Through psychological intervention, active communication, appropriate refusal, self disclosure in the experimental group were significantly higher than the control group ( t =2.48, 3.48, 2.29, P <0.05); the scores of gregariousness, excitement, mental health, adaptation in new environment in the experimental group were significantly higher than those in the control group ( t =2.31, 2.18, 2.10,2.33, P <0.05), sensitivity and suspicion, concern, tension, adaptation and anxiety were significantly lower than those in the control group ( t =-2.20, -2.08, -2.17, -2.20, -2.14, P <0.05). Conclusion Personality informed interventionshowed substantial effects on interpersonal communication ability and personality traits among obese college students.

OBJECTIVE: To explore the association of Ezrin and E-cadherin expression with the invasion, metastasis and prognois of nasopharyngeal carcinoma. METHODS: Imunohistochemical SP staining was used to detect the expression of Ezrin and E-cadherin in 42 nasopharyngeal carcinoma and 10 chronic nasopharyngitis specimens. RESULTS: Ezrin protein expression in the nasopharyngeal carcinoma tissues was significantly higher than that in the chronic nasopharyngitis tissues (P<0.05). E-cadherin expression in the nasopharyngeal carcinoma tissues was significantly lower than that in the chronic nasopharyngitis tissues (P<0.05). Expressions of both Ezrin and E-cadherin of nasopharyngeal carcinoma were closely associated with T staging,the cervical lymph node metastases and clinical staging (P<0.05). A negative correlation was found between Ezrin and E-cadherin expression in the nasopharyngeal carcinoma tissues (r=-0.450, P<0.05). Survival analysis showed that the abnormal expression of Ezrin and E-cadhrin, clinical staging and the cervical lymph node metastases were associated with the survival rate of patients with nasopharyngeal carcinoma. CONCLUSION A negative correlation is found between Ezrin and E-cadherin expression in the nasopharyngeal carcinoma tissues. Ezrin and E-cadherin are closely related to clinical staging and the cervical lymph node metastases of nasopharyngeal carcinoma,suggesting that they may be important tumor markers for nasopharyngeal carcinoma. Combined detection of the expressions of Ezrin and E-cadherin is helpful for clinical doctors to determine the prognosis of patients with nasopharyngeal carcinoma.
Adult ; Aged ; Antigens, CD ; Cadherins ; genetics ; metabolism ; Carcinoma, Squamous Cell ; metabolism ; Cytoskeletal Proteins ; genetics ; metabolism ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; metabolism ; Neoplasm Invasiveness ; Prognosis ; Young Adult

Objective:To study the protective effect of Mongolian medicine Bateri-7 on radiation-induced intestinal injury in mice.Methods:C57BL/6J male mice were randomly divided into control group, irradiation group and irradiation plus drug administration group, with 10 or 15 mice in each group. For irradiation group, the mice were given a single dose of 12 Gy 60Co γ-rays with total body irradiation. For drug treatment, the mice were gavaged with Bateri-7 (530 mg/kg) 7 d before irradiation until 3 d after IR. At 6 h and 24 h after irradiation, the Tunel positive cells in intestine were detected immunohistochemically. At 3.5 d after irradiation, the structure of intestinal villi was observed by HE staining, and the BrdU and Ki67 positive cells were detected immunohistochemically. The expression levels of IL-6, TNF-α and Cxcl-5 were detected by qPCR. The FITC-dextran in peripheral blood was also determined. Results:The survival of irradiated mice was significantly increased by Bateri-7 ( χ2= 5.84, P < 0.05), but there was no significant difference in weight between two groups ( P > 0.05). The villi length of small intestine in the irradiation plus drug group was significantly longer than that in the irradiation group ( t = 20.24, P < 0.05), and there was no significant difference in the depth of intestinal crypt between two groups ( P > 0.05). At 6 and 24 h after irradiation, the number of Tunel positive cells in intestinal crypts in the irradiation plus drug group was significantly reduced in comparison with the irradiation group ( t = 3.52, 2.90, P < 0.05). At 3.5 d after irradiation, the level of FITC-dextran in serum and the expressions of IL-6, TNF-α and Cxcl-5 in small intestine of mice in the irradiation plus drug group were significantly lower than those in the irradiation group, respectively( t = 6.92, 7.01, 7.18, 13.16, P < 0.05). The number of BrdU and Ki67 positive cells in the crypt of mice in the irradiation plus drug group was higher than that of the irradiation group ( t = 3.91, 2.57, P < 0.05). Conclusions:Mongolian medicine Bateri-7 can effectively alleviate irradiation-induced intestinal injury of mice, which may have a good preventive and therapeutic effect on radiation enteritis.

Objective:To investigate the anatomy of rectus femoris muscle flap and the anterolateral thigh muscle flap and their clinical application in reconstruction of large soft tissue defects after the removal of oral malignant tumour.Methods:From December 2006 to June 2009, 8 specimens of Chinese adult cadavers fixed in 10% formaldehyde were dissected to perform anatomy of anterolateral thigh region at the School of Basic Medical Sciences, Kunming Medical University. Anatomical images were analysed using Image-Pro Plus 6.0. Then, a retrospective study was performed on 19 patients who had postoperative defects after oral malignant tumour surgery and the defects were reconstructed with the rectus femoris muscle flap and the anterolateral thigh muscle flap from March 2020 to July 2022 at the Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital, Kunming Medical University. The postoperative defects of the 19 patients ranged from 3.0 cm×6.0 cm to 5.0 cm×10.0 cm. Ten rectus femoris muscle flaps, 8 anterolateral thigh muscle flaps and 1 combined rectus femoris muscle flap and anterolateral thigh muscle flap were used. The muscular flaps sized from 4.0 cm × 8.0 cm to 6.0 cm × 11.0 cm. Regular postoperative outpatient follow-ups were conducted.Results:The lengths of vessels of the harvested rectus femoris muscle flap and anterolateral thigh muscle flap were 63.4 mm± 12.9 mm and 112.5 mm± 19.6 mm, respectively. The starting outer diameters of the lateral circumflex thigh artery, the oblique branch of the lateral circumflex thigh artery and the descending branch of the lateral circumflex thigh artery were 2.92 mm±0.72 mm, 1.88 mm±0.23 mm and 2.29 mm±0.43 mm, respectively. Postoperative follow-up lasted for 7 to 32 months, with 17.5 months in average. Seventeen flaps were completely survived and the rectus femoris muscle flap was completely mucosalised 5 weeks after surgery. However, 2 rectus femoris muscle flaps had necrosis of which one was changed to a tongue flap reconstruction and the other encountered flap necrosis during postoperative radiotherapy and healed after debridement and dressing changes. There was no postoperative complication in the donor sites. Other than the 2 patients, all other 17 patients had satisfactory clinical outcomes.Conclusion:Both of the starting outer diameters and length of vessels of the femoris muscle flap and the anterolateral thigh muscle flap meet the requirements for reconstruction of maxillofacial defects, and both muscular flaps are simple to prepare, in good reconstructive results with few complication, as well as an excellent outcome. They are feasible approaches for reconstruction of large soft tissue defects left after the removal of an oral malignant tumour.

Objective:To investigate the clinical outcomes of sublingual gland flap in the repair of postoperative jaw defects because of chronic phosphorous osteomyelitis(PNJ)and medication-related osteonecrosis of the jaw(MRONT).Methods:3 patients with PNJ and 2 with MRONJ were treated by sublingual gland flap in the repair of the postoperative jaw defet.The treatment effects were evalua-ted by clinical obseration.Results:In the 5 patients the wound healed well within 2 weeks postoperatively,with no infection and with normal sublingual gland function after surgery.Conclusion:The use of sublingual gland flap is an effective and feasible method for re-pairing local defects in the mandibles after surgery for chronic PNJ and MRONJ.

2 patients with lateral orbital malignant tumors were treated by tumor resection and autologous pedicled coronoid-temporalis muscle flap repair of the orbital wall defect.The flaps survived well without obvious facial collapse deformity and with good orbital wall func-tion and aesthetic effect,the mouth open pattern,the intra-oral occlusion and the masticatory function were satisfactory.

Objective:To investigate mevalonic acid(MEV)on reversing the antitumor effects of fluvastatin sodium(FS)on tongue squamous cell carcinoma(TSCC)cells.Methods:TSCC HSC-4 cells were treated with different concentrations of FS and MEV re-spectively or in combination.Cell counting kit-8,flow cytometry,wound healing,immunofluorescence and western blotting assays were conducted to examine cell proliferation,apoptosis and migration capacities,as well as the expression levels of Ras homolog family member A(RHOA),tissue factor(TF)and B-cell lymphoma-2-associated X(BAX)proteins,respectively.Results:FS inhibited HSC-4 cell proliferation and migration,decreased the expression of RHOA and TF,and increased BAX expression.MEV reversed the above antitumor effects of FS and promoted intracellular RHOA and TF expression.Conclusion:MEV reverses the antitumor effects of FS on HSC-4 cells in vitro.