[Objective] To observe the therapeutic effects of headache prescription on migraine without aura. [Methods] 54 patients with migraine were randomly divided into two groups: Patients in control group(n=27) were treated by nimodipine and flunarine,etc; Patients in treatment group(n=27) were treated by self made headache prescription, the treatment period was both 5 days; then determine efficacy.[Results] 27 patients in treatment group had 6 cases in clinical cure,14 in excellent,6 in effect,1 in vain, the clinical total effective rate of Chinese medicine group was 96.30%,while,27 patients in treatment group had 2 cases in clinical control ed,8 in excellent,9 in effect,8 in vain, the clinical total effective rate of Chinese medicine group was 70.37%. The difference between the two groups had the remarkable significance.[Conclusion] The therapeutic effects of headache prescription on migraine without aura has better therapeutic effects on migraine.