1.Voicing Changes of Adult Patients with Obstructive Sleep Apnea hypopnea Syndrome (OSAHS) after H- uvulopalatopharyngoplasty (H- UPPP)
Rong HU ; Wen XU ; Lizhen HOU ; Li ZHANG ; Jingying YE ; Jun WANG
Journal of Audiology and Speech Pathology 2009;17(3):239-241
Objective To investigate voicing changes of adult patients with obstructive sleep apnea hypopnea syndrome (OSAHS) before and after H-uvulopalatopharyngoplasty (H-UPPP). Methods 56 adult OSAHS pa-tients and 40 healthy people were included in the study. Acoustic parameters and formant frequencies were measured for each patient before and after H- UPPP, and also for the control group. Results Acoustic parameters: each group demonstrated no differences in all the parameters except for normalized noised energy (NNE). NNE increased after H-UPPP. Formant frequency: F1, B1, F2, B2, F3 of OSAHS patients were significantly lower than normal control. There was no significant difference in the formant frequency before operation and one week after; however, F1 and F2 were lower than the normal control one week after surgery. One month after surgery, F1 and F2 were ob-viously higher than that obtained in one week. All the other parameters compared with normal controls showed no significant discrepancies. Conclusion Acoustic characteristics of adult OSAHS patients were different from healthy person. After H-UPPP, the vocal tracts of patients changed, thus causing improvement to the acoustic parameters and voicing qualities, especially at the formant frequency. After the surgery, the formant frequencies of the patients increased gradually to the range of healthy people.
2.Studies on purification of the extract of fructus Gardeniae for injection by macroreticular resins.
Gang CHEN ; Shi-xiang HOU ; Li-min YE ; Ping HU
China Journal of Chinese Materia Medica 2005;30(3):188-190
OBJECTIVETo purify the extract of fructus gardeniae for injection by macroreticular resins in purification process of traditional Chinese medicine (TCM) Injections.
METHODUsing fructus gardeniae as sample, on base of obtaining the extract by employing macroreticular resin, quality evaluation and rationality of purification methods had been studied by the quantitative analysis of active ingredients and the characteristics of micromeritics, safety and stability of the extract.
RESULTThe experiment showed the extract of fructus gardeniae for injection had been produced successfully by macroreticular resin.
CONCLUSIONUsing macroreticular resins is a promising purification way of TCM injections, whereas a more consummate method of quality evaluation must be established to ensure safety, efficiency and stability of the preparation in the process.
Animals ; Drugs, Chinese Herbal ; administration & dosage ; isolation & purification ; toxicity ; Fruit ; chemistry ; Gardenia ; chemistry ; Injections ; Iridoids ; isolation & purification ; Mice ; Plants, Medicinal ; chemistry ; Pyrans ; isolation & purification ; Quality Control ; Resins, Synthetic ; Technology, Pharmaceutical ; methods
3.Clinical analysis of umbilical cord derived mesenchymal stem cells transplantation for patients with systemic lupus erythematosus
Dandan WANG ; Huayong ZHANG ; Xuebing FENG ; Bingzhu HUA ; Bujun LIU ; Hong WANG ; Shengqin YE ; Xiang HU ; Xiaofeng ZENG ; Yayi HOU ; Lingyun SUN
Chinese Journal of Rheumatology 2010;14(2):76-79
Objective To explore the clinical efficacy and safety of umbilical cord derived mesenchymal stem cells transplantation(UC-MSCT)for patients with refractory systemic lupus erythematosus (SLE).Methods Twelve patients with refractory SLE were enrolled in this study.UC-MSCs(≥106/kg cell number)were infused intravenously for each patient. The clinical manifestations and laboratory parameters were compared before and after MSCT. Results The twelve patients were followed up for one to twenty-six months after MSCT.The systemic lupus erythematosus disease activity index(SLEDAI)score decreased from 18±4 to 10±4 one month after MSCT(n=12,P<0.01)and then decreased to 7±4 at three month follow-up.Nine patients showed improvement of 24 h proteinuria[(2103±749)mg vs(3359±1248)mg,P<0.01]one month after MSCT.Further improvement of 24 h proteinuria was observed in eight patients[(1427±616)mg vs(3342±1333)mg,P<0.01]at three months post MSCT.Serum creatinine of five patients decreased significantly and ten patients showed an increase of serum albumin. Serum complement C3 increased in three patients and four patients showed obvious amelioration of hematological abnormalities. There was no transplantation related complications for all the patients. Conclusion UC-MSCT is effective and safe for refractory SLE,but further observation is required to evaluate its long term efficacy.
4.Paroxysmal Supraventricular Tachycardia in an Infant with Hand, Foot, and Mouth Disease.
Peng HU ; Shu HOU ; Peng Fei DU ; Jia Bin LI ; Ying YE
Annals of Dermatology 2012;24(2):200-202
An 11-month-old male infant was admitted to our hospital with fever, fussiness, poor feeding, vomiting, and tachypnea for two days prior. Physical examination revealed sporadic papules and vesicles occurring on his hands, feet, face, and perianal mucosa. Enterovirus 71 was identified from both throat swab and vesicle fluid using virus isolation techniques. The patient's heart rate fluctuated in a very narrow range from 180~210/beats/min regardless of his physiologic state. An electrocardiogram showed P-waves buried within or occurring just after regular, narrow, QRS complexes. The patient was diagnosed as having hand, foot, and mouth disease in combination with paroxysmal supraventricular tachycardia (PSVT). The child recovered well with symptomatic treatment, including intravenous administration of acyclovir, glucocorticoids, immunoglobulin, adenosine, and sotalol. PSVT was terminated within 36 hours of hospitalization. The skin lesions became crusted on the third day, and then proceeded to heal spontaneously. Here we report on this unusual case and review the associated literature.
Acyclovir
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Adenosine
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Administration, Intravenous
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Animals
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Child
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Electrocardiography
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Enterovirus
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Fever
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Foot
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Foot-and-Mouth Disease
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Glucocorticoids
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Hand
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Heart Rate
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Hospitalization
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Humans
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Immunoglobulins
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Infant
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Male
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Mouth
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Mouth Diseases
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Mucous Membrane
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Pharynx
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Physical Examination
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Skin
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Sotalol
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Tachycardia, Supraventricular
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Tachypnea
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Viruses
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Vomiting
5.Studies on the constituents in rhizome of Homalomena occuta.
Yong-mei HU ; Zhong-lin YANG ; Wen-cai YE ; Qi-hou CHONG
China Journal of Chinese Materia Medica 2003;28(4):342-344
OBJECTIVEBio-active constituents were expected to abstain from Homalomena occuta.
METHODSExtracts from the plant with 95% alcohol were distributed by several solvents and isolated via column chromatography on silica and Saphadex 20-LH gel.
RESULTSThirteen compounds were isolated from this plant. Among them seven natural products were identified via spectral methods as beta-stigmastol(H1) beta-D-Glucopyranoside(3)- stigmast-5-en-3-yl(H2); oplodiol(1); oplopanone(2); homalomenol(3); bullatantriol(4); 1 beta, 4 beta, 7 alpha-trihydroxyeudesmane(5).
CONCLUSIONAll these compounds were isolated from this plant for the first time.
Araceae ; chemistry ; Naphthols ; chemistry ; isolation & purification ; Plants, Medicinal ; chemistry ; Rhizome ; chemistry ; Sitosterols ; chemistry ; isolation & purification ; Stigmasterol ; chemistry ; isolation & purification
6.The preparation of the polylacticacid nanoparticles of cucurbitacin and their drug loading.
Ji-Fen ZHANG ; Shi-Xiang HOU ; Hui-Lian LIU ; Li WANG ; Ping HU ; Li-Min YE ; Gao-Sen WANG
China Journal of Chinese Materia Medica 2005;30(6):436-439
This paper introduced an experimental study of the preparation of polylacticacid (PLA) nanoparticles of cucurbitacin (CuC) using a precipitation method. The residual acetone, ratio of CuC PLA precipitates, and the relationships between the ratios of two precipitates and drug incorporation rates were measured. It appeared that the nanoparticles with 60% of PLA incorporated with 5.5% of CuC were formed when acetone was injected into the aqueous phase. As the acetone gradually evaporated, drug incorporation/encapsulation continued, with most of CuC (about 70%) formed new crystalline cores and suspended in the form of microcrystals in the medium, resulting a suspension containing both nanoparticles and microcrystals. We also concluded that this system may not necessarily be suitable for all lipophilic drugs to be prepared to PLA nanoparticles with good incorporation rate. The drug incorporation depended on the interactions among drug, PLA, and organic solvents, in addition to the solubility of the drug.
Antineoplastic Agents, Phytogenic
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administration & dosage
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Chemical Precipitation
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Cucurbitaceae
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chemistry
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Cucurbitacins
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Delayed-Action Preparations
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Drug Compounding
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methods
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Drug Delivery Systems
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Lactic Acid
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Microspheres
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Nanotechnology
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Particle Size
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Plants, Medicinal
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chemistry
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Polyesters
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Polymers
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Triterpenes
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administration & dosage
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isolation & purification
7.Clinical application anatomy and endoscopic views of interventricular foramen
Qiang CAI ; Xian-Hou YUAN ; Yi-Hao TIAN ; Qian-Xue CHEN ; Ren-Zhong LIU ; Qiang SHI ; Zhi-Hong JIAN ; Ying-Hu YE ; Guo-An WANG ;
Chinese Journal of Microsurgery 2000;0(04):-
Objective To study the clinical application anatomy of interventricular foramen and offer a base for operation.Methods Interventricular foramens were observed in 15 adult cadaveric brainThirty- two patients of obstructive hydrocephalus were operated to observe the structure of interventricular foramen un- der neuroendoscope.Results Interventricular foramen was a poriform structure which consists of fornixan- terior pole of thalamencephalon and choroid plexus and was a oval shape in most of themThe plane of the fo- ramen was a included angle with the median sagittal planeThe septal veinthalamostriate veinthalamen- cephal and even the floor of third ventricle could be observed clearly in endoscope.At the same timewe found the foramen had a significant change in obstructive hydrocephalus.Conclusion The interventricular foramen has a simple relatively structure but a variation on size and shape especially in obstructive hydroceph- alusA clearly comprehension of it's structure and adjacent is a base to microsurgery and endoscopic surgery on the foramen.
8.Application of intraoperative magnetic resonance imaging and multimodal navigation in surgical resection of glioblastoma.
Fang-Ye LI ; Xiao-Lei CHEN ; Xiao-Yong SAI ; Jia-Shu ZHANG ; Shen HU ; Jin-Jiang LI ; Gang ZHENG ; Ting ZHANG ; Ye LI ; Meng-Zhuo HOU ; Bai-Nan XU
Chinese Journal of Surgery 2013;51(6):542-546
OBJECTIVETo evaluate the efficacy of intraoperative magnetic resonance imaging (iMRI) and multimodal navigation in surgical resection of glioblastoma.
METHODSBetween February 2009 and July 2010, 76 glioblastoma patients underwent surgical resection guided by iMRI and multimodal navigation. The cohort consisted of 43 male and 33 female patients, with a mean age of 49 years (range: 14-79 years). Rates of gross total resection (GTR) and extent of resection (EoR) were calculated at first and final iMRI scans.Pearson χ(2) test was used to compare the rates of GTR.
RESULTSiMRI and multimodal navigation were successfully implemented in all cases. Rates of GTR were misestimated by neurosurgeons in 24 cases (31.6%), which were confirmed by first iMRI. Total tumor resection were achieved in 20 cases (26.3%) as a result of iMRI scan, increasing the rates of gross total resection from 52.6% to 78.9% (χ(2) = 11.692, P = 0.001). Extent of resection in 28 patients who underwent further tumor resection were increased from 81.5% to 98.1%, leading to the overall extent of resection improved from 92.3% to 98.4%. At 3-month follow-up, 3 cases (3.9%) developed permanent neurologic deficits. The mean clinical follow-up was 15.6 months (range 3.0-45.0 months). The 2-year overall survival rate was 19.7%. The median progression-free survival of gross total resection group was 12 months (95% CI: 10.1-13.9 months), compared with 9 months (95%CI: 7.9-10.1 months) of the subtotal resection group (χ(2) = 4.756, P = 0.029). The overall survival of gross total resection group was 16 months (95% CI: 13.7-18.3 months), compared with 12 months (95% CI: 9.7-14.3 months) of the subtotal resection group (χ(2) = 7.885, P = 0.005).
CONCLUSIONCombined with multimodal navigation, iMRI helps maximize surgical resection of glioblastoma, preserving neurological function while increasing progression-free survival and overall survival.
Adolescent ; Adult ; Aged ; Brain Neoplasms ; surgery ; Female ; Glioblastoma ; surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Monitoring, Intraoperative ; methods ; Neuronavigation ; Young Adult
9.Self-assessment characteristics of voice handicap index for voice disorders and its influencing factors
Hong-Yan LI ; Wen XU ; De-Min HAN ; Rong HU ; Hui-Ying HU ; Li-Zhen HOU ; Li ZHANG ; Jing-Ying YE ; Jun WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2009;44(2):109-113
Objective To investigate the self-assessment characteristics of Voice Handicap Index (VHI) for voice disorders and its influencing factors. Methods One thousand seven hundred and sixty six dysphonic patients and 120 control subjects were included in this study. Two hundred twenty seven patients were treated with phonosurgery or Botulinumtoxin injection. VHI was used for self-assessment Results Dysphonic patients had worse VHI scores than control (z from 8.039 to 17.043, P=0.000). There was a significant difference among the VHI scores of different diseases. VHI scores were descending in order among spasmodic dysphonia, vocal fold paralysis, functional dysphoina, sulcus vocalis, benign and malignant tumor of vocal fold, vocal fold cyst, Reinke' s edema, vocal fold polyp, vocal fold keratosis and chronic laryngitis, vocal nodule. The emotional scores were the highest in spasmodic dysphunia, and followed by functional dysphoina. In another group, the physical scores were higher than functional scores and emotional scores. Treatment resulted in statistical improvement in VHI scores (P<0.05). The total scores were different significantly between different educational background and age groups(F from 8.701 to 27. 371, P=0.000). The higher the educational degree, the higher the VHI scores. As to age groups, the juvenile group' s scores were the lowest, while the youth' s group the highest, then the scores declined when ages increased. Conclusion As a useful supplementary instrument to measure the voice disorder severity and the treatment' s effect, VHI can comprehensively assess the voice handicap' s affect to the life quality and the difference after the treatment, especially in physical, functional and emotional aspects, but it is somehow subject to the educational degree and age.
10.Treatment of displaced humeral supracondylar fractures in children with external fixation using plaster or splint.
Ping-xian TAN ; Gan-hu YE ; Shao-dong REN ; Zhi-qi HOU ; Guo-xin ZHOU ; Yong-gang TU ; Ying TAN ; Zhi-sen ZHOU
China Journal of Orthopaedics and Traumatology 2011;24(8):667-671
OBJECTIVETo investigate the therapeutic effects of closed reduction and external fixation (plaster or splint) for the treatment of displaced humeral supracondylar fractures in children.
METHODSFrom March 2007 to September 2009,33 children (15 female and 18 male) with humeral supracondylar fractures treated in our hospital, ranging from 3 to 12 years old with an average of 6.4 years old. All the fractures were extension-type injuries, the flexion injures were excluded in our study. The humeral supracondylar fractures were classified according to Gartland classification. There were 21 Type H and 12 type III. In the initial treatment, all the patients were treated with closed reduction and external immobilization. The blood supply of the damaged upper extremity was evaluated before and after treatment. Clinical assessment was obtained at final follow-up using Flynn criteria, and radiologic assessment was obtained using Baumann and lateral humerocapitellar angles.
RESULTSAll the children were treated successfully with closed reduction in the initial time; 24 children maintained limb alignment by external immobilization. Nine patients lost position due to the swelling around the elbow which affected unstable external fixation during the follow-up, 5 of which were treated with a repeated closed reduction and internal fixation with Kirschner wires, 4 of which were treated with traction. Thirty-one patients had a satisfactory outcome and 2 patients had an unsatisfactory outcome according to the Flynn criteria at the latest follows-up.
CONCLUSIONClosed reduction and external stabilization is an important method for the treatment of displaced humeral supracondylar fractures in children. Making regular follow-up visits after closed reduction and casting is important for patients to maintain acceptable alignment, avoid complications and diagnose any loss of reduction.
Casts, Surgical ; Child ; Child, Preschool ; External Fixators ; Female ; Fracture Fixation, Internal ; Humans ; Humeral Fractures ; surgery ; Male ; Splints