It has been proved that erythropoietin has neuroprotective effect and therapeutic action on cerebral ischemia in vivo and in vitro. The mechanisms of these actions may be involved in anti-exitotoxicity of aminoglutaric acid, regulating the synthesis of nitric oxide, antioxidation, antiinflammatory, inhibiting neuron apoptosis, accelerating angiogenesis, neurogenesis, neurotrophy and others. In addition, exogenous erythropoietin can enter brain tissue through blood-brain barrier and exert neuroprotection. So it is indicated that erythropoietin can be expected to be a new drug to prevent and treat cerebral ischemia.

Macrofungi are rich in natural bioactive compounds so they have much medicinal value.Their immunomodulating and anticancer activity particularly attracts more attention.Based on the polysaccharides molecular structure and their relation to these activities,this paper discusses their mechanism of the immune responses and introduces the important instances of these polysaccharides along with their immunomodulating and/or anticancer activity isolated from putative medicinal mushrooms.

Objective Ethanol, acid and alkali were used in the traditional Bererine extracting which required quite a few extracting time and polluted the environment. Water instead of ethanol was used. Microwave irradiation was chosen as the extracting method. Methods The best parameters, microwave power, extracting time, solid-liquid ratio were got in the experiment. According to the orthogonal experimental design, the optimum extracting condition was determined. Results Microwave irradiation, compared with the traditional extracting techniques, was with short extracting time. Conclusion The method was practicable and the product possessed the virtue of high purity, safe quality and free pollution.

As a minimally invasive method of examination, magnetic resonance spectroscopy can provide information of brain metabolism and biochemistry, objectively reflect brain metabolite changes. Different manifestations were described in the diseases such as brain injury and brain tumor. As a result, magnetic resonance spectroscopy can be a helpful technology to give information of diagnosis and prognosis in neurosurgery for brain injury, brain tumor as well as brain abscess and epilepsy.

Objective To evaluate the value of IL15mRNA determination in the early diagnosis and differential diagnosis of acute rejection(AR) after liver transplantation.Methods RT-PCR was used to detect the mRNA of IL-15 in serum and bile on the 30th day after liver transplantation in 43 patients subject to orthotopic piggy-back liver transplantation.Serum and bile of the patients were cultured for bacteria.The acute rejection was confirmed pathologically. Results Acute rejection(occurred) in 16 out of 43 cases as the AR group and bacterial infection(BI) in 12 cases as the BI group.The (remaining) 15 patients were uneventful as the control group.Before diagnosis of AR and BI,the gene expression rate of IL-5 in bile was significantly higher in AR group((62.5 %)) than in BI group((16.7 %)) and control group((13.3 %))(P

OBJECTIVE: To provide reference for the application of automatic tablet packing machine in the inpatients dispensary.METHODS: The working principle and flow,the main structure and function of the automatic tablet packing machine used in our hospital were introduced,and its application value was evaluated and the problems remained to be dealt with were pointed out.RESULTS: The automatic tablet packing machine had the advantages of high accuracy and efficiency,and reduced working intensity,however,the costs for the packaging and consumables,and the low drug quality were the problems remained to be solved.CONCLUSIONS: Automatic tablet packing machine is suitable for the dispensing of oral single dose of tablets for inpatient patients,and it helps to improve the work quality and the service level in the dispensary for inpatients.

New method of prostate cancer has grown more precise with the development of medical imaging.Multi-parametric MRI targeted biopsy and fusion biopsy reduce the cores,at the same time they have similar positive rates compared to systematic biopsy.The most used biopsy methods are still transrectal guided transrectal biopsy and transperineal biopsy in China.If we can predict biopsy result before the operation by physical and laboratory examination,it will help improve the detection rate and avoid repeating biopsies.And it has been indicated that age,tPSA,PSAD,fPSA/tPSA,PV,DRE,PHI and PCA3 are the predicting factors.Chinese Prostate Cancer Consortium Risk Calculator is fit for Chinses people.

Objective To explore the application value of endoscopy in the diagnosis and treatment of patients with gastrointestinal bleeding.Methods The clinical data of 74 patients with digestive tract hemorrhage underwent gastroscopy and treatment were retrospectively analyzed.The effect of gastroscopy was compared at different time and different treatment methods.Results Endoscopic examination showed 23 cases of duodenal ulcer disease (31.08％),including 15 cases of gastric ulcer(20.27％),10 cases of acute gastric mucosal lesion (13.51％),8 cases of gastric cancer(10.81％),gastrointestinal complex ulcer in 7 cases (9.46％),4 cases of gastritis (5.41％),anastomotic ulcer or erosion in 4 cases (5.41％),no lesions in 3 cases (4.05 ％).71 cases were clearly diagnosed by gastroscopy,the detection rate was 95.95％,the hemorrhage in 48h positive rate was 100.00％,which was significantly higher than 87.50％ of the hemorrhage 48h detection rate (x2 =13.33,P ＜ 0.05).71 patients received endoscopic treatment,67 patients were successful,the success rate was 94.37％,the injection of hemostatic success in 16 cases (94.12％),spraying hemostasis successfully in 51 cases (94.44％),there was no significant difference (x2 =-0.01,P ＞ 0.05).Conclusion In the patients with gastrointestinal bleeding,gastroscopy has advantages of high diagnostic accuracy,accurate curative effect,can shorten the bleeding time,improve the success rate of hemostasis,improve the prognosis,with high clinical value.

Acupuncture, Ear ; adverse effects ; Female ; Humans ; Middle Aged ; Vertigo ; etiology

Objective To perform APACHEⅡand SOFA in assessmentof EICU patients with sepsis ,and analyze the risk factors. Methods A retrospective analysis from January 2014 to October 2015 in EICU of our hos-pital ,a total of 83 patients suffered from sepsis ,including sepsis group(30 cases)and septic shock(53 cases). PCT,PT,APTT,lactic acid,mechanical ventilation time and APACHE Ⅱ and SOFA score were collected, through the receiver-operating characteristic curve(ROC)index to predict the prognosis of patients with sepsis.Re-sults The mortality of the patients in the septic shock group,PT,APTT,APACHEⅡ,SOFA score,mechanical ventilation time and PCT were significantly higher than thosein the sepsis group(P<0.001). APTT,APACHEⅡ, SOFA score and mechanical ventilation time had significant difference (P ≤ 0.001) between survival and dead. The lactic acid level of the dead group was significantly higher than that in the survival group(P=0.038). The ar-ea under curve(AUC=0.806)of APACHEⅡscore was better than the SOFA score(AUC=0.765).The outcome of sepsis had correlation with APACHEⅡ,SOFA score,lactic acid,and mechanical ventilation time(P<0.05). Conclusion APACHE II and SOFA scores can accurately predict mortalityoutcome in emergency intensive care units patients with sepsis,especially the APACHEⅡscore.We can measure blood coagulation function,APACHEⅡ,SOFA score,PCT,lactic acid and mechanical ventilation time to assess the severity of patients with sepsis.