Objectives: To investigate the effects of the extract mixture of alfalfa and perilla on lowering serum lipid, protecting liver and aortic wall in rats. Methods: Sixty SD rats were divided into six groups and were fed different diet. After seven or fourteen days, the rats were put to death and measured for serum lipids, cholesterol content of liver and aortic wall, and pathological change of the tissue. Results: There was a significant increase of serum TC, LDL-C, cholesterol content of liver and aortic wall in the high-fat fed rats. Under light microscope, there were lipid droplets and cholesterol crystal in liver of group high-fat. Compared with the group high-fat, the rats had a significant decrease of those measurements in serum or in tissue in the alfalfa and perilla group. Conclusions: The extract mixture of alfalfa and perilla could prevent the increase of serum TC, LDL-C, cholesterol content of liver and aortic wall in high-fat fed rats, and also prevent the fatty infiltration and cholesterol deposit of liver.

Five inner ears were removed from five rabbits under aneasthesia. The hard, thick bones of outer and middle ears were trimmed off, and the auditory ossicles were taken away. The cochleae were fixed with 2％ glutaraldehyde in phosphate buffer for eight hours, then they were decalcified in 10％ EDTA-2Na solution for ten days, and the softened shells of the cochleae were stripped off, and post-fixed in 1％ OsO_4 for an hour, dried at critical point, coated with gold, and observed under SEM.The rabbit cochlea shows two and a half turns, the modiolus is about 3.5mm high, and the organ of Corti lies on the basilar membrane of the spiral lamina. The outer hair cells usually form three parallel rows on the middle and basal turns but occasionally four rows on the top half turn. The inner hair cells form only a single row. Every bunch of the outer hairs consists of about 93-114 stereocilia which together show a "W" shape. Every bunch of inner hairs has about 50 cilia which together show an arch shape. The cilia on the top turn are longer than those on the base. The length and width of the inner and outer hair cells and four other kinds of cells were measured according to photos, and the numbers of these kinds of cells were estimated.Other three cochleae fixed at the time of 1, 2 or 4 hours after death were also observed. In the cochlea fixed four hours after death, the majority of the auditory hairs were found fallen down, which means the fixation of cochlea should be carried out within less than four hours after death.Some of the structural similarities and differences of cochleae among rabbit,human being and guinea pig were also compared in this paper.

Neuroblastoma (NB)is a common malignant solid tumor in childhood,which has various clinical manifestations.It is difficult to diagnose and to prone to early metastasis.It is one of the main diseases causing death in childhood.The treatment of children with high-risk NB is still very challenging.At present,the treatments of NB mainly concentrated in the surgery,chemotherapy,radiation therapy and transplantation technology,etc.In recent years,more studies focus on targeted therapy and molecular biology (genetics) treatment.Targeted therapy is targeted to different specific loci of tumor,so as to kill tumor cells and reduce the impact on the normal tissue,which supplies more safe and effective treatments for children with NB.

Adrenocortical carcinoma (ACC) is a rare disease with poor prognosis.Patients usually present with signs of steroid hormone excess (e.g.Cushing's syndrome, Conn's syndrome, virilization) or an abdominal mass.In functional cases, Cushing's syndrome is the most frequent presentation.Mitotane is still the most important single drug for ACC treatment, and it plays a role in adjuvant therapy postoperatively as well as in advanced disease.In advanced ACC, a combination of mitotane with etoposide, doxorubicin, cisplatin or streptozotocin with mitotane may be used.Targeted therapies, such as insulin-like growth factor Ⅰ (IGF- Ⅰ)receptor inhibitor and multiple kinase inhibitors like sunitinib and sorafenib hold great promises.

Gastric cancer is one of the most common malignancies in China. Currently, surgical resection, chemotherapy and radiotherapy are still the main therapeutic methods.The postoperative 5-year survival of patients with gastric cancer is lower than 60%. As a means of adjuvant therapy, immunotherapy has the potential to improve the survival of patients with gastric cancer, because its therapeutic targeting and toxicity profile does not overlap with those of conventional therapies. The effector cells of the immune system (T, B and NK cells), when activated, are able to lyse and destroy tumor cells through specific recognition of tumor-associated antigens. However, most immunotherapy research in gastric cancer is still limited to the preclinical stage due to the weakness of its antigenicity. With the development of tumor immunobiology and genetic engineering, immunotherapy has become the focus of research for the treatment of gastric cancer.

Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Lymphatic Diseases ; etiology ; pathology ; Male

Dental Implantation ; standards ; Humans ; Terminology as Topic

Objective To explore the mental-behavior characteristics in serious internet game addicts.Methods To investigate internet addiction questionnaire, EPQ, social support questionnaire, purpose in life test and sensation seeking scale in 30 serious internet game addicts ( age from 16 ～ 25 years) and 43 non-addicts.Results Internet addicts have obviously lower social support questionnaire score, subjective support score, purpose in life test score and sensation seeking TAS score than non-addicts( P<0.05 or P<0.01 ). Objective support score, the use score for social support and sensation seeking score can forecast the internet addiction extent of the internet addict group. Internet addicts have obviously lower L score of EPQ than non-addicts ( P<0.01 ). There is the negative correlation between N score of the internet addicts and sensation seeking score( r=-0. 452, P<0.05). Conclusions Serious internet game addicts have the metal characteristics of low social support, low purpose in life and low adventure; sensation seeking and social support scale have prognosticative function for internet addiction degree; serious internet game addicts of low N score have high sensation seeking characteristic.

To promote the development of key discipline construction in hospitals,we described the integration of refined management into the construction of key disciplines and different aspects including personnel training,featured specialty,research,and hardware were discussed.We concluded that refined management in essential to the development of hospital,and a mechanism needs to be established to ensure the long-term effect.

Objective To explore how to perform effective health management for the metabolic syndrome(MS) in the health examination center. Methods A total of 153 subjects diagnosed with MS and the same number of healthy controls were analyzed. All patients received health management for 12 months and an impact evaluation was conducted. Results Waist circumference, IBM, SBP, DBP, blood lipids of MS group were remarkably higher than those in normal control group, and there was statistical significance (P