1.An investigation of reosseointegration according to time course after mechanical loosening of the osseointegrated implant fixtures.
Sun Hae YE ; Jin Hyun CHO ; Cheong Hee LEE
Journal of Dental Rehabilitation and Applied Science 2015;31(3):203-211
PURPOSE: The purpose of this study was to investigate the reosseointegration periods when the rough surface implants, which had complete bone-implant ankylosis, suddenly losed the osseointegration. MATERIALS AND METHODS: The implants with RBM surface treatment were inserted into both tibias of 23 rabbits. Two implants were submerged into each side. After six weeks, the primary removal torque was measured by Digital torque gauge, and then the implants were replaced and submerged to estimate the level of reosseointegration. After assigned healing periods for each group, the removal torque was measured again. BIC (Bone-Implant contact, %) ratio was measured through histomorphometric analysis.Paired t-test was processed by SPSS 14.0. One-way ANOVA and Tukey's post-hoc test was processed to analyze statistically significant differences among the groups. RESULTS: In comparison with the primary removal torque, the secondary removal torque was increased after 11 days and significantly increased from 2 weeks. In fluorochrome labeling, the origin of mineralization was observed after 7 days, which showed as fluorescent bands around the boneimplant interfaces. After 11 days, the bone formation was apparent, and it is increased continuously with the passage of the time. CONCLUSION: In 11 days after the implant replacement, the secondary removal torque was almost as same as the primary value, and was significantly higher from 2 weeks. The mineralized shapes were observed in 7 days after the implant replacement, and then thebone formation appeared visibly in 11 days.
Ankylosis
;
Osseointegration
;
Osteogenesis
;
Rabbits
;
Tibia
;
Torque
2.The Association between Vitamin D and Health-Related Quality of Life in Korean Adults.
Ji Sun KIM ; Young Eun CHOI ; Jin Kyung BAEK ; Ho Jin CHO ; Ye Seul KIM
Korean Journal of Family Medicine 2016;37(4):221-227
BACKGROUND: We examined the relationship between vitamin D status and health-related quality of life, and explored other related factors in the general Korean population. METHODS: We used data from the 2007-2012 Korea National Health and Nutrition Examination Survey on 14,104 adults, aged 20-49 years, who had consented to serum vitamin D measurement and answered health-related quality of life questions. EuroQol-5 was used for measurement. Serum vitamin D levels were measured at intervals of 0-9.99, 10-19.99, 20-29.99, and ≥30 ng/mL. RESULTS: Participants with higher serum vitamin D (serum 25-hydroxyvitamin D) levels were significantly less likely to report problems with depression and anxiety. After adjustment for age, gender, income level, education level, marital status, alcohol consumption, smoking status, and the existence of depressive disorders, the odds ratio for reporting a problem with depression and anxiety was 0.60 (95% confidence interval [CI], 0.39-0.91). The odds ratio for the prevalence of any problem was 0.69 (95% CI, 0.53-0.89) before adjustment, but was not statistically significant after adjustment. No significant associations were observed for problems with mobility, self-care, usual activity, or pain and discomfort. CONCLUSION: This is the first study to examine the associations between vitamin D and health-related quality of life for the general Korean population. Vitamin D status was not significantly associated with the dimensions of EuroQol-5 except for depression and anxiety problems.
Adult*
;
Alcohol Drinking
;
Anxiety
;
Depression
;
Depressive Disorder
;
Education
;
Humans
;
Korea
;
Marital Status
;
Nutrition Surveys
;
Odds Ratio
;
Prevalence
;
Quality of Life*
;
Self Care
;
Smoke
;
Smoking
;
Vitamin D*
;
Vitamins*
3.Synchronous metastasis from double primary cancers in a single left supraclavicular lymph node.
Ye An KIM ; Hye Sook MIN ; Sun Wook CHO ; Young Joo PARK
The Korean Journal of Internal Medicine 2017;32(6):1121-1122
No abstract available.
Lymph Nodes*
;
Neoplasm Metastasis*
4.Hibernoma of Lower Chest Wall, Left: One Case Report.
Yong Sun JUN ; Chan Gui CHUN ; Ye Jee JUN ; Woo Ho CHO ; Jong Boum CHOI
The Korean Journal of Thoracic and Cardiovascular Surgery 1997;30(4):467-470
Hibernoma is a rare, benign soft tissue tumor that is derived from the remnants of fetal brown tissue. The term hibernoma was proposed in 1914 by Cery because of its morphologic similarity to the cel s of the so-called hibernating gland of animals. The most common site of hibernomas is the subcutaneous tissue of the back, especially the interscapular area. These tumors are considered benign and malignant transformation has not been reported. We experienced a case of hibernoma, 60-year-old woman had suffered from the palpable mass without pain or tenderness on posterolateral lower chest wall, left. The tumor was extirpated under the impression of angiolipoma, but was confirmed hibernoma. She was discharged without complication.
Adipose Tissue, Brown
;
Angiolipoma
;
Animals
;
Female
;
Humans
;
Lipoma*
;
Middle Aged
;
Subcutaneous Tissue
;
Thoracic Wall*
;
Thorax*
6.Treatment of Tibial Fractures with the Ilizarov Method
Hae Ryong SONG ; Se Hyun CHO ; Kyung Hoi KOO ; Hyung Bin PARK ; Yeon Cheon JUNG ; Sun Cheol HWANG ; Jai Soo KIM ; Byoung Suck KIM ; Ye Soo PARK
The Journal of the Korean Orthopaedic Association 1994;29(2):655-664
Between 1987 and 1992, 86 tibial fractures were treated with the Ilizarov external fixator at Gyeong-Sang National University Hospital and Okpo Hospital. The mean follow-up period was 31.4 months. Sixty-six were open fractures and twenty were closed fractures with severe comminution. In 66 open fractures, there were 9 Gustilo type I, 10 type II, and 47 type III fractures. Of 66 open fractures, 22 had bone defects ranged from 2cm to 17cm and 16 had extensive loss of soft tissue. Twenty-two bone defects were treated with cancellous bone grafts in 8 cases, bifocal osteosynthesis with bone graft in 12 cases, and trifocal osteosynthesis with bone graft in 2 cases. Thirty-four extensive soft tissue defects were treated with split-thickness skin graft, musculocutaneous flap, soft tissue transportation with ring used in bifocal, trifocal osteosynthesis, and acute shortening of fracture site. Of 20 closed fractures, 14 were treated with cancellous bone graft for decreasing union time and 6 were treated with monofocal compression without bone graft. The mean time to union was 20.5 weeks in closed fractures, and 35.4 weeks in open fractures. Of 40 complications, 12 were knee and ankle joint contractures, 12 were soft tissue and bone infections of pin tract, 5 were refracture, 5 were angular deformities of 10 degree or more, 5 were delayed union, and 2 were nonunion. According to Tucker's classification, the results were graded as excellent in 31, good in 38, fair in 12, and poor in 5 cases. Primary or secondary bone graft is necessary for early bony union and anatomical reduction combined with bone graft could prevent the complications of delayed union and nonunion.
Ankle Joint
;
Classification
;
Congenital Abnormalities
;
Contracture
;
External Fixators
;
Follow-Up Studies
;
Fractures, Closed
;
Fractures, Open
;
Ilizarov Technique
;
Knee
;
Myocutaneous Flap
;
Skin
;
Tibia
;
Tibial Fractures
;
Transplants
;
Transportation
7.Diagnostic Neuroimaging in Headache Patients: A Systematic Review and Meta-Analysis
Ye Eun JANG ; Eun Young CHO ; Hee Yea CHOI ; Sun Mi KIM ; Hye Youn PARK
Psychiatry Investigation 2019;16(6):407-417
OBJECTIVE: Neuroimaging in headache patients identifies clinically significant neurological abnormalities and plays an important role in excluding secondary headache diagnoses. We performed a systematic review and meta-analysis of the existing guidelines and studies surrounding neuroimaging in headache patients. METHODS: The research question involved determining the prevalence of detecting clinically significant neurological abnormalities using neuroimaging in patients suspected of primary headache. Searches of the PubMed and Embase databases were conducted on English-language studies published from 1991 to 2016, and the reference lists of the retrieved articles were also checked manually. All headache subtypes and patients aged ≥15 years were included in the analysis. RESULTS: Ten studies met the selection criteria. The pooled prevalence of detecting clinically significant abnormalities in the neuroimaging of headache patients was 8.86% (95% confidence interval: 5.12–15.33%). Subsequently, diverse subgroup analyses were performed based on the detection method, headache type, study type, study region, age group, and disease type. CONCLUSION: The present findings indicate that limited neuroimaging methods should be carefully considered for headache diagnostic purposes when there are red flag symptoms. Limitations and suggested directions for future studies on neuroimaging in headache patients are described.
Diagnosis
;
Headache
;
Humans
;
Magnetic Resonance Imaging
;
Methods
;
Neuroimaging
;
Patient Selection
;
Prevalence
;
Tomography, X-Ray Computed
8.Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner
Ye Seul CHOI ; Hee Jeong CHO ; Hye Jin JUNG
The Korean Journal of Physiology and Pharmacology 2022;26(5):367-375
Gastric cancer stem cells (GCSCs) are a major cause of radioresistance and chemoresistance in gastric cancer (GC). Therefore, targeting GCSCs is regarded as a powerful strategy for the effective treatment of GC. Atorvastatin is a widely prescribed cholesterol-lowering drug that inhibits 3-hydroxy-3-methylglutaryl-coenzyme A reductase, a rate-limiting enzyme in the mevalonate pathway. The anticancer activity of atorvastatin, a repurposed drug, is being investigated; however, its therapeutic effect and molecular mechanism of action against GCSCs remain unknown. In this study, we evaluated the anticancer effects of atorvastatin on MKN45-derived GCSCs. Atorvastatin significantly inhibited the proliferative and tumorsphere-forming abilities of MKN45 GCSCs in a mevalonate pathway-independent manner. Atorvastatin induced cell cycle arrest at the G0/G1 phase and promoted apoptosis by activating the caspase cascade. Furthermore, atorvastatin exerted an antiproliferative effect against MKN45 GCSCs by inhibiting the expression of cancer stemness markers, such as CD133, CD44, integrin α6, aldehyde dehydrogenase 1A1, Oct4, Sox2, and Nanog, through the downregulation of β-catenin, signal transducer and activator of transcription 3, and protein kinase B activities. Additionally, the combined treatment of atorvastatin and sorafenib, a multi-kinase targeted anticancer drug, synergistically suppressed not only the proliferation and tumorsphere formation of MKN45 GCSCs but also the in vivo tumor growth in a chick chorioallantoic membrane model implanted with MKN45 GCSCs. These findings suggest that atorvastatin can therapeutically eliminate GCSCs.
9.Cholesterol side-chain cleavage enzyme deficiency caused by a novel homozygous variant in P450 sidechain cleavage enzyme gene (CYP11A1) in a 46,XX Korean girl
Ye Ji KIM ; Sun CHO ; Hwa Young KIM ; Young Hwa JUNG ; Jung Min KO ; Chang Won CHOI ; Jaehyun KIM
Journal of Genetic Medicine 2023;20(1):25-29
The CYP11A1 gene encodes for the cholesterol side-chain cleavage enzyme (P450scc), which initiates steroid hormone biosynthesis. Defective P450scc activity results in severe glucocorticoid and mineralocorticoid deficiencies. We describe a case of P450scc deficiency due to a novel homozygous CYP11A1 variant inherited from the mother with a possibility of uniparental disomy (UPD). The patient was a female, had no family history of endocrine disease, and showed adrenal insufficiency at 13 days of age. Hormonal analysis with an adrenocorticotropic hormone stimulation test showed both glucocorticoid and mineralocorticoid deficiencies, presumed to be a defect of the early stage of steroidogenesis. Exome sequencing reported a novel homozygous frameshift variant of CYP11A1 (c.284_285del, p.Asn95Serfs*10), which was inherited from the mother.Additionally, homozygosity in 15q22.31q26.2, which included CYP11A1, was identified using a chromosomal microarray. It was suggested that the possibility of maternal UPD was involved as the cause of a P450scc deficiency by unmasking the maternally derived affected allele. To our understanding, P450scc deficiency associated with UPD encompassing CYP11A1 had not been reported in Korea before. Genetic analysis can help diagnose rare causes of primary adrenal insufficiency, including P450scc deficiency.
10.Clinical Feasibility of Suppression Head Impulse Test in Vestibulopathy Patients
Yun Jin KANG ; Beom Cho JUN ; Ye Sun CHO ; Ji Hyung LIM ; Do Yeon KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2018;61(2):76-84
BACKGROUND AND OBJECTIVES: The suppression head impulse (SHIMP) test has emerged as one of the new vestibular function tests. The SHIMP test is an analysis of anti-compensatory saccadic movements in gazing moving targets as the head moves. In this study, we investigated the accuracy and sensitivity of the test. SUBJECTS AND METHOD: We analyzed the results of SHIMP test (gain, amplitude, and latency) in 24 cases, which included normal, vestibular neuritis, benign paroxysmal positional vertigo (BPPV), Meniere's disease, bilateral vestibular function loss, temporal bone fracture, tuberculosis meningitis and acoustic schwannoma patients. We also carried out a physical exam, audiologic study, video electronystagmography (vENG) and a conventional video head impulse test to evaluate the feasibility of SHIMP test in cases of vesitibulopathy. RESULTS: In patients with vestibulopathy, the analysis of SHIMP test indicated high sensitivity and accuracy, which were supported by accompanying audio-vestibular studies. Patients suspected with BPPV, vestibular neuronitis and Meniere's disease showed low vestibulo ocular reflex (VOR) gain and delayed anticompensatory saccade with smaller and more scattered amplitudes than the control. Patients with bilateral vestibular function loss, temporal bone fracture, tuberculosis meningitis, and acoustic schwannoma showed delayed latency, and small amplitude or few anticompensatory saccades. Finally, changes in the SHIMP test values might be a hint that patients had recovered from vestibular neuronitis and tuberculosis meningitis. CONCLUSION: We found the feasibility of SHIMP test in detecting the pathologic condition of VOR in vestibulopathy patients. We argue that the usefulness of SHIMP test might be extended to evaluating the effectiveness of rehabilitation.
Benign Paroxysmal Positional Vertigo
;
Electronystagmography
;
Head Impulse Test
;
Head
;
Humans
;
Meniere Disease
;
Methods
;
Neuroma, Acoustic
;
Reflex, Vestibulo-Ocular
;
Rehabilitation
;
Saccades
;
Temporal Bone
;
Tuberculosis, Meningeal
;
Vestibular Function Tests
;
Vestibular Neuronitis