1.Comparison of Benign and Malignant Microcalcifications.
Hae Jung PARK ; So Hee HAHM ; Jae Won AHN ; Ye Ri LEE ; Oak KIM
Journal of the Korean Radiological Society 1995;33(3):471-475
PURPOSE: To evaluate morphologic characteristics of the microcalcifications on mammography that were confirmed pathologically. MATERIALS AND METHODS: Forty five cases of microcalcifications on mammography (fifteen cases of benign lesion, thirty cases of maiignancy) were retrospectively reviewed. RESULTS: The number of microcalcifications within 1 cm2 were more than 5 in 22 cases (73%) of 30 malignancy and less than 5 in 11 cases (73%) of 15 benignity. The heterogeneity of microcalcifications were seen in 26 cases of malignancy (87%) and the homogeneity of microcaicifications were 11 cases of benignity (73%). The morphologic characteristics of the microcalcifications were linear-V shape in 9 cases (30%), punctate shape in 8 cases (27%), fine stippled shape in 7 cases (23%), and round dot shape in 6 cases (20%) of malignancy and, round dot shape in 11 cases (73%), punctate shape in 2 cases (13%), and linear-V shape in 2 cases (13%) of benignity. CONCLUSION: Numerous irregular microcalcifications that are heterogenous in size and morphology were strong indicators of malignancy.
Mammography
;
Population Characteristics
;
Retrospective Studies
2.Radiographic Features of Tuberculous Osteitis in Greater Trochanter and Ischium.
So Hee HAHM ; Ye Ri LEE ; Dong Jin KIM ; Ki Jun SUNG
Journal of the Korean Radiological Society 1996;35(5):793-797
PURPOSE: To evaluate, if possible, the radiographic features of tuberculous osteitis in the greater trochanter and ischium, and to determine the cause of the lesions. MATERIALS AND METHODS: We retrospectively reviewed the plain radiographic findings of 14 ptients with histologically proven tuberculous osteitis involvingthe greater trochanter and ischium. In each case, the following were analyzed : morphology of bone destruction, including cortical erosion; periosteal reaction ; presence or abscence of calcific shadows in adjacent softtissue. On the basis of an analysis of radiographic features and correlation of the anatomy with adjacent structures we attempted to determine causes. RESULTS: Of the 14 cases evaluated, 12 showed varrious degrees of extrinsic erosion on the outer cortical bone of the greater trochanter and ischium ; in two cases, bone destruction was so severe that the radiographic features of advanced perforated osteomyelitis were simulated. Inaddition to findings of bone destruction, in these twelve cases, the presence of sequestrum or calcific shadows was seen in adjacent soft tissue. CONCLUSION: Tuberculous osteitis in the greater trochanter and ischium showed the characteristic findings of chronic extrinsic erosion. On the basis of these findings we can suggest that the selesions result from an extrinsic pathophysiologic cause such as adjacent bursitis.
Bursitis
;
Femur*
;
Ischium*
;
Osteitis*
;
Osteomyelitis
3.Phytochemical Study on the Aerial Parts of Codonopsis lanceolata
Ye Dam NOH ; So-Ri SON ; Min Goo JUN ; Dae Sik JANG
Natural Product Sciences 2023;29(4):200-205
Codonopsis lanceolata, which is predominantly found in Korea and East Asia, has attracted considerable scientific attention due to its long-standing use in traditional medicine. However, despite both its roots and stems being utilized as functional food and medicinal resources, there has been limited phytochemical investigation into its aerial parts. Therefore, the aim of this study is to isolate compounds present in the aerial parts of C. lanceolata. Through repeated chromatography, two alkaloids (1 and 2), seven flavones (3-9), and three isoflavones (10-12) and one type of phenylpropanoid (13) and polyacetylene (14) were isolated from a 70% ethanol extract of C. lanceolata. The structure of each compound was determined through the analysis of spectroscopic data ( 1 H and 13 C NMR), and by comparing them with previous research results. Among the isolates, the presence of methyl 2-formyl-5-(methoxymethyl)-1H-pyrrole-1-butanoate (1), chrysoeriol 5-O-β-D-glucopyranoside (3), apigenin-5-O-β-D-glucopyranoside (5), and 3′-O-methylorobol 7-O-β-D-glucopyranoside (12) were reported for the first time in plants belonging to the Campanula family in this study. In addition, the current study marked the isolation of luteolin 4′-O-β-D-glucopyranoside (4) from C. lanceolata for the first time.
4.A Case of Severe Hypercalcemia after Treatment with Teriparatide for Osteoporosis.
Ja Won KOO ; Jung Hoon LEE ; Na Eun JANG ; Hyuck KIM ; Hwa Young SEOK ; Ye Ri SO ; A Ri SHIN ; Joo Hee CHO ; Sang Ho LEE
Korean Journal of Bone Metabolism 2012;19(1):53-58
Recombinant human parathyroid hormone 1-34 (rHPTH; 1-34, teriparatide) increases bone mass and increases osteoporotic fracture by stimulating new bone formation. It was approved in the United States for treatment of osteoporosis in men and women, and its effectiveness and safety was proved. Mild hypercalcemia was observed, but persistent and severe hypercalcemia was not observed in the studies of teriparatide. In this case, severe hypercalcemia was developed from patient having gait disturbance who was treated with vitamin D, calcium and teripartide for two months to treat osteoporosis after subtrochanteric fracture. Hypercalcemia was resolved with discontinuation of teriparatide. Severe hypercalcemia is not a common complication of teriparatide and monitoring of serum calcium level is routinely not recommended. But it is necessary to pay close attention to patients who were treated with teriparatide, especially in immobilized patients.
Calcium
;
Female
;
Gait
;
Humans
;
Hypercalcemia
;
Male
;
Osteogenesis
;
Osteoporosis
;
Osteoporotic Fractures
;
Parathyroid Hormone
;
Teriparatide
;
United States
;
Vitamin D
5.A Case of Severe Hypercalcemia after Treatment with Teriparatide for Osteoporosis.
Ja Won KOO ; Jung Hoon LEE ; Na Eun JANG ; Hyuck KIM ; Hwa Young SEOK ; Ye Ri SO ; A Ri SHIN ; Joo Hee CHO ; Sang Ho LEE
Korean Journal of Bone Metabolism 2012;19(1):53-58
Recombinant human parathyroid hormone 1-34 (rHPTH; 1-34, teriparatide) increases bone mass and increases osteoporotic fracture by stimulating new bone formation. It was approved in the United States for treatment of osteoporosis in men and women, and its effectiveness and safety was proved. Mild hypercalcemia was observed, but persistent and severe hypercalcemia was not observed in the studies of teriparatide. In this case, severe hypercalcemia was developed from patient having gait disturbance who was treated with vitamin D, calcium and teripartide for two months to treat osteoporosis after subtrochanteric fracture. Hypercalcemia was resolved with discontinuation of teriparatide. Severe hypercalcemia is not a common complication of teriparatide and monitoring of serum calcium level is routinely not recommended. But it is necessary to pay close attention to patients who were treated with teriparatide, especially in immobilized patients.
Calcium
;
Female
;
Gait
;
Humans
;
Hypercalcemia
;
Male
;
Osteogenesis
;
Osteoporosis
;
Osteoporotic Fractures
;
Parathyroid Hormone
;
Teriparatide
;
United States
;
Vitamin D
6.A Case of Adrenocortical Carcinoma Secreting Cortisol, Androgen and Aldosterone.
Jae Ho CHOI ; Ye Ri SO ; Yu Chul HWANG ; In Kyung JEONG ; Kyu Jeung AHN ; Ho Yeon CHUNG ; Seung Ae YANG
Endocrinology and Metabolism 2011;26(3):239-242
Primary adrenocortical carcinoma is a rare tumor, and is characterized by a peri-tumor mass effect and hormone excess signs. Adrenocortical carcinoma most commonly secretes cortisol, but tumors that secrete other adrenal hormones (aldosterone, androgen) are rare. Herein, we report the case of a 70-year-old woman with cortisol, androgen, and aldosterone-secreting adrenal carcinoma. The patient complained of generalized weakness, moon face, and central obesity. On laboratory examination, hypokalemia and metabolic alkalosis was detected. On the hormone test, cortisol, DHEA-S, and aldosterone were all increased. Abdominal CT showed a large right adrenal mass. She underwent right adrenalectomy and the histology revealed the presence of an adrenocortical carcinoma. After adrenalectomy, the patient was treated with hydrocortisone and mitotane.
Adrenalectomy
;
Adrenocortical Carcinoma
;
Aged
;
Aldosterone
;
Alkalosis
;
Cushing Syndrome
;
Female
;
Humans
;
Hydrocortisone
;
Hypokalemia
;
Mitotane
;
Obesity, Abdominal
7.A Case of Fulminant Type 1 Diabetes Mellitus with Human Leukocyte Antigen DR4-DQ4.
Ye Ri SO ; Ja Won KOO ; Young Hak CHO ; You Cheol HWANG ; Kyu Jeung AHN ; Ho Yeon CHUNG ; In Kyung JEONG
Endocrinology and Metabolism 2012;27(4):314-317
The clinical characteristics of fulminant type 1 diabetes are abrupt onset of disease, very short (<1 week) duration of diabetic symptoms, ketoacidosis at diagnosis, negativity for islet-related autoantibodies, virtually no C-peptide secretion (fasting plasma C-peptide <0.3 ng/mL), a near normal hemoglobin A1c (HbA1c) level and an elevated serum pancreatic enzyme level. The pathogenesis has not yet been clarified, however the involvement of both genetic background and viral infections has been suggested. We reported a case of fulminant type 1 diabetes. A 37-year-old woman was admitted with stuporous consciousness to our hospital. Four days prior to the admission, she was hospitalized with the diagnosis of acute pancreatitis in another hospital, and at that time her glucose level was 79 mg/dL. Three days after the hospitalization, her state of consciousness became stuporous and she was transferred to our hospital. The laboratory results were as follows: pH 6.94, glucose 1,602 mg/dL, and HbA1c 5.5%. She was negative for islet-related autoantibodies and viral antibodies. HLA haplotypes were DRB1*04:05/*04:06, DQB1*03:02/*04:01 which might be a considerable risk allele for fulminant type 1 diabetes. She was diagnosed with fulminant type 1 diabetes, and has been treated with multiple component insulin regimens.
Adult
;
Alleles
;
Antibodies, Viral
;
Autoantibodies
;
C-Peptide
;
Consciousness
;
Diabetes Mellitus, Type 1
;
Female
;
Glucose
;
Haplotypes
;
Hemoglobins
;
HLA Antigens
;
Hospitalization
;
Humans
;
Hydrogen-Ion Concentration
;
Insulin
;
Ketosis
;
Leukocytes
;
Pancreatitis
;
Plasma
;
Stupor
8.A Comparative Study of Anxiety, Pain and Maternal-fetal Attachment between Women who became Pregnant after Infertility Treatment and became Pregnant Naturally.
Hee Ja YOON ; Seung Shin LEE ; Song Hee YE ; Ah Reum HAN ; So Ri LIM ; Hyun Jung CHUNG ; Jum Mi PARK
Korean Journal of Women Health Nursing 2016;22(2):71-77
PURPOSE: This study was a comparative study to understand the levels of anxiety, pain and maternal-fetal attachment between women who became pregnant after infertility treatment and became pregnant naturally. METHODS: This study used a comparative survey design. Data were collected by 50 couples of natural pregnancy and of who became pregnant after infertility treatment who visited delivery room in C Medical hospital, Seoul. These couples were to have first baby, and cervix dilatation of women was less than 3 cm regardless of diagnosis. RESULTS: The score of anxiety of infertile women was significantly higher than that of naturally pregnant women; however, that of spouses showed no difference. The pain score for infertile women was significantly higher in both the active and transition phases. Pain scores that reported by their spouses did not show differences in either phase. The score of maternal-fetal attachment showed no difference between two groups of women. CONCLUSION: The result showed the importance of nursing intervention to reduce women's anxiety and pain, through both antenatal-childbirth education programs and assertive nursing interventions. It is necessary to develop and evaluate new intervention which would be more effective for reducing pain and anxiety for couples who became pregnant after infertility treatment.
Anxiety*
;
Cervix Uteri
;
Delivery Rooms
;
Diagnosis
;
Dilatation
;
Education
;
Family Characteristics
;
Female
;
Humans
;
Infertility*
;
Nursing
;
Pregnancy
;
Pregnant Women
;
Seoul
;
Spouses
9.A case of mammary-like glands carcinoma of the vulva.
Young Saeng KIM ; Bon Ho KU ; Yu Kyung CHOI ; Jong Hun KIM ; Hee Jung SOHN ; So Ya PAIK ; Ye Ri LEE
Korean Journal of Medicine 2009;76(5):605-610
Mammary-like glands are poorly recognized structures of normal vulvar skin. Here, we report the first case of primary mammary-like gland adenocarcinoma of the vulva in Korea and discuss the differential diagnosis and treatment of this rare tumor. A 62-year-old woman presented with an itching sensation and palpable mass of the vulva. Abdominal computed tomography showed multiple variable-sized nodules with peripheral rim enhancement in the liver. The pathology of the vulva and liver lesions was consistent with invasive ductal carcinoma of the breast, with positive staining for estrogen receptors, progesterone receptors, HER-2, and GCDFP-15. Ultrasonography and magnetic resonance imaging of the breast were normal. Given the histological findings in conjunction with the absence of a breast lesion, a diagnosis of primary mammary-like gland adenocarcinoma of the vulva was made. She died of pneumonia 7 weeks after the diagnosis.
Adenocarcinoma
;
Breast
;
Carcinoma, Ductal
;
Diagnosis, Differential
;
Female
;
Humans
;
Korea
;
Liver
;
Magnetic Resonance Imaging
;
Middle Aged
;
Pneumonia
;
Pruritus
;
Receptors, Estrogen
;
Receptors, Progesterone
;
Sensation
;
Skin
;
Vulva
10.A Case of Early Adenocarcinoma at Esophagogastric Junction Treated with Cap-pitted Endoscopic Mucosal Resection.
Ye Ri SO ; Dae Ho KIM ; Hyun A YUN ; Hwa Young SEOK ; Seong Hun HONG ; Sang Wan JUNG ; Jae Myung CHA ; Joung Il LEE ; Kwang Ro JOO ; Hyun Phil SHIN ; Jae Jun PARK ; Jung Won JEOUN
The Ewha Medical Journal 2012;35(2):124-128
Surgery is the primary treatment for adenocarcinoma originating from the esophagogastric junction. However, many physicians attempt various endoscopic treatments for the cases of early adenocarcinoma and high-grade dysplasia of esophagogastric junction in order to avoid the high risk of complications associated with surgical resection. Recently, there is an increasing tendency to use endoscopic mucosal resection for the management of early esophageal cancer due to low morbidity and mortality rates. We report here on a case of early adenocarcinoma at esophagogastric junction successfully treated with endoscopic mucosal resection.
Adenocarcinoma
;
Endoscopy
;
Esophageal Neoplasms
;
Esophagogastric Junction