For the purpose of elucidating relation between red cell electrolyte concentrations and serum digoxin level, measurement of red cell electrolyte concentrations and seum digoxin level by radioimmunoassay were done in 46 normal controls and 63 patients of CHF including 8 patients with digitalis intoxication. The results obtained were as follows: 1. Red cell sodium concentration and ratio of red cell sodium to red cell potassium concentration in normal males were significantly higher than those of females, and red cell potassium concentration in normal males was significantly lower than that of normal females. 2. Red cell potassium concentration in patients of CHF was significantly higher than that of normal controls, but there was no difference in the red cell sodium concentration between the groups. 3. There was no relation between red cell electrolyte concentrations and serum digoxin level, and red cell electrolyte concentration did not exactly estimate serum digoxin level. 4. Red cell electrolyte concentrations in the patient of CHF were valuable in detecting digitalis toxicity.
Digitalis ; Digoxin* ; Female ; Humans ; Male ; Potassium ; Radioimmunoassay ; Sodium

No abstract available.
Flail Chest*

No abstract available.
Aortic Stenosis, Supravalvular*

No abstract available.
Animals ; Cloning, Molecular* ; Interleukin-2* ; Mice*

Purpose: To determine the incidence and the time to failure of repaired short external rotator muscles through aposterolateral approach in total hip arthroplasties; and to describe the correlation between failure of the repaired short external rotator muscles and the hip dislocation rate. Materials and Methods: Between January 2003 and October 2003, 51 patients (55 cases) were treated with primary, uncemented total hip arthroplasties. The average patient`s age was 51 years (33 men, 19 women). After the short external rotator muscles were repaired, two 26-gauge wires were stitched as a marker to the abductor tendons and short external rotator tendons. The distance between the two opposing reference points was less than 1.2 cm. The distance between the markers was determined on radiographs that were obtained 1 day, 2 weeks, and 3 months post-operatively. A distance of more than 2.5 cm, or an invisible one, indicated failure. Results: Of a total of 52 repaired short external rotator muscles, 45 (86.5%) failed. Twenty-five(48.1%) failed within the first day, 15 (28.8%) within 2 weeks, and 5 (9.6%) within 3 months post-operatively. Regardless of the time of failure of the repaired short external rotator muscles, postoperative hip dislocations did not occur. Conclusion: The repair of short external rotator muscles after total hip arthroplasties has a high failure rate and contributes little to the prevention of hip dislocations.
Arthroplasty ; Arthroplasty, Replacement, Hip* ; Hip ; Hip Dislocation ; Humans ; Incidence ; Male ; Muscles* ; Tendons

Essential thrombocythemia in childhood is a rare clonal myeloproliferative disorder in the multipotent stem cell origin and is associated with an increased risk of thrombohemorrhagic complications. The one of diagnostic criteria is a platelet count of more than 600,000/mm3. We diagnosed this disease in 8 year old boy incidentally and treated with hydroxyurea. We report a case of essential thrombocythemia to summarize the current trends in the diagnosis and management with a brief review of related literatures.
Child ; Diagnosis ; Humans ; Hydroxyurea ; Male ; Multipotent Stem Cells ; Myeloproliferative Disorders ; Platelet Count ; Thrombocythemia, Essential*

PURPOSE: This study was aimed to investigate age-related changes of CD5+ B lymphocytes in healthy Korean neonates. METHODS: Sixty healthy neonatal infants were enrolled in this study; at birth(n=10), day 1(n=10), day 2(n=10), day 3(n=10), day 4 (n=10) and day 5 (n=10). Phenotypic analysis of CD5+ B lymphocytes was performed on blood samples using standard flow-cytometric techniques. RESULTS: The percentage of lymphocyte was significantly increased from at birth to day 5. The percentage of CD19+ lymphocyte was decreased from at birth to day 4, but statistically not significant. The percentage of CD5+ /CD19- lymphocyte on day 5 was significantly lower than that of at birth. The percentage of CD5-/CD19+ lymphocyte was not changed. The percentage of CD5+ /CD19- lymphocyte on day 1 was significantly higher than that of at birth, then it gradually decreased with aging to the at birth figure. The percentage of CD5+ /CD19+ lymphocyte was decreased from at birth to day 5, but the changes were not significant. The percentage of CD5+ / CD19+ lymphocyte in CD19+ lymphocyte was decreased from at birth to day 5, but it was not statistically significant. CONCLUSION: CD5+ B lymphocyte counts are considerably higher than previously established adult values and the age-related changes are very important in interpretating CD5+ B lymphocyte. These data may serve as a reference range for studies in early neonatal period.
Adult ; Aging ; B-Lymphocytes* ; Humans ; Infant ; Infant, Newborn ; Lymphocyte Count ; Lymphocyte Subsets ; Lymphocytes ; Parturition ; Reference Values

BACKGROUND AND OBJECTIVES: Many people experience problems with a dry nasal mucous membrane, often without wondering why. The cause of problem is known as rhinitis sicca, senile rhinitis, and atrophic rhinitis, etc. A common form of treatment for patients who have such symptoms has been to begin by rinsing the inside of the nose with saline solution, to drop peanut oil, to apply antibiotic-ointment and moisturizing agents. Lanolin has been know as a safe skin moisturizing agent and used to treat dry nose. The purpose of this study was to evaluate the effect of lanolin on a group of patients seeking treatment for dryness of the nose. MATERIAL AND METHODS: Ninety-three patients experiencing problems with dry nasal mucosa were selected from the out-patient clinic. Fifty-seven patients, average age 36.3 years old, were treated with 1:2 mixture of lanolin and vaseline ointment. Thirty-six patients, average age 32.0 years, were treated with vaseline ointment. Both ointments were applied three times a day for two weeks. The efficacy of treatment was determined with pre and post-treatment six symptoms on a visual analogue scale: nasal obstruction, crust formation, mucosal dryness, respiratory discomfort, sleep disturbance, and general discomfort. RESULTS: For subjects treated with lanolin, the average VAS value for nasal obstruction was 5.84+/-2.28 and it decreased to 2.89+/-1.29, while the corresponding values for subjects treated with vaseline were 4.39+/-1.77 decreasing to 3.11+/- 1.24 (p<0.05). Crust formation of lanolin treated subjects were 5.67+/-2.39 and it decreased to 2.09+/-1.46, while the vaseline treated subjects were 4.83+/-1.99 decreasing to 2.33+/-1.31 (p<0.05). Average total symptom improvement was 65.7% (from 27.95+/-9.30 to 9.86+/-4.58) in lanolin treated group, while it was 44.8% (from 20.9+/-76.59 to 11.64+/-4.18) in vaseline treated group. CONCLUSION: We found that the efficacy of lanolin was statistically signigicantly better than that of vaseline. During the study period, there was no local reactions have been reported, nor have any allergic reactions. The present study underlines the fact that the way to treat nasal mucosal dryness is to use lanolin ointment.
Humans ; Hypersensitivity ; Lanolin* ; Mucous Membrane ; Nasal Mucosa ; Nasal Obstruction ; Nose* ; Ointments ; Outpatients ; Petrolatum ; Rhinitis ; Rhinitis, Atrophic ; Skin ; Sodium Chloride

Melanocytic nevus may be histologically associated with clefts or slits of nests, resembling lymphatic or vascular spaces. This unique histologic feature is known as an artifact of injection or tissue processing. The pseudovascular space may resemble the lymphatic invasion of malignant melanoma. Therefore it is important that dermatologists are aware of this histologic variant of melanoctic nevus in order to prevent misdiagnosis. We report three cases of melanocytic nevi with pseudovascular spaces in a 48-year-old, 43-year-old and 44-year-old women. Histologic examination of one case identified a compound melanocytic nevus and two cases identified intradermal nevi. Nevus cell nests were clustered in the dermis or dermoepidermal junction. Vessel-like spaces also were seen in the nevus cell nest. Immunohistochemically, the cells lining the pseudovascular space were positive for S-100 protein, and negative for factor VIII-related antigen and CD31 stain. We concluded that these spaces were lined by nevomelanocytes and were not truly vascular. We herein report on three melanocytic nevi with pseudovascular spaces.
Adult ; Artifacts ; Dermis ; Diagnostic Errors ; Female ; Humans ; Melanoma ; Middle Aged ; Nevus ; Nevus, Intradermal ; Nevus, Pigmented* ; S100 Proteins ; von Willebrand Factor

Chemotherapy-induced acral erythema (CIAE) is a toxic reaction to a number of different chemotherapeutic agents, and causes symmetrical, well-demarcated, painful erythema on the palms and soles which is self-limiting. CIAE with bullous reaction in relation to methotrexate has been reported, but it is more commonly associated with cytosine arabinoside. The differential diagnosis of this condition from more serious conditions such as graft-vs-host disease or toxic epidermal necrolysis is essential. In this paper, we report the case of a 65-year-old man who developed bullous acral erythema after the administration of high-dose methotrexate for the treatment of Non-Hodgkin's lymphoma.
Aged ; Cytarabine ; Diagnosis, Differential ; Erythema* ; Graft vs Host Disease ; Hand-Foot Syndrome ; Humans ; Lymphoma, Non-Hodgkin ; Methotrexate ; Stevens-Johnson Syndrome